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Influenza A Virus Subtype H7N9
Influenza A virus subtype H7N9 (A/H7N9) is a bird flu strain of the species Influenza virus A (avian influenza virus or bird flu virus). Avian influenza A H7 viruses normally circulate amongst avian populations with some variants known to occasionally infect humans. An H7N9 virus was first reported to have infected humans in March 2013, in China. Cases continued to be reported throughout April and then dropped to only a few cases during the summer months. At the closing of the year, 144 cases had been reported of which 46 had died.WHO: Global Alert and Response: Human infection with avian influenza A(H7N9) virus – update
(accessed November 7, 2013)
It is known that influenza tends to strike during the winter months, and the second wave, w ...
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Anhui
Anhui , (; formerly romanized as Anhwei) is a landlocked province of the People's Republic of China, part of the East China region. Its provincial capital and largest city is Hefei. The province is located across the basins of the Yangtze River and the Huai River, bordering Jiangsu to the east, Zhejiang to the southeast, Jiangxi to the south, Hubei to the southwest, Henan to the northwest, and Shandong for a short section in the north. With a population of 63.65 million, Anhui is the 8th most populous province in China. It is the 22nd largest Chinese province based on area, and the 12th most densely-populated region of all 34 Chinese provincial regions. Anhui's population is mostly composed of Han Chinese. Languages spoken within the province include Jianghuai Mandarin, Wu, Hui, Gan and small portion of Zhongyuan Mandarin Chinese. The name "Anhui" derives from the names of two cities: Anqing and Huizhou (now Huangshan City). The abbreviation for Anhui is "" after the histo ...
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Viral Neuraminidase
Viral neuraminidase is a type of neuraminidase found on the surface of influenza viruses that enables the virus to be released from the host cell. Neuraminidases are enzymes that cleave sialic acid (also called neuraminic acid) groups from glycoproteins. Neuraminidase inhibitors are antiviral agents that inhibit influenza viral neuraminidase activity and are of major importance in the control of influenza. Viral neuraminidases are the members of the glycoside hydrolase family 3CAZY GH_34which comprises enzymes with only one known activity; sialidase or neuraminidase . Neuraminidases cleave the terminal sialic acid residues from carbohydrate chains in glycoproteins. Sialic acid is a negatively charged sugar associated with the protein and lipid portions of lipoproteins. To infect a host cell, the influenza virus attaches to the exterior cell surface using hemagglutinin, a molecule found on the surface of the virus that binds to sialic acid groups. Sialic acids are found ...
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Keiji Fukuda
is a Japanese-American physician and epidemiologist, specializing in influenza epidemiology. He was an Assistant Director-General of the World Health Organization (WHO) from 2009 to 2016, and the Director of the School of Public Health at the University of Hong Kong (HKU) between 2017 and 2021. Early life and education Fukuda was born in Tokyo, Japan, to a physician family. His parents were physicians; his father, David Minoru Fukuda, was an anesthesiologist and his mother, Michiko Fukuda (née Nakamura) was an obstetrician-gynecologist, although she did not practice in the United States. The Fukudas immigrated from Japan to Vermont in 1955, and the senior Fukuda started practicing anesthesiology in Barre, Vermont, in 1957. Fukuda's mother passed away in 1993 and his father in 2006. Fukuda's older sister, Mariko, is a teacher and his younger brother, Christopher, is a urologist. At the urging of one of his high school teachers, Fukuda went to Oberlin College in 1973 for u ...
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Bird Migration
Bird migration is the regular seasonal movement, often north and south along a flyway, between breeding and wintering grounds. Many species of bird migrate. Migration carries high costs in predation and mortality, including from hunting by humans, and is driven primarily by the availability of food. It occurs mainly in the northern hemisphere, where birds are funneled onto specific routes by natural barriers such as the Mediterranean Sea or the Caribbean Sea. Migration of species such as storks, turtle doves, and swallows was recorded as many as 3,000 years ago by Ancient Greek authors, including Homer and Aristotle, and in the Book of Job. More recently, Johannes Leche began recording dates of arrivals of spring migrants in Finland in 1749, and modern scientific studies have used techniques including bird ringing and satellite tracking to trace migrants. Threats to migratory birds have grown with habitat destruction, especially of stopover and wintering sites, a ...
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East Asian – Australasian Flyway
East or Orient is one of the four cardinal directions or points of the compass. It is the opposite direction from west and is the direction from which the Sun rises on the Earth. Etymology As in other languages, the word is formed from the fact that east is the direction where the Sun rises: ''east'' comes from Middle English ''est'', from Old English ''ēast'', which itself comes from the Proto-Germanic *''aus-to-'' or *''austra-'' "east, toward the sunrise", from Proto-Indo-European *aus- "to shine," or "dawn", cognate with Old High German ''*ōstar'' "to the east", Latin ''aurora'' 'dawn', and Greek ''ēōs'' 'dawn, east'. Examples of the same formation in other languages include Latin oriens 'east, sunrise' from orior 'to rise, to originate', Greek ανατολή anatolé 'east' from ἀνατέλλω 'to rise' and Hebrew מִזְרָח mizraḥ 'east' from זָרַח zaraḥ 'to rise, to shine'. ''Ēostre'', a Germanic goddess of dawn, might have been a personificatio ...
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Influenza A Virus Subtype H9N2
Influenza A virus subtype H9N2 (A/H9N2) is a subtype of the species Influenza A virus ( bird flu virus). Since 1998 a total of 86 cases of human infection with H9N2 viruses have been reported. Infection in birds H9N2 is the most common subtype of influenza viruses in Chinese chickens and thus causes great economic loss for the poultry industry, even under the long-term vaccination programs. Recent human infections with avian influenza virus revealed that H9N2 is the gene donor for H7N9 and H10N8 viruses that are infecting humans too. The crucial role of H9N2 viruses due to the wide host range, adaptation to both poultry and mammals and extensive gene reassortment. In China, which is regarded as a breeding ground of avian influenza viruses, the H9N2 virus has been detected in multiple avian species, including chicken, duck, quail, pheasant, partridge, pigeon, silky chicken, chukar and egret. Epidemiological and genetic studies revealed that the hemagglutinin (HA) gene of the H ...
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China
China, officially the People's Republic of China (PRC), is a country in East Asia. It is the world's most populous country, with a population exceeding 1.4 billion, slightly ahead of India. China spans the equivalent of five time zones and borders fourteen countries by land, the most of any country in the world, tied with Russia. Covering an area of approximately , it is the world's third largest country by total land area. The country consists of 22 provinces, five autonomous regions, four municipalities, and two Special Administrative Regions (Hong Kong and Macau). The national capital is Beijing, and the most populous city and financial center is Shanghai. Modern Chinese trace their origins to a cradle of civilization in the fertile basin of the Yellow River in the North China Plain. The semi-legendary Xia dynasty in the 21st century BCE and the well-attested Shang and Zhou dynasties developed a bureaucratic political system to serve hereditary monarchies, or ...
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United States
The United States of America (U.S.A. or USA), commonly known as the United States (U.S. or US) or America, is a country primarily located in North America. It consists of 50 states, a federal district, five major unincorporated territories, nine Minor Outlying Islands, and 326 Indian reservations. The United States is also in free association with three Pacific Island sovereign states: the Federated States of Micronesia, the Marshall Islands, and the Republic of Palau. It is the world's third-largest country by both land and total area. It shares land borders with Canada to its north and with Mexico to its south and has maritime borders with the Bahamas, Cuba, Russia, and other nations. With a population of over 333 million, it is the most populous country in the Americas and the third most populous in the world. The national capital of the United States is Washington, D.C. and its most populous city and principal financial center is New York City. Paleo-Americ ...
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Japan
Japan ( ja, 日本, or , and formally , ''Nihonkoku'') is an island country in East Asia. It is situated in the northwest Pacific Ocean, and is bordered on the west by the Sea of Japan, while extending from the Sea of Okhotsk in the north toward the East China Sea, Philippine Sea, and Taiwan in the south. Japan is a part of the Ring of Fire, and spans Japanese archipelago, an archipelago of List of islands of Japan, 6852 islands covering ; the five main islands are Hokkaido, Honshu (the "mainland"), Shikoku, Kyushu, and Okinawa Island, Okinawa. Tokyo is the Capital of Japan, nation's capital and largest city, followed by Yokohama, Osaka, Nagoya, Sapporo, Fukuoka, Kobe, and Kyoto. Japan is the List of countries and dependencies by population, eleventh most populous country in the world, as well as one of the List of countries and dependencies by population density, most densely populated and Urbanization by country, urbanized. About three-fourths of Geography of Japan, the c ...
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Netherlands
) , anthem = ( en, "William of Nassau") , image_map = , map_caption = , subdivision_type = Sovereign state , subdivision_name = Kingdom of the Netherlands , established_title = Before independence , established_date = Spanish Netherlands , established_title2 = Act of Abjuration , established_date2 = 26 July 1581 , established_title3 = Peace of Münster , established_date3 = 30 January 1648 , established_title4 = Kingdom established , established_date4 = 16 March 1815 , established_title5 = Liberation Day , established_date5 = 5 May 1945 , established_title6 = Kingdom Charter , established_date6 = 15 December 1954 , established_title7 = Caribbean reorganisation , established_date7 = 10 October 2010 , official_languages = Dutch , languages_type = Regional languages , languages_sub = yes , languages = , languages2_type = Recognised languages , languages2_sub = yes , languages2 = , demonym = Dutch , capital = Amsterdam , largest_city = capital , ...
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Influenza A Virus Subtype H7N7
Influenza A virus subtype H7N7 (A/H7N7) is a subtype of Influenza A virus, a genus of Orthomyxovirus, the viruses responsible for influenza. Highly pathogenic strains (HPAI) and low pathogenic strains (LPAI) exist. H7N7 can infect humans, birds, pigs, seals, and horses in the wild; and has infected mice in laboratory studies. This unusual zoonotic potential represents a pandemic threat. In 2003, 89 people in the Netherlands were confirmed to have been infected by H7N7 following an outbreak in poultry on approximately 255 farms. One death was recorded - a veterinarian who had been testing chickens for the virus - and all infected flocks were culled. Most affected people had mild symptoms including conjunctivitis. Antibodies were found in over half of 500 people tested according to the final official report by the Dutch government: As at least 50% of the people exposed to infected poultry had H7 antibodies detectable with the modified assay, it was estimated that avian influenz ...
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Influenza A Virus Subtype H7N3
Influenza A virus subtype H7N3 (A/H7N3) is a subtype of the species Influenza A virus (sometimes called bird flu virus). In North America, the presence of H7N3 was confirmed at several poultry farms in British Columbia in February 2004; flocks were culled to halt the spread of the virus. Two humans, both poultry workers, were infected and had symptoms including conjunctivitis and mild influenza-like illness. Both fully recovered and were treated with oseltamivir. In 1963, H7N3 was first found in Britain, in turkeys. For the first time since 1979, H7N3 was found in the UK in April 2006. It infected birds and one poultry worker (whose only symptom was conjunctivitis) in a Norfolk, England Witford Lodge Farm. Oseltamivir was used for prevention and 35,000 chickens were culled. In 2005, H7N3 was detected in migratory bird droppings in Taiwan. On September 27, 2007, another outbreak of H7N3 was detected in a poultry operation in Saskatchewan, Canada. The Canadian Food Inspection ...
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