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Idorsia
Idorsia is a Swiss pharmaceutical research company in Allschwil, near Basel, Switzerland. After Actelion was bought by Johnson & Johnson Johnson & Johnson (J&J) is an American multinational corporation founded in 1886 that develops medical devices, pharmaceuticals, and consumer packaged goods. Its common stock is a component of the Dow Jones Industrial Average and the company i ... in 2017, the Actelion founders, Jean-Paul and Martine Clozel, started their new business, located just across the road from the Actelion headquarters. The company expects to be profitable in 2025. Products Table current as of May 2, 2022, listing the drugs that have reached at least phase 3 trials. References {{Finance links , name = Idorsia AG , symbol = , reuters = IDIA.S , bloomberg = IDIA:SW , sec_cik = , yahoo = IDIA.SW , google = Pharmaceutical companies of Switzerland Swiss companies established in 2017 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Daridorexant
Daridorexant, sold under the brand name Quviviq, is an orexin antagonist medication which is used for the treatment of insomnia. Daridorexant is taken by mouth. Side effects of daridorexant include headache, somnolence, and fatigue. The medication is a dual orexin receptor antagonist (DORA). It acts as a selective dual antagonist of the orexin receptors OX1 and OX2. Daridorexant has a relatively short elimination half-life of 8hours and a time to peak of about 1 to 2hours. It is not a benzodiazepine or Z-drug and does not interact with GABA receptors, instead having a distinct mechanism of action. Daridorexant was approved for medical use in the United States in January 2022 and became available in May 2022. It was approved in the European Union in April 2022, and is the first orexin receptor antagonist to become available in European Union. The medication is a schedule IV controlled substance in the United States and may have a modest potential for misuse. Besides ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Daridorexant
Daridorexant, sold under the brand name Quviviq, is an orexin antagonist medication which is used for the treatment of insomnia. Daridorexant is taken by mouth. Side effects of daridorexant include headache, somnolence, and fatigue. The medication is a dual orexin receptor antagonist (DORA). It acts as a selective dual antagonist of the orexin receptors OX1 and OX2. Daridorexant has a relatively short elimination half-life of 8hours and a time to peak of about 1 to 2hours. It is not a benzodiazepine or Z-drug and does not interact with GABA receptors, instead having a distinct mechanism of action. Daridorexant was approved for medical use in the United States in January 2022 and became available in May 2022. It was approved in the European Union in April 2022, and is the first orexin receptor antagonist to become available in European Union. The medication is a schedule IV controlled substance in the United States and may have a modest potential for misuse. Besides ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Martine Clozel
Martine Clozel (born 27 December 1955) is a scientist, entrepreneur and co-founder of Actelion and Idorsia. Education and career Clozel studied at the University of Nancy and the University of California in San Francisco. She also attended further training in physiology and pharmacology at McGill University. In 1997, she founded Actelion with her husband Jean-Paul Clozel. The company was sold in 2017 to the American pharmaceutical and consumer products company Johnson & Johnson for US$30 billion. Martine Clozel founded the pharmaceutical company Idorsia in 2017 and has since served as head of research. She is one of the most successful female company founders in Switzerland. Awards * Officer of the Legion of Honour The National Order of the Legion of Honour (french: Ordre national de la Légion d'honneur), formerly the Royal Order of the Legion of Honour ('), is the highest French order of merit, both military and civil. Established in 1802 by Napoleon ... * Prix Sui ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clazosentan
Clazosentan (INN, trade name Pivlaz) is a drug belonging to the class of endothelin receptor antagonists. Mechanism The endothelin 1 receptor is one of the strongest known vasoconstrictors. After subarachnoidal bleedings, irritation of the blood vessels can lead to a vasospasm and thus to an ischaemia, an insufficient blood supply to brain tissue. One possible effect of this is, in turn, an ischaemic stroke. Trials In a randomized trial with patients who had aneurysmal subarachnoid bleeding and were being treated with endovascular coiling Endovascular coiling is an endovascular treatment for intracranial aneurysms and bleeding throughout the body. The procedure reduces blood circulation to the aneurysm through the use of microsurgical detachable platinum wires, with the clinician in ..., 15 mg/h clazosentan significantly reduced vasospasm-related morbidity and all-cause mortality. Clazosentan, however, did not improve the neurological outcome as measured by the extende ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clazosentan
Clazosentan (INN, trade name Pivlaz) is a drug belonging to the class of endothelin receptor antagonists. Mechanism The endothelin 1 receptor is one of the strongest known vasoconstrictors. After subarachnoidal bleedings, irritation of the blood vessels can lead to a vasospasm and thus to an ischaemia, an insufficient blood supply to brain tissue. One possible effect of this is, in turn, an ischaemic stroke. Trials In a randomized trial with patients who had aneurysmal subarachnoid bleeding and were being treated with endovascular coiling Endovascular coiling is an endovascular treatment for intracranial aneurysms and bleeding throughout the body. The procedure reduces blood circulation to the aneurysm through the use of microsurgical detachable platinum wires, with the clinician in ..., 15 mg/h clazosentan significantly reduced vasospasm-related morbidity and all-cause mortality. Clazosentan, however, did not improve the neurological outcome as measured by the extende ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Actelion
Actelion is a pharmaceuticals and biotechnology company established in December 1997, headquartered in Allschwil near Basel, Switzerland. Actelion focuses on the manufacture of drugs that treat rare diseases and orphan diseases. Some of the drugs it has produced have been used to treat patients with symptoms related to central nervous system disorders, irregular heart conditions, immune system disorders and cancer. One of the focuses of Actelion is treating individuals with pulmonary arterial hypertension (PAH), a heart condition that leaves patients with a short life expectancy (7–9 years) even with treatment. Actelion scientists were among the first to work in the field of endothelian receptor antagonists. Actelion was initially financed with venture capital provided through a syndicate including Atlas Venture, Sofinnova and HealthCap. Actelion develops and sells drugs in the continents of Asia, Europe and North and South America. Actelion has 29 operative affiliates ar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Swiss Performance Index
The Swiss Performance Index (SPI) is a wide total-return index that tracks equity primarily listed on SIX Swiss Exchange with a free-float of at least 20%, and excluding investment companies. The index covers large, mid and small caps and is weighted by market capitalization. Most constituents, although not all, are domiciled in Switzerland or the Principality of Liechtenstein. The SPI is Switzerland's most closely followed performance index. It is used as a benchmark for mutual funds, index funds and ETFs, and as an underlying index for derivative financial instruments such as options, futures and structured products. In 2020, the SPI, along with other SIX indices, was endorsed under the EU Benchmarks Regulation and is registered with the European Securities and Markets Authority, which means that it can be used as an underlying for financial products sold in the EU. SPI Universe The underlying share universe of the SPI is the Swiss All Share Index and includes approxima ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Allschwil
, neighboring_municipalities= Baselland (BL), Binningen, Buschwiller (FR-68), Hégenheim (FR-68), Neuwiller (FR-68), Oberwil, Saint-Louis (FR-68), Schönenbuch , twintowns = Pfullendorf (Germany), Blaj (Romania) } Allschwil () is a town and a municipality in the district of Arlesheim in the canton of Basel-Country in Switzerland. Allschwil is a seamless suburb of Basel and is located between Basel to the east and Alsace in France to the west. The official language of Allschwil is (the Swiss variety of Standard) German, but the main spoken language is the local variant of the Alemannic Swiss German dialect. History The modern municipality of Allschwil is first mentioned in 1118 as ''Almswilre''. Prehistoric Allschwil The region around Allschwil has been occupied since at least the Middle Paleolithic. Archeological finds from the municipality include a few scattered Middle Paleolithic items, cups from the Glockenbecherkultur (c. 2400–1800 BC), a mid-Bronze Age hoard ( ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Myocardial Infarction
A myocardial infarction (MI), commonly known as a heart attack, occurs when blood flow decreases or stops to the coronary artery of the heart, causing damage to the heart muscle. The most common symptom is chest pain or discomfort which may travel into the shoulder, arm, back, neck or jaw. Often it occurs in the center or left side of the chest and lasts for more than a few minutes. The discomfort may occasionally feel like heartburn. Other symptoms may include shortness of breath, nausea, feeling faint, a cold sweat or feeling tired. About 30% of people have atypical symptoms. Women more often present without chest pain and instead have neck pain, arm pain or feel tired. Among those over 75 years old, about 5% have had an MI with little or no history of symptoms. An MI may cause heart failure, an irregular heartbeat, cardiogenic shock or cardiac arrest. Most MIs occur due to coronary artery disease. Risk factors include high blood pressure, smoking, diabetes, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fabry Disease
Fabry disease, also known as Anderson–Fabry disease, is a rare genetic disease that can affect many parts of the body, including the kidneys, heart, and skin. Fabry disease is one of a group of conditions known as lysosomal storage diseases. The genetic mutation that causes Fabry disease interferes with the function of an enzyme that processes biomolecules known as sphingolipids, leading to these substances building up in the walls of blood vessels and other organs. It is inherited in an X-linked manner. Fabry disease is sometimes diagnosed using a blood test that measures the activity of the affected enzyme called alpha-galactosidase, but genetic testing is also sometimes used, particularly in females. The treatment for Fabry disease varies depending on the organs affected by the condition, and the underlying cause can be addressed by replacing the enzyme that is lacking. The first descriptions of the condition were made simultaneously by dermatologist Johannes Fabry and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
