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History Of Aspirin
Aspirin (acetylsalicylic acid) is a novel organic compound that does not occur in nature, and was first successfully synthesised in 1899. In 1897, scientists at the drug and dye firm Bayer began investigating acetylated organic compounds as possible new medicines, following the success of acetanilide ten years earlier. By 1899, Bayer created acetylsalicylic acid and named the drug 'Aspirin', going on to sell it around the world. The word ''Aspirin'' was Bayer's brand name, rather than the generic name of the drug; however, Bayer's rights to the trademark were lost or sold in many countries. Aspirin's popularity grew over the first half of the twentieth century, leading to fierce competition with the proliferation of aspirin brands and products. Aspirin's popularity declined after the development of acetaminophen/paracetamol in 1956 and ibuprofen in 1962. In the 1960s and 1970s, John Vane and others discovered the basic mechanism of aspirin's effects, while clinical trials and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acetylsalicylic Acid
Aspirin, also known as acetylsalicylic acid (ASA), is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain, fever, and/or inflammation, and as an antithrombotic. Specific inflammatory conditions which aspirin is used to treat include Kawasaki disease, pericarditis, and rheumatic fever. Aspirin is also used long-term to help prevent further heart attacks, ischaemic strokes, and blood clots in people at high risk. For pain or fever, effects typically begin within 30 minutes. Aspirin works similarly to other NSAIDs but also suppresses the normal functioning of platelets. One common adverse effect is an upset stomach. More significant side effects include stomach ulcers, stomach bleeding, and worsening asthma. Bleeding risk is greater among those who are older, drink alcohol, take other NSAIDs, or are on other blood thinners. Aspirin is not recommended in the last part of pregnancy. It is not generally recommended in children with infections because of the risk of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Edward Stone (clergyman)
Edward Stone (1702–1768) was a Church of England cleric who discovered the active ingredient of aspirin. Life Edward Stone was born in Princes Risborough, Buckinghamshire, England, in 1702. His parents were Edward Stone, a gentleman farmer, and his first wife Elizabeth Reynolds. His mother having died, his father took a second wife, Elizabeth Grubb, in 1707; the Grubb family was to play a major role in Stone's life. Stone went to Wadham College, Oxford, in 1720, where in 1730 he became a Fellow. In 1728 or 1729 he was ordained deacon and priest, and served as curate at Charlton-on-Otmoor. From 1738 Stone held a living at Horsenden, Buckinghamshire, to which he was presented by John Grubb, brother to his stepmother. He married Elizabeth Grubb(e) at Mercers' Hall Chapel, Cheapside (a non-parochial church), London, on 7 July 1741: she was John Grubb's daughter. As was required at that period, Stone resigned as Fellow of Wadham on marrying. In 1745, Stone became chaplain to Si ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thomas John MacLagan
Thomas John MacLagan (1838 – 20 March 1903) was a Scottish doctor and pharmacologist from Perthshire who pioneered the clinical use of thermometers and the use of salicin as an anti-inflammatory and treatment for rheumatism. Personal life MacLagan was born in Scone, Scotland, Scone, Perthshire in 1838. He married Isabella Scudamore, from Kent, in 1869. Between the years of 1870 and 1880 they had four children, three sons and a daughter. Education He attended University of Glasgow, Glasgow University at the age of 15, to study humanities before going on to study medicine at the University of Edinburgh Medical School, University of Edinburgh. He graduated from there with an MD in 1860, entitled 'On Oxaluria'. He then spent two years in Europe, visiting medical schools in Paris, Vienna and Munich, where he learned French and German. Medical career On his return to Britain MacLagan spent a brief period as resident medical officer at a dispensary in Jersey before returning t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Filipendula Ulmaria - Angervaks
''Filipendula'' is a genus of 12 species of perennial herbaceous flowering plants in the family Rosaceae, native to the temperate regions of the Northern Hemisphere. Well-known species include meadowsweet (''Filipendula ulmaria'') and dropwort (''Filipendula vulgaris''), both native to Europe, and queen-of-the-forest (''Filipendula occidentalis'') and queen-of-the-prairie (''Filipendula rubra''), native to North America. The species grow to between 0.5–2 m tall, with large inflorescences of small five-petalled flowers, creamy-white to pink-tinged in most species, dark pink in ''F. rubra''. ''Filipendula'' fruit are unusual, sometimes described as an indehiscent follicle, or as an achene. ''Filipendula'' species are used as food plants by the larvae of some Lepidoptera species: emperor moth, grey pug, grizzled skipper, Hebrew character, lime-speck pug, mottled beauty and the satellite have all been recorded on meadowsweet. The species were in the past sometimes treated ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Salicylic Acid
Salicylic acid is an organic compound with the formula HOC6H4CO2H. A colorless, bitter-tasting solid, it is a precursor to and a metabolite of aspirin (acetylsalicylic acid). It is a plant hormone, and has been listed by the EPA Toxic Substances Control Act (TSCA) Chemical Substance Inventory as an experimental teratogen. The name is from Latin ''salix'' for willow tree. It is an ingredient in some anti-acne products. Salts and esters of salicylic acid are known as salicylates. Uses Medicine Salicylic acid as a medication is commonly used to remove the outer layer of the skin. As such, it is used to treat warts, psoriasis, acne vulgaris, ringworm, dandruff, and ichthyosis. Similar to other hydroxy acids, salicylic acid is an ingredient in many skincare products for the treatment of seborrhoeic dermatitis, acne, psoriasis, calluses, corns, keratosis pilaris, acanthosis nigricans, ichthyosis, and warts. Uses in manufacturing Salicylic acid is used as a food preservative ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Raffaele Piria
Raffaele Piria (Scilla 20 August 1814 – Turin 18 July 1865) was an Italian chemist from Scilla, who lived in Palmi. He converted the substance Salicin into a sugar and a second component, which on oxidation becomes salicylic acid, a major component of the analgesic drug Aspirin (acetylsalicylic acid). Other reactions discovered by Piria were the conversion of aspartic acid to malic acid by action of nitrogen dioxide Nitrogen dioxide is a chemical compound with the formula . It is one of several nitrogen oxides. is an intermediate in the industrial synthesis of nitric acid, millions of tons of which are produced each year for use primarily in the producti ..., and the reaction of aromatic nitro compounds with sulfite towards aminosulfonic acids. References {{DEFAULTSORT:Piria, Raffaele Italian chemists People from Scilla, Calabria People from Palmi 1814 births 1865 deaths University of Pisa faculty ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Filipendula Ulmaria
''Filipendula ulmaria'', commonly known as meadowsweet or mead wort, is a perennial herbaceous plant in the family Rosaceae that grows in damp meadows. It is native throughout most of Europe and Western Asia (Near east and Middle east). It has been introduced and naturalised in North America. Meadowsweet has also been referred to as queen of the meadow, pride of the meadow, meadow-wort, meadow queen, lady of the meadow, dollof, meadsweet, and bridewort. Description The stems, growing up to 120 cm, are tall, erect and furrowed, reddish to sometimes purple. The leaves are dark-green on the upper side and whitish and downy underneath, much divided, interruptedly pinnate, having a few large serrate leaflets and small intermediate ones. Terminal leaflets are large, 4–8 cm long, and three- to five-lobed. Meadowsweet has delicate, graceful, creamy-white flowers clustered close together in irregularly-branched cymes, having a very strong, sweet smell redolent of antisep ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Johann Andreas Buchner
Johann Andreas Buchner (6 April 1783, Munich – 5 June 1852, Munich) was a German pharmacologist working in the area of alkaloids. He was the father of pharmacologist Ludwig Andreas Buchner (1813–1897). He studied at Johann Bartholomäus Trommsdorff's pharmaceutical institute in Erfurt, obtaining his PhD in 1807. In 1809 he became ''Oberapotheker'' of the ''Zentral-Stiftungs-Apotheke'' for hospitals in Munich. In 1818 he was appointed an associate professor of pharmacy, medical formula instruction and toxicology at the University of Landshut, where he later became a full professor of pharmacy (1822). When the university relocated to Munich, he moved back to his home town, where he lived and worked until his death. He is credited with isolating salicin from willow bark (1828) and the discovery of berberine (from the root bark of ''Berberis vulgaris''). New ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alkaloids
Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar structure may also be termed alkaloids. In addition to carbon, hydrogen and nitrogen, alkaloids may also contain oxygen, sulfur and, more rarely, other elements such as chlorine, bromine, and phosphorus.Chemical Encyclopedia: alkaloids xumuk.ru Alkaloids are produced by a large variety of organisms including , , |
Organic Chemistry
Organic chemistry is a subdiscipline within chemistry involving the scientific study of the structure, properties, and reactions of organic compounds and organic materials, i.e., matter in its various forms that contain carbon atoms.Clayden, J.; Greeves, N. and Warren, S. (2012) ''Organic Chemistry''. Oxford University Press. pp. 1–15. . Study of structure determines their structural formula. Study of properties includes physical and chemical properties, and evaluation of chemical reactivity to understand their behavior. The study of organic reactions includes the chemical synthesis of natural products, drugs, and polymers, and study of individual organic molecules in the laboratory and via theoretical ( in silico) study. The range of chemicals studied in organic chemistry includes hydrocarbons (compounds containing only carbon and hydrogen) as well as compounds based on carbon, but also containing other elements, especially oxygen, nitrogen, sulfur, phosphorus (included in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Civil War
The American Civil War (April 12, 1861 – May 26, 1865; also known by other names) was a civil war in the United States. It was fought between the Union ("the North") and the Confederacy ("the South"), the latter formed by states that had seceded. The central cause of the war was the dispute over whether slavery would be permitted to expand into the western territories, leading to more slave states, or be prevented from doing so, which was widely believed would place slavery on a course of ultimate extinction. Decades of political controversy over slavery were brought to a head by the victory in the 1860 U.S. presidential election of Abraham Lincoln, who opposed slavery's expansion into the west. An initial seven southern slave states responded to Lincoln's victory by seceding from the United States and, in 1861, forming the Confederacy. The Confederacy seized U.S. forts and other federal assets within their borders. Led by Confederate President Jefferson Davis, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Peruvian Bark
Jesuit's bark, also known as cinchona bark, Peruvian bark or China bark, is a former remedy for malaria, as the bark contains quinine used to treat the disease. The bark of several species of the genus ''Cinchona'', family Rubiaceae indigenous to the western Andes of South America, was discovered as a folk medicine treatment for malaria by Jesuit missionaries in Peru during the 17th century. History The western history of cinchona bark dates back more than 350 years. Circa 1650, the physician Sebastiano Bado declared that this bark had proved more precious to mankind than all the gold and silver that the Spaniards had obtained from South America. In the 18th century, the Italian professor of medicine Bernardino Ramazzini said that the introduction of Peruvian bark would be of the same importance to medicine that the discovery of gunpowder was to the art of war, an opinion endorsed by contemporary writers on the history of medicine. The value of Jesuit's bark, and the controvers ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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