Thomas John MacLagan (1838 – 20 March 1903) was a Scottish doctor and pharmacologist from

Perthshire Perthshire (locally: ; gd, Siorrachd Pheairt), officially the County of Perth, is a historic county and registration county in central Scotland. Geographically it extends from Strathmore in the east, to the Pass of Drumochter in the north, ...

who pioneered the clinical use of

thermometer A thermometer is a device that temperature measurement, measures temperature or a temperature gradient (the degree of hotness or coldness of an object). A thermometer has two important elements: (1) a temperature sensor (e.g. the bulb of a merc ...

s and the use of

salicin Salicin is an alcoholic β-glucoside. Salicin is produced in (and named after) willow (''Salix'') bark. It is a biosynthetic precursor to salicylaldehyde. Medicinal aspects Salicin is found in the bark of and leaves of willows, poplars and va ...

as an anti-inflammatory and treatment for rheumatism.

Personal life

MacLagan was born in Scone, Perthshire in 1838. He married Isabella Scudamore, from Kent, in 1869. Between the years of 1870 and 1880 they had four children, three sons and a daughter.

Education

He attended Glasgow University at the age of 15, to study humanities before going on to study medicine at the

University of Edinburgh The University of Edinburgh ( sco, University o Edinburgh, gd, Oilthigh Dhùn Èideann; abbreviated as ''Edin.'' in post-nominals) is a public research university based in Edinburgh, Scotland. Granted a royal charter by King James VI in 15 ...

. He graduated from there with an MD in 1860, entitled 'On Oxaluria'. He then spent two years in Europe, visiting medical schools in Paris, Vienna and Munich, where he learned French and German.

Medical career

On his return to Britain MacLagan spent a brief period as resident medical officer at a dispensary in

Jersey Jersey ( , ; nrf, Jèrri, label=Jèrriais ), officially the Bailiwick of Jersey (french: Bailliage de Jersey, links=no; Jèrriais: ), is an island country and self-governing Crown Dependencies, Crown Dependency near the coast of north-west F ...

before returning to

Scotland Scotland (, ) is a country that is part of the United Kingdom. Covering the northern third of the island of Great Britain, mainland Scotland has a border with England to the southeast and is otherwise surrounded by the Atlantic Ocean to the ...

to take up a post in

Dundee Dundee (; sco, Dundee; gd, Dùn Dè or ) is Scotland's fourth-largest city and the 51st-most-populous built-up area in the United Kingdom. The mid-year population estimate for 2016 was , giving Dundee a population density of 2,478/km2 or ...

. He was medical superintendent at Dundee Royal Infirmary from 1864 to 1866, during which time he had to cope with several major

fever Fever, also referred to as pyrexia, is defined as having a body temperature, temperature above the human body temperature, normal range due to an increase in the body's temperature Human body temperature#Fever, set point. There is not a single ...

epidemic An epidemic (from Ancient Greek, Greek ἐπί ''epi'' "upon or above" and δῆμος ''demos'' "people") is the rapid spread of disease to a large number of patients among a given population within an area in a short period of time. Epidemics ...

s of

typhus Typhus, also known as typhus fever, is a group of infectious diseases that include epidemic typhus, scrub typhus, and murine typhus. Common symptoms include fever, headache, and a rash. Typically these begin one to two weeks after exposure. ...

typhoid Typhoid fever, also known as typhoid, is a disease caused by '' Salmonella'' serotype Typhi bacteria. Symptoms vary from mild to severe, and usually begin six to 30 days after exposure. Often there is a gradual onset of a high fever over several ...

cholera Cholera is an infection of the small intestine by some strains of the bacterium ''Vibrio cholerae''. Symptoms may range from none, to mild, to severe. The classic symptom is large amounts of watery diarrhea that lasts a few days. Vomiting and ...

and

smallpox Smallpox was an infectious disease caused by variola virus (often called smallpox virus) which belongs to the genus Orthopoxvirus. The last naturally occurring case was diagnosed in October 1977, and the World Health Organization (WHO) c ...

and became noted for pioneering the clinical use of thermometers. He carried out research into the effect of salicin, an extract from willow bark and a known anti-rheumatic treatment. This work was followed by

Carl Thiersch Karl Thiersch, also spelled Carl Thiersch (20 April 1822 – 28 April 1895), was a German surgeon born in Munich. His father was educationist Friedrich Thiersch, his father-in-law was renowned chemist Justus von Liebig. One brother, Ludwig, was ...

, and in 1874

salicylic acid Salicylic acid is an organic compound with the formula HOC6H4CO2H. A colorless, bitter-tasting solid, it is a precursor to and a metabolite of aspirin (acetylsalicylic acid). It is a plant hormone, and has been listed by the EPA Toxic Substance ...

was synthesised, the active ingredient in

Aspirin Aspirin, also known as acetylsalicylic acid (ASA), is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain, fever, and/or inflammation, and as an antithrombotic. Specific inflammatory conditions which aspirin is used to treat inc ...

. He later established a practice in London, having been encouraged to move there by former patients the Earl and Countess of Southesk, and treated patients such as

Thomas Carlyle Thomas Carlyle (4 December 17955 February 1881) was a Scottish essayist, historian and philosopher. A leading writer of the Victorian era, he exerted a profound influence on 19th-century art, literature and philosophy. Born in Ecclefechan, Dum ...

and the royal family. At the time of his death in 1903, it was said that he "deserves a niche in the Temple of Fame as one of the great benefactors of the human race." Maclagan's original microscope is in the collection of the Tayside Medical History Museum.

Death

MacLagan died in London on 20 March 1903 of stomach cancer at the age of 65.

References

19th-century Scottish medical doctors Medical doctors from Dundee 1838 births 1903 deaths Health in Dundee Alumni of the University of Edinburgh {{Scotland-med-bio-stub