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Harry Harris (geneticist)
Harry Harris FRS, FCRP (30 September 1919 – 17 July 1994.), was a British-born biochemist. His work showed that human genetic variation was not rare and disease-causing but instead was common and usually harmless. He was the first to demonstrate, with biochemical tests, that with the exception of identical twins we are all different at the genetic level. This work paved the way for many well-known genetic concepts and procedures such as DNA fingerprinting, the prenatal diagnosis of disorders using genetic markers, the extensive heterogeneity of inherited diseases, and the mapping of human genes to chromosomes Education Born in Manchester, Harris attended Manchester Grammar School before continuing his education at Trinity College, Cambridge and Manchester Royal Infirmary, where he received a Bachelor of Arts (1941), a Bachelor of Medicine (1943), a Master of Arts (1946) (for "The Aetiology of Premature Baldness") and a Doctorate in Medicine (1949). Royal Air Force: 1944–4 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Manchester
Manchester () is a city in Greater Manchester, England. It had a population of 552,000 in 2021. It is bordered by the Cheshire Plain to the south, the Pennines to the north and east, and the neighbouring city of Salford to the west. The two cities and the surrounding towns form one of the United Kingdom's most populous conurbations, the Greater Manchester Built-up Area, which has a population of 2.87 million. The history of Manchester began with the civilian settlement associated with the Roman fort ('' castra'') of ''Mamucium'' or ''Mancunium'', established in about AD 79 on a sandstone bluff near the confluence of the rivers Medlock and Irwell. Historically part of Lancashire, areas of Cheshire south of the River Mersey were incorporated into Manchester in the 20th century, including Wythenshawe in 1931. Throughout the Middle Ages Manchester remained a manorial township, but began to expand "at an astonishing rate" around the turn of the 19th century. Manchest ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pharmacogenetics
Pharmacogenomics is the study of the role of the genome in drug response. Its name ('' pharmaco-'' + ''genomics'') reflects its combining of pharmacology and genomics. Pharmacogenomics analyzes how the genetic makeup of an individual affects their response to drugs. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating DNA mutations (including single-nucleotide polymorphisms, copy number variations, and insertions/deletions) with pharmacokinetic (drug absorption, distribution, metabolism, and elimination), pharmacodynamic (effects mediated through a drug's biological targets), and/or immunogenic endpoints. Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficiency with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that pharmaceutical drug treatments can deviate from what is dubbed as the "one ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Joseph L
Joseph is a common male given name, derived from the Hebrew Yosef (יוֹסֵף). "Joseph" is used, along with "Josef", mostly in English, French and partially German languages. This spelling is also found as a variant in the languages of the modern-day Nordic countries. In Portuguese and Spanish, the name is "José". In Arabic, including in the Quran, the name is spelled '' Yūsuf''. In Persian, the name is "Yousef". The name has enjoyed significant popularity in its many forms in numerous countries, and ''Joseph'' was one of the two names, along with '' Robert'', to have remained in the top 10 boys' names list in the US from 1925 to 1972. It is especially common in contemporary Israel, as either "Yossi" or "Yossef", and in Italy, where the name "Giuseppe" was the most common male name in the 20th century. In the first century CE, Joseph was the second most popular male name for Palestine Jews. In the Book of Genesis Joseph is Jacob's eleventh son and Rachel's first s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hans Grüneberg
Hans Grüneberg (26 May 1907 – 23 October 1982), whose name was also written as Hans Grueneberg and Hans Gruneberg, was a British geneticist. Grüneberg was born in Wuppertal–Elberfeld in Germany. He obtained an MD from the University of Bonn, a PhD in biology from the University of Berlin and a DSc from the University of London. He arrived in London in 1933, at the invitation of J.B.S. Haldane and Sir Henry Dale. He was elected a Fellow of the Royal Society in 1956. Most of his work focused on mouse genetics, in which his speciality was the study of pleiotropic effects of mutations on the development of the mouse skeleton. He was the first person to describe siderocytes and sideroblasts, atypical nucleated erythrocytes with granules of iron accumulated in perinuclear mitochondria. This he reported in the journal ''Nature''. The Grüneberg ganglion, an olfactory ganglion in rodents, was first described by Hans Grueneberg in 1973. Career * Honorary Research Assista ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Robert Guthrie
Robert Guthrie, MD, Ph.D. (June 28, 1916 – June 24, 1995) was an American microbiologist, best known for developing the bacterial inhibition assay used to screen infants for phenylketonuria at birth, before the development of irreversible neurological damage. Guthrie also pioneered the collection of whole blood on specially designed filter paper, commonly known as "Guthrie cards" as a sample medium that could be easily collected, transported and tested. Although Guthrie is best known for developing the test for phenylketonuria, he worked tirelessly to raise awareness of the need to screen for treatable conditions and adapted his method to early screening tests for galactosemia and maple syrup urine disease. Early life Guthrie received his doctorate from the University of Minnesota, although his education took a circuitous route, as he eventually earned six degrees in six years, including both a medical doctorate and a doctor of philosophy. While in school, Guthrie married ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
John Maynard Smith
John Maynard Smith (6 January 1920 – 19 April 2004) was a British theoretical and mathematical evolutionary biologist and geneticist. Originally an aeronautical engineer during the Second World War, he took a second degree in genetics under the well-known biologist J. B. S. Haldane. Maynard Smith was instrumental in the application of game theory to evolution with George R. Price, and theorised on other problems such as the evolution of sex and signalling theory. Biography Early years John Maynard Smith was born in London, the son of the surgeon Sidney Maynard Smith, but following his father's death in 1928, the family moved to Exmoor, where he became interested in natural history. Quite unhappy with the lack of formal science education at Eton College, Maynard Smith took it upon himself to develop an interest in Darwinian evolutionary theory and mathematics, after having read the work of old Etonian J. B. S. Haldane, whose books were in the school's library despite ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Victor A
The name Victor or Viktor may refer to: * Victor (name), including a list of people with the given name, mononym, or surname Arts and entertainment Film * ''Victor'' (1951 film), a French drama film * ''Victor'' (1993 film), a French short film * ''Victor'' (2008 film), a 2008 TV film about Canadian swimmer Victor Davis * ''Victor'' (2009 film), a French comedy * ''Victor'', a 2017 film about Victor Torres by Brandon Dickerson * ''Viktor'' (film), a 2014 Franco/Russian film Music * ''Victor'' (album), a 1996 album by Alex Lifeson * "Victor", a song from the 1979 album '' Eat to the Beat'' by Blondie Businesses * Victor Talking Machine Company, early 20th century American recording company, forerunner of RCA Records * Victor Company of Japan, usually known as JVC, a Japanese electronics corporation originally a subsidiary of the Victor Talking Machine Company ** Victor Entertainment, or JVCKenwood Victor Entertainment, a Japanese record label ** Victor Interactive ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kurt Hirschhorn
Kurt Hirschhorn (May 18, 1926) - November 25, 2022 was an Austrian-born American pediatrician, medical geneticist, and cytogeneticist who identified the chromosomal defects that underlie Wolf–Hirschhorn syndrome. Early life Hirschhorn was born in Vienna. Fleeing anti-Semitic persecution, the family relocated to Switzerland, then to the US, briefly in New York City before settling in Pittsburgh, Pennsylvania. Career Hirschhorn was Professor of Pediatrics, Genetics and Genomic Sciences, and Medicine Chairman Emeritus of Pediatrics at the Icahn School of Medicine at Mount Sinai in New York City. He is a fellow of the Hastings Center, an independent bioethics research institution. Honors and awards In 1995, Hirschhorn received the William Allan Award in human medical genetics. Personal life Hirschhorn is married to Rochelle Hirschhorn, who was chief of the Division of Medical Genetics at New York University for 24 years. Their son Joel Hirschhorn is also a human geneticist. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Archibald Garrod
Sir Archibald Edward Garrod (25 November 1857 – 28 March 1936) was an English physician who pioneered the field of inborn errors of metabolism. He also discovered alkaptonuria, understanding its inheritance. He served as Regius Professor of Medicine at the University of Oxford from 1920 to 1927.Rolleston, J. D. (2004"Garrod, Sir Archibald Edward (1857–1936)" rev. Alexander G. Bearn, in ''Oxford Dictionary of National Biography'', Oxford University Press. Education and personal life Archibald was the fourth son of Sir Alfred Baring Garrod, a renowned physician who received his medical degree at the age of 23 and became a professor of medicine at University College, London by the time he was 32. He discovered the abnormal uric acid metabolism associated with gout. Garrod's father also successfully estimated the weight of crystals he obtained from a known quantity of blood, resulting in what Garrod called “the first quantitative biochemical investigation made on the livi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Society Of Human Genetics
The American Society of Human Genetics (ASHG), founded in 1948, is a professional membership organization for specialists in human genetics. As of 2009, the organization had approximately 8,000 members. The Society's members include researchers, academicians, clinicians, laboratory practice professionals, genetic counselors, nurses, and others who have a special interest in the field of human genetics. As the field of human genetics has expanded, ASHG has founded additional organizations within its membership body, including the following: * National Society of Genetic Counselors, founded in 1979, as an advocacy group for the nascent field of genetic counseling. * American Board of Medical Genetics, founded in 1981, to certify practitioners in human genetics. * American Board of Genetic Counseling, founded in 1991, to certify genetic counselors. * American College of Medical Genetics, founded in 1991, as a specialty board for medical geneticists at the doctoral level. It achie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Academy Of Sciences
The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the National Academy of Medicine (NAM). As a national academy, new members of the organization are elected annually by current members, based on their distinguished and continuing achievements in original research. Election to the National Academy is one of the highest honors in the scientific field. Members of the National Academy of Sciences serve ''pro bono'' as "advisers to the nation" on science, engineering, and medicine. The group holds a congressional charter under Title 36 of the United States Code. Founded in 1863 as a result of an Act of Congress that was approved by Abraham Lincoln, the NAS is charged with "providing independent, objective advice to the nation on matters related to science and technology. ... to provide scien ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Royal College Of Physicians
The Royal College of Physicians (RCP) is a British professional membership body dedicated to improving the practice of medicine, chiefly through the accreditation of physicians by examination. Founded by royal charter from King Henry VIII in 1518, the RCP is the oldest medical college in England. It set the first international standard in the classification of diseases, and its library contains medical texts of great historical interest. The college is sometimes referred to as the Royal College of Physicians of London to differentiate it from other similarly named bodies. The RCP drives improvements in health and healthcare through advocacy, education and research. Its 40,000 members work in hospitals and communities across over 30 medical specialties with around a fifth based in over 80 countries worldwide. The college hosts six training faculties: the Faculty of Forensic and Legal Medicine, the Faculty for Pharmaceutical Medicine, the Faculty of Occupational Medicine the Fac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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