HLA-B

	HLA-B HLA-B (major histocompatibility complex, class I, B) is a human gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria. HLA is the human version of the major histocompatibility complex (MHC), a gene family that occurs in many species. Genes in this complex are separated into three basic groups: class I, class II, and class III. In humans, the HLA-B gene and two related genes, HLA-A and HLA-C, are the major genes in MHC class I. MHC class I genes provide instructions for making proteins that are present on the surface of almost all cells. On the cell surface, these proteins are bound to protein fragments (peptides) that have been exported from within the cell. MHC class I proteins display these peptides to t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	HLA-B27 Human leukocyte antigen (HLA) B27 (subtypes B2701-2759) is a class I surface antigen encoded by the B locus in the major histocompatibility complex (MHC) on chromosome 6 and presents antigenic peptides (derived from self and non-self antigens) to T cells. HLA-B27 is strongly associated with ankylosing spondylitis and other associated inflammatory diseases, such as psoriatic arthritis, inflammatory bowel disease, and reactive arthritis. Prevalence The prevalence of HLA-B27 varies markedly in the global population. For example, about 8% of Caucasian race, Caucasians, 4% of North African#People, North Africans, 2–9% of Han Chinese, Chinese, and 0.1–0.5% of persons of Yamato people, Japanese descent possess the gene that codes for this antigen. In northern Scandinavia (Lapland (region), Lapland), 24% of people are HLA-B27 positive, while 1.8% have associated ankylosing spondylitis. Disease associations The relationship between HLA-B27 and many diseases has not yet been fully elu ... [...More Info...] [...Related Items...] OR:* [Wikipedia] [Google] [Baidu]
	HLA-B15 HLA-B15 (B15) is an HLA- B serotype. The serotype identifies the B15 gene-allele protein products of HLA-B. B15 is a broad antigen can be subdivided into several split antigens that are often used in characterization. These are B62, B63, B70, B71, B72, B75, B76, B77. B15 is the largest allele grouping for any known human autosomal locus, identified as of August 2008 there are more than 150 alleles and ~140 amino acid sequence variants from those gene products. Some of these alleles are discussed below. Other alleles, such as B46 evolved from B15. One reason for the diversity of this group is that B15 is among a group of alleles enriched in the original humans that left Africa and dispersed across East Asia and Australia. As people traveled east the frequency of many alleles dropped or disappeared from migrants. However B15 persisted, expanded and diversified. The wide range and complex environment selected for new alleles and promoted their expansion. B46 for exa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	HLA-B7 HLA-B7 (B7) is an HLA- B serotype. The serotype identifies the more common HLA-B07 gene products. (For terminology help see: HLA-serotype tutorial) B7, previously HL-A7, was one of the first 'HL-A' antigens recognized, largely because of the frequency of B0702 in Northern and Western Europe and the United States. B7 is found in two major haplotypes in Europe, where it reaches peak frequency in Ireland. One haplotype A3-B7-DR15-DQ1 can be found over a vast region and is in apparent selective disequilibrium. B7 is a risk factor for cervical cancer, sarcoidosis, and early-onset spondylarthropathies. Serology Alleles In disease Cervical cancer HLA-B7 along with HLA-DQ8 increased risk for cervical cancer in at risk Costa Rican women and Asian Indians Sarcoidosis A weak relationship between HLA-B7 and sarcoidosis has been known for 30+ years, yet has not consistently been reproducible in all studies however. A common serologically defined haplotype in Europeans is HLA A3- ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	HLA-B52 HLA-B52 (B52) is an HLA- B serotype. The serotype identifies the more common HLA-B52 gene products. B52 is a split antigen of the broad antigen B5, and is a sister type of B51. B5201 likely formed as a result of a gene conversion event between another HLA-B allele and HLA-B5101. There are a number of alleles within the B52 allele group. Serotype Alleles There are 18 alleles, with 14 amino acid sequence variants in B52. Of these only 9 are frequent enough to have been reliably serotyped. B5201 is the most common, but others have a large regional abundance. Disease In ulcerative colitis HLA-B52 appears to have the strongest linkage to ulcerative colitis in Japan. This form of disease is frequently found with Takayasu's arteritis. In Takayasu's arteritis Takayasu's arteritis appears to have an independent link to B52 associated disease. The association with B5201 increases risk of pulmonary infarction, ischemic heart disease, aortic regurgitation, systemic hyperten ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	HLA-B51 HLA-B51 (B51) is an HLA- B serotype. The serotype identifies the more common HLA-B51 gene products. B51 is a split antigen of the broad antigen B5, and is a sister serotype of B52. There are many alleles within the B51 allele group. B51 is associated with several diseases, including Behçet's disease. Serotype Alleles There are 71 alleles, 57 amino acid sequence variants in B51 of which 4 are nulls. Of these only 9 are frequent enough to have been reliably serotyped. B5101 is the most common, but others have a large regional abundance. Disease associations By serotype Bw51 was associated with Behçet's disease, in endemic (versus epidemic) mucocutaneous lymph node syndrome, susceptibility to the virus that causes German measles infection. In Behçet's disease Behçet's disease is an inflammation of the wall of blood vessels that can involve the eyes, skin, and the rest of the body. Several alleles of B51 (B5101, B5108, B5105, and B5104) are found in disea ... [...More Info...] [...Related Items...] OR:* [Wikipedia] [Google] [Baidu]
	HLA-B44 HLA-B44 (B44) is an HLA- B serotype. The serotype identifies the B44 gene-allele protein products of HLA-B. B44 is a split antigen of the broad antigen B12, and is a sister type of B45. Serotype Alleles Disease HLA-B44 increases recurrent sinopulmonary infections. Protective effects: HLA-B44 appears to be protective against autoimmune lymphoproliferative syndrome in patients with C95 defect (ALPS type Ia). B44 may be a cofactor in ankylosing spondylitis Ankylosing spondylitis (AS) is a type of arthritis characterized by long-term inflammation of the joints of the spine typically where the spine joins the pelvis. Occasionally areas affected may include other joints such as the shoulders or hip ... References {{HLA-B serotypes 4 ... [...More Info...] [...Related Items...] OR:* [Wikipedia] [Google] [Baidu]
	HLA-B14 HLA-B14 (B14) is a HLA- B serotype. The serotype identifies the B45 gene-allele protein products of HLA-B. B14 is a broad antigen composed to two, B64 and B65, split antigen Split(s) or The Split may refer to: Places Split, Croatia, the largest coastal city in Croatia * Split Island, Canada, an island in the Hudson Bay * Split Island, Falkland Islands * Split Island, Fiji, better known as Hạfliua Arts, enterta ...s. In the case of B14 the recognition of the broad antigen is more useful than split antigen recognition because of the relatively poor discrimination of the split antigens (see Table below). Serotype HLA-B64 This serotype does not have good recognition of any of the alleles, relatively speaking recognizes B1401 better. HLA-B65 This serotype recognizes B1402 and B1403 but less so than B14 and to a minor degree it recognized B1401. References {{HLA-B serotypes 1 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	HLA-B45 HLA-B45 (B45) is an HLA- B serotype. The serotype identifies the B45 gene-allele protein products of HLA-B. B45 is a split antigen of the broad antigen B12 Vitamin B12, also known as cobalamin, is a water-soluble vitamin involved in metabolism. It is one of eight B vitamins. It is required by animals, which use it as a cofactor in DNA synthesis, in both fatty acid and amino acid metabolism. It ..., and is a sister type of B44. Gene products of 45 not 44 Serotype Alleles It was reported that a novel haplotype was found in Italian bone marrow donors. A2-CW1601-B45- DRB11101-DRB30301-DQA10102-DQB10502. This haplotype indicates possible very recent ancestry from Africa, with the Cw1601 and B45 components and also with the DR11-DQ5.2 component both extremely rare in Europe. References {{HLA-B serotypes 4 ... [...More Info...] [...Related Items...] OR:* [Wikipedia] [Google] [Baidu]
	HLA-B18 HLA-B18 (B18) is an HLA- B serotype A serotype or serovar is a distinct variation within a species of bacteria or virus or among immune cells of different individuals. These microorganisms, viruses, or cells are classified together based on their surface antigens, allowing the epi .... The serotype identifies the more common HLA-B18 gene products. (For terminology help see: HLA-serotype tutorial) B1801, the most common allele is at highest frequencies in Northern Italy and the Balkans, a peak frequency distribution it shares with B3501. Serotype B18:06 is one of the four B alleles that reacts with neither Bw4 nor Bw6. The others are B46:01, B55:03, and B73:01. Allele frequencies References {{DEFAULTSORT:Hla-B18 1 ... [...More Info...] [...Related Items...] OR:* [Wikipedia] [Google] [Baidu]
	HLA-B70 HLA-B70 (B70) is an HLA- B serotype. The serotype identifies certain B15 gene-allele protein products of HLA-B. B70 is one of many split antigen Split(s) or The Split may refer to: Places Split, Croatia, the largest coastal city in Croatia * Split Island, Canada, an island in the Hudson Bay * Split Island, Falkland Islands * Split Island, Fiji, better known as Hạfliua Arts, entert ...s of the broad antigen, B15. Serotype Alleles References {{HLA-B serotypes 7 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	HLA-B5 HLA-B5 (B5) is an HLA- B serotype. B5 is a broad antigen serotype that recognizes the B51 and B52 split antigen Split(s) or The Split may refer to: Places * Split, Croatia, the largest coastal city in Croatia * Split Island, Canada, an island in the Hudson Bay * Split Island, Falkland Islands * Split Island, Fiji, better known as Hạfliua Arts, entert ... serotypes. Serotype References {{HLA-B serotypes 0 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	HLA-B8 HLA-B8 (B8) is an HLA- B serotype. The serotype identifies the HLA-B08 gene products. (For terminology help see: HLA-serotype tutorial) HLA-B8, previously known as HL-A8 was one of the first identified of the HLA antigens. It coined the "Super B8" haplotype, also called the ancestral European haplotype because of its common occurrence in Europe, particular the isles and Scandinavia. B8 is a component gene-allele of the AH8.1 haplotype in Northern and Western Europeans. Genes between B8 and DR3 DR3 was a Danish national television channel, produced by the public service broadcaster, DR. The channel was mainly focused on sport, humor, science, music, documentary and fiction. It was launched on 28 January 2013, replacing DR HD. DR3 progr ... on this haplotype are frequently associated with autoimmune disease. Serotype Alleles References {{DEFAULTSORT:Hla-B8 0 ... [...More Info...] [...Related Items...] OR:* [Wikipedia] [Google] [Baidu]

	HLA-B HLA-B (major histocompatibility complex, class I, B) is a human gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria. HLA is the human version of the major histocompatibility complex (MHC), a gene family that occurs in many species. Genes in this complex are separated into three basic groups: class I, class II, and class III. In humans, the HLA-B gene and two related genes, HLA-A and HLA-C, are the major genes in MHC class I. MHC class I genes provide instructions for making proteins that are present on the surface of almost all cells. On the cell surface, these proteins are bound to protein fragments (peptides) that have been exported from within the cell. MHC class I proteins display these peptides to t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	HLA-B27 Human leukocyte antigen (HLA) B27 (subtypes B2701-2759) is a class I surface antigen encoded by the B locus in the major histocompatibility complex (MHC) on chromosome 6 and presents antigenic peptides (derived from self and non-self antigens) to T cells. HLA-B27 is strongly associated with ankylosing spondylitis and other associated inflammatory diseases, such as psoriatic arthritis, inflammatory bowel disease, and reactive arthritis. Prevalence The prevalence of HLA-B27 varies markedly in the global population. For example, about 8% of Caucasian race, Caucasians, 4% of North African#People, North Africans, 2–9% of Han Chinese, Chinese, and 0.1–0.5% of persons of Yamato people, Japanese descent possess the gene that codes for this antigen. In northern Scandinavia (Lapland (region), Lapland), 24% of people are HLA-B27 positive, while 1.8% have associated ankylosing spondylitis. Disease associations The relationship between HLA-B27 and many diseases has not yet been fully elu ... [...More Info...] [...Related Items...] OR:* [Wikipedia] [Google] [Baidu]
	HLA-B15 HLA-B15 (B15) is an HLA- B serotype. The serotype identifies the B15 gene-allele protein products of HLA-B. B15 is a broad antigen can be subdivided into several split antigens that are often used in characterization. These are B62, B63, B70, B71, B72, B75, B76, B77. B15 is the largest allele grouping for any known human autosomal locus, identified as of August 2008 there are more than 150 alleles and ~140 amino acid sequence variants from those gene products. Some of these alleles are discussed below. Other alleles, such as B46 evolved from B15. One reason for the diversity of this group is that B15 is among a group of alleles enriched in the original humans that left Africa and dispersed across East Asia and Australia. As people traveled east the frequency of many alleles dropped or disappeared from migrants. However B15 persisted, expanded and diversified. The wide range and complex environment selected for new alleles and promoted their expansion. B46 for exa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	HLA-B7 HLA-B7 (B7) is an HLA- B serotype. The serotype identifies the more common HLA-B07 gene products. (For terminology help see: HLA-serotype tutorial) B7, previously HL-A7, was one of the first 'HL-A' antigens recognized, largely because of the frequency of B0702 in Northern and Western Europe and the United States. B7 is found in two major haplotypes in Europe, where it reaches peak frequency in Ireland. One haplotype A3-B7-DR15-DQ1 can be found over a vast region and is in apparent selective disequilibrium. B7 is a risk factor for cervical cancer, sarcoidosis, and early-onset spondylarthropathies. Serology Alleles In disease Cervical cancer HLA-B7 along with HLA-DQ8 increased risk for cervical cancer in at risk Costa Rican women and Asian Indians Sarcoidosis A weak relationship between HLA-B7 and sarcoidosis has been known for 30+ years, yet has not consistently been reproducible in all studies however. A common serologically defined haplotype in Europeans is HLA A3- ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	HLA-B52 HLA-B52 (B52) is an HLA- B serotype. The serotype identifies the more common HLA-B52 gene products. B52 is a split antigen of the broad antigen B5, and is a sister type of B51. B5201 likely formed as a result of a gene conversion event between another HLA-B allele and HLA-B5101. There are a number of alleles within the B52 allele group. Serotype Alleles There are 18 alleles, with 14 amino acid sequence variants in B52. Of these only 9 are frequent enough to have been reliably serotyped. B5201 is the most common, but others have a large regional abundance. Disease In ulcerative colitis HLA-B52 appears to have the strongest linkage to ulcerative colitis in Japan. This form of disease is frequently found with Takayasu's arteritis. In Takayasu's arteritis Takayasu's arteritis appears to have an independent link to B52 associated disease. The association with B5201 increases risk of pulmonary infarction, ischemic heart disease, aortic regurgitation, systemic hyperten ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	HLA-B51 HLA-B51 (B51) is an HLA- B serotype. The serotype identifies the more common HLA-B51 gene products. B51 is a split antigen of the broad antigen B5, and is a sister serotype of B52. There are many alleles within the B51 allele group. B51 is associated with several diseases, including Behçet's disease. Serotype Alleles There are 71 alleles, 57 amino acid sequence variants in B51 of which 4 are nulls. Of these only 9 are frequent enough to have been reliably serotyped. B5101 is the most common, but others have a large regional abundance. Disease associations By serotype Bw51 was associated with Behçet's disease, in endemic (versus epidemic) mucocutaneous lymph node syndrome, susceptibility to the virus that causes German measles infection. In Behçet's disease Behçet's disease is an inflammation of the wall of blood vessels that can involve the eyes, skin, and the rest of the body. Several alleles of B51 (B5101, B5108, B5105, and B5104) are found in disea ... [...More Info...] [...Related Items...] OR:* [Wikipedia] [Google] [Baidu]
	HLA-B44 HLA-B44 (B44) is an HLA- B serotype. The serotype identifies the B44 gene-allele protein products of HLA-B. B44 is a split antigen of the broad antigen B12, and is a sister type of B45. Serotype Alleles Disease HLA-B44 increases recurrent sinopulmonary infections. Protective effects: HLA-B44 appears to be protective against autoimmune lymphoproliferative syndrome in patients with C95 defect (ALPS type Ia). B44 may be a cofactor in ankylosing spondylitis Ankylosing spondylitis (AS) is a type of arthritis characterized by long-term inflammation of the joints of the spine typically where the spine joins the pelvis. Occasionally areas affected may include other joints such as the shoulders or hip ... References {{HLA-B serotypes 4 ... [...More Info...] [...Related Items...] OR:* [Wikipedia] [Google] [Baidu]
	HLA-B14 HLA-B14 (B14) is a HLA- B serotype. The serotype identifies the B45 gene-allele protein products of HLA-B. B14 is a broad antigen composed to two, B64 and B65, split antigen Split(s) or The Split may refer to: Places Split, Croatia, the largest coastal city in Croatia * Split Island, Canada, an island in the Hudson Bay * Split Island, Falkland Islands * Split Island, Fiji, better known as Hạfliua Arts, enterta ...s. In the case of B14 the recognition of the broad antigen is more useful than split antigen recognition because of the relatively poor discrimination of the split antigens (see Table below). Serotype HLA-B64 This serotype does not have good recognition of any of the alleles, relatively speaking recognizes B1401 better. HLA-B65 This serotype recognizes B1402 and B1403 but less so than B14 and to a minor degree it recognized B1401. References {{HLA-B serotypes 1 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	HLA-B45 HLA-B45 (B45) is an HLA- B serotype. The serotype identifies the B45 gene-allele protein products of HLA-B. B45 is a split antigen of the broad antigen B12 Vitamin B12, also known as cobalamin, is a water-soluble vitamin involved in metabolism. It is one of eight B vitamins. It is required by animals, which use it as a cofactor in DNA synthesis, in both fatty acid and amino acid metabolism. It ..., and is a sister type of B44. Gene products of 45 not 44 Serotype Alleles It was reported that a novel haplotype was found in Italian bone marrow donors. A2-CW1601-B45- DRB11101-DRB30301-DQA10102-DQB10502. This haplotype indicates possible very recent ancestry from Africa, with the Cw1601 and B45 components and also with the DR11-DQ5.2 component both extremely rare in Europe. References {{HLA-B serotypes 4 ... [...More Info...] [...Related Items...] OR:* [Wikipedia] [Google] [Baidu]
	HLA-B18 HLA-B18 (B18) is an HLA- B serotype A serotype or serovar is a distinct variation within a species of bacteria or virus or among immune cells of different individuals. These microorganisms, viruses, or cells are classified together based on their surface antigens, allowing the epi .... The serotype identifies the more common HLA-B18 gene products. (For terminology help see: HLA-serotype tutorial) B1801, the most common allele is at highest frequencies in Northern Italy and the Balkans, a peak frequency distribution it shares with B3501. Serotype B18:06 is one of the four B alleles that reacts with neither Bw4 nor Bw6. The others are B46:01, B55:03, and B73:01. Allele frequencies References {{DEFAULTSORT:Hla-B18 1 ... [...More Info...] [...Related Items...] OR:* [Wikipedia] [Google] [Baidu]
	HLA-B70 HLA-B70 (B70) is an HLA- B serotype. The serotype identifies certain B15 gene-allele protein products of HLA-B. B70 is one of many split antigen Split(s) or The Split may refer to: Places Split, Croatia, the largest coastal city in Croatia * Split Island, Canada, an island in the Hudson Bay * Split Island, Falkland Islands * Split Island, Fiji, better known as Hạfliua Arts, entert ...s of the broad antigen, B15. Serotype Alleles References {{HLA-B serotypes 7 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	HLA-B5 HLA-B5 (B5) is an HLA- B serotype. B5 is a broad antigen serotype that recognizes the B51 and B52 split antigen Split(s) or The Split may refer to: Places * Split, Croatia, the largest coastal city in Croatia * Split Island, Canada, an island in the Hudson Bay * Split Island, Falkland Islands * Split Island, Fiji, better known as Hạfliua Arts, entert ... serotypes. Serotype References {{HLA-B serotypes 0 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	HLA-B8 HLA-B8 (B8) is an HLA- B serotype. The serotype identifies the HLA-B08 gene products. (For terminology help see: HLA-serotype tutorial) HLA-B8, previously known as HL-A8 was one of the first identified of the HLA antigens. It coined the "Super B8" haplotype, also called the ancestral European haplotype because of its common occurrence in Europe, particular the isles and Scandinavia. B8 is a component gene-allele of the AH8.1 haplotype in Northern and Western Europeans. Genes between B8 and DR3 DR3 was a Danish national television channel, produced by the public service broadcaster, DR. The channel was mainly focused on sport, humor, science, music, documentary and fiction. It was launched on 28 January 2013, replacing DR HD. DR3 progr ... on this haplotype are frequently associated with autoimmune disease. Serotype Alleles References {{DEFAULTSORT:Hla-B8 0 ... [...More Info...] [...Related Items...] OR:* [Wikipedia] [Google] [Baidu]