|
HLA-B5
HLA-B5 (B5) is an HLA- B serotype. B5 is a broad antigen serotype that recognizes the B51 and B52 split antigen Split(s) or The Split may refer to: Places * Split, Croatia, the largest coastal city in Croatia * Split Island, Canada, an island in the Hudson Bay * Split Island, Falkland Islands * Split Island, Fiji, better known as Hạfliua Arts, entert ... serotypes. Serotype References {{HLA-B serotypes 0 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HLA-B
HLA-B (major histocompatibility complex, class I, B) is a human gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria. HLA is the human version of the major histocompatibility complex (MHC), a gene family that occurs in many species. Genes in this complex are separated into three basic groups: class I, class II, and class III. In humans, the HLA-B gene and two related genes, HLA-A and HLA-C, are the major genes in MHC class I. MHC class I genes provide instructions for making proteins that are present on the surface of almost all cells. On the cell surface, these proteins are bound to protein fragments (peptides) that have been exported from within the cell. MHC class I proteins display these peptides to t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HLA-B51
HLA-B51 (B51) is an HLA- B serotype. The serotype identifies the more common HLA-B*51 gene products. B51 is a split antigen of the broad antigen B5, and is a sister serotype of B52. There are many alleles within the B*51 allele group. B51 is associated with several diseases, including Behçet's disease. Serotype Alleles There are 71 alleles, 57 amino acid sequence variants in B51 of which 4 are nulls. Of these only 9 are frequent enough to have been reliably serotyped. B*5101 is the most common, but others have a large regional abundance. Disease associations By serotype Bw51 was associated with Behçet's disease, in endemic (versus epidemic) mucocutaneous lymph node syndrome, susceptibility to the virus that causes German measles infection. In Behçet's disease Behçet's disease is an inflammation of the wall of blood vessels that can involve the eyes, skin, and the rest of the body. Several alleles of B51 (B*5101, B*5108, B*5105, and B*5104) are found in disea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HLA-B52
HLA-B52 (B52) is an HLA- B serotype. The serotype identifies the more common HLA-B*52 gene products. B52 is a split antigen of the broad antigen B5, and is a sister type of B51. B*5201 likely formed as a result of a gene conversion event between another HLA-B allele and HLA-B*5101. There are a number of alleles within the B*52 allele group. Serotype Alleles There are 18 alleles, with 14 amino acid sequence variants in B52. Of these only 9 are frequent enough to have been reliably serotyped. B*5201 is the most common, but others have a large regional abundance. Disease In ulcerative colitis HLA-B52 appears to have the strongest linkage to ulcerative colitis in Japan. This form of disease is frequently found with Takayasu's arteritis. In Takayasu's arteritis Takayasu's arteritis appears to have an independent link to B52 associated disease. The association with B*5201 increases risk of pulmonary infarction, ischemic heart disease, aortic regurgitation, systemic hyperten ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Leukocyte Antigen
The human leukocyte antigen (HLA) system or complex is a complex of genes on chromosome 6 in humans which encode cell-surface proteins responsible for the regulation of the immune system. The HLA system is also known as the human version of the major histocompatibility complex (MHC) found in many animals. Mutations in HLA genes may be linked to autoimmune disease such as type I diabetes, and celiac disease. The HLA gene complex resides on a 3 Mbp stretch within chromosome 6, p-arm at 21.3. HLA genes are highly polymorphic, which means that they have many different alleles, allowing them to fine-tune the adaptive immune system. The proteins encoded by certain genes are also known as ''antigens'', as a result of their historic discovery as factors in organ transplants. HLAs corresponding to MHC class I ( A, B, and C), all of which are the HLA Class1 group, present peptides from inside the cell. For example, if the cell is infected by a virus, the HLA system brings fragme ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Serotype
A serotype or serovar is a distinct variation within a species of bacteria or virus or among immune cells of different individuals. These microorganisms, viruses, or cells are classified together based on their surface antigens, allowing the epidemiologic classification of organisms to the subspecies level. A group of serovars with common antigens is called a serogroup or sometimes ''serocomplex''. Serotyping often plays an essential role in determining species and subspecies. The ''Salmonella'' genus of bacteria, for example, has been determined to have over 2600 serotypes. ''Vibrio cholerae'', the species of bacteria that causes cholera, has over 200 serotypes, based on cell antigens. Only two of them have been observed to produce the potent enterotoxin that results in cholera: O1 and O139. Serotypes were discovered by the American microbiologist Rebecca Lancefield in 1933. Role in organ transplantation The immune system is capable of discerning a cell as being 'self' or 'n ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Broad Antigen
Broad(s) or The Broad(s) may refer to: People * A slang term for a woman. * Broad (surname), a surname Places * Broad Peak, on the border between Pakistan and China, the 12th highest mountain on Earth * The Broads, a network of mostly navigable rivers and lakes in the English counties of Norfolk and Suffolk, United Kingdom **The Broads include several areas of navigable water known as Broads; the largest is Hickling Broad (see :Norfolk Broads) * The Broads (New Hampshire), a wide portion of Lake Winnipesaukee in Belknap County, New Hampshire, United States * Broad Bay (other) * Broad Canal, East Cambridge, Massachusetts, United States * Broad Channel, a neighborhood in Queens, United States * Broad Crag, a fell in the English Lake District, United Kingdom * Broad Creek (other) * Broad River (other) * Broad Run (other) * Broad Sound (other) * Broad Valley, Graham Land, Antarctica * Broad Water, a salt water lagoon near Tywyn, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Split Antigen
Split(s) or The Split may refer to: Places * Split, Croatia, the largest coastal city in Croatia * Split Island, Canada, an island in the Hudson Bay * Split Island, Falkland Islands * Split Island, Fiji, better known as Hạfliua Arts, entertainment, and media Films * ''Split'' (1989 film), a science fiction film * ''Split'' (2016 American film), a psychological horror thriller film * ''Split'' (2016 Canadian film), also known as ''Écartée'', a Canadian drama film directed by Lawrence Côté-Collins * ''Split'' (2016 South Korean film), a sports drama film * '' Split: A Divided America'', a 2008 documentary on American politics * ''The Split'' (1959 film) or ''The Manster'', a U.S.-Japanese horror film * ''The Split'' (film), a 1968 heist film Games * Split (poker), the division of winnings in the card game * Split (blackjack), a possible player decision in the card game Music Albums * ''Split'' (The Groundhogs album), 1971 * ''Split'' (Lush album), 1994 * ''Split' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
