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Hydrophilization
Hydrophilization is a process used for hydrophobic drugs to increase their release rate from capsules, which is dependent on the rate of dissolution, by covering the surface of the drug particles with minute droplets of a hydrophilic polymer solution. Method The process is accomplished by vigorous mixing of the hydrophobic drug with the aqueous solution of the hydrophilic polymer solution, leading to production of small particles of the drug covered with small droplets of the hydrophilic polymer solution. Uses This process in tablet or capsule formulations enhance the disintegration of the drug/excipient bulk and so enhance the rate of dissolution of the hydrophobic drug. Examples of the hydrophilic polymers are methyl cellulose and hydroxyethyl cellulose Hydroxyethyl cellulose is a gelling and thickening agent derived from cellulose. It is widely used in cosmetics, cleaning solutions, and other household products. Hydroxyethyl cellulose and methyl cellulose are frequently used ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dissolution (chemistry)
Solvation (or dissolution) describes the interaction of a solvent with dissolved molecules. Both ionized and uncharged molecules interact strongly with a solvent, and the strength and nature of this interaction influence many properties of the solute, including solubility, reactivity, and color, as well as influencing the properties of the solvent such as its viscosity and density. If the attractive forces between the solvent and solute particles are greater than the attractive forces holding the solute particles together, the solvent particles pull the solute particles apart and surround them. The surrounded solute particles then move away from the solid solute and out into the solution. Ions are surrounded by a concentric shell of solvent. Solvation is the process of reorganizing solvent and solute molecules into solvation complexes and involves bond formation, hydrogen bonding, and van der Waals forces. Solvation of a solute by water is called hydration. Solubility of solid ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Methyl Cellulose
Methyl cellulose (or methylcellulose) is a compound derived from cellulose. It is sold under a variety of trade names and is used as a thickener and emulsifier in various food and cosmetic products, and also as a bulk-forming laxative. Like cellulose, it is not digestible, not toxic, and not an allergen. In 2020, it was the 422nd most commonly prescribed medication in the United States, with more than 100thousand prescriptions. Uses Methyl cellulose has a wide range of uses. Medical Constipation Methyl cellulose is used to treat constipation. Effects generally occur within three days. It is taken by mouth and is recommended with sufficient water. Side effects may include abdominal pain. It is classified as a bulk forming laxative. It works by increasing the amount of stool present which improves intestinal contractions. It is available over the counter. It is sold under the brand name Citrucel among others. Artificial tears and saliva The lubricating property of me ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hydroxyethyl Cellulose
Hydroxyethyl cellulose is a gelling and thickening agent derived from cellulose. It is widely used in cosmetics, cleaning solutions, and other household products. Hydroxyethyl cellulose and methyl cellulose are frequently used with hydrophobic drugs in capsule formulations, to improve the drugs' dissolution in the gastrointestinal fluids. This process is known as hydrophilization. Hydroxyethyl cellulose is also used extensively in the oil & gas industry as a drilling mud additive under the name HEC as well in industrial applications, paint & coatings, ceramics, adhesives, emulsion polymerization, inks, construction, welding rods, pencils and joint fillers. Hydroxyethyl cellulose can be one of the main ingredients in water-based personal lubricants. It is also a key ingredient in the formation of big bubbles as it possesses the ability to dissolve in water but also provide structural strength to the soap bubble. Among other similar chemicals, it is often used as slime Slime m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
