Hydrophilization is a process used for hydrophobic drugs to increase their release rate from capsules, which is dependent on the rate of

dissolution Dissolution may refer to: Arts and entertainment Books * ''Dissolution'' (''Forgotten Realms'' novel), a 2002 fantasy novel by Richard Lee Byers * ''Dissolution'' (Sansom novel), a 2003 historical novel by C. J. Sansom Music * Dissolution, in mu ...

, by covering the surface of the drug particles with minute droplets of a hydrophilic polymer solution.

Method

The process is accomplished by vigorous mixing of the hydrophobic drug with the aqueous solution of the hydrophilic polymer solution, leading to production of small particles of the drug covered with small droplets of the hydrophilic polymer solution.

Uses

This process in tablet or capsule formulations enhance the disintegration of the drug/excipient bulk and so enhance the rate of

of the hydrophobic drug. Examples of the hydrophilic polymers are

methyl cellulose Methyl cellulose (or methylcellulose) is a compound derived from cellulose. It is sold under a variety of trade names and is used as a thickener and emulsifier in various food and cosmetic products, and also as a bulk-forming laxative. Like cellu ...

and

hydroxyethyl cellulose Hydroxyethyl cellulose is a gelling and thickening agent derived from cellulose. It is widely used in cosmetics, cleaning solutions, and other household products. Hydroxyethyl cellulose and methyl cellulose are frequently used with hydrophobic dru ...

References

{{Reflist Dosage forms