|
Hormetic
Hormesis is a characteristic of many biological processes, namely a biphasic or triphasic response to exposure to increasing amounts of a substance or condition. Within the hormetic zone, the biological response to low exposures to toxins and other stressors is generally favorable. The term "hormesis" comes from Greek ''hórmēsis'' "rapid motion, eagerness", itself from ancient Greek ''hormáein'' "to set in motion, impel, urge on", the same Greek root as the word ''hormone''. The term 'hormetics' has been proposed for the study and science of hormesis. In toxicology, hormesis is a dose response phenomenon to xenobiotics or other stressors characterized by a low-dose stimulation, with zero dose and high-dose inhibition, thus resulting in a J-shaped or an inverted U-shaped dose response (e.g. the arms of the "U" are inhibitory or toxic concentrations whereas the curve region stimulates a beneficial response.) Generally speaking, hormesis pertains to the study of benefits of exposur ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hormesis Dose Response Graph
Hormesis is a characteristic of many biological processes, namely a biphasic or triphasic response to exposure to increasing amounts of a substance or condition. Within the hormetic zone, the biological response to low exposures to toxins and other stressors is generally favorable. The term "hormesis" comes from Greek ''hórmēsis'' "rapid motion, eagerness", itself from ancient Greek ''hormáein'' "to set in motion, impel, urge on", the same Greek root as the word ''hormone''. The term 'hormetics' has been proposed for the study and science of hormesis. In toxicology, hormesis is a dose response phenomenon to xenobiotics or other stressors characterized by a low-dose stimulation, with zero dose and high-dose inhibition, thus resulting in a J-shaped or an inverted U-shaped dose response (e.g. the arms of the "U" are inhibitory or toxic concentrations whereas the curve region stimulates a beneficial response.) Generally speaking, hormesis pertains to the study of benefits of exposu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mithridate
Mithridate, also known as mithridatium, mithridatum, or mithridaticum, is a semi-mythical remedy with as many as 65 ingredients, used as an antidote for poisoning, and said to have been created by Mithridates VI Eupator of Pontus in the 1st century BC. It was one of the most complex and highly sought-after drugs during the Middle Ages and Renaissance, particularly in Italy and France, where it was in continual use for centuries. An updated recipe called theriac (Theriacum Andromachi) was known well into the 19th century.Mithridate . Mithridate takes its name from its inventor, Mithridates VI, king of the ancient Anatolian |
Edward Calabrese
Edward J. Calabrese is an American toxicologist and professor in the department of environmental health sciences at the University of Massachusetts Amherst. He is the editor emeritus of the scientific journal '' Dose-Response''. Education Calabrese grew up in Bridgewater, Massachusetts. He received his B.S. from Bridgewater State College in 1968 and his M.A. and Ph.D. from the University of Massachusetts Amherst in 1972 and 1973, respectively. Academic career Calabrese began working at the University of Massachusetts Amherst in 1976. Research Early in his career, Calabrese conducted research on carcinogens. However, he is best known for his research into, and championing of, hormesis Hormesis is a characteristic of many biological processes, namely a biphasic or triphasic response to exposure to increasing amounts of a substance or condition. Within the hormetic zone, the biological response to low exposures to toxins and othe ..., which he has called "the fundamental dose-respons ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chester M
Chester is a cathedral city and the county town of Cheshire, England. It is located on the River Dee, close to the English–Welsh border. With a population of 79,645 in 2011,"2011 Census results: People and Population Profile: Chester Locality"; downloaded froCheshire West and Chester: Population Profiles, 17 May 2019 it is the most populous settlement of Cheshire West and Chester (a unitary authority which had a population of 329,608 in 2011) and serves as its administrative headquarters. It is also the historic county town of Cheshire and the second-largest settlement in Cheshire after Warrington. Chester was founded in 79 AD as a "castrum" or Roman fort with the name Deva Victrix during the reign of Emperor Vespasian. One of the main army camps in Roman Britain, Deva later became a major civilian settlement. In 689, King Æthelred of Mercia founded the Minster Church of West Mercia, which later became Chester's first cathedral, and the Angles extended and strengthened ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rudolph Arndt
Rudolf Gottfried Arndt (31 March 1835 – 29 January 1900) was a German psychiatrist from Bialken, district of Marienwerder. Biography Arndt studied in Greifswald and Halle. As a student, his instructors included Felix von Niemeyer (1820–1871), Heinrich Adolf von Bardeleben (1819–1895), and Heinrich Philipp August Damerow (1798–1866). He was conferred doctor of medicine on 20 February 1860. From 1861 he maintained a private practice, and also participated in the Second Schleswig War (1864), Austro-Prussian War (1866) and Franco-Prussian War (1870–71). In 1867 he obtained his habilitation, subsequently serving as director of the ''Irren-Heil- und Pflege-Anstalt'' in Greifswald. In 1873 he became an associate professor of psychiatry at Greifswald. He died of angina pectoris. He is known today for the " Arndt-Schulz rule", a pharmacologic principle of homeopathy that is named in conjunction with German chemist Hugo Schulz (1853-1932). He is also remembered f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hugo Schulz
Hugo Paul Friedrich Schulz (August 6, 1853 – July 13, 1932) was a German pharmacologist from Wesel, Rhenish Prussia. He studied medicine in the universities of Heidelberg and Bonn, where he did scientific work in the physiological institute of Eduard Friedrich Wilhelm Pflüger (1829-1910). In 1877 he earned his doctorate, and afterwards worked in the pharmacological institute of Karl Binz (1832-1913) at Bonn. In 1883 he was appointed professor of pharmacology at the University of Greifswald. Schulz is known for his research of a phenomenon known as hormesis, showing that toxins can have the opposite effect in small doses than in large doses. This he demonstrated in experiments using chemical compounds on yeast cells. From his research came the " Arndt-Schulz rule", a law concerning dosages in toxicology; named along with Dr. Rudolf Arndt (1835-1900). Schultz published a number of works in the field of pharmacology, including the well-regarded ''Pharmakotherapie'' (1898), a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pharmacologist
Pharmacology is a branch of medicine, biology and pharmaceutical sciences concerned with drug or medication action, where a drug may be defined as any artificial, natural, or endogenous (from within the body) molecule which exerts a biochemical or physiological effect on the cell, tissue, organ, or organism (sometimes the word ''pharmacon'' is used as a term to encompass these endogenous and exogenous bioactive species). More specifically, it is the study of the interactions that occur between a living organism and chemicals that affect normal or abnormal biochemical function. If substances have medicinal properties, they are considered pharmaceuticals. The field encompasses drug composition and properties,functions,sources,synthesis and drug design, molecular and cellular mechanisms, organ/systems mechanisms, signal transduction/cellular communication, molecular diagnostics, interactions, chemical biology, therapy, and medical applications and antipathogenic capabilities. Th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Dose Makes The Poison
"The dose makes the poison" ( la, dosis sola facit venenum 'only the dose makes the poison') is an adage intended to indicate a basic principle of toxicology. It is credited to Paracelsus who expressed the classic toxicology maxim "All things are poison, and nothing is without poison; the dosage alone makes it so a thing is not a poison." This is often condensed to: "The dose makes the poison" or in Latin, . It means that a substance can produce the harmful effect associated with its toxic properties only if it reaches a susceptible biological system within the body in a high enough concentration (i.e., dose). The principle relies on the finding that all chemicals—even water and oxygen—can be toxic if too much is eaten, drunk, or absorbed. "The toxicity of any particular chemical depends on many factors, including the extent to which it enters an individual’s body." [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paracelsus
Paracelsus (; ; 1493 – 24 September 1541), born Theophrastus von Hohenheim (full name Philippus Aureolus Theophrastus Bombastus von Hohenheim), was a Swiss physician, alchemist, lay theologian, and philosopher of the German Renaissance. He was a pioneer in several aspects of the " medical revolution" of the Renaissance, emphasizing the value of observation in combination with received wisdom. He is credited as the "father of toxicology". Paracelsus also had a substantial influence as a prophet or diviner, his "Prognostications" being studied by Rosicrucians in the 1600s. Paracelsianism is the early modern medical movement inspired by the study of his works. Biography Paracelsus was born in Egg an der Sihl, a village close to the Etzel Pass in Einsiedeln, Schwyz. He was born in a house right next to a bridge across the Sihl river (known as ''Teufelsbrücke''). The historical house, dated to the 14th century, was destroyed in 1814. The ''Restaurant Krone'' now stands in its pl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Swiss People
The Swiss people (german: die Schweizer, french: les Suisses, it, gli Svizzeri, rm, ils Svizzers) are the citizens of Switzerland or people of Swiss abroad, Swiss ancestry. The number of Swiss nationality law, Swiss nationals has grown from 1.7 million in 1815 to 8.7 million in 2020. More than 1.5 million Swiss citizens hold multiple citizenship. About 11% of citizens Swiss abroad, live abroad (0.8 million, of whom 0.6 million hold multiple citizenship). About 60% of those living abroad reside in the European Union (0.46 million). The largest groups of Swiss descendants and nationals outside Europe are found in the Swiss Americans, United States, Brazil and Swiss Canadian, Canada. Although the Switzerland as a federal state, modern state of Switzerland originated in 1848, the period of romantic nationalism, it is not a nation-state, and the Swiss are not a single ethnic group, but rather are a Confederation, confederacy (') or ' ("nation of will", "nation by choice", tha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Renaissance
The Renaissance ( , ) , from , with the same meanings. is a period in European history marking the transition from the Middle Ages to modernity and covering the 15th and 16th centuries, characterized by an effort to revive and surpass ideas and achievements of classical antiquity. It occurred after the Crisis of the Late Middle Ages and was associated with great social change. In addition to the standard periodization, proponents of a "long Renaissance" may put its beginning in the 14th century and its end in the 17th century. The traditional view focuses more on the early modern aspects of the Renaissance and argues that it was a break from the past, but many historians today focus more on its medieval aspects and argue that it was an extension of the Middle Ages. However, the beginnings of the period – the early Renaissance of the 15th century and the Italian Proto-Renaissance from around 1250 or 1300 – overlap considerably with the Late Middle Ages, conventionally da ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
