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Health Among The Amish
Health among the Amish is characterized by higher incidences of particular genetic disorders, especially among the Old Order Amish. These disorders include dwarfism, Angelman syndrome, and various metabolic disorders, such as Tay-Sachs disease, as well as an unusual distribution of blood types. Overview Amish represent a collection of different demes or genetically closed communities. Since almost all Amish descend from about 500 18th-century founders, genetic disorders that come out due to inbreeding exist in more isolated districts (an example of the founder effect). These disorders include dwarfism ( Ellis–van Creveld syndrome), Angelman syndrome, and various metabolic disorders, as well as an unusual distribution of blood types. Some of these disorders are quite rare, or unique, and are serious enough to increase the mortality rate among Amish children. The majority of Amish accept these as "Gottes Wille" (God's will); they reject use of preventive genetic tests prio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetic Disorder
A genetic disorder is a health problem caused by one or more abnormalities in the genome. It can be caused by a mutation in a single gene (monogenic) or multiple genes (polygenic) or by a chromosomal abnormality. Although polygenic disorders are the most common, the term is mostly used when discussing disorders with a single genetic cause, either in a gene or chromosome. The mutation responsible can occur spontaneously before embryonic development (a ''de novo'' mutation), or it can be Heredity, inherited from two parents who are carriers of a faulty gene (autosomal recessive inheritance) or from a parent with the disorder (autosomal dominant inheritance). When the genetic disorder is inherited from one or both parents, it is also classified as a hereditary disease. Some disorders are caused by a mutation on the X chromosome and have X-linked inheritance. Very few disorders are inherited on the Y linkage, Y chromosome or Mitochondrial disease#Causes, mitochondrial DNA (due to t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Exogamy
Exogamy is the social norm of marrying outside one's social group. The group defines the scope and extent of exogamy, and the rules and enforcement mechanisms that ensure its continuity. One form of exogamy is dual exogamy, in which two groups continually intermarry with each other. In social science, exogamy is viewed as a combination of two related aspects: biological and cultural. Biological exogamy is marriage of nonblood-related beings, regulated by forms of incest law. Cultural exogamy is marrying outside a specific cultural group; the opposite being endogamy, marriage within a social group. Biology of exogamy Exogamy often results in two individuals that are not closely genetically related marrying each other; that is, outbreeding as opposed to inbreeding. In moderation, this benefits the offspring as it reduces the risk of the offspring inheriting two copies of a defective gene. Increasing the genetic diversity of the offspring improves the chances of offspring reprod ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Birth Control
Birth control, also known as contraception, anticonception, and fertility control, is the use of methods or devices to prevent unwanted pregnancy. Birth control has been used since ancient times, but effective and safe methods of birth control only became available in the 20th century. Planning, making available, and using birth control is called family planning. Some cultures limit or discourage access to birth control because they consider it to be morally, religiously, or politically undesirable. The World Health Organization and Centers for Disease Control and Prevention, United States Centers for Disease Control and Prevention provide guidance on the safety of birth control methods among women with specific medical conditions. The most effective methods of birth control are Sterilization (medicine), sterilization by means of vasectomy in males and tubal ligation in females, intrauterine devices (IUDs), and contraceptive implant, implantable birth control. This is follo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Innate Immune System
The innate, or nonspecific, immune system is one of the two main immunity strategies (the other being the adaptive immune system) in vertebrates. The innate immune system is an older evolutionary defense strategy, relatively speaking, and is the dominant immune system response found in plants, fungi, insects, and primitive multicellular organisms (see Beyond vertebrates).. The major functions of the innate immune system are to: * recruit immune cells to infection sites by producing chemical factors, including chemical mediators called cytokines * activate the complement cascade to identify bacteria, activate cells, and promote clearance of antibody complexes or dead cells * identify and remove foreign substances present in organs, tissues, blood and lymph, by specialized white blood cells * activate the adaptive immune system through antigen presentation * act as a physical and chemical barrier to infectious agents; via physical measures such as skin and chemical measures such a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Industrial Farming
Industrial agriculture is a form of modern farming that refers to the industrialized production of crops and animals and animal products like eggs or milk. The methods of industrial agriculture include innovation in agricultural machinery and farming methods, genetic technology, techniques for achieving economies of scale in production, the creation of new markets for consumption, the application of patent protection to genetic information, and global trade. These methods are widespread in developed nations and increasingly prevalent worldwide. Most of the meat, dairy, eggs, fruits, and vegetables available in supermarkets are produced in this way. Historical development and future prospects Industrial agriculture arose hand in hand with the Industrial Revolution in general. The identification of nitrogen, potassium, and phosphorus (referred to by the acronym NPK) as critical factors in plant growth led to the manufacture of synthetic fertilizers, making possible more intens ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Allergic Sensitizer
Allergies, also known as allergic diseases, refer a number of conditions caused by the hypersensitivity of the immune system to typically harmless substances in the environment. These diseases include hay fever, food allergies, atopic dermatitis, allergic asthma, and anaphylaxis. Symptoms may include red eyes, an itchy rash, sneezing, coughing, a runny nose, shortness of breath, or swelling. Note: food intolerances and food poisoning are separate conditions. Common allergens include pollen and certain foods. Metals and other substances may also cause such problems. Food, insect stings, and medications are common causes of severe reactions. Their development is due to both genetic and environmental factors. The underlying mechanism involves immunoglobulin E antibodies (IgE), part of the body's immune system, binding to an allergen and then to a receptor on mast cells or basophils where it triggers the release of inflammatory chemicals such as histamine. Diagnosis is typica ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hutterite
Hutterites (german: link=no, Hutterer), also called Hutterian Brethren (German: ), are a communal ethnoreligious group, ethnoreligious branch of Anabaptism, Anabaptists, who, like the Amish and Mennonites, trace their roots to the Radical Reformation of the early 16th century and have formed intentional communities. The founder of the Hutterites, Jacob Hutter, "established the Hutterite colonies on the basis of the Schleitheim Confession, a classic Anabaptist statement of faith" of 1527, and the first communes were formed in 1528. Since the death of Hutter in 1536, the beliefs of the Hutterites, especially those espousing a community of goods and nonresistance, have resulted in hundreds of years of diaspora in many countries. The Hutterites embarked on a series of migrations through central and eastern Europe. Nearly extinct by the 18th century, they migrated to Russian Empire, Russia in 1770 and about a hundred years later to North America. Over the course of 140 years, their p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Asthma
Asthma is a long-term inflammatory disease of the airways of the lungs. It is characterized by variable and recurring symptoms, reversible airflow obstruction, and easily triggered bronchospasms. Symptoms include episodes of wheezing, coughing, chest tightness, and shortness of breath. These may occur a few times a day or a few times per week. Depending on the person, asthma symptoms may become worse at night or with exercise. Asthma is thought to be caused by a combination of genetic and environmental factors. Environmental factors include exposure to air pollution and allergens. Other potential triggers include medications such as aspirin and beta blockers. Diagnosis is usually based on the pattern of symptoms, response to therapy over time, and spirometry lung function testing. Asthma is classified according to the frequency of symptoms, forced expiratory volume in one second (FEV1), and peak expiratory flow rate. It may also be classified as atopic or non-atopic, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Middlefield, Ohio
Middlefield is a village in Middlefield Township, Geauga County, Ohio, United States. The population was 2,748 at the 2020 census. It is part of the Cleveland metropolitan area. Middlefield is known for being the center of the world's fourth largest Amish settlement, and its significant manufacturing base, which includes Gold Key Processing, Inc., Duncan Toys and KraftMaid. Because of its central location, home of the areas' public schools and prominent business and retail presence, Middlefield village is considered the hub community for Huntsburg, Parkman, and Middlefield Townships. History Once named "Batavia," the village received its current name because it was the midway point between Painesville and Warren. Middlefield was established in 1799 by James Thompson and his father, Isaac Thompson, and incorporated in 1901. Joseph Johnson settled north of Middlefield on what is now known as Johnson Corners in 1800. In 1818, James Thompson built a hotel. This hotel, later na ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Maple Syrup Urine Disease
Maple syrup urine disease (MSUD) is an autosomal recessive metabolic disorder affecting branched-chain amino acids. It is one type of organic acidemia. The condition gets its name from the distinctive sweet odor of affected infants' urine and earwax, particularly prior to diagnosis and during times of acute illness. Signs and symptoms The disease is named for the presence of sweet-smelling urine, similar to maple syrup, when the person goes into metabolic crisis. The smell is also detected in ear wax of an affected individual during metabolic crisis. In populations to whom maple syrup is unfamiliar, the aroma can be likened to fenugreek, and fenugreek ingestion may impart the aroma to urine. Symptoms of MSUD varies between patients and is greatly related to the amount of residual enzyme activity. Classic MSUD Infants with classic MSUD will display subtle symptoms within the first 24–48 hours. Subtle symptoms include poor feeding, either bottle or breast, lethargy, and irrita ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Strasburg, Pennsylvania
Strasburg is a borough in Lancaster County, Pennsylvania. It developed as a linear village stretching about along the Great Conestoga Road, later known as the Strasburg Road.Susan M. Zacher, NRHP Nomination Form Strasburg/ref> The population was 3,132 at the 2020 census. The town was named after the French city of Strasbourg, the native home of an early settler. The town is often called "Train Town USA" because of the many railroad attractions in and around town, including the Strasburg Rail Road and the Railroad Museum of Pennsylvania. Much of the movie ''Witness'' was filmed on a farm nearby. Much of the borough was listed as a historic district by the National Register of Historic Places in 1983. History The Old Conestoga Road was in use by 1714, and by 1750 a tavern and some log houses were built near the current site of Strasburg. The community grew as regional trade with Philadelphia grew. By 1759, there were 32 taxable properties in the town, including about ten hot ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clinic For Special Children
The Clinic for Special Children (CSC) is a primary pediatrics, pediatric care and genetics, gene research clinic located in Strasburg, Pennsylvania. The facility specializes in genetic problems of the plain sects, such as the Amish and Old Order Mennonites. It was founded in 1989. The most common genetic disorders treated by the Clinic are glutaric acidemia type I (GA1), which is common in the Amish population and maple syrup urine disease (MSUD), which has a high prevalence in the Old Order Mennonites. Establishment The Clinic for Special Children was founded by the Plain community with Dr. D. Holmes Morton and his wife, Caroline in 1989. The clinic building was barn raising, raised by the Plain community and completed in 1990 while an addition was added in 2000. In addition to patient care facilities, the Clinic also houses its own laboratories, providing rapid biochemical genetics, biochemical and molecular genetics, molecular genetic testing. The Clinic sees over 1,100 acti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
