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HYMAI
In molecular biology, Hydatidiform mole associated and imprinted (non-protein coding), also known as HYMAI, is a long non-coding RNA. It is an imprinted gene, which is paternally expressed. Overexpression of HYMAI and the protein-coding gene PLAG1 causes transient neonatal diabetes mellitus type 1 (TNDM1). See also * Long noncoding RNA Long non-coding RNAs (long ncRNAs, lncRNA) are a type of RNA, generally defined as transcripts more than 200 nucleotides that are not translated into protein. This arbitrary limit distinguishes long ncRNAs from small non-coding RNAs, such as m ... References Further reading * * *{{cite journal, vauthors=Arima T, Wake N , title=Establishment of the primary imprint of the HYMAI/PLAGL1 imprint control region during oogenesis. , journal=Cytogenet Genome Res , year= 2006 , volume= 113 , issue= 1–4 , pages= 247–252 , pmid=16575187 , doi=10.1159/000090839 , url=https://pubmed.ncbi.nlm.nih.gov/16575187 Non-coding RNA ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Long Non-coding RNA
Long non-coding RNAs (long ncRNAs, lncRNA) are a type of RNA, generally defined as transcripts more than 200 nucleotides that are not translated into protein. This arbitrary limit distinguishes long ncRNAs from small non-coding RNAs, such as microRNAs (miRNAs), small interfering RNAs (siRNAs), Piwi-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs), and other short RNAs. Long intervening/intergenic noncoding RNAs (lincRNAs) are sequences of lncRNA which do not overlap protein-coding genes. Long non-coding RNAs include intergenic lincRNAs, intronic ncRNAs, and sense and antisense lncRNAs, each type showing different genomic positions in relation to genes and exons. Abundance In 2007 a study found only one-fifth of transcription across the human genome is associated with protein-coding genes, indicating at least four times more long non-coding than coding RNA sequences. Large-scale complementary DNA (cDNA) sequencing projects such as FANTOM reveal the complexity of this t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PLAG1
Zinc finger protein PLAG1 is a protein that in humans is encoded by the ''PLAG1'' gene. Function Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas. Interactions PLAG1 has been shown to interact Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ... with Karyopherin alpha 2. References Further reading * * * * * * * * * * * * * * * * * * External links * Transcription factors {{gene-8-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transient Neonatal Diabetes Mellitus
Transient neonatal diabetes mellitus (TNDM) is a form of neonatal diabetes presenting at birth that is not permanent. This disease is considered to be a type of maturity onset diabetes of the young Maturity-onset diabetes of the young (MODY) refers to any of several hereditary forms of diabetes mellitus caused by mutations in an autosomal dominant gene disrupting insulin production. MODY is often referred to as monogenic diabetes to disting ... (MODY). Types Cause This condition has to do with genetics and is often associated with having an added Chromosome 7 gene (mostly from the paternal side). The form on chromosome 6 can involve imprinting. Diagnosis Management See also * Permanent neonatal diabetes mellitus References Further readingGeneReview/NIH/UW entry on 6q24-Related Transient Neonatal Diabetes Mellitush1> External links Diabetes Neonatology {{perinatal-disorder-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Long Noncoding RNA
Long non-coding RNAs (long ncRNAs, lncRNA) are a type of RNA, generally defined as transcripts more than 200 nucleotides that are not translated into protein. This arbitrary limit distinguishes long ncRNAs from small non-coding RNAs, such as microRNAs (miRNAs), small interfering RNAs (siRNAs), Piwi-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs), and other short RNAs. Long intervening/intergenic noncoding RNAs (lincRNAs) are sequences of lncRNA which do not overlap protein-coding genes. Long non-coding RNAs include intergenic lincRNAs, intronic ncRNAs, and sense and antisense lncRNAs, each type showing different genomic positions in relation to genes and exons. Abundance In 2007 a study found only one-fifth of transcription across the human genome is associated with protein-coding genes, indicating at least four times more long non-coding than coding RNA sequences. Large-scale complementary DNA (cDNA) sequencing projects such as FANTOM reveal the complexity of this tr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
