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HS-110
Heat Biologics Inc. is a US biotechnology company focused on the field of immunotherapy. Heat Biologics was founded by Jeff Wolf and Eckhard Podack, in conjunction with the University of Miami and Seed-One Ventures. The company is based in Morrisville, North Carolina. History In 2008, Heat Biologics was founded by Jeff Wolf and Eckhard Podack, in conjunction with the University of Miami and Seed-One Ventures. The company relocated to North Carolina in 2011. NCBiotech provided $225,000 of initial funding the same year. On July 24, 2013, Heat Biologics stock went public on NASDAQ under ticker symbol HTBX. In 2017, Heat Biologics acquired an 80% controlling interest in Pelican Therapeutics. Morrisville, North Carolina became the company's headquarters in 2019. In 2020, the Leonard M. Miller School of Medicine collaborated with Heat Biologics to develop a COVID-19 vaccine using gp-96 to express antigens associated with COVID-19. In 2021, Heat Biologics began Phase 2 clinical tr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Public Company
A public company is a company whose ownership is organized via shares of stock which are intended to be freely traded on a stock exchange or in over-the-counter markets. A public (publicly traded) company can be listed on a stock exchange (listed company), which facilitates the trade of shares, or not ( unlisted public company). In some jurisdictions, public companies over a certain size must be listed on an exchange. In most cases, public companies are ''private'' enterprises in the ''private'' sector, and "public" emphasizes their reporting and trading on the public markets. Public companies are formed within the legal systems of particular states, and therefore have associations and formal designations which are distinct and separate in the polity in which they reside. In the United States, for example, a public company is usually a type of corporation (though a corporation need not be a public company), in the United Kingdom it is usually a public limited company (plc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Miami
The University of Miami (UM, UMiami, Miami, U of M, and The U) is a private research university in Coral Gables, Florida. , the university enrolled 19,096 students in 12 colleges and schools across nearly 350 academic majors and programs, including the Leonard M. Miller School of Medicine in Miami's Health District, the law school on the main campus, and the Rosenstiel School of Marine and Atmospheric Science on Virginia Key with research facilities in southern Miami-Dade County. The University of Miami offers 138 undergraduate, 140 master's, and 67 doctoral degree programs. Since its founding in 1925, the university has attracted students from all 50 states and 173 foreign countries. With 16,954 faculty and staff as of 2021, the University of Miami is the second largest employer in Miami-Dade County. The university's main campus in Coral Gables spans , has over of buildings, and is located south of Downtown Miami, the heart of the nation's ninth largest and world's ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immune Checkpoint
Immune checkpoints are regulators of the immune system. These pathways are crucial for self-tolerance, which prevents the immune system from attacking cells indiscriminately. However, some cancers can protect themselves from attack by stimulating immune checkpoint targets. Inhibitory checkpoint molecules are targets for cancer immunotherapy due to their potential for use in multiple types of cancers. Currently approved checkpoint inhibitors block CTLA4 and PD-1 and PD-L1. For the related basic science discoveries, James P. Allison and Tasuku Honjo won the Tang Prize in Biopharmaceutical Science and the Nobel Prize in Physiology or Medicine in 2018. Stimulatory checkpoint molecules Four stimulatory checkpoint molecules are members of the tumor necrosis factor (TNF) receptor superfamily—CD27, CD40, OX40, GITR and CD137. Another two stimulatory checkpoint molecules belong to the B7-CD28 superfamily—CD28 itself and ICOS. * CD27: This molecule supports antigen-specific ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nivolumab
Nivolumab, sold under the brand name Opdivo, is a medication used to treat a number of types of cancer. This includes melanoma, lung cancer, malignant pleural mesothelioma, renal cell carcinoma, Hodgkin lymphoma, head and neck cancer, urothelial carcinoma, colon cancer, esophageal squamous cell carcinoma, liver cancer, gastric cancer, and esophageal or gastroesophageal junction (GEJ) cancer. It is used by slow injection into a vein. The most common side effects include fatigue, rash, musculoskeletal pain, pruritus, diarrhea, nausea, asthenia, cough, dyspnea, constipation, decreased appetite, back pain, arthralgia, upper respiratory tract infection, pyrexia, headache, abdominal pain, and vomiting. Use during pregnancy may harm the baby and use when breastfeeding is not recommended. Nivolumab is a human IgG4 monoclonal antibody that blocks PD-1. It is a type of immunotherapy and works as a checkpoint inhibitor, blocking a signal that prevents activation of T cells from attackin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cyclophosphamide
Cyclophosphamide (CP), also known as cytophosphane among other names, is a medication used as chemotherapy and to suppress the immune system. As chemotherapy it is used to treat lymphoma, multiple myeloma, leukemia, ovarian cancer, breast cancer, small cell lung cancer, neuroblastoma, and sarcoma. As an immune suppressor it is used in nephrotic syndrome, granulomatosis with polyangiitis, and following organ transplant, among other conditions. It is taken by mouth or injection into a vein. Most people develop side effects. Common side effects include low white blood cell counts, loss of appetite, vomiting, hair loss, and bleeding from the bladder. Other severe side effects include an increased future risk of cancer, infertility, allergic reactions, and pulmonary fibrosis. Cyclophosphamide is in the alkylating agent and nitrogen mustard family of medications. It is believed to work by interfering with the duplication of DNA and the creation of RNA. Cyclophosphamide was ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
COVID-19
Coronavirus disease 2019 (COVID-19) is a contagious disease caused by a virus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The first known case was identified in Wuhan, China, in December 2019. The disease quickly spread worldwide, resulting in the COVID-19 pandemic. The symptoms of COVID‑19 are variable but often include fever, cough, headache, fatigue, breathing difficulties, loss of smell, and loss of taste. Symptoms may begin one to fourteen days after exposure to the virus. At least a third of people who are infected do not develop noticeable symptoms. Of those who develop symptoms noticeable enough to be classified as patients, most (81%) develop mild to moderate symptoms (up to mild pneumonia), while 14% develop severe symptoms (dyspnea, hypoxia, or more than 50% lung involvement on imaging), and 5% develop critical symptoms (respiratory failure, shock, or multiorgan dysfunction). Older people are at a higher risk of developing se ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Leonard M
Leonard or ''Leo'' is a common English masculine given name and a surname. The given name and surname originate from the Old High German ''Leonhard'' containing the prefix ''levon'' ("lion") from the Greek Λέων ("lion") through the Latin '' Leo,'' and the suffix ''hardu'' ("brave" or "hardy"). The name has come to mean "lion strength", "lion-strong", or "lion-hearted". Leonard was the name of a Saint in the Middle Ages period, known as the patron saint of prisoners. Leonard is also an Irish origin surname, from the Gaelic ''O'Leannain'' also found as O'Leonard, but often was anglicised to just Leonard, consisting of the prefix ''O'' ("descendant of") and the suffix ''Leannan'' ("lover"). The oldest public records of the surname appear in 1272 in Huntingdonshire, England, and in 1479 in Ulm, Germany. Variations The name has variants in other languages: * Leen, Leendert, Lenard (Dutch) * Lehnertz, Lehnert (Luxembourgish) * Len (English) * :hu:Lénárd (Hungarian) * L ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
NASDAQ
The Nasdaq Stock Market () (National Association of Securities Dealers Automated Quotations Stock Market) is an American stock exchange based in New York City. It is the most active stock trading venue in the US by volume, and ranked second on the list of stock exchanges by market capitalization of shares traded, behind the New York Stock Exchange. The exchange platform is owned by Nasdaq, Inc., which also owns the Nasdaq Nordic stock market network and several U.S.-based stock and options exchanges. History 1971–2000 "Nasdaq" was initially an acronym for the National Association of Securities Dealers Automated Quotations. It was founded in 1971 by the National Association of Securities Dealers (NASD), now known as the Financial Industry Regulatory Authority (FINRA). On February 8, 1971, the Nasdaq stock market began operations as the world's first electronic stock market. At first, it was merely a "quotation system" and did not provide a way to perform electronic tr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immunotherapy
Immunotherapy or biological therapy is the treatment of disease by activating or suppressing the immune system. Immunotherapies designed to elicit or amplify an immune response are classified as ''activation immunotherapies,'' while immunotherapies that reduce or suppress are classified as '' suppression immunotherapies''. Immunotherapy is under preliminary research for its potential to treat various forms of cancer. Cell-based immunotherapies are effective for some cancers. Immune effector cells such as lymphocytes, macrophages, dendritic cells, natural killer cells, and cytotoxic T lymphocytes work together to defend the body against cancer by targeting abnormal antigens expressed on the surface of tumor cells. Vaccine-induced immunity to COVID-19 relies mostly on an immunomodulatory T cell response. Therapies such as granulocyte colony-stimulating factor (G-CSF), interferons, imiquimod and cellular membrane fractions from bacteria are licensed for medical use. Others includ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Morrisville, North Carolina
Morrisville is a town located primarily in Wake County, North Carolina, United States (a small portion extends into neighboring Durham County). The population was 18,576 at the 2010 census. The U.S. Census Bureau estimated the town's population to be 28,846 as of July 1, 2019. Morrisville is part of the Research Triangle metropolitan region. The regional name originated after the 1959 creation of the Research Triangle Park, located midway between the cities of Raleigh and Durham. The Research Triangle region encompasses the U.S. Census Bureau's Combined Statistical Area (CSA) of Raleigh-Durham- Cary. The estimated population of the Raleigh-Durham-Cary CSA was 1,565,223 as of July 1, 2006, with the Raleigh-Cary Metropolitan Statistical Area (MSA) portion estimated at 994,551 residents. The operational headquarter of an American -Chinese multinational technology company Lenovo is located in the municipal limits. History The area was originally named in 1852 after Jeremiah Morri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biotechnology
Biotechnology is the integration of natural sciences and engineering sciences in order to achieve the application of organisms, cells, parts thereof and molecular analogues for products and services. The term ''biotechnology'' was first used by Károly Ereky in 1919, meaning the production of products from raw materials with the aid of living organisms. Definition The concept of biotechnology encompasses a wide range of procedures for modifying living organisms according to human purposes, going back to domestication of animals, cultivation of the plants, and "improvements" to these through breeding programs that employ artificial selection and hybridization. Modern usage also includes genetic engineering as well as cell and tissue culture technologies. The American Chemical Society defines biotechnology as the application of biological organisms, systems, or processes by various industries to learning about the science of life and the improvement of the value of materi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biotechnology
Biotechnology is the integration of natural sciences and engineering sciences in order to achieve the application of organisms, cells, parts thereof and molecular analogues for products and services. The term ''biotechnology'' was first used by Károly Ereky in 1919, meaning the production of products from raw materials with the aid of living organisms. Definition The concept of biotechnology encompasses a wide range of procedures for modifying living organisms according to human purposes, going back to domestication of animals, cultivation of the plants, and "improvements" to these through breeding programs that employ artificial selection and hybridization. Modern usage also includes genetic engineering as well as cell and tissue culture technologies. The American Chemical Society defines biotechnology as the application of biological organisms, systems, or processes by various industries to learning about the science of life and the improvement of the value of materi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
