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HLA-A33
A33 frequencies A33 shows two different distributions that can be discriminated by subtyping capability of SSP-PCR. A*3301 distribution The first distribution appears to have a Western distribution that introgresses into Europe as a result of the Post-neolithic periods. It is commonly found in linkage disequilibration within the A*3301-Cw*0802-B*1402 haplotype which can be extended to DRB1 and DQB1 in certain instances (See Below). The source of its general expansion appears to be the middle east or the levant, as it is found in the Palestinian population. B14 splits into B64 (B*1401) and B65 (B*1402) but the only Arabian people which show both antigens are the United Arab Emirates. A*3303 distribution Certain alleles confound population histories. At the top of that list is A*3303. This allele appears to jump, figuratively, out of West Africa into South Asia. The point of origin is Africa, most likely central or western Africa given the low levels in East Africa (altho ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Subsaharan Africa
Sub-Saharan Africa is, geographically, the area and regions of the continent of Africa that lies south of the Sahara. These include West Africa, East Africa, Central Africa, and Southern Africa. Geopolitically, in addition to the African countries and territories that are situated fully in that specified region, the term may also include polities that only have part of their territory located in that region, per the definition of the United Nations (UN). This is considered a non-standardized geographical region with the number of countries included varying from 46 to 48 depending on the organization describing the region (e.g. UN, WHO, World Bank, etc.). The African Union uses a different regional breakdown, recognizing all 55 member states on the continent - grouping them into 5 distinct and standard regions. The term serves as a grouping counterpart to North Africa, which is instead grouped with the definition of MENA (i.e. Middle East–North Africa) as it is part of t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SSP-PCR
The polymerase chain reaction (PCR) is a method widely used to rapidly make millions to billions of copies (complete or partial) of a specific DNA sample, allowing scientists to take a very small sample of DNA and amplify it (or a part of it) to a large enough amount to study in detail. PCR was invented in 1983 by the American biochemist Kary Mullis at Cetus Corporation; Mullis and biochemist Michael Smith, who had developed other essential ways of manipulating DNA, were jointly awarded the Nobel Prize in Chemistry in 1993. PCR is fundamental to many of the procedures used in genetic testing and research, including analysis of ancient samples of DNA and identification of infectious agents. Using PCR, copies of very small amounts of DNA sequences are exponentially amplified in a series of cycles of temperature changes. PCR is now a common and often indispensable technique used in medical laboratory research for a broad variety of applications including biomedical research and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Linkage Disequilibration
In population genetics, linkage disequilibrium (LD) is the non-random association of alleles at different loci in a given population. Loci are said to be in linkage disequilibrium when the frequency of association of their different alleles is higher or lower than what would be expected if the loci were independent and associated randomly. Linkage disequilibrium is influenced by many factors, including selection, the rate of genetic recombination, mutation rate, genetic drift, the system of mating, population structure, and genetic linkage. As a result, the pattern of linkage disequilibrium in a genome is a powerful signal of the population genetic processes that are structuring it. In spite of its name, linkage disequilibrium may exist between alleles at different loci without any genetic linkage between them and independently of whether or not allele frequencies are in equilibrium (not changing with time). Furthermore, linkage disequilibrium is sometimes referred to as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Yayoi
The started at the beginning of the Neolithic in Japan, continued through the Bronze Age, and towards its end crossed into the Iron Age. Since the 1980s, scholars have argued that a period previously classified as a transition from the Jōmon period should be reclassified as Early Yayoi. The date of the beginning of this transition is controversial, with estimates ranging from the 10th to the 3rd centuries BC. The period is named after the neighbourhood of Tokyo where archaeologists first uncovered artifacts and features from that era in the late 19th century. Distinguishing characteristics of the Yayoi period include the appearance of new Yayoi pottery styles and the start of an intensive rice agriculture in paddy fields. A hierarchical social class structure dates from this period and has its origin in China. Techniques in metallurgy based on the use of bronze and iron were also introduced from China via Korea to Japan in this period. The Yayoi followed the Jōmon period and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HLA DR3-DQ2
HLA DR3-DQ2 is double serotype that specifically recognizes cells from individuals who carry a multigene HLA DR, DQ haplotype. Certain HLA DR and DQ genes have known involvement in autoimmune diseases. DR3- DQ2, a multigene haplotype, stands out in prominence because it is a factor in several prominent diseases, namely coeliac disease and juvenile diabetes. In coeliac disease, the DR3-DQ2 haplotype is associated with highest risk for disease in first degree relatives, highest risk is conferred by DQA1*0501:DQB1*0201 homozygotes and semihomozygotes of DQ2, and represents the overwhelming majority of risk. HLA DR3-DQ2 encodes DQ2.5cis isoform of HLA-DQ, this isoform is described frequently as 'the DQ2 isoform', but in actuality there are two major DQ2 isoform. The DQ2.5 isoform, however, is many times more frequently associated with autoimmune disease, and as a result to contribution of DQ2.2 is often ignored. The frequency of both diseases changes with respect to both the envi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neolithic
The Neolithic period, or New Stone Age, is an Old World archaeological period and the final division of the Stone Age. It saw the Neolithic Revolution, a wide-ranging set of developments that appear to have arisen independently in several parts of the world. This "Neolithic package" included the introduction of farming, domestication of animals, and change from a hunter-gatherer lifestyle to one of settlement. It began about 12,000 years ago when farming appeared in the Epipalaeolithic Near East, and later in other parts of the world. The Neolithic lasted in the Near East until the transitional period of the Chalcolithic (Copper Age) from about 6,500 years ago (4500 BC), marked by the development of metallurgy, leading up to the Bronze Age and Iron Age. In other places the Neolithic followed the Mesolithic (Middle Stone Age) and then lasted until later. In Ancient Egypt, the Neolithic lasted until the Protodynastic period, 3150 BC.Karin Sowada and Peter Grave. Egypt in th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phoenicia
Phoenicia () was an ancient thalassocratic civilization originating in the Levant region of the eastern Mediterranean, primarily located in modern Lebanon. The territory of the Phoenician city-states extended and shrank throughout their history, and they possessed several enclaves such as Arwad and Tell Sukas (modern Syria). The core region in which the Phoenician culture developed and thrived stretched from Tripoli and Byblos in northern Lebanon to Mount Carmel in modern Israel. At their height, the Phoenician possessions in the Eastern Mediterranean stretched from the Orontes River mouth to Ashkelon. Beyond its homeland, the Phoenician civilization extended to the Mediterranean from Cyprus to the Iberian Peninsula. The Phoenicians were a Semitic-speaking people of somewhat unknown origin who emerged in the Levant around 3000 BC. The term ''Phoenicia'' is an ancient Greek exonym that most likely described one of their most famous exports, a dye also known as Tyrian purpl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mycenaean Greece
Mycenaean Greece (or the Mycenaean civilization) was the last phase of the Bronze Age The Bronze Age is a historic period, lasting approximately from 3300 BC to 1200 BC, characterized by the use of bronze, the presence of writing in some areas, and other early features of urban civilization. The Bronze Age is the second pri ... in Ancient Greece, spanning the period from approximately 1750 to 1050 BC.. It represents the first advanced and distinctively Greek civilization in mainland Greece with its palatial states, urban organization, works of art, and writing system.Lazaridis, Iosif et al.Genetic origins of the Minoans and Mycenaeans. ''Nature'', 2017Supplementary Information "The Mycenaeans", pp. 2–3).. The Mycenaeans were mainland Greeks, Greek peoples who were likely stimulated by their contact with insular Minoan civilization, Minoan Crete and other Mediterranean Sea, Mediterranean cultures to develop a more sophisticated sociopolitical culture of their own. The ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mediterranean
The Mediterranean Sea is a sea connected to the Atlantic Ocean, surrounded by the Mediterranean Basin and almost completely enclosed by land: on the north by Western and Southern Europe and Anatolia, on the south by North Africa, and on the east by the Levant. The Sea has played a central role in the history of Western civilization. Geological evidence indicates that around 5.9 million years ago, the Mediterranean was cut off from the Atlantic and was partly or completely desiccated over a period of some 600,000 years during the Messinian salinity crisis before being refilled by the Zanclean flood about 5.3 million years ago. The Mediterranean Sea covers an area of about , representing 0.7% of the global ocean surface, but its connection to the Atlantic via the Strait of Gibraltar—the narrow strait that connects the Atlantic Ocean to the Mediterranean Sea and separates the Iberian Peninsula in Europe from Morocco in Africa—is only wide. The Mediterranean Sea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
India
India, officially the Republic of India (Hindi: ), is a country in South Asia. It is the seventh-largest country by area, the second-most populous country, and the most populous democracy in the world. Bounded by the Indian Ocean on the south, the Arabian Sea on the southwest, and the Bay of Bengal on the southeast, it shares land borders with Pakistan to the west; China, Nepal, and Bhutan to the north; and Bangladesh and Myanmar to the east. In the Indian Ocean, India is in the vicinity of Sri Lanka and the Maldives; its Andaman and Nicobar Islands share a maritime border with Thailand, Myanmar, and Indonesia. Modern humans arrived on the Indian subcontinent from Africa no later than 55,000 years ago., "Y-Chromosome and Mt-DNA data support the colonization of South Asia by modern humans originating in Africa. ... Coalescence dates for most non-European populations average to between 73–55 ka.", "Modern human beings—''Homo sapiens''—originated in Africa. Then, int ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Indo-Aryans
Indo-Aryan peoples are a diverse collection of Indo-European peoples speaking Indo-Aryan languages in the Indian subcontinent. Historically, Aryan were the Indo-European pastoralists who migrated from Central Asia into South Asia and introduced Proto-Indo-Aryan language. The Indo-Aryan language speakers are found across South Asia. History Proto-Indo-Iranians The introduction of the Indo-Aryan languages in the Indian subcontinent was the result of a migration of Indo-Aryan people from Central Asia into the northern Indian subcontinent (modern-day Bangladesh, Bhutan, India, Nepal, Pakistan, and Sri Lanka). These migrations started approximately 1,800 BCE, after the invention of the war chariot, and also brought Indo-Aryan languages into the Levant and possibly Inner Asia. Another group of the Indo-Aryans migrated further westward and founded the Mitanni kingdom in northern Syria; (c. 1500–1300 BC) the other group were the Vedic people. Christopher I. Beckwith su ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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