George P. Smith (chemist)
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George P. Smith (chemist)
George Pearson Smith (born 10 March 1941) is an American biologist and Nobel laureate. He is a Curators' Distinguished Professor Emeritus of Biological Sciences at the University of Missouri in Columbia, Missouri, US. Career Born in Norwalk, Connecticut, he earned his A.B. degree from Haverford College in biology, was a high school teacher and lab technician for a year, and earned his PhD degree in bacteriology and immunology from Harvard University. He was a postdoc at the University of Wisconsin (with future Nobel laureate Oliver Smithies) before moving to Columbia, Missouri and joining the University of Missouri faculty in 1975. He spent the 1983–1984 academic year at Duke University with Robert Webster where he began the work that led to him being awarded a Nobel Prize. He is best known for phage display, a technique where a specific protein sequence is artificially inserted into the coat protein gene of a bacteriophage, causing the protein to be expressed on the ...
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Stockholm
Stockholm () is the Capital city, capital and List of urban areas in Sweden by population, largest city of Sweden as well as the List of urban areas in the Nordic countries, largest urban area in Scandinavia. Approximately 980,000 people live in the Stockholm Municipality, municipality, with 1.6 million in the Stockholm urban area, urban area, and 2.4 million in the Metropolitan Stockholm, metropolitan area. The city stretches across fourteen islands where Mälaren, Lake Mälaren flows into the Baltic Sea. Outside the city to the east, and along the coast, is the island chain of the Stockholm archipelago. The area has been settled since the Stone Age, in the 6th millennium BC, and was founded as a city in 1252 by Swedish statesman Birger Jarl. It is also the county seat of Stockholm County. For several hundred years, Stockholm was the capital of Finland as well (), which then was a part of Sweden. The population of the municipality of Stockholm is expected to reach o ...
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University Of Wisconsin
A university () is an institution of higher (or tertiary) education and research which awards academic degrees in several academic disciplines. Universities typically offer both undergraduate and postgraduate programs. In the United States, the designation is reserved for colleges that have a graduate school. The word ''university'' is derived from the Latin ''universitas magistrorum et scholarium'', which roughly means "community of teachers and scholars". The first universities were created in Europe by Catholic Church monks. The University of Bologna (''Università di Bologna''), founded in 1088, is the first university in the sense of: *Being a high degree-awarding institute. *Having independence from the ecclesiastic schools, although conducted by both clergy and non-clergy. *Using the word ''universitas'' (which was coined at its foundation). *Issuing secular and non-secular degrees: grammar, rhetoric, logic, theology, canon law, notarial law.Hunt Janin: "The university ...
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Mondoweiss
''Mondoweiss'' is a news website that began as a general-interest blog written by Philip Weiss on ''The New York Observer'' website. It subsequently developed into a broader collaborative venture after fellow journalist Adam Horowitz joined it as co-editor.Michelle Goldberg, 'Idiosyncratic and influential anti-Zionist blogger Philip Weiss has a complicated relationship with Israel, American Jewry, and himself,’The Tablet 20 January 2011 In 2010, Weiss described the website’s purpose as one of covering American foreign policy in the Middle East from a 'progressive Jewish perspective’. In 2011, it defined its aims as fostering greater fairness for Palestinians in American foreign policy, and as providing American Jews with an alternative identity to that expressed by Zionist ideology, which he regards as antithetical to American liberalism. Originally supported by Type Media Center, it is a part of the Center for Economic Research and Social Change. Staff Philip Weiss has ...
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Tel Aviv
Tel Aviv-Yafo ( he, תֵּל־אָבִיב-יָפוֹ, translit=Tēl-ʾĀvīv-Yāfō ; ar, تَلّ أَبِيب – يَافَا, translit=Tall ʾAbīb-Yāfā, links=no), often referred to as just Tel Aviv, is the most populous city in the Gush Dan metropolitan area of Israel. Located on the Israeli coastal plain, Israeli Mediterranean coastline and with a population of , it is the Economy of Israel, economic and Technology of Israel, technological center of the country. If East Jerusalem is considered part of Israel, Tel Aviv is the country's second most populous city after Jerusalem; if not, Tel Aviv is the most populous city ahead of West Jerusalem. Tel Aviv is governed by the Tel Aviv-Yafo Municipality, headed by Mayor Ron Huldai, and is home to many List of diplomatic missions in Israel, foreign embassies. It is a Global city, beta+ world city and is ranked 57th in the 2022 Global Financial Centres Index. Tel Aviv has the List of cities by GDP, third- or fourth-largest e ...
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Haaretz
''Haaretz'' ( , originally ''Ḥadshot Haaretz'' – , ) is an Israeli newspaper. It was founded in 1918, making it the longest running newspaper currently in print in Israel, and is now published in both Hebrew and English in the Berliner format. The English edition is published and sold together with the ''International New York Times''. Both Hebrew and English editions can be read on the internet. In North America, it is published as a weekly newspaper, combining articles from the Friday edition with a roundup from the rest of the week. It is considered Israel's newspaper of record. It is known for its left-wing and liberal stances on domestic and foreign issues. As of 2022, ''Haaretz'' has the third-largest circulation in Israel. It is widely read by international observers, especially in its English edition, and discussed in the international press. According to the Center for Research Libraries, among Israel's daily newspapers, "''Haaretz'' is considered the most infl ...
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Boycott, Divestment And Sanctions
Boycott, Divestment and Sanctions (BDS) is a Palestinian-led movement promoting boycotts, divestments, and economic sanctions against Israel. Its objective is to pressure Israel to meet what the BDS movement describes as Israel's obligations under international law, defined as withdrawal from the occupied territories, removal of the separation barrier in the West Bank, full equality for Arab-Palestinian citizens of Israel, and "respecting, protecting, and promoting the rights of Palestinian refugees to return to their homes and properties". The movement is organized and coordinated by the Palestinian BDS National Committee. BDS is modeled after the anti-apartheid movement in South Africa. Its proponents compare the Palestinians' plight to that of apartheid-era black South Africans. Protests and conferences in support of the movement have been held in several countries. Its mascot, which features on its logotype, is Handala, a symbol of Palestinian identity and "right of ...
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Frances Arnold
Frances Hamilton Arnold (born July 25, 1956) is an American chemical engineer and Nobel Laureate. She is the Linus Pauling Professor of Chemical Engineering, Bioengineering and Biochemistry at the California Institute of Technology (Caltech). In 2018, she was awarded the Nobel Prize in Chemistry for pioneering the use of directed evolution to engineer enzymes. Since January 2021, she serves as an external co-chair of President Joe Biden's Council of Advisors on Science and Technology (PCAST). Early life and education Arnold is the daughter of Josephine Inman (née Routheau) and nuclear physicist William Howard Arnold, and the granddaughter of Lieutenant General William Howard Arnold. She grew up in the Pittsburgh suburb of Edgewood, and the Pittsburgh neighborhoods of Shadyside and Squirrel Hill, graduating from the city's Taylor Allderdice High School in 1974. As a high schooler, she hitchhiked to Washington, D.C., to protest the Vietnam War and lived on her own, working as a ...
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Greg Winter
Sir Gregory Paul Winter (born 14 April 1951) is a Nobel Prize-winning English people, English Molecular Biologist, molecular biologist best known for his work on the therapeutic use of monoclonal antibodies. His research career has been based almost entirely at the MRC Laboratory of Molecular Biology and the MRC Centre for Protein Engineering, in Cambridge, England. He is credited with having invented techniques to both Humanized antibody, humanise (1986) and, later, to fully humanise using phage display, antibodies for therapeutic uses.ThScientific Founders of Bicycle Therapeutics Ltd. – Christian Heinis and Sir Greg Winter, FRS. Previously, antibodies had been derived from mice, which made them difficult to use in human therapeutics because the human immune system had anti-mouse reactions to them. For these developments Winter was awarded the 2018 Nobel Prize in Chemistry along with George Smith (chemist), George Smith and Frances Arnold. He is a Fellow of Trinity College ...
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Filamentous Phage
Filamentous bacteriophage is a family of viruses (''Inoviridae'') that infect bacteria. The phages are named for their filamentous shape, a worm-like chain (long, thin and flexible, reminiscent of a length of cooked spaghetti), about 6 nm in diameter and about 1000-2000 nm long. The coat of the virion comprises five types of viral protein, which are located during phage assembly in the inner membrane of the host bacteria, and are added to the nascent virion as it extrudes through the membrane. The simplicity of this family makes it an attractive model system to study fundamental aspects of molecular biology, and it has also proven useful as a tool in immunology and nanotechnology. Characteristics Filamentous bacteriophages are among the simplest living organisms known, with far fewer genes than the classical tailed bacteriophages studied by the phage group. The family contains 29 defined species, divided between 23 genera. However, mining of genomic and metagenomic ...
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Peptide
Peptides (, ) are short chains of amino acids linked by peptide bonds. Long chains of amino acids are called proteins. Chains of fewer than twenty amino acids are called oligopeptides, and include dipeptides, tripeptides, and tetrapeptides. A polypeptide is a longer, continuous, unbranched peptide chain. Hence, peptides fall under the broad chemical classes of biological polymers and oligomers, alongside nucleic acids, oligosaccharides, polysaccharides, and others. A polypeptide that contains more than approximately 50 amino acids is known as a protein. Proteins consist of one or more polypeptides arranged in a biologically functional way, often bound to ligands such as coenzymes and cofactors, or to another protein or other macromolecule such as DNA or RNA, or to complex macromolecular assemblies. Amino acids that have been incorporated into peptides are termed residues. A water molecule is released during formation of each amide bond.. All peptides except cyclic pep ...
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Bacteriophage
A bacteriophage (), also known informally as a ''phage'' (), is a duplodnaviria virus that infects and replicates within bacteria and archaea. The term was derived from "bacteria" and the Greek φαγεῖν ('), meaning "to devour". Bacteriophages are composed of proteins that encapsulate a DNA or RNA genome, and may have structures that are either simple or elaborate. Their genomes may encode as few as four genes (e.g. MS2) and as many as hundreds of genes. Phages replicate within the bacterium following the injection of their genome into its cytoplasm. Bacteriophages are among the most common and diverse entities in the biosphere. Bacteriophages are ubiquitous viruses, found wherever bacteria exist. It is estimated there are more than 1031 bacteriophages on the planet, more than every other organism on Earth, including bacteria, combined. Viruses are the most abundant biological entity in the water column of the world's oceans, and the second largest component of biom ...
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Viral Coat Protein
A capsid is the protein shell of a virus, enclosing its genetic material. It consists of several oligomeric (repeating) structural subunits made of protein called protomers. The observable 3-dimensional morphological subunits, which may or may not correspond to individual proteins, are called capsomeres. The proteins making up the capsid are called capsid proteins or viral coat proteins (VCP). The capsid and inner genome is called the nucleocapsid. Capsids are broadly classified according to their structure. The majority of the viruses have capsids with either helical or icosahedral structure. Some viruses, such as bacteriophages, have developed more complicated structures due to constraints of elasticity and electrostatics. The icosahedral shape, which has 20 equilateral triangular faces, approximates a sphere, while the helical shape resembles the shape of a spring, taking the space of a cylinder but not being a cylinder itself. The capsid faces may consist of one or more ...
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