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Gene Brown (professor)
Gene Monte Brown (1926 – 4 August 2017) was a Professor Emeritus of Biochemistry at the Massachusetts Institute of Technology. He joined the department in 1954 and served as its head from 1977 to 1985. He served as the Dean of Science at MIT from 1985 to 1991. He is notable for his interest in and commitment to undergraduate education, and taught the department's biochemistry course for over 50 years. Early life and education Brown was born in Pioneer, Missouri and raised in nearby Cassville until around age nine, when his family moved to Idaho. He was the first member of his family to attend high school and the only member of his graduating high school class to attend college. After a year as a college student in Idaho, he joined the Army Air Corps, where he was assigned to work in chemical warfare operations. His tasks included teaching safety lessons, which he later described as "whetting isteaching interest" for his later activities as an educator. Brown used the GI Bil ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pioneer, Missouri
Pioneer is an unincorporated community in Barry County, Missouri Missouri is a U.S. state, state in the Midwestern United States, Midwestern region of the United States. Ranking List of U.S. states and territories by area, 21st in land area, it is bordered by eight states (tied for the most with Tennessee ..., United States. History A post office called Pioneer was established in 1883, and remained in operation until 1934. The community was named for the local pioneer settlers. References Unincorporated communities in Barry County, Missouri Unincorporated communities in Missouri {{BarryCountyMO-geo-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Boris Magasanik
Boris Magasanik (December 19, 1919December 25, 2013) was a microbiologist and biochemist who was the Jacques Monod Professor Emeritus of Microbiology in the Department of Biology at the Massachusetts Institute of Technology. After moving from Harvard Medical School in 1960, Magasanik spent the rest of his research career at MIT, including an influential decade as the head of the Department of Biology from 1967–77. Magasanik's research interests focused on gene regulation, including study of nitrogen metabolic regulation in bacteria, catabolite repression, and intracellular signaling via two-component systems. Magasanik retired in 1990 and died in 2013. Early life and education Magasanik was born in Kharkiv, Ukraine on December 19, 1919, to a family he later described as "belonging to the capitalist class" and who left for Vienna after Kharkiv was captured by Communist forces during the then-ongoing Ukrainian civil war. Raised in Vienna, Magasanik began his university education st ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Coenzyme
A cofactor is a non-protein chemical compound or metallic ion that is required for an enzyme's role as a catalyst (a catalyst is a substance that increases the rate of a chemical reaction). Cofactors can be considered "helper molecules" that assist in biochemical transformations. The rates at which these happen are characterized in an area of study called enzyme kinetics. Cofactors typically differ from ligands in that they often derive their function by remaining bound. Cofactors can be divided into two types: inorganic ions and complex organic molecules called coenzymes. Coenzymes are mostly derived from vitamins and other organic essential nutrients in small amounts. (Note that some scientists limit the use of the term "cofactor" for inorganic substances; both types are included here.) Coenzymes are further divided into two types. The first is called a "prosthetic group", which consists of a coenzyme that is tightly (or even covalently) and permanently bound to a protein. The ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Coenzyme A
Coenzyme A (CoA, SHCoA, CoASH) is a coenzyme, notable for its role in the synthesis and oxidation of fatty acids, and the oxidation of pyruvate in the citric acid cycle. All genomes sequenced to date encode enzymes that use coenzyme A as a substrate, and around 4% of cellular enzymes use it (or a thioester) as a substrate. In humans, CoA biosynthesis requires cysteine, pantothenic acid, pantothenate (vitamin B5), and adenosine triphosphate (ATP). In acetyl-CoA, its acetyl form, coenzyme A is a highly versatile molecule, serving metabolic functions in both the Anabolism, anabolic and Catabolism, catabolic pathways. Acetyl-CoA is utilised in the post-translational regulation and allosteric regulation of pyruvate dehydrogenase and carboxylase to maintain and support the partition of Pyruvic acid, pyruvate synthesis and degradation. Discovery of structure Coenzyme A was identified by Fritz Lipmann in 1946, who also later gave it its name. Its structure was determined during the e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pantethine
Pantethine (bis-pantethine or co-enzyme pantethine) is a dimeric form of pantetheine, which is produced from pantothenic acid (vitamin B5) by the addition of cysteamine. Pantethine was discovered by Gene Brown, a PhD student at the time. Pantethine is two molecules of pantetheine linked by a disulfide bridge. Pantetheine is an intermediate in the production of coenzyme A by the body. Most vitamin B5 supplements are in the form of calcium pantothenate, a salt of pantothenic acid, with doses in the range of 5 to 10 mg/day. In contrast, pantethine is sold as a dietary supplement for lowering blood cholesterol and triglycerides at doses of 500 to 1200 mg/day. Dietary supplement Pantethine is available in the United States as a dietary supplement because of evidence for lowering elevated LDL-cholesterol and triglycerides and raising HDL-cholesterol. In multiple clinical trials of patients with elevated cholesterol and triglycerides, total and LDL cholesterol were decreased ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lactobacillus Bulgaricus
''Lactobacillus delbrueckii'' subsp. ''bulgaricus'' (until 2014 known as ''Lactobacillus bulgaricus'') is one of over 200 published species in the ''Lactobacillus'' genome complex (LGC) and is the main bacterium used for the production of yogurt. It also plays a crucial role in the ripening of some cheeses, as well as in other processes involving naturally fermented products. It is defined as homofermentive lactic acid bacteria due to lactic acid being the single end product of its carbohydrate digestion. It is also considered a probiotic. It is a gram-positive rod that may appear long and filamentous. It is Motility, non-motile and does not form spores. It is also non-pathogenic. It is regarded as aciduric or Acidophile (organisms), acidophilic, since it requires a low pH (around 5.4–4.6) to grow effectively. In addition, it is Anaerobic organism, anaerobic. As it grows on raw dairy products, it creates and maintains the acidic environment that it needs to thrive via its produ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chemical Compound
A chemical compound is a chemical substance composed of many identical molecules (or molecular entities) containing atoms from more than one chemical element held together by chemical bonds. A molecule consisting of atoms of only one element is therefore not a compound. A compound can be transformed into a different substance by a chemical reaction, which may involve interactions with other substances. In this process, bonds between atoms may be broken and/or new bonds formed. There are four major types of compounds, distinguished by how the constituent atoms are bonded together. Molecular compounds are held together by covalent bonds; ionic compounds are held together by ionic bonds; intermetallic compounds are held together by metallic bonds; coordination complexes are held together by coordinate covalent bonds. Non-stoichiometric compounds form a disputed marginal case. A chemical formula specifies the number of atoms of each element in a compound molecule, using the s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Prokaryote
A prokaryote () is a single-celled organism that lacks a nucleus and other membrane-bound organelles. The word ''prokaryote'' comes from the Greek πρό (, 'before') and κάρυον (, 'nut' or 'kernel').Campbell, N. "Biology:Concepts & Connections". Pearson Education. San Francisco: 2003. In the two-empire system arising from the work of Édouard Chatton, prokaryotes were classified within the empire Prokaryota. But in the three-domain system, based upon molecular analysis, prokaryotes are divided into two domains: ''Bacteria'' (formerly Eubacteria) and ''Archaea'' (formerly Archaebacteria). Organisms with nuclei are placed in a third domain, Eukaryota. In the study of the origins of life, prokaryotes are thought to have arisen before eukaryotes. Besides the absence of a nucleus, prokaryotes also lack mitochondria, or most of the other membrane-bound organelles that characterize the eukaryotic cell. It was once thought that prokaryotic cellular components within the cytop ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Metabolism
Metabolism (, from el, μεταβολή ''metabolē'', "change") is the set of life-sustaining chemical reactions in organisms. The three main functions of metabolism are: the conversion of the energy in food to energy available to run cellular processes; the conversion of food to building blocks for proteins, lipids, nucleic acids, and some carbohydrates; and the elimination of metabolic wastes. These enzyme-catalyzed reactions allow organisms to grow and reproduce, maintain their structures, and respond to their environments. The word metabolism can also refer to the sum of all chemical reactions that occur in living organisms, including digestion and the transportation of substances into and between different cells, in which case the above described set of reactions within the cells is called intermediary (or intermediate) metabolism. Metabolic reactions may be categorized as ''catabolic'' – the ''breaking down'' of compounds (for example, of glucose to pyruvate by ce ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
UROP
An Undergraduate Research Opportunities Program provides funding and/or credit to undergraduate students who volunteer for faculty-mentored research projects pertaining to all academic disciplines. Participating universities Universities involved include the University of Hawaii, The University of Queensland, Boston University, the Georgia Institute of Technology (Georgia Tech), the University of California, Irvine, California State University, Long Beach, the Massachusetts Institute of Technology (MIT), the University of Michigan, the Hong Kong University of Science and Technology (HKUST), the University of Minnesota, the University of Illinois Urbana-Champaign, the RWTH Aachen University, Imperial College London, the University of New Hampshire, and the Nanyang Technological University. Founding and purpose The MIT program was founded in 1969, and the program at the University of Michigan was founded in the 1989 (primarily to help minorities and women break into science and mat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Academy Of Arts And Sciences
The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and other Founding Fathers of the United States. It is headquartered in Cambridge, Massachusetts. Membership in the academy is achieved through a thorough petition, review, and election process. The academy's quarterly journal, ''Dædalus'', is published by MIT Press on behalf of the academy. The academy also conducts multidisciplinary public policy research. History The Academy was established by the Massachusetts legislature on May 4, 1780, charted in order "to cultivate every art and science which may tend to advance the interest, honor, dignity, and happiness of a free, independent, and virtuous people." The sixty-two incorporating fellows represented varying interests and high standing in the political, professional, and commercial secto ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thereza Imanishi-Kari
Thereza Imanishi-Kari is an associate professor of pathology at Tufts University. Her research focuses on the origins of autoimmune diseases, particularly systemic lupus erythematosus, studied using mice as model organisms. Previously she had been a faculty member at the Massachusetts Institute of Technology. She is notable for her role in what became known as the "Baltimore affair", in which a 1986 paper she co-authored with David Baltimore was the subject of research misconduct allegations. Following a series of investigations, she was fully exonerated of the charges in 1996. Early life and education A native of Brazil, Thereza Imanishi-Kari earned a BS degree in biology from the University of Sao Paulo near her home town of Indaiatuba, Brazil. Subsequently, she studied at Kyoto University, in Kyoto, Japan, and the University of Helsinki in Finland, which awarded her a PhD in the field of immunogenetics. Research Imanishi-Kari's research focuses on immunology, particularly on u ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
