Gene Brown (professor)
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Gene Monte Brown (1926 – 4 August 2017)Gene Brown, professor emeritus of biology, dies at 91
/ref> was a
Professor Emeritus ''Emeritus'' (; female: ''emerita'') is an adjective used to designate a retired chair, professor, pastor, bishop, pope, director, president, prime minister, rabbi, emperor, or other person who has been "permitted to retain as an honorary title ...
of Biochemistry at the
Massachusetts Institute of Technology The Massachusetts Institute of Technology (MIT) is a private land-grant research university in Cambridge, Massachusetts. Established in 1861, MIT has played a key role in the development of modern technology and science, and is one of the ...
. He joined the department in 1954 and served as its head from 1977 to 1985. He served as the Dean of Science at MIT from 1985 to 1991. He is notable for his interest in and commitment to undergraduate education, and taught the department's biochemistry course for over 50 years.


Early life and education

Brown was born in Pioneer, Missouri and raised in nearby Cassville until around age nine, when his family moved to
Idaho Idaho ( ) is a state in the Pacific Northwest region of the Western United States. To the north, it shares a small portion of the Canada–United States border with the province of British Columbia. It borders the states of Montana and Wyomi ...
. He was the first member of his family to attend high school and the only member of his graduating high school class to attend college. After a year as a college student in Idaho, he joined the
Army Air Corps Army Air Corps may refer to the following army aviation corps: * Army Air Corps (United Kingdom), the army aviation element of the British Army * Philippine Army Air Corps (1935–1941) * United States Army Air Corps (1926–1942), or its p ...
, where he was assigned to work in chemical warfare operations. His tasks included teaching safety lessons, which he later described as "whetting isteaching interest" for his later activities as an educator. Brown used the GI Bill to attend
Colorado A&M Colorado State University (Colorado State or CSU) is a public land-grant research university in Fort Collins, Colorado. It is the flagship university of the Colorado State University System. Colorado State University is classified among "R1: ...
to finish his undergraduate degree in chemistry. He was encouraged by a biochemistry professor there to attend graduate school. Brown received his PhD from the
University of Wisconsin A university () is an institution of higher (or tertiary) education and research which awards academic degrees in several academic disciplines. Universities typically offer both undergraduate and postgraduate programs. In the United States, ...
in 1953 under the supervision of
Esmond Snell Esmond Emerson Snell (September 22, 1914 – December 9, 2003) was an American biochemist who spent his career researching vitamins and nutritional requirements of bacteria and yeast. He is well known for his study of lactic acid-producing bacte ...
, although Snell moved to the
University of Texas The University of Texas at Austin (UT Austin, UT, or Texas) is a public research university in Austin, Texas. It was founded in 1883 and is the oldest institution in the University of Texas System. With 40,916 undergraduate students, 11,075 ...
partway through Brown's education. After defending his thesis in Wisconsin, Brown worked briefly as a
postdoctoral fellow A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). The ultimate goal of a postdoctoral research position is to p ...
with Snell in Texas.


Academic career

Brown was offered a faculty position at MIT by
Jack Buchanan Walter John Buchanan (2 April 1891 – 20 October 1957) was a Scottish theatre and film actor, singer, dancer, producer and director. He was known for three decades as the embodiment of the debonair man-about-town in the tradition of George G ...
, who at the time was interested in recruiting biochemists. Brown began at MIT in 1954 as an instructor and later advanced through the ranks to
full professor Professor (commonly abbreviated as Prof.) is an academic rank at universities and other post-secondary education and research institutions in most countries. Literally, ''professor'' derives from Latin as a "person who professes". Professors ...
. He served as the associate head of the department from 1967 to 1977 and as the head from 1977 to 1985, succeeding
Boris Magasanik Boris Magasanik (December 19, 1919December 25, 2013) was a microbiologist and biochemist who was the Jacques Monod Professor Emeritus of Microbiology in the Department of Biology at the Massachusetts Institute of Technology. After moving from Harv ...
. Under his leadership, funding was obtained and plans were made for the launch of MIT's
Whitehead Institute Whitehead Institute for Biomedical Research is a non-profit research institute located in Cambridge, Massachusetts, United States that is dedicated to improving human health through basic biomedical research. It was founded as a fiscally indepen ...
. In 1985 Brown became the Dean of Science at MIT. During his tenure as dean, he worked on curricular issues, including the development of a communication requirement to be incorporated into the undergraduate program and the planning stages of a new building for biology research. He was also involved in investigating what became known as the "Baltimore affair", a high-profile allegation of
research misconduct Scientific misconduct is the violation of the standard codes of scholarly conduct and ethical behavior in the publication of professional scientific research. A '' Lancet'' review on ''Handling of Scientific Misconduct in Scandinavian countrie ...
against then-MIT faculty members
David Baltimore David Baltimore (born March 7, 1938) is an American biologist, university administrator, and 1975 Nobel laureate in Physiology or Medicine. He is President Emeritus and Distinguished Professor of Biology at the California Institute of Technol ...
and
Thereza Imanishi-Kari Thereza Imanishi-Kari is an associate professor of pathology at Tufts University. Her research focuses on the origins of autoimmune diseases, particularly systemic lupus erythematosus, studied using mice as model organisms. Previously she had been ...
. (They were eventually cleared of misconduct.) Brown closed his research laboratory during his service as dean, citing time pressure; after he resigned in 1991, he moved to spending his time on teaching and administrative work in the department. Brown became a fellow of the
American Academy of Arts and Sciences The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, a ...
in 1999.


Teaching

Brown is notable for his longevity as an educator, having started teaching the department's undergraduate biochemistry class when he arrived in 1954. In 2004 he was honored for teaching it continuously for 50 years. Brown also taught other undergraduate courses and served as the department's coordinator for
undergraduate research Undergraduate research is often described as the exploration of a specific research topic by an undergraduate student that seeks to make an original contribution to the disciplinIt is a fairly recent concept in the academic community, with roots i ...
. In 1994 Brown was one of four MIT professors named that year as MacVicar Fellows, which provided support for faculty interested in developing improvements to undergraduate education. MIT gives two teaching awards named after Brown: the Gene Brown Prize, which recognizes academic and teaching excellence among undergraduates, and the Gene Brown-Merck Teaching Award, which recognizes excellence in teaching among graduate students.


Research

Brown's research interests focused on metabolic biochemistry, particularly in
prokaryote A prokaryote () is a single-celled organism that lacks a nucleus and other membrane-bound organelles. The word ''prokaryote'' comes from the Greek πρό (, 'before') and κάρυον (, 'nut' or 'kernel').Campbell, N. "Biology:Concepts & Conne ...
s. His PhD work involved isolating and identifying a
compound Compound may refer to: Architecture and built environments * Compound (enclosure), a cluster of buildings having a shared purpose, usually inside a fence or wall ** Compound (fortification), a version of the above fortified with defensive struc ...
needed for the growth of ''
Lactobacillus bulgaricus ''Lactobacillus delbrueckii'' subsp. ''bulgaricus'' (until 2014 known as ''Lactobacillus bulgaricus'') is one of over 200 published species in the ''Lactobacillus'' genome complex (LGC) and is the main bacterium used for the production of yogurt. ...
'', which proved to be
pantethine Pantethine (bis-pantethine or co-enzyme pantethine) is a dimeric form of pantetheine, which is produced from pantothenic acid (vitamin B5) by the addition of cysteamine. Pantethine was discovered by Gene Brown, a PhD student at the time. Pante ...
, an intermediate in the synthesis of coenzyme A. He based his research as a faculty member on broadening this work to identifying additional
coenzyme A cofactor is a non-protein chemical compound or metallic ion that is required for an enzyme's role as a catalyst (a catalyst is a substance that increases the rate of a chemical reaction). Cofactors can be considered "helper molecules" that ass ...
s and studying their biosynthesis. He was particularly instrumental in understanding the biosynthesis of
folic acid Folate, also known as vitamin B9 and folacin, is one of the B vitamins. Manufactured folic acid, which is converted into folate by the body, is used as a dietary supplement and in food fortification as it is more stable during processing and ...
and related
pteridine Pteridine is an aromatic chemical compound composed of fused pyrimidine and pyrazine rings. A pteridine is also a group of heterocyclic compounds containing a wide variety of substitutions on this structure. Pterins and flavins are classes of s ...
compounds, and later described this work as the research he was most proud of.


Personal life

While working in Texas with Snell, Brown met a faculty member there who taught music theory. On the second date they had they decided to get married and they did on June 15th, known as Flag Day.


References


External links


MIT Infinite History
interview with Gene Brown
From the Farm to MIT
Elemental MIT interview with scientists who grew up in farming communities {{DEFAULTSORT:Brown, Gene 1926 births 2017 deaths People from Barry County, Missouri Fellows of the American Academy of Arts and Sciences Massachusetts Institute of Technology School of Science faculty American biochemists People from Cassville, Missouri