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Gurmarin
Gurmarin is a 35-residue polypeptide from the Asclepiad vine ''Gymnema sylvestre'' (Gurmar). It has been utilized as a pharmacological Pharmacology is a branch of medicine, biology and pharmaceutical sciences concerned with drug or medication action, where a drug may be defined as any artificial, natural, or endogenous (from within the body) molecule which exerts a biochemica ... tool in the study of sweet-taste transduction because of its ability to selectively inhibit the neural response to sweet taste in rats. This rat inhibition appears to have high specificity to sugar (sweetener) molecules like sucrose, glucose, and saccharin as well as the amino acid glycine. As a sweet-taste-suppressing protein, Gurmarin shows signs of being reversible in nature although having little to no effect on the sweet taste sensation in humans suggesting the protein is only active on rodent sweet taste receptors. ref: Appl Microbiol Biotechnol. 2012 Nov;96(3):619-30 References Protein d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polypeptide
Peptides (, ) are short chains of amino acids linked by peptide bonds. Long chains of amino acids are called proteins. Chains of fewer than twenty amino acids are called oligopeptides, and include dipeptides, tripeptides, and tetrapeptides. A polypeptide is a longer, continuous, unbranched peptide chain. Hence, peptides fall under the broad chemical classes of biological polymers and oligomers, alongside nucleic acids, oligosaccharides, polysaccharides, and others. A polypeptide that contains more than approximately 50 amino acids is known as a protein. Proteins consist of one or more polypeptides arranged in a biologically functional way, often bound to ligands such as coenzymes and cofactors, or to another protein or other macromolecule such as DNA or RNA, or to complex macromolecular assemblies. Amino acids that have been incorporated into peptides are termed residues. A water molecule is released during formation of each amide bond.. All peptides except cyclic peptides ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Asclepiadaceae
The Asclepiadoideae are a subfamily of plants in the family Apocynaceae. Formerly, they were treated as a separate family under the name Asclepiadaceae, e.g. by APG II, and known as the milkweed family. They form a group of perennial herbs, twining shrubs, lianas or rarely trees but notably also contain a significant number of leafless stem succulents. The name comes from the type genus ''Asclepias'' (milkweeds). There are 348 genera, with about 2,900 species. They are mainly located in the tropics to subtropics, especially in Africa and South America. The florally advanced tribe Stapelieae within this family contains the relatively familiar stem succulent genera such as ''Huernia, Stapelia'' and ''Hoodia''. They are remarkable for the complex mechanisms they have developed for pollination, which independently parallel the unrelated Orchidaceae, especially in the grouping of their pollen into pollinia. The fragrance from the flowers, often called "carrion", attracts flies. The ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gymnema Sylvestre
''Gymnema sylvestre'' is a perennial woody vine native to Asia (including the Arabian Peninsula), Africa and Australia. It has been used in Ayurvedic medicine. Common names include gymnema, Australian cowplant, and Periploca of the woods, and the Hindi term ''gurmar'', which means "sugar destroyer". The leaves and extracts contain gymnemic acids, the major bioactive constituents that interact with taste receptors on the tongue to temporarily suppress the taste of sweetness. Description The plant is a climber with leaves having soft hairs on the upper surface. The leaves are elongated-oval in shape. It has a small, yellow, umbelliferous inflorescence that is produced throughout the year. Properties ''Gymnema sylvestre'' has a long history of use in herbal medicine and a broad range of therapeutic properties. Blocks sweet taste sensations Its leaves contain triterpenoid saponins, flavonols, and gurmarin. The major biologically active plant molecules are gymnemic acids, a cl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pharmacological
Pharmacology is a branch of medicine, biology and pharmaceutical sciences concerned with drug or medication action, where a drug may be defined as any artificial, natural, or endogenous (from within the body) molecule which exerts a biochemical or physiological effect on the cell, tissue, organ, or organism (sometimes the word ''pharmacon'' is used as a term to encompass these endogenous and exogenous bioactive species). More specifically, it is the study of the interactions that occur between a living organism and chemicals that affect normal or abnormal biochemical function. If substances have medicinal properties, they are considered pharmaceuticals. The field encompasses drug composition and properties,functions,sources,synthesis and drug design, molecular and cellular mechanisms, organ/systems mechanisms, signal transduction/cellular communication, molecular diagnostics, interactions, chemical biology, therapy, and medical applications and antipathogenic capabilities. Th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
