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Ghanshyam Swarup
Ghanshyam Swarup (born 1953) is an Indian molecular biologist, a J. C. Bose National Fellow and the head of the ''Ghanshyam Swarup Research Group'' of the Centre for Cellular and Molecular Biology. He is known for his studies on glaucoma and the discovery of protein tyrosine phosphatase, a new protein influencing the regulation of cell proliferation. Swarup is an elected fellow of the Indian Academy of Sciences, the Indian National Science Academy and the National Academy of Sciences, India. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards, in 1996, for his contributions to biological sciences. Biography Ghanshyam Swarup, born on 23 November 1953 in the Indian state of Uttar Pradesh, graduated in science from Chhatrapati Shahu Ji Maharaj University and continued his studies there to secure a ma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Uttar Pradesh
Uttar Pradesh (; , 'Northern Province') is a state in northern India. With over 200 million inhabitants, it is the most populated state in India as well as the most populous country subdivision in the world. It was established in 1950 after India had become a republic. It was a successor to the United Provinces (UP) during the period of the Dominion of India (1947–1950), which in turn was a successor to the United Provinces (UP) established in 1935, and eventually of the United Provinces of Agra and Oudh established in 1902 during the British Raj. The state is divided into 18 divisions and 75 districts, with the state capital being Lucknow, and Prayagraj serving as the judicial capital. On 9 November 2000, a new state, Uttaranchal (now Uttarakhand), was created from Uttar Pradesh's western Himalayan hill region. The two major rivers of the state, the Ganges and its tributary Yamuna, meet at the Triveni Sangam in Prayagraj, a Hindu pilgrimage site. Ot ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chhatrapati Shahu Ji Maharaj University
Aerial view of Chhatrapati Shahu Ji Maharaj University Campus Chhatrapati Shahu Ji Maharaj University (CSJMU), formerly Kanpur University, is a public state university located in Kanpur, Uttar Pradesh, India. It is administered under the state legislature of the government of Uttar Pradesh. Administration The administration is the Chancellor, the Vice Chancellor and the members of the executive council, the court and the academic council of the university. The Kulpati (Vice-Chancellor) is a whole-time salaried officer of the university and is appointed by the chancellor from amongst the names submitted to him by a committee constituted in accordance with the provisions above U.P. Universities Act 1973. Colleges The university is affiliating university all non engineering, non medical (including pharmacy), non MBA degree, non MCA degree offering colleges of Auraiya district, Etawah district, Farrukhabad district, Kannauj district, Kanpur Dehat district, Kanpur Nagar distri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1953 Births
Events January * January 6 – The Asian Socialist Conference opens in Rangoon, Burma. * January 12 – Estonian émigrés found a government-in-exile in Oslo. * January 14 ** Marshal Josip Broz Tito is chosen President of Yugoslavia. ** The CIA-sponsored Robertson Panel first meets to discuss the UFO phenomenon. * January 15 – Georg Dertinger, foreign minister of East Germany, is arrested for spying. * January 19 – 71.1% of all television sets in the United States are tuned into ''I Love Lucy'', to watch Lucy give birth to Little Ricky, which is more people than those who tune into Dwight Eisenhower's inauguration the next day. This record has yet to be broken. * January 20 – Dwight D. Eisenhower is sworn in as the 34th President of the United States. * January 24 ** Mau Mau Uprising: Rebels in Kenya kill the Ruck family (father, mother, and six-year-old son). ** Leader of East Germany Walter Ulbricht announces that agriculture will be col ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Optineurin
Optineurin is a protein that in humans is encoded by the ''OPTN'' gene. Function This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. OPTN is a host intrinsic restriction factor against neuroinvasive HSV-1 infection. Model organisms Model organisms have been used in the study of OPTN function. A conditional knockout mouse line, called ''Optntm1a(EUCOMM)Wtsi'' was generated as part of t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein Tyrosine Phosphatase
Protein tyrosine phosphatases (EC 3.1.3.48, systematic name protein-tyrosine-phosphate phosphohydrolase) are a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins: : proteintyrosine phosphate + H2O = proteintyrosine + phosphate Protein tyrosine (pTyr) phosphorylation is a common post-translational modification that can create novel recognition motifs for protein interactions and cellular localization, affect protein stability, and regulate enzyme activity. As a consequence, maintaining an appropriate level of protein tyrosine phosphorylation is essential for many cellular functions. Tyrosine-specific protein phosphatases (PTPase; ) catalyse the removal of a phosphate group attached to a tyrosine residue, using a cysteinyl-phosphate enzyme intermediate. These enzymes are key regulatory components in signal transduction pathways (such as the MAP kinase pathway) and cell cycle control, and are important in the control of cell growth, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Department Of Science And Technology (India)
The Department of Science and Technology (DST) is a department within the Ministry of Science and Technology in India. It was established in May 1971 to promote new areas of science and technology and to play the role of a nodal department for organising, coordinating and promoting Scientific and Technological activities in the country. It gives funds to various approved scientific projects in India. It also supports various researchers in India to attend conferences abroad and to go for experimental works. Jitendra Singh is Minister of State (Independent Charge), while S. Chandrasekhar is its secretary. Open access Department of Science and Technology (India) supports open access to scientific knowledge, originated from the public-funded research in India. In December 2014, the DST and the Department of Biotechnology (DBT), Government of India had jointly adopted their Open Access Policy. Scientific Programmes Autonomous S&T Institutions The autonomous science and tec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Guha Research Conference
Guha Research Conference (GRC) is a professional society set up by Indian scholars to develop the field of Biochemistry. It was established in 1960, and is named after Biresh Chandra Guha (1904-1962). The first four GRC meetings were held alongside the annual conference of the Indian Science Congress. Subsequently, under the guidance of Pushpa Mittra Bhargava, it was registered as a society with a convener elected annually, to organize the annual conference. According to Parthasarathi Benerjee, affiliation to GRC, "acts as the token, assuring easier access to prizes of several sorts." During its formative years (1960–65), GRC had 33 professionals from major national institutes such as AIIMS, CMC Vellore, IISc, Tata Memorial Centre, Indian Institute of Chemical Biology, Banaras Hindu University, Bhabha Atomic Research Centre, and TIFR. By 2004, the membership had grown to 114 members. References Related Pages * Pushpa Mittra Bhargava * Gordon Research Conferences Gordon Re ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ResearchGate
ResearchGate is a European commercial social networking site for scientists and researchers to share papers, ask and answer questions, and find collaborators. According to a 2014 study by ''Nature'' and a 2016 article in ''Times Higher Education'', it is the largest academic social network in terms of active users, although other services have more registered users, and a 2015–2016 survey suggests that almost as many academics have Google Scholar profiles. While reading articles does not require registration, people who wish to become site members need to have an email address at a recognized institution or to be manually confirmed as a published researcher in order to sign up for an account. Members of the site each have a user profile and can upload research output including papers, data, chapters, negative results, patents, research proposals, methods, presentations, and software source code. Users may also follow the activities of other users and engage in discussions with th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pathogenesis
Pathogenesis is the process by which a disease or disorder develops. It can include factors which contribute not only to the onset of the disease or disorder, but also to its progression and maintenance. The word comes from Greek πάθος ''pathos'' 'suffering, disease' and γένεσις ''genesis'' 'creation'. Description Types of pathogenesis include microbial infection, inflammation, malignancy and tissue breakdown. For example, bacterial pathogenesis is the process by which bacteria cause infectious illness. Most diseases are caused by multiple processes. For example, certain cancers arise from dysfunction of the immune system (skin tumors and lymphoma after a renal transplant, which requires immunosuppression), Streptococcus pneumoniae is spread through contact with respiratory secretions, such as saliva, mucus, or cough droplets from an infected person and colonizes the upper respiratory tract and begins to multiply. The pathogenic mechanisms of a disease (or cond ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mutation
In biology, a mutation is an alteration in the nucleic acid sequence of the genome of an organism, virus, or extrachromosomal DNA. Viral genomes contain either DNA or RNA. Mutations result from errors during DNA or viral replication, mitosis, or meiosis or other types of damage to DNA (such as pyrimidine dimers caused by exposure to ultraviolet radiation), which then may undergo error-prone repair (especially microhomology-mediated end joining), cause an error during other forms of repair, or cause an error during replication (translesion synthesis). Mutations may also result from insertion or deletion of segments of DNA due to mobile genetic elements. Mutations may or may not produce detectable changes in the observable characteristics (phenotype) of an organism. Mutations play a part in both normal and abnormal biological processes including: evolution, cancer, and the development of the immune system, including junctional diversity. Mutation is the ultimate source o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Optineurin
Optineurin is a protein that in humans is encoded by the ''OPTN'' gene. Function This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. OPTN is a host intrinsic restriction factor against neuroinvasive HSV-1 infection. Model organisms Model organisms have been used in the study of OPTN function. A conditional knockout mouse line, called ''Optntm1a(EUCOMM)Wtsi'' was generated as part of t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
