Galbulimima Belgraveana
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Galbulimima Belgraveana
''Galbulimima belgraveana'' is a hallucinogenic plant. Its common names include agara and white magnolia. It is native to northeastern Australia, Malaysia, and Papua New Guinea. Papuans (who tend to use this drug the most) boil the bark and the leaves together with another plant, called ''Homalomena ''Homalomena'' is a genus of flowering plants in the family Araceae. ''Homalomena'' are found in southern Asia and the southwestern Pacific. Many ''Homalomena'' have a strong smell of anise. The name derives apparently from a mistranslated Mala ...'', in order to make tea. This tea leads to a deep sleep, in which it is said that vivid dreams and visions occur. The plant itself grows to about 90 feet, it has no petals and its flower are a yellow-brown colour. Several psychoactive alkaloids structurally related to himbacine, a muscarinic receptor antagonist, have been isolated from the plant, but the primary psychoactive constituent responsible for the plant's hallucinogenic e ...
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Hallucinogen
Hallucinogens are a large, diverse class of psychoactive drugs that can produce altered states of consciousness characterized by major alterations in thought, mood, and perception as well as other changes. Most hallucinogens can be categorized as either being psychedelics, dissociatives, or deliriants. However, certain hallucinogens such as Fly agaric as well as other gabaergic hallucinogenics are more often considered to technically be hypnotics, therefore indicating another separate subcategory of drugs which can substantially alter visual perception. Etymology The word ''hallucinogen'' is derived from the word ''hallucination''. The term ''hallucinate'' dates back to around 1595–1605, and is derived from the Latin ''hallūcinātus'', the past participle of ''(h)allūcināri'', meaning "to wander in the mind." Characteristics Leo Hollister gave five criteria for classifying a drug as hallucinogenic.Glennon RA. Classical drugs: an introductory overview. In Lin GC and Gle ...
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Australia
Australia, officially the Commonwealth of Australia, is a Sovereign state, sovereign country comprising the mainland of the Australia (continent), Australian continent, the island of Tasmania, and numerous List of islands of Australia, smaller islands. With an area of , Australia is the largest country by area in Oceania and the world's List of countries and dependencies by area, sixth-largest country. Australia is the oldest, flattest, and driest inhabited continent, with the least fertile soils. It is a Megadiverse countries, megadiverse country, and its size gives it a wide variety of landscapes and climates, with Deserts of Australia, deserts in the centre, tropical Forests of Australia, rainforests in the north-east, and List of mountains in Australia, mountain ranges in the south-east. The ancestors of Aboriginal Australians began arriving from south east Asia approximately Early human migrations#Nearby Oceania, 65,000 years ago, during the Last Glacial Period, last i ...
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Malaysia
Malaysia ( ; ) is a country in Southeast Asia. The federation, federal constitutional monarchy consists of States and federal territories of Malaysia, thirteen states and three federal territories, separated by the South China Sea into two regions: Peninsular Malaysia and Borneo's East Malaysia. Peninsular Malaysia shares a land and maritime Malaysia–Thailand border, border with Thailand and Maritime boundary, maritime borders with Singapore, Vietnam, and Indonesia. East Malaysia shares land and maritime borders with Brunei and Indonesia, and a maritime border with the Philippines and Vietnam. Kuala Lumpur is the national capital, the country's largest city, and the seat of the Parliament of Malaysia, legislative branch of the Government of Malaysia, federal government. The nearby Planned community#Planned capitals, planned capital of Putrajaya is the administrative capital, which represents the seat of both the Government of Malaysia#Executive, executive branch (the Cabine ...
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Papua New Guinea
Papua New Guinea (abbreviated PNG; , ; tpi, Papua Niugini; ho, Papua Niu Gini), officially the Independent State of Papua New Guinea ( tpi, Independen Stet bilong Papua Niugini; ho, Independen Stet bilong Papua Niu Gini), is a country in Oceania that comprises the eastern half of the island of New Guinea and its offshore islands in Melanesia (a region of the southwestern Pacific Ocean north of Australia). Its capital, located along its southeastern coast, is Port Moresby. The country is the world's third largest island country, with an area of . At the national level, after being ruled by three external powers since 1884, including nearly 60 years of Australian administration starting during World War I, Papua New Guinea established its sovereignty in 1975. It became an independent Commonwealth realm in 1975 with Elizabeth II as its queen. It also became a member of the Commonwealth of Nations in its own right. There are 839 known languages of Papua New Guinea, one of ...
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Homalomena
''Homalomena'' is a genus of flowering plants in the family Araceae. ''Homalomena'' are found in southern Asia and the southwestern Pacific. Many ''Homalomena'' have a strong smell of anise. The name derives apparently from a mistranslated Malayan vernacular name, translated as , meaning flat, and ''mene'' = moon. The plants of this genus are clump-forming evergreen perennials with mainly heart-shaped or arrowheaded shaped leaves. The flowers are tiny and without petals, enclosed in a usually greenish spathe hidden by the leaves. Some authors have proposed splitting the genus and moving all the neotropical species of ''Homalomena'' to '' Adelonema.'' ;Species #'' Homalomena adiensis'' A.Hay - western New Guinea #'' Homalomena aeneifolia'' Alderw. - Sulawesi #'' Homalomena agens'' Kurniawan & P.C.Boyce - Kalimantan Timur #'' Homalomena ardua'' P.C.Boyce & S.Y.Wong - Sarawak #'' Homalomena argentea'' Ridl. - Peninsular Malaysia, Borneo #'' Homalomena aromatica'' (Spreng.) Sch ...
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Himbacine
Himbacine is an alkaloid isolated from the bark of Australian magnolias. Himbacine has been synthesized using a Diels-Alder reaction as a key step. Himbacine's activity as a muscarinic receptor antagonist, with specificity for the muscarinic acetylcholine receptor M2, made it a promising starting point in Alzheimer's disease Alzheimer's disease (AD) is a neurodegeneration, neurodegenerative disease that usually starts slowly and progressively worsens. It is the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in short-term me ... research. The development of a muscarinic antagonist based on himbacine failed but an analog, vorapaxar, has been approved by the FDA as a thrombin receptor antagonist. References

Muscarinic antagonists Naphthofurans Piperidine alkaloids Lactones {{pharmacology-stub ...
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Muscarinic Receptor Antagonist
A muscarinic receptor antagonist (MRA) is a type of anticholinergic agent that blocks the activity of the muscarinic acetylcholine receptor. The muscarinic receptor is a protein involved in the transmission of signals through certain parts of the nervous system, and muscarinic receptor antagonists work to prevent this transmission from occurring. Notably, muscarinic antagonists reduce the activation of the parasympathetic nervous system. The normal function of the parasympathetic system is often summarised as "rest-and-digest", and includes slowing of the heart, an increased rate of digestion, narrowing of the airways, promotion of urination, and sexual arousal. Muscarinic antagonists counter this parasympathetic "rest-and-digest" response, and also work elsewhere in both the central and peripheral nervous systems. Drugs with muscarinic antagonist activity are widely used in medicine, in the treatment of low heart rate, overactive bladder, respiratory problems such as asthma ...
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Magnoliales
The Magnoliales are an order of flowering plants. Classification The Magnoliales include six families: * Annonaceae (custard apple family, over 2000 species of trees, shrubs, and lianas; mostly tropical but some temperate) * Degeneriaceae (two species of trees found on Pacific islands) * Eupomatiaceae (two species of trees and shrubs found in New Guinea and eastern Australia) * Himantandraceae (two species of trees and shrubs, found in tropical areas in Southeast Asia and Australia) * Magnoliaceae (about 225 species including magnolias and tulip trees) * Myristicaceae (several hundred species including nutmeg) APG system The APG system (1998), APG II system (2003), APG III system (2009), and APG IV system (2016) place this order in the clade magnoliids, circumscribed as follows: In these systems, published by the APG, the Magnoliales are a basal group, excluded from the eudicots. Earlier systems The Cronquist system (1981) placed the order in the subclass Magnoliidae of cl ...
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