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GAS5
Growth arrest-specific 5 is a non-protein coding RNA that in humans is encoded by the GAS5 gene. GAS5 noncoding RNA, which accumulates in growth arrested cells, acts as a decoy hormone response element for the glucocorticoid receptor (GR) and hence blocks the upregulation of gene expression by activated GR. A number of studies have linked GAS5 to apoptosis and it may play a role in the progression of some types of cancer. The GAS5 introns host several snoRNA sequences, including Small nucleolar RNA SNORD81, SNORD81, Small nucleolar RNA SNORD47, SNORD47, Small nucleolar RNA snR60/Z15/Z230/Z193/J17, SNORD80, Small nucleolar RNA SNORD79, SNORD79, Small nucleolar RNA SNORD78, SNORD78, Small nucleolar RNA SNORD44, SNORD44, Small nucleolar RNA SNORD77, SNORD77, Small nucleolar RNA SNORD24, SNORD76, Small nucleolar RNA SNORD75, SNORD75 and Z18 small nucleolar RNA, SNORD74. These intronic sequences are more conserved than the exons of the host gene, these sorts of genes are often called ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Noncoding RNA
A non-coding RNA (ncRNA) is a functional RNA molecule that is not translated into a protein. The DNA sequence from which a functional non-coding RNA is transcribed is often called an RNA gene. Abundant and functionally important types of non-coding RNAs include transfer RNAs (tRNAs) and ribosomal RNAs (rRNAs), as well as small RNAs such as microRNAs, siRNAs, piRNAs, snoRNAs, snRNAs, exRNAs, scaRNAs and the long ncRNAs such as Xist and HOTAIR. The number of non-coding RNAs within the human genome is unknown; however, recent transcriptomic and bioinformatic studies suggest that there are thousands of non-coding transcripts. Many of the newly identified ncRNAs have not been validated for their function. There is no consensus in the literature on how much of non-coding transcription is functional. Some researchers have argued that many ncRNAs are non-functional (sometimes referred to as "junk RNA"), spurious transcriptions. Others, however, disagree, arguing instead that ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Small Nucleolar RNA SNORD24
In molecular biology, U24 is a member of the C/D class of snoRNA which contain the C (UGAUGA) and D (CUGA) box motifs. C/D box snoRNAs have been shown to act as methylation guides for a number of RNA targets. U24 is encoded within an intron of the gene for ribosomal protein L7a in mammals, chicken and Fugu. The U76/SNORD76 snoRNA is found in an intron of the uRNA host gene (UHG) growth arrest specific 5 (GAS5) transcript gene. snoRNAs Z20 and U76 snoRNAs show clear similarity to U24. An experiment that looked at 22 different non-small-cell lung cancer Lung cancer, also known as lung carcinoma (since about 98–99% of all lung cancers are carcinomas), is a malignant lung tumor characterized by uncontrolled cell growth in tissues of the lung. Lung carcinomas derive from transformed, mali ... tissues found that SNORD33, SNORD66 and SNORD76 were over-expressed relative to matched noncancerous lung tissues. References External links * Small nuclear RNA {{ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Small Nucleolar RNA SNORD79
In molecular biology, snoRNA U79 (also known as SNORD79 or Z22) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. U79 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. snoRNA U79 is found in intron 7 of the GAS5 gene in humans and is also present in mice. U79 is predicted to guide the 2'O-ribose methylation of 28S ribosomal RNA Ribosomal ribonucleic acid (rRNA) is a type of non-coding RNA which is the primary component of ribosomes, essential to all cells. rRNA is a ribozyme which carries out protein ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a basic unit of heredity and the molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and noncoding genes. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes (many different genes) as well as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Small Nucleolar RNA SnR60/Z15/Z230/Z193/J17
In molecular biology, snoRNA snR60 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA snR60 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. snoRNA snR60 was initially discovered using a computational screen of the ''Saccharomyces cerevisiae ''Saccharomyces cerevisiae'' () (brewer's yeast or baker's yeast) is a species of yeast (single-celled fungus microorganisms). The species has been instrumental in winemaking, baking, and brewing since ancient times. It is believed to have b ...'' genome, subseq ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Small Nucleolar RNA SNORD75
In molecular biology, Small Nucleolar RNA SNORD75 (also known as U75) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. U75 (SNORD75) belongs to the C/D box class of snoRNAs which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2′-O-methylation of substrate RNAs. The mouse snoRNA Z19 is orthologous to human U75. U75 is predicted to guide the 2′-O-ribose methylation of 28S ribosomal RNA Ribosomal ribonucleic acid (rRNA) is a type of non-coding RNA which is the primary component of ribosomes, essential to all cells. rRNA is a ribozyme which carries out protein synthesis in ribosomes. Ribosomal RNA is transcribed fr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Small Nucleolar RNA SNORD77
In molecular biology, SNORD77 (also known as U77) belongs to the C/D family of snoRNAs. It is predicted to guide 2'O-ribose methylation of large 28S rRNA Ribosomal ribonucleic acid (rRNA) is a type of non-coding RNA which is the primary component of ribosomes, essential to all cells. rRNA is a ribozyme which carries out protein synthesis in ribosomes. Ribosomal RNA is transcribed from ribos ... subunit at position A1521. The C/D snoRNAs U44, U47, U74, U75, U76, U78, U79, U80 and U81 share the same host gene as U77 (non-coding). References External links * Small nuclear RNA {{molecular-cell-biology-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Small Nucleolar RNA SNORD44
In molecular biology, snoRNA U44 (also known as SNORD44) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA U44 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. U44 was originally cloned from HeLa cells and expression verified by northern blotting. It is predicted to guide 2'O-ribose methylation of 18S ribosomal RNA Ribosomal ribonucleic acid (rRNA) is a type of non-coding RNA which is the primary component of ribosomes, essential to all cells. rRNA is a ribozyme which carries out protein synth ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Small Nucleolar RNA SNORD78
In molecular biology, SNORD78 (also known as U78) belongs to the C/D family of snoRNAs. It is predicted to guide 2'O-ribose methylation of the large 28S rRNA subunit at position G4593. The snoRNAs Small nucleolar RNA SNORD44, U44, Small nucleolar RNA SNORD47, U47, Small nucleolar RNA SNORD74, U74, Small nucleolar RNA SNORD75, U75, Small nucleolar RNA SNORD76, U76, Small nucleolar RNA SNORD77, U77, Small nucleolar RNA SNORD79, U79, Small nucleolar RNA SNORD80, U80 and Small nucleolar RNA SNORD81, U81, also of the C/D family, share the same host gene with U78 (protein non-coding). References External links * Small nuclear RNA {{molecular-cell-biology-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Small Nucleolar RNA SNORD47
In molecular biology, SNORD47 (also known as U47) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA U57 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. This snoRNA was originally cloned from HeLa cells and expression verified by northern blotting. It is predicted to guide 2'O-ribose methylation of ribosomal RNA Ribosomal ribonucleic acid (rRNA) is a type of non-coding RNA which is the primary component of ribosomes, essential to all cells. rRNA is a ribozyme which carries out protein synthesi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular And Cellular Biology
''Molecular and Cellular Biology'' is a biweekly peer-reviewed scientific journal covering all aspects of molecular and cellular biology. It is published by the American Society for Microbiology and the editor-in-chief is Peter Tontonoz (University of California, Los Angeles). It was established in 1981. The h-index (1981-2021) is 338. Abstracting and indexing The journal is abstracted and indexed in: According to the ''Journal Citation Reports'', the journal has a 2021 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly mean number of citations of articles published in the last two years in a given journal, as ... of 5.069. References External links * Molecular and cellular biology journals Delayed open access journals Publications established in 1981 English-language journals Biweekly journals American Society for Microbiology academic journals [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Small Nucleolar RNA SNORD81
In molecular biology, U81 (also sometimes called Z23 snoRNA) is a member of the C/D class of snoRNA which contain the C (UGAUGA) and D (CUGA) box motifs. U81 acts as a guanine methylation guide and is found in intron An intron is any Nucleic acid sequence, nucleotide sequence within a gene that is not expressed or operative in the final RNA product. The word ''intron'' is derived from the term ''intragenic region'', i.e. a region inside a gene."The notion of ... 11 of the gas5 gene in mammals. References External links * Small nuclear RNA {{molecular-cell-biology-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
