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Furanolactone
A furanolactone is a heterocyclic chemical compound that contains both a lactone and a furan ring structure. Examples include: * The salvinorins, including the hallucinogenic compound salvinorin A * Columbin, a bitter diterpenoid from '' Calumbae Radix'' * Limonoids such as limonin, nomilin, and nomilinic acid * Tinosporide, a diterpenoid originally isolated from ''Tinospora cordifolia ''Tinospora cordifolia'' (common names gurjo, heart-leaved moonseed, guduchi or giloy) is a herbaceous vine of the family Menispermaceae indigenous to tropical regions of the Indian subcontinent. It has been used in Ayurveda to treat various diso ...'' References {{reflist Lactones 3-Furyl compounds ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Salvinorin A Structure
Salvinorins are a group of natural chemical compounds and their structural analogs. Several salvinorins have been isolated from ''Salvia divinorum''. They are classified as diterpenoid furanolactones. Salvinorin A is a hallucinogen with dissociative effects. Several salvinorins have been isolated and characterized. Occurrence Originally isolated from ''S. divinorum'', salvinorins are also detected in smaller amounts in: * '' Salvia recognita'' (salvinorin A, 212.9 μg/g) * ''Salvia absconditiflora'' (salvinorin A at 51.5 μg/g, and salvinorin B at 402.2 μg/g) * ''Salvia glutinosa'' (salvinorin A, 38.9 μg/g) * '' Salvia potentillifolia'' (salvinorin B, 2352.0 μg/g) * '' Salvia adenocaulon'' (salvinorin B, 768.8 μg/g) For comparison, the amount of salvinorin A in ''S. divinorum'' ranges from 0.89 to 3.70 mg/g. All fractions reported are based on dry mass. Interestingly, the above reported species are not very closely related to ''S. divinorum''. Associated compounds I ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tinospora Cordifolia
''Tinospora cordifolia'' (common names gurjo, heart-leaved moonseed, guduchi or giloy) is a herbaceous vine of the family Menispermaceae indigenous to tropical regions of the Indian subcontinent. It has been used in Ayurveda to treat various disorders, but there is no clinical evidence for the effectiveness of such treatment. Botanical description It is a large, deciduous, extensively-spreading, climbing vine with several elongated twining branches. Leaves are simple, alternate, and exstipulate with long petioles up to long which are roundish and pulvinate, both at the base and apex with the basal one longer and twisted partially and half way around. It gets its name heart-leaved moonseed by its heart-shaped leaves and its reddish fruit. Lamina are broadly ovate or ovate cordate, long or broad, seven nerved and deeply cordate at base, membranous, pubescent above, whitish tomentose with a prominent reticulum beneath. Flowers are unisexual, small on separate plants and appearin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tinosporide
Tinosporide is a chemical compound classified as a diterpenoid and a furanolactone. It was first isolated from the plant ''Tinospora cordifolia'', from which it derives its name. It has since been found in other plants of the genus ''Tinospora'', such as ''Tinospora glabra''. Because ''Tinospora cordifolia ''Tinospora cordifolia'' (common names gurjo, heart-leaved moonseed, guduchi or giloy) is a herbaceous vine of the family Menispermaceae indigenous to tropical regions of the Indian subcontinent. It has been used in Ayurveda to treat various diso ...'' has been used in traditional herbal medicine, there has been research directed at exploring the potential pharmacology of tinosporide and related compounds. Related compounds Other diterpenoid furanolactones with a similar structure include columbin, palmarin, and chasmanthin. File:columbin.svg, Columbin File:palmarin.svg, Palmarin File:chasmanthin.svg, Chasmanthin External links Furans Lactones Diterpenoids Heteroc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Limonin
Limonin is a limonoid, and a bitter, white, crystalline substance found in citrus and other plants. It is also known as limonoate D-ring-lactone and limonoic acid di-delta-lactone. Chemically, it is a member of the class of compounds known as furanolactones. Sources Limonin is enriched in citrus fruits and is often found at higher concentrations in seeds, for example orange and lemon seeds. Presence in citrus products Limonin and other limonoid compounds contribute to the bitter taste of some citrus food products. Researchers have proposed removal of limonoids from orange juice and other products (known as "debittering") through the use of polymeric films. Research Limonin is under basic research Basic research, also called pure research or fundamental research, is a type of scientific research with the aim of improving scientific theories for better understanding and prediction of natural or other phenomena. In contrast, applied resear ... to assess its possible biologica ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Limonoid
Limonoids are phytochemicals of the triterpenoid class which are abundant in sweet or sour-scented citrus fruit and other plants of the families Cucurbitaceae, Rutaceae, and Meliaceae. Certain limonoids are antifeedants such as azadirachtin from the neem tree.{{cite journal, title=Biological activity of limonoids from the rutales, journal=Phytochemistry, volume=31, pages=377–394, authors=Donald E.Champagne, Opender Koul, Murray B. Isman, Geoffrey G. E.Scudder, G. H. Neil Towers, year=1992, issue=2, doi=10.1016/0031-9422(92)90003-9 Chemically, the limonoids consist of variations of the furanolactone core structure. The prototypical structure consists of four six-membered rings and a furan ring. Limonoids are classed as tetranortriterpenoid, tetranortriterpenes. Citrus fruits contain the limonoids limonin, nomilin and nomilinic acid, while both neem seeds and leaves contain the limonoid azadirachtin, although higher concentrations are present in the former. See also * Tetran ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Heterocycle
A heterocyclic compound or ring structure is a cyclic compound that has atoms of at least two different chemical element, elements as members of its ring(s). Heterocyclic chemistry is the branch of organic chemistry dealing with the synthesis, properties, and applications of these heterocycles. Examples of heterocyclic compounds include all of the nucleic acids, the majority of drugs, most biomass (cellulose and related materials), and many natural and synthetic dyes. More than half of known compounds are heterocycles. 59% of US FDA-approved drugs contain nitrogen heterocycles. Classification The study of heterocyclic chemistry focuses especially on unsaturated derivatives, and the preponderance of work and applications involves unstrained 5- and 6-membered rings. Included are pyridine, thiophene, pyrrole, and furan. Another large class of heterocycles refers to those fused to benzene rings. For example, the fused benzene derivatives of pyridine, thiophene, pyrrole, and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Salvinorin A
Salvinorin A is the main active psychotropic molecule in '' Salvia divinorum''. Salvinorin A is considered a dissociative hallucinogen. It is structurally distinct from other naturally occurring hallucinogens (such as DMT, psilocybin, and mescaline) because it contains no nitrogen atoms; hence, it is not an alkaloid (and cannot be rendered as a salt), but rather is a terpenoid. It also differs in subjective experience, compared to other hallucinogens, and has been described as dissociative. Salvinorin A can produce psychoactive experiences in humans with a typical duration of action being several minutes to an hour or so, depending on the method of ingestion. Salvinorin A is found with several other structurally related salvinorins. Salvinorin is a ''trans''-neoclerodane diterpenoid. It acts as a kappa opioid receptor agonist and is the first known compound acting on this receptor that is not an alkaloid. History Salvinorin A was first described and named in 1982 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hallucinogen
Hallucinogens are a large, diverse class of psychoactive drugs that can produce altered states of consciousness characterized by major alterations in thought, mood, and perception as well as other changes. Most hallucinogens can be categorized as either being psychedelics, dissociatives, or deliriants. However, certain hallucinogens such as Fly agaric as well as other gabaergic hallucinogenics are more often considered to technically be hypnotics, therefore indicating another separate subcategory of drugs which can substantially alter visual perception. Etymology The word ''hallucinogen'' is derived from the word ''hallucination''. The term ''hallucinate'' dates back to around 1595–1605, and is derived from the Latin ''hallūcinātus'', the past participle of ''(h)allūcināri'', meaning "to wander in the mind." Characteristics Leo Hollister gave five criteria for classifying a drug as hallucinogenic.Glennon RA. Classical drugs: an introductory overview. In Lin GC and Gle ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
