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Friedreich
Nikolaus Friedreich (1 July 1825 in Würzburg – 6 July 1882 in Heidelberg) was a German pathologist and neurologist, and a third generation physician in the Friedreich family. His father was psychiatrist Johann Baptist Friedreich (1796–1862), and his grandfather was pathologist Nicolaus Anton Friedreich (1761–1836), who is remembered for his early description of idiopathic facial paralysis, which would later be known as Bell's palsy.''Bell's paralysis''
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Biography

In the early part of his career he studied and practiced medicine at the

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Friedreich's Ataxia
Friedreich's ataxia (FRDA or FA) is an autosomal-recessive genetic disease that causes difficulty walking, a loss of sensation in the arms and legs, and impaired speech that worsens over time. Symptoms generally start between 5 and 20 years of age. Many develop hypertrophic cardiomyopathy and require a mobility aid such as a cane, walker, or wheelchair in their teens. As the disease progresses, some affected people lose their sight and hearing. Other complications may include scoliosis and diabetes mellitus. The condition is caused by mutations in the ''FXN'' gene on chromosome 9, which makes a protein called frataxin. In FRDA, cells produce less frataxin. Degeneration of nerve tissue in the spinal cord causes the ataxia; particularly affected are the sensory neurons essential for directing muscle movement of the arms and legs through connections with the cerebellum. The spinal cord becomes thinner, and nerve cells lose some myelin sheath. No effective treatment is kn ...
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Johann Baptist Friedreich
Johann Baptist Friedreich (19 April 1796, in Würzburg – 19 January 1862, in Würzburg) was a German forensic physician and psychiatrist. He was a prominent member of the so-called "somatic school" of psychiatry in Germany. He studied medicine at the University of Würzburg, where in 1820 he obtained his habilitation. In 1830 he was named a professor of physiology at the university, however in 1832, along with physician Johann Lukas Schönlein and surgeon Cajetan von Textor, he was removed from his post for political reasons. He then worked as a court physician in Weißenburg, later performing similar duties in Straubing, Ansbach and finally in Erlangen, where in 1850 he became an honorary professor of forensic medicine.ADB:Friedreich, Johann Baptist
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Friedreich's Sign
In medicine, Friedreich's sign is the exaggerated drop in diastolic central venous pressure seen in constrictive pericarditis (particularly with a stiff calcified pericardium) and manifested as abrupt collapse of the neck veins or marked descent of the central venous pressure waveform. The normal jugular venous waveform contains two descents, x and y. The x descent, which corresponds to the combination of right atrial relaxation and depression of the atrial floor during ventricular contraction, is normally dominant. The y descent occurs as a result of passive ventricular filling during early diastole and is usually absent in patients with tamponade. In constrictive pericarditis, the characteristic sharp and deep y descent reflects rapid filling in early diastole which occurs when the unyielding pericardium elevates atrial pressure and limits ventricular filling to the early diastolic period. Friedreich’s diastolic collapse of the cervical veins, describes a sharp and deep y descent ...
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Leopold Auerbach
Leopold Auerbach (27 April 1828 – 30 September 1897) was a German anatomist and neuropathologist born in Breslau. Education and career Auerbach studied medicine at the Universities of Breslau, Berlin and the Leipzig. He became a physician in 1849, obtained his habilitation in 1863. From 1872 he was an associate professor of neuropathology at the University of Breslau. Discoveries Auerbach was among the first physicians to diagnose the nervous system using histological staining methods. He published a number of papers on neuropathological problems and muscle-related disorders. He is credited with the discovery of ''Plexus myentericus Auerbachi'', or Auerbach's plexus, a layer of ganglion cells that provide control of movements of the gastro-intestinal tract, also known as the "myenteric plexus". "Friedreich–Auerbach disease" is named after Auerbach and pathologist Nikolaus Friedreich (1825-1882). It is a rare disease characterized by hemi-hypertrophy of the facial features ...
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Ataxia
Ataxia is a neurological sign consisting of lack of voluntary coordination of muscle movements that can include gait abnormality, speech changes, and abnormalities in eye movements. Ataxia is a clinical manifestation indicating dysfunction of the parts of the nervous system that coordinate movement, such as the cerebellum. Ataxia can be limited to one side of the body, which is referred to as hemiataxia. Several possible causes exist for these patterns of neurological dysfunction. Dystaxia is a mild degree of ataxia. Friedreich's ataxia has gait abnormality as the most commonly presented symptom. The word is from Greek α- negative prefix+ -τάξις rder= "lack of order". Types Cerebellar The term cerebellar ataxia is used to indicate ataxia due to dysfunction of the cerebellum. The cerebellum is responsible for integrating a significant amount of neural information that is used to coordinate smoothly ongoing movements and to participate in motor planning. Although a ...
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Wilhelm Heinrich Erb
Wilhelm Heinrich Erb (30 November 1840 – 29 October 1921) was a German neurologist. He was born in Winnweiler, and died in Heidelberg. Academic career In 1864 he received his medical degree from the University of Heidelberg, where for several years he served as an assistant to pathologist Nikolaus Friedreich (1825-1882). As a young man, he also worked for a period of time under Ludwig von Buhl (1816-1880) in Munich. In 1880 Erb attained the chair of special pathology at the University of Leipzig, where he was also appointed head of its policlinic. In 1883 he succeeded Friedreich at the University of Heidelberg, where he worked until his retirement in 1907. Psychiatrist Emil Kraepelin (1856-1926) and neurologists Ernst Julius Remak (1849-1911), Max Nonne (1861-1959) and Paul Julius Möbius (1853–1907)
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Pes Cavus
Pes cavus, also known as high arch, is a human foot type in which the sole of the foot is distinctly hollow when bearing weight. That is, there is a fixed plantar flexion of the foot. A high arch is the opposite of a flat foot and is somewhat less common. Signs and symptoms Pain and disability As with certain cases of flat feet, high arches may be painful due to metatarsal compression; however, high arches— particularly if they are flexible or properly cared-for—may be an asymptomatic condition. People with pes cavus sometimes—though not always—have difficulty finding shoes that fit and may require support in their shoes. Children with high arches who have difficulty walking may wear specially-designed insoles, which are available in various sizes and can be made to order. Individuals with pes cavus frequently report foot pain, which can lead to a significant limitation in function. The range of complaints reported in the literature include metatarsalgia, pain under th ...
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Friedrich Schultze
Friedrich Schultze (12 August 1848 – 14 October 1934) was a German neurologist and native of Rathenow, Brandenburg. He is known for being the founder of child neurology. In 1871 he earned his doctorate at Heidelberg, and afterwards spent several years as an assistant to pathologist Nikolaus Friedreich (1825–1882). In 1887 he was invited as a "full professor" to the University of Dorpat, and shortly afterwards became director of the medical clinic and policlinic at the University of Bonn, where he spent the remainder of his career. Schultze is remembered for his numerous medical publications involving neuroanatomical and neuropathological investigations that he performed. In 1884 he was credited with being the first physician to describe a neurological disorder that later became known as Charcot-Marie-Tooth disease. He also provided an early description of acroparesthesia. In 1891 with Wilhelm Heinrich Erb (1840–1921) and Adolph Strümpell (1853–1925), he founded the ...
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Bell's Palsy
Bell's palsy is a type of facial paralysis that results in a temporary inability to control the facial muscles on the affected side of the face. In most cases, the weakness is temporary and significantly improves over weeks. Symptoms can vary from mild to severe. They may include muscle twitching, weakness, or total loss of the ability to move one or, in rare cases, both sides of the face. Other symptoms include drooping of the eyelid, a change in taste, and pain around the ear. Typically symptoms come on over 48 hours. Bell's palsy can trigger an increased sensitivity to sound known as hyperacusis. The cause of Bell's palsy is unknown and it can occur in any age. Risk factors include diabetes, a recent upper respiratory tract infection, and pregnancy. It results from a dysfunction of cranial nerve VII (the facial nerve). Many believe that this is due to a viral infection that results in swelling. Diagnosis is based on a person's appearance and ruling out other possible causes. ...
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Diastole
Diastole ( ) is the relaxed phase of the cardiac cycle when the chambers of the heart are re-filling with blood. The contrasting phase is systole when the heart chambers are contracting. Atrial diastole is the relaxing of the atria, and ventricular diastole the relaxing of the ventricles. The term originates from the Greek word (''diastolē''), meaning "dilation", from (''diá'', "apart") + (''stéllein'', "to send"). Role in cardiac cycle A typical heart rate is 75 beats per minute (bpm), which means that the cardiac cycle that produces one heartbeat, lasts for less than one second. The cycle requires 0.3 sec in ventricular systole (contraction)—pumping blood to all body systems from the two ventricles; and 0.5 sec in diastole (dilation), re-filling the four chambers of the heart, for a total of 0.8 sec to complete the cycle. Early ventricular diastole During early ventricular diastole, pressure in the two ventricles begins to drop from the peak reached during systo ...
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Pericardium
The pericardium, also called pericardial sac, is a double-walled sac containing the heart and the roots of the great vessels. It has two layers, an outer layer made of strong connective tissue (fibrous pericardium), and an inner layer made of serous membrane (serous pericardium). It encloses the pericardial cavity, which contains pericardial fluid, and defines the middle mediastinum. It separates the heart from interference of other structures, protects it against infection and blunt trauma, and lubricates the heart's movements. The English name originates from the Ancient Greek prefix "''peri-''" (περί; "around") and the suffix "''-cardion''" (κάρδιον; "heart"). Anatomy The pericardium is a tough fibroelastic sac which covers the heart from all sides except at the cardiac root (where the great vessels join the heart) and the bottom (where only the serous pericardium exists to cover the upper surface of the central tendon of diaphragm). The fibrous pericardiu ...
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Adolf Kussmaul
Adolph Kußmaul (german: Carl Philipp Adolf Konrad Kußmaul; 22 February 1822 – 28 May 1902) was a German physician and a leading clinician of his time. He was born as the son and grandson of physicians at Graben near Karlsruhe and studied at Heidelberg. He entered the army after graduation and spent two years as an army surgeon. This was followed by a period as a general practitioner before he went to Würzburg to study for his doctorate under Virchow. He was subsequently Professor of Medicine at Heidelberg (1857), Erlangen (1859), Freiburg (1859) and Straßburg (1876). Beyond his medical skills he was also active in literature. He is regarded as one of the creators of the term Biedermeier. He died in Heidelberg. Eponymous terms His name continues to be used in eponyms. He described two medical signs and one disease which have eponymous names that remain in use: * Kussmaul breathing - Very deep and labored breathing with normal, rapid or reduced frequency seen in severe Diab ...
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