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Frederick P. Gay
Frederick Parker Gay (July 22, 1874 – July 14, 1939) was an American bacteriologist who combated typhoid fever and leprosy as well as studied the mechanism of immunity. He was a charter member of the Explorers Club. Early life Frederick was born in Boston, Massachusetts, to George Frederick Gay and Louisa Maria Parker. In 1894 he was part of an Arctic expedition led by Frederick Cook. He graduated from Harvard University in 1897 after a trip around the world. He went to the Philippine Islands in the Spanish–American War fighting Emilio Aguinaldo. He graduated from Johns Hopkins Medical School in 1901. With funding from Rockefeller Institute of Medical Research, he became a demonstrator in pathology at University of Pennsylvania. Scientist In 1906 he worked at the Danvers State Hospital in Massachusetts and began to collaborate with Elmer Ernest Southard in the study of anaphylaxis. They induced reactions in guinea pigs with horse serum and published their f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Boston
Boston (), officially the City of Boston, is the state capital and most populous city of the Commonwealth of Massachusetts, as well as the cultural and financial center of the New England region of the United States. It is the 24th- most populous city in the country. The city boundaries encompass an area of about and a population of 675,647 as of 2020. It is the seat of Suffolk County (although the county government was disbanded on July 1, 1999). The city is the economic and cultural anchor of a substantially larger metropolitan area known as Greater Boston, a metropolitan statistical area (MSA) home to a census-estimated 4.8 million people in 2016 and ranking as the tenth-largest MSA in the country. A broader combined statistical area (CSA), generally corresponding to the commuting area and including Providence, Rhode Island, is home to approximately 8.2 million people, making it the sixth most populous in the United States. Boston is one of the oldest ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Frederick Cook
Frederick Albert Cook (June 10, 1865 – August 5, 1940) was an American explorer, physician, and ethnographer who claimed to have reached the North Pole on April 21, 1908. That was nearly a year before Robert Peary, who similarly claimed to have reached the North Pole on April 6, 1909. Both men's accounts have been disputed ever since. His expedition was the first, and the only one with a United States national, to find a previously unknown, to people of European descent, North American Arctic island, Meighen Island. In December 1909, after reviewing Cook's limited records, a commission of the University of Copenhagen ruled his claim unproven. In 1911, Cook published a memoir of his expedition that continued his claim. His account of reaching the summit of Denali (Mount McKinley) in Alaska has also been discredited. Biography Cook was born in Hortonville, New York, in Sullivan County. (His birthplace is sometimes listed as Callicoon or Delaware, both also in Sullivan ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biology
Biology is the scientific study of life. It is a natural science with a broad scope but has several unifying themes that tie it together as a single, coherent field. For instance, all organisms are made up of cells that process hereditary information encoded in genes, which can be transmitted to future generations. Another major theme is evolution, which explains the unity and diversity of life. Energy processing is also important to life as it allows organisms to move, grow, and reproduce. Finally, all organisms are able to regulate their own internal environments. Biologists are able to study life at multiple levels of organization, from the molecular biology of a cell to the anatomy and physiology of plants and animals, and evolution of populations.Based on definition from: Hence, there are multiple subdisciplines within biology, each defined by the nature of their research questions and the tools that they use. Like other scientists, biologists use the sc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alexin
Humoral immunity is the aspect of immunity that is mediated by macromolecules - including secreted antibodies, complement proteins, and certain antimicrobial peptides - located in extracellular fluids. Humoral immunity is named so because it involves substances found in the humors, or body fluids. It contrasts with cell-mediated immunity. Humoral immunity is also referred to as antibody-mediated immunity. The study of the molecular and cellular components that form the immune system, including their function and interaction, is the central science of immunology. The immune system is divided into a more primitive innate immune system and an acquired or adaptive immune system of vertebrates, each of which contain both humoral and cellular immune elements. Humoral immunity refers to antibody production and the coinciding processes that accompany it, including: Th2 activation and cytokine production, germinal center formation and isotype switching, and affinity maturation and memo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Serology
Serology is the scientific study of Serum (blood), serum and other body fluids. In practice, the term usually refers to the medical diagnosis, diagnostic identification of Antibody, antibodies in the serum. Such antibodies are typically formed in response to an infection (against a given microorganism), against other foreign proteins (in response, for example, to a Acute hemolytic transfusion reaction, mismatched blood transfusion), or to one's own proteins (in instances of autoimmune disease). In either case, the procedure is simple. Serological tests Serological tests are diagnostic methods that are used to identify antibodies and antigens in a patient's sample. Serological tests may be performed to diagnose infections and autoimmune illnesses, to check if a person has immunity (medical), immunity to certain diseases, and in many other situations, such as determining an individual's blood type. Serological tests may also be used in forensic serology to investigate crime scene evid ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jules Bordet
Jules Jean Baptiste Vincent Bordet (; 13 June 1870 – 6 April 1961) was a Belgian immunologist and microbiologist. The bacterial genus ''Bordetella'' is named after him. The Nobel Prize in Physiology or Medicine was awarded to him in 1919 for his discoveries relating to immunity. Education and early life Bordet was born at Soignies, Belgium. He graduated as Doctor of Medicine from the Free University of Brussels in 1892 and began his work at the Pasteur Institute in Paris in 1894, in the laboratory of Elie Metchnikoff, who had just discovered phagocytosis of bacteria by white blood cells, an expression of cellular immunity. Career In 1895 Bordet made his discovery that the bacteriolytic effect of acquired specific antibody is significantly enhanced ''in vivo'' by the presence of innate serum components which he termed alexine (but which are now known as complement). Four years later, in 1899, he described a similar destructive process involving complement, "hemolysis", in wh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Serum (blood)
Serum () is the fluid and solute component of blood which does not play a role in Coagulation, clotting. It may be defined as blood plasma without the clotting factors, or as blood with all cells and clotting factors removed. Serum includes all proteins not used in Coagulation, blood clotting; all electrolytes, antibodies, antigens, hormones; and any exogenous substances (e.g., drugs or microorganisms). Serum does not contain white blood cells (leukocytes), red blood cells (erythrocytes), platelets, or clotting factors. The study of serum is serology. Serum is used in numerous diagnostic tests as well as blood typing. Measuring the concentration of various molecules can be useful for many applications, such as determining the therapeutic index of a drug candidate in a clinical trial. To obtain serum, a blood sample is allowed to clot (coagulation). The sample is then centrifuged to remove the clot and blood cells, and the resulting liquid wikt:supernatant, supernatant is serum. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Guinea Pig
The guinea pig or domestic guinea pig (''Cavia porcellus''), also known as the cavy or domestic cavy (), is a species of rodent belonging to the genus ''Cavia'' in the family Caviidae. Breeders tend to use the word ''cavy'' to describe the animal, while in scientific and laboratory contexts, it is far more commonly referred to by the common name ''guinea pig''. Despite their common name, guinea pigs are not native to Guinea, nor are they closely related biologically to pigs, and the origin of the name is still unclear. They originated in the Andes of South America. Studies based on biochemistry and hybridization suggest they are domesticated animals that do not exist naturally in the wild, descendants of a closely related cavy species such as '' C. tschudii''. They were originally domesticated as livestock for a source of meat, and are still consumed in some parts of the world. In Western society, the guinea pig has enjoyed widespread popularity as a pet since its introducti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anaphylaxis
Anaphylaxis is a serious, potentially fatal allergic reaction and medical emergency that is rapid in onset and requires immediate medical attention regardless of use of emergency medication on site. It typically causes more than one of the following: an itchy rash, throat closing due to swelling which can obstruct or stop breathing; severe tongue swelling which can also interfere with or stop breathing; shortness of breath, vomiting, lightheadedness, loss of consciousness, low blood pressure, and medical shock. These symptoms typically start in minutes to hours and then increase very rapidly to life-threatening levels. Urgent medical treatment is required to prevent serious harm or death, even if the patient has used an epipen or has taken other medications in response, and even if symptoms appear to be improving. Common causes include allergies to insect bites and stings, allergies to foods – including nuts, milk, fish, shellfish, eggs and some fresh fruits or dried fruits; a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Elmer Ernest Southard
Elmer Ernest (E. E.) Southard (July 28, 1876February 8, 1920) was an American neuropsychiatrist, neuropathologist, professor and author. Born in Boston, Massachusetts, Southard lived in the city for nearly his entire life. He attended Boston Latin School and completed his education at Harvard University. At Harvard, Southard distinguished himself as a chess player. After briefly studying in Germany, he returned to the United States as a pathologist at Danvers State Hospital. Southard held academic appointments at Harvard University and its medical school. He headed the Boston Psychopathic Hospital when it opened in 1912, pioneering the study of brain pathology with particular interests in shell shock and schizophrenia. Southard published several books, including ''Shell Shock and Other Neuropsychiatric Problems'' with nearly 1,000 case histories. He was president of the American Medico-Psychological Association and the Boston Society of Psychiatry and Neurology, and held advis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rockefeller Institute Of Medical Research
The Rockefeller University is a private Private or privates may refer to: Music * " In Private", by Dusty Springfield from the 1990 album ''Reputation'' * Private (band), a Denmark-based band * "Private" (Ryōko Hirosue song), from the 1999 album ''Private'', written and also recorde ... Medical research, biomedical Research university, research and graduate-only university in New York City, New York (state), New York. It focuses primarily on the biological and medical sciences and provides doctoral and postdoctoral education. It is Carnegie Classification of Institutions of Higher Education, classified among "R2: Doctoral Universities – High research activity." Rockefeller is the oldest biomedical research institute in the United States. In 2018, the faculty included 82 tenured and tenure-track members, including 37 members of the National Academy of Sciences, 17 members of the National Academy of Medicine, seven Lasker Award recipients, and five Nobel Prize, Nobel lau ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Emilio Aguinaldo
Emilio Aguinaldo y Famy (: March 22, 1869February 6, 1964) was a Filipino revolutionary, statesman, and military leader who is the youngest president of the Philippines (1899–1901) and is recognized as the first president of the Philippines and of an Asian constitutional republic. He led Philippine forces first against Spain in the Philippine Revolution (1896–1898), then in the Spanish–American War (1898), and finally against the United States during the Philippine–American War (1899–1901). Aguinaldo remains a controversial figure in Filipino history. Though he has been recommended as a national hero of the Philippines, many have criticized him for the deaths of the revolutionary leader Andrés Bonifacio and general Antonio Luna, as well as his collaboration with the Japanese Empire during their occupation of the Philippines in World War II. "Aguinaldo's collaboration with Japan began with his contact with Gen. Masami Maeda, Homma's chief of staff. ..Aguinaldo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
