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Fluorodeoxyglucose (18F)
18F.html" ;"title="sup>18F">sup>18Fluorodeoxyglucose (INN), or fluorodeoxyglucose F 18 (USAN and USP), also commonly called fluorodeoxyglucose and abbreviated 18F.html" ;"title="sup>18F">sup>18FDG, 2- 18F.html" ;"title="sup>18F">sup>18FDG or FDG, is a radiopharmaceutical, specifically a radiotracer, used in the medical imaging modality positron emission tomography (PET). Chemically, it is 2-deoxy-2- 18F.html" ;"title="sup>18F">sup>18Fluoro-D-glucose, a glucose analog, with the positron-emitting radionuclide fluorine-18 substituted for the normal hydroxyl group at the C-2 position in the glucose molecule. The uptake of 18F.html" ;"title="sup>18F">sup>18FDG by tissues is a marker for the tissue uptake of glucose, which in turn is closely correlated with certain types of tissue metabolism. After 18F.html" ;"title="sup>18F">sup>18FDG is injected into a patient, a PET scanner can form two-dimensional or three-dimensional images of the distribution of 18F.html" ;"title="sup>18F"> ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chemical Communications
''ChemComm'' (or ''Chemical Communications''), formerly known as ''Journal of the Chemical Society D: Chemical Communications'' (1969–1971), ''Journal of the Chemical Society, Chemical Communications'' (1972–1995), is a peer-reviewed scientific journal published by the Royal Society of Chemistry. It covers all aspects of chemistry. In January 2012, the journal moved to publishing 100 issues per year. The current chair of the Editorial Board is Douglas Stephan (University of Toronto, Canada), while the executive editor is Richard Kelly. Abstracting and indexing The journal is abstracted and indexed in: * Chemical Abstracts * Science Citation Index * Current Contents/Physical, Chemical & Earth Sciences * Scopus * Index Medicus/MEDLINE/PubMed According to the ''Journal Citation Reports'', the journal has a 2021 impact factor of 6.065. See also * ''New Journal of Chemistry'' * ''Chemical Society Reviews'' * ''Chemical Science'' * ''RSC Advances ''RSC Advances'' is an online-o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neurosciences
Neuroscience is the science, scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its functions and disorders. It is a Multidisciplinary approach, multidisciplinary science that combines physiology, anatomy, molecular biology, developmental biology, cytology, psychology, physics, computer science, chemistry, medicine, statistics, and Mathematical Modeling, mathematical modeling to understand the fundamental and emergent properties of neurons, glia and neural circuits. The understanding of the biological basis of learning, memory, behavior, perception, and consciousness has been described by Eric Kandel as the "epic challenge" of the Biology, biological sciences. The scope of neuroscience has broadened over time to include different approaches used to study the nervous system at different scales. The techniques used by neuroscientists have expanded enormously, from molecular biology, molecular and cell biology, cellular studies of indivi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cyclotron
A cyclotron is a type of particle accelerator invented by Ernest O. Lawrence in 1929–1930 at the University of California, Berkeley, and patented in 1932. Lawrence, Ernest O. ''Method and apparatus for the acceleration of ions'', filed: January 26, 1932, granted: February 20, 1934 A cyclotron accelerates charged particles outwards from the center of a flat cylindrical vacuum chamber along a spiral path. The particles are held to a spiral trajectory by a static magnetic field and accelerated by a rapidly varying electric field. Lawrence was awarded the 1939 Nobel Prize in Physics for this invention. The cyclotron was the first "cyclical" accelerator. The primary accelerators before the development of the cyclotron were electrostatic accelerators, such as the Cockcroft–Walton accelerator and Van de Graaff generator. In these accelerators, particles would cross an accelerating electric field only once. Thus, the energy gained by the particles was limited by the maximum elec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Radioligand
A radioligand is a radioactive biochemical substance (in particular, a ligand that is radiolabeled) that is used for diagnosis or for research-oriented study of the receptor systems of the body. In a neuroimaging application the radioligand is injected into the pertinent tissue, or infused into the bloodstream. It binds to its receptor. When the radioactive isotope in the ligand decays it can be measured by positron emission tomography (PET) or single-photon emission computed tomography (SPECT). In ''in vivo'' systems it is often used to quantify the binding of a test molecule to the binding site of a radioligand. The higher the affinity of the molecule the more radioligand is displaced from the binding site and the increasing radioactive decay can be measured by scintillography. This assay is commonly used to calculate the binding constant of molecules to receptors. The transport of the radioligand is described by receptor kinetics. History Radioligands are credited with maki ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Radioactive
Radioactive decay (also known as nuclear decay, radioactivity, radioactive disintegration, or nuclear disintegration) is the process by which an unstable atomic nucleus loses energy by radiation. A material containing unstable nuclei is considered radioactive. Three of the most common types of decay are alpha decay ( ), beta decay ( ), and gamma decay ( ), all of which involve emitting one or more particles. The weak force is the mechanism that is responsible for beta decay, while the other two are governed by the electromagnetism and nuclear force. A fourth type of common decay is electron capture, in which an unstable nucleus captures an inner electron from one of the electron shells. The loss of that electron from the shell results in a cascade of electrons dropping down to that lower shell resulting in emission of discrete X-rays from the transitions. A common example is iodine-125 commonly used in medical settings. Radioactive decay is a stochastic (i.e. random) process ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Electrophilic Fluorination
Electrophilic fluorination is the combination of a carbon-centered nucleophile with an electrophilic source of fluorine to afford organofluorine compounds. Although elemental fluorine and reagents incorporating an oxygen-fluorine bond can be used for this purpose, they have largely been replaced by reagents containing a nitrogen-fluorine bond.Badoux, J.; Cahard, D. '' Org. React.'' 2007, ''69'', 347. Electrophilic fluorination offers an alternative to nucleophilic fluorination methods employing alkali or ammonium fluorides and methods employing sulfur fluorides for the preparation of organofluorine compounds. Development of electrophilic fluorination reagents has always focused on removing electron density from the atom attached to fluorine; however, compounds containing nitrogen-fluorine bonds have proven to be the most economical, stable, and safe electrophilic fluorinating agents. Electrophilic N-F reagents are either neutral or cationic and may possess either sp2- or sp3-hybridi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Los Alamos National Laboratory
Los Alamos National Laboratory (often shortened as Los Alamos and LANL) is one of the sixteen research and development laboratories of the United States Department of Energy (DOE), located a short distance northwest of Santa Fe, New Mexico, in the American southwest. Best known for its central role in helping develop the first atomic bomb, LANL is one of the world's largest and most advanced scientific institutions. Los Alamos was established in 1943 as Project Y, a top-secret site for designing nuclear weapons under the Manhattan Project during World War II.The site was variously called Los Alamos Laboratory and Los Alamos Scientific Laboratory. Chosen for its remote yet relatively accessible location, it served as the main hub for conducting and coordinating nuclear research, bringing together some of the world's most famous scientists, among them numerous Nobel Prize winners. The town of Los Alamos, directly north of the lab, grew extensively through this period. After ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gulf War
The Gulf War was a 1990–1991 armed campaign waged by a 35-country military coalition in response to the Iraqi invasion of Kuwait. Spearheaded by the United States, the coalition's efforts against Iraq were carried out in two key phases: Operation Desert Shield, which marked the military buildup from August 1990 to January 1991; and Operation Desert Storm, which began with the aerial bombing campaign against Iraq on 17 January 1991 and came to a close with the American-led Liberation of Kuwait on 28 February 1991. On 2 August 1990, Iraq invaded the neighbouring State of Kuwait and had fully occupied the country within two days. Initially, Iraq ran the occupied territory under a puppet government known as the "Republic of Kuwait" before proceeding with an outright annexation in which Kuwaiti sovereign territory was split, with the "Saddamiyat al-Mitla' District" being carved out of the country's northern portion and the "Kuwait Governorate" covering the rest. Varying spe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oxygen-18
Oxygen-18 (, Ω) is a natural, stable isotope of oxygen and one of the environmental isotopes. is an important precursor for the production of fluorodeoxyglucose (FDG) used in positron emission tomography (PET). Generally, in the radiopharmaceutical industry, enriched water () is bombarded with hydrogen ions in either a cyclotron or linear accelerator, creating fluorine-18. This is then synthesized into FDG and injected into a patient. It can also be used to make an extremely heavy version of water when combined with tritium (hydrogen-3): or . This compound has a density almost 30% greater than that of natural water. The accurate measurements of rely on proper procedures of analysis, sample preparation and storage. Paleoclimatology In ice cores, mainly Arctic and Antarctic, the ratio of to (known as δ) can be used to determine the temperature of precipitation through time. Assuming that atmospheric circulation and elevation has not changed significantly over the poles, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Abass Alavi
, image = , image_size = , birth_place = Tabriz, Iran , nationality = American , field = Molecular imaging , work_institutions = University of PennsylvaniaDepartment of Radiology , alma_mater = Tehran University of Medical Sciences (M.D., 1964)University of Bologna (Honorary M.D., 2007)Shiraz University (Honorary Ph.D, 2007)University of the Sciences (Honorary D.Sc, 2008)Tabriz University of Medical Sciences (Honorary M.D., 2015) Gdańsk Medical University (Honorary M.D., 2016) , prizes = Georg Charles de Hevesy Nuclear Pioneer Award (2004) Benedict Cassen Prize (2012) Abass Alavi ( fa, عباس علوی) is an Iranian-American physician-scientist specializing in the field of molecular imaging, most notably in the imaging modality of positron emission tomography (PET). In August 1976, he was part of the team that performed the first human PET studies of the brain and whole body using the radiotracer 8Fluor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brookhaven National Laboratory
Brookhaven National Laboratory (BNL) is a United States Department of Energy national laboratory located in Upton, Long Island, and was formally established in 1947 at the site of Camp Upton, a former U.S. Army base and Japanese internment camp. Its name stems from its location within the Town of Brookhaven, approximately 60 miles east of New York City. It is managed by Stony Brook University and Battelle Memorial Institute. Research at BNL includes nuclear and high energy physics, energy science and technology, environmental and bioscience, nanoscience, and national security. The 5,300 acre campus contains several large research facilities, including the Relativistic Heavy Ion Collider and National Synchrotron Light Source II. Seven Nobel Prizes have been awarded for work conducted at Brookhaven Lab. Overview BNL is staffed by approximately 2,750 scientists, engineers, technicians, and support personnel, and hosts 4,000 guest investigators every year. The laboratory has ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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