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Florence Margaret Durham
Florence Margaret Durham (6 April 1869 – 25 June 1949) was a British geneticist at Cambridge in the early 1900s and an advocate of the theory of Mendelian inheritance, at a time when it was still controversial. She was part of an informal school of genetics at Cambridge led by her brother-in-law William Bateson. Her work on the heredity of coat colours in mice and canaries helped to support and extend Mendel's law of heredity. It is also one of the first examples of epistasis. National Institute for Medical Research Early life and education Florence Margaret Durham was born in 1869 in London, one of six daughters of surgeon Arthur Edward Durham (1833–1895) and his wife Mary Ann Cantwell. Her father was an alcoholic and her mother was strongly opposed to alcohol. In 1891 and 1892, Florence Durham achieved second class honours in the Natural Sciences Tripos Part I and II (physiology) at Girton College. From 1893 to 1899 she lectured in Biology at Royal Holloway College and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The University Women's Club
The University Women's Club, originally the University Club for Ladies, is a British private members club founded in 1883. As the popular gentlemen's clubs did not accept any women as members, its creation was intended to provide an equivalent club accessible to women. By its own definition, it is a club for "graduate and professional women of varied backgrounds and interests". Members include lawyers, scientists, writers and musicians, as well as businesswomen. The club house is located at 2 Audley Square, on South Audley Street, Mayfair, London. History The University Club for Ladies was founded in 1883 by Gertrude Jackson of Girton College, Cambridge. In January 1887, it opened its premises at 31 Bond Street. By 1894, the location was not large enough to serve the purposes of the growing club and it expanded by moving to new premises at Maddox Street. By 1904, the club had moved to 4 George Street, Hanover Square, where a number of bedrooms were available and by 1913, membe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Complex Traits
Complex traits, also known as quantitative traits, are traits that do not behave according to simple Mendelian inheritance laws. More specifically, their inheritance cannot be explained by the genetic segregation of a single gene. Such traits show a continuous range of variation and are influenced by both environmental and genetic factors. Compared to strictly Mendelian traits, complex traits are far more common, and because they can be hugely polygenic, they are studied using statistical techniques such as QTL mapping rather than classical genetics methods. Examples of complex traits include height, circadian rhythms, enzyme kinetics, and many diseases including diabetes and Parkinson's disease. One major goal of genetic research today is to better understand the molecular mechanisms through which genetic variants act to influence complex traits. History When Mendel’s work on inheritance was rediscovered in 1900, scientists debated whether Mendel’s laws could account for t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Guinea Pig
The guinea pig or domestic guinea pig (''Cavia porcellus''), also known as the cavy or domestic cavy (), is a species of rodent belonging to the genus ''Cavia'' in the family Caviidae. Breeders tend to use the word ''cavy'' to describe the animal, while in scientific and laboratory contexts, it is far more commonly referred to by the common name ''guinea pig''. Despite their common name, guinea pigs are not native to Guinea, nor are they closely related biologically to pigs, and the origin of the name is still unclear. They originated in the Andes of South America. Studies based on biochemistry and hybridization suggest they are domesticated animals that do not exist naturally in the wild, descendants of a closely related cavy species such as '' C. tschudii''. They were originally domesticated as livestock for a source of meat, and are still consumed in some parts of the world. In Western society, the guinea pig has enjoyed widespread popularity as a pet since its introducti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Board Of Trade
The Board of Trade is a British government body concerned with commerce and industry, currently within the Department for International Trade. Its full title is The Lords of the Committee of the Privy Council appointed for the consideration of all matters relating to Trade and Foreign Plantations, but is commonly known as the Board of Trade, and formerly known as the Lords of Trade and Plantations or Lords of Trade, and it has been a committee of the Privy Council of the United Kingdom. The board has gone through several evolutions, beginning with extensive involvement in colonial matters in the 17th century, to powerful regulatory functions in the Victorian Era and early 20th century. It was virtually dormant in the last third of 20th century. In 2017, it was revitalised as an advisory board headed by the International Trade Secretary who has nominally held the title of President of the Board of Trade, and who at present is the only privy counsellor of the board, the other m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Syphilis
Syphilis () is a sexually transmitted infection caused by the bacterium ''Treponema pallidum'' subspecies ''pallidum''. The signs and symptoms of syphilis vary depending in which of the four stages it presents (primary, secondary, latent, and tertiary). The primary stage classically presents with a single chancre (a firm, painless, non-itchy skin ulceration usually between 1 cm and 2 cm in diameter) though there may be multiple sores. In secondary syphilis, a diffuse rash occurs, which frequently involves the palms of the hands and soles of the feet. There may also be sores in the mouth or vagina. In latent syphilis, which can last for years, there are few or no symptoms. In tertiary syphilis, there are gummas (soft, non-cancerous growths), neurological problems, or heart symptoms. Syphilis has been known as "the great imitator" as it may cause symptoms similar to many other diseases. Syphilis is most commonly spread through sexual activity. It may also be transmi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Organoarsenic Compound
Organoarsenic chemistry is the chemistry of compounds containing a chemical bond between arsenic and carbon. A few organoarsenic compounds, also called "organoarsenicals," are produced industrially with uses as insecticides, herbicides, and fungicides. In general these applications are declining in step with growing concerns about their impact on the environment and human health. The parent compounds are arsane and arsenic acid. Despite their toxicity, organoarsenic biomolecules are well known. History 140px, Cacodyl (tetramethyldiarsine) was one of the first organoarsenic compounds. Surprising for an area now considered of minor importance, organoarsenic chemistry played a prominent role in the history of the field of chemistry. The oldest known organoarsenic compound, the foul smelling cacodyl was reported in "cacodyl" (1760) and is sometimes classified as the first synthetic organometallic compound. The compound Salvarsan was one of the first pharmaceuticals, earning a Nobel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neosalvarsan
Neosalvarsan is a synthetic chemotherapeutic that is an organoarsenic compound. It became available in 1912 and superseded the more toxic and less water-soluble salvarsan as an effective treatment for syphilis. Because both of these arsenicals carried considerable risk of side effects, they were replaced for this indication by penicillin in the 1940s. Both salvarsan and neosalvarsan were developed in the laboratory of Paul Ehrlich in Frankfurt, Germany. Their discoveries were the result of the first organized team effort to optimize the biological activity of a lead compound through systematic chemical modifications. This scheme is the basis for most modern pharmaceutical research. Both salvarsan and neosalvarsan are prodrug A prodrug is a medication or compound that, after intake, is metabolized (i.e., converted within the body) into a pharmacologically active drug. Instead of administering a drug directly, a corresponding prodrug can be used to improve how the drug ...sth ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Henry Hallett Dale
Sir Henry Hallett Dale (9 June 1875 – 23 July 1968) was an English pharmacologist and physiologist. For his study of acetylcholine as agent in the chemical transmission of nerve pulses (neurotransmission) he shared the 1936 Nobel Prize in Physiology or Medicine with Otto Loewi. Early life and education Henry Hallett Dale was born in Islington, London, to Charles James Dale, a pottery manufacturer from Staffordshire, and his wife, Frances Anne Hallett, daughter of a furniture manufacturer, from South Devon.Feldberg W, rev. Tansey EM (2004–2011)Dale, Sir Henry Hallett (1875–1968) ''Oxford Dictionary of National Biography'', Oxford University Press, 2004; online edn, Jan 2011. Retrieved 2011-07-08. Henry was the third of seven children, one of whom (his younger brother, Benjamin Dale) became an accomplished composer and warden of the Royal Academy of Music. Henry was educated at the local Tollington Park College and then The Leys School Cambridge (one of the school's hous ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Primula
''Primula'' () is a genus of herbaceous flowering plants in the family Primulaceae. They include the primrose ('' P. vulgaris''), a familiar wildflower of banks and verges. Other common species are '' P. auricula'' (auricula), '' P. veris'' (cowslip), and '' P. elatior'' (oxlip). These species and many others are valued for their ornamental flowers. They have been extensively cultivated and hybridised (in the case of the primrose, for many hundreds of years). ''Primula'' are native to the temperate Northern Hemisphere, south into tropical mountains in Ethiopia, Indonesia, and New Guinea, and in temperate southern South America. Almost half of the known species are from the Himalayas. ''Primula'' has over 500 species in traditional treatments, and more if certain related genera are included within its circumscription.''Primula''. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Surrey
Surrey () is a ceremonial and non-metropolitan county in South East England, bordering Greater London to the south west. Surrey has a large rural area, and several significant urban areas which form part of the Greater London Built-up Area. With a population of approximately 1.2 million people, Surrey is the 12th-most populous county in England. The most populated town in Surrey is Woking, followed by Guildford. The county is divided into eleven districts with borough status. Between 1893 and 2020, Surrey County Council was headquartered at County Hall, Kingston-upon-Thames (now part of Greater London) but is now based at Woodhatch Place, Reigate. In the 20th century several alterations were made to Surrey's borders, with territory ceded to Greater London upon its creation and some gained from the abolition of Middlesex. Surrey is bordered by Greater London to the north east, Kent to the east, Berkshire to the north west, West Sussex to the south, East Sussex to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
John Innes Centre
The John Innes Centre (JIC), located in Norwich, Norfolk, England, is an independent centre for research and training in plant and microbial science founded in 1910. It is a registered charity (No 223852) grant-aided by the Biotechnology and Biological Sciences Research Council (BBSRC), the European Research Council (ERC) and the Bill and Melinda Gates Foundation and is a member of the Norwich Research Park. In 2017, the John Innes Centre was awarded a gold Athena SWAN Charter award for equality in the workplace. History The John Innes Horticultural Institution was founded in 1910 at Merton Park, Surrey (now London Borough of Merton), with funds bequeathed by John Innes, a merchant and philanthropist. The Institution occupied Innes's former estate at Merton Park until 1945 when it moved to Bayfordbury, Hertfordshire. It moved to its present site in 1967. [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sex Linkage
Sex linked describes the sex-specific patterns of inheritance and presentation when a gene mutation (allele) is present on a sex chromosome (allosome) rather than a non-sex chromosome (autosome). In humans, these are termed X-linked recessive, X-linked dominant and Y-linked. The inheritance and presentation of all three differ depending on the sex of both the parent and the child. This makes them characteristically different from autosomal dominance and recessiveness. There are many more X-linked conditions than Y-linked conditions, since humans have several times as many genes on the X chromosome than the Y chromosome. Only females are able to be carriers for X-linked conditions; males will always be affected by any X-linked condition, since they have no second X chromosome with a healthy copy of the gene. As such, X-linked recessive conditions affect males much more commonly than females. In X-linked recessive inheritance, a son born to a carrier mother and an unaffected fath ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
