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Fern P. Rathe
Fern Pfafflin Rathe (January 8, 1930September 27, 2013) was an American organic chemist who helped discover cathomycin, an antibiotic used to treat strains of the bacteria ''Staphylococcus'', while working at pharmaceutical company Merck & Co. Early life and education Fern Pfafflin was born in La Crosse, Wisconsin, on January 8, 1930. She was the only child of Edward and Bessie (Chalsma) Pfafflin. She was raised on a family farm near New Amsterdam, Wisconsin, attending a one-room rural schoolhouse. She graduated as the valedictorian of Holmen High School in 1948. Pfafflin attended Carleton College and received her bachelor's degree in 1952, majoring in chemistry and zoology. She met her husband, John Rathe, at Carleton and they married in August 1953. Career in chemical research After graduating, Rathe worked as a biochemist for Merck and Company in Rahway, New Jersey, as a part of the research team of Karl August Folkers. One of the projects she was involved in was a search ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Novobiocin
Novobiocin, also known as albamycin or cathomycin, is an aminocoumarin antibiotic that is produced by the actinomycete '' Streptomyces niveus'', which has recently been identified as a subjective synonym for ''S. spheroides'' a member of the class Actinomycetia. Other aminocoumarin antibiotics include clorobiocin and coumermycin A1.Alessandra da Silva Eustáquio (2004) Biosynthesis of aminocoumarin antibiotics in Streptomyces: Generation of structural analogues by genetic engineering and insights into the regulation of antibiotic production. DISSERTATION Novobiocin was first reported in the mid-1950s (then called streptonivicin). Clinical use It is active against ''Staphylococcus epidermidis'' and may be used to differentiate it from the other coagulase-negative ''Staphylococcus saprophyticus'', which is resistant to novobiocin, in culture. Novobiocin was licensed for clinical use under the tradename Albamycin (Upjohn) in the 1960s. Its efficacy has been demonstrated in preclini ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Moline, Illinois
Moline ( ) is a city located in Rock Island County, Illinois, United States. With a population of 42,985 in 2020, it is the largest city in Rock Island County. Moline is one of the Quad Cities, along with neighboring East Moline, Illinois, East Moline and Rock Island, Illinois, Rock Island in Illinois and the cities of Davenport, Iowa, Davenport and Bettendorf, Iowa, Bettendorf in Iowa. The Quad Cities have an estimated population of 381,342. The city is the ninth-most populated city in Illinois outside the Chicago Metropolitan Area. The John Deere World Headquarters, corporate headquarters of Deere & Company is located in Moline, as was Montgomery Elevator, which was founded and headquartered in Moline until 1997, when it was acquired by Kone Elevator, which has its U.S. Division headquartered in Moline. Quad City International Airport, Black Hawk College, and the Quad Cities campus of Western Illinois University-Quad Cities are located in Moline. Moline is a retail hub for the Il ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2013 Deaths
This is a list of deaths of notable people, organised by year. New deaths articles are added to their respective month (e.g., Deaths in ) and then linked here. 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 See also * Lists of deaths by day The following pages, corresponding to the Gregorian calendar, list the historical events, births, deaths, and holidays and observances of the specified day of the year: Footnotes See also * Leap year * List of calendars * List of non-standard ... * Deaths by year {{DEFAULTSORT:deaths by year ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1930 Births
Year 193 ( CXCIII) was a common year starting on Monday (link will display the full calendar) of the Julian calendar. At the time, it was known as the Year of the Consulship of Sosius and Ericius (or, less frequently, year 946 '' Ab urbe condita''). The denomination 193 for this year has been used since the early medieval period, when the Anno Domini calendar era became the prevalent method in Europe for naming years. Events By place Roman Empire * January 1 – Year of the Five Emperors: The Roman Senate chooses Publius Helvius Pertinax, against his will, to succeed the late Commodus as Emperor. Pertinax is forced to reorganize the handling of finances, which were wrecked under Commodus, to reestablish discipline in the Roman army, and to suspend the food programs established by Trajan, provoking the ire of the Praetorian Guard. * March 28 – Pertinax is assassinated by members of the Praetorian Guard, who storm the imperial palace. The Empire is auctioned o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Journal Of The American Chemical Society
The ''Journal of the American Chemical Society'' is a weekly peer-reviewed scientific journal that was established in 1879 by the American Chemical Society. The journal has absorbed two other publications in its history, the ''Journal of Analytical and Applied Chemistry'' (July 1893) and the ''American Chemical Journal'' (January 1914). It covers all fields of chemistry. Since 2021, the editor-in-chief is Erick M. Carreira (ETH Zurich). In 2014, the journal moved to a hybrid open access publishing model. Abstracting and indexing The journal is abstracted and indexed in Chemical Abstracts Service, Scopus, EBSCO databases, ProQuest databases, Index Medicus/MEDLINE/PubMed, and the Science Citation Index Expanded. According to the ''Journal Citation Reports'', the journal has a 2021 impact factor of 16.383. Editors-in-chief The following people are or have been editor-in-chief: * 1879–1880 – Hermann Endemann * 1880–1881 – Gideon E. Moore * 1881–1882 – Hermann Endemann ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Parkinson's Disease
Parkinson's disease (PD), or simply Parkinson's, is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. The symptoms usually emerge slowly, and as the disease worsens, non-motor symptoms become more common. The most obvious early symptoms are tremor, rigidity, slowness of movement, and difficulty with walking. Cognitive and behavioral problems may also occur with depression, anxiety, and apathy occurring in many people with PD. Parkinson's disease dementia becomes common in the advanced stages of the disease. Those with Parkinson's can also have problems with their sleep and sensory systems. The motor symptoms of the disease result from the death of cells in the substantia nigra, a region of the midbrain, leading to a dopamine deficit. The cause of this cell death is poorly understood, but involves the build-up of misfolded proteins into Lewy bodies in the neurons. Collectively, the main motor symptoms are also known as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Guttenberg, Iowa
Guttenberg is a city in Clayton County, Iowa, United States, along the Mississippi River. The population was 1,817 at the time of the 2020 census, down from 1,987 at the 2000 census. History Prairie La Porte, meaning "the door to the prairie," was the first name given to Guttenberg by French explorers in 1673. The Guttenberg area was a site of Sac and Fox campgrounds until 1823. The Louisiana Purchase of 1803 transferred ownership to the United States and the Black Hawk Purchase of 1833 finally opened the area for legal settlement. Guttenberg’s past is preserved today in the many limestone buildings built by German immigrants in the mid-to-late 19th century. These structures were used for both residential and commercial purposes. Many such as the Albertus Building are pre-Civil War era and are preserved in the Front Street Historic District. Guttenberg's riverfront location was pivotal in its early commercial development. The town first served as a focal point for westw ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ninety-Nines
The Ninety-Nines: International Organization of Women Pilots, also known as The 99s, is an international organization that provides networking, mentoring, and flight scholarship opportunities to recreational and professional female pilots. Founded in 1929, the Ninety-Nines has 153 chapters and 27 regional 'sections' across the globe as of 2022, including a 'virtual' chapter, Ambassador 99s, which meets online for those who are too busy or mobile to be in one region for long. Amelia Earhart was elected as their first president in 1931, and the organization has continued to make a significant impact supporting the advancement of women in aviation since its inception. In 1982, the Ninety-Nines received the National Aviation Hall of Fame Spirit of Flight Award, and were inducted into the Oklahoma Air Space Museum Hall of Fame in 2001. In 2002, the organization was selected as the recipient of the Frank G. Brewer Trophy by the National Aeronautic Association, and in 2014 became induc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Karl August Folkers
Karl August Folkers (September 1, 1906 – December 7, 1997) was an American biochemist who made major contributions to the isolation and identification of bioactive natural products. Career Folkers graduated from the College of Liberal Arts and Sciences at the University of Illinois in 1928. In 1986, the institution awarded him its Alumni Achievement Award. His career was mainly spent at Merck. He played a prominent role in the isolation of vitamin B12 in 1947, which is one of the most structural complex of the vitamins. As a Merck Pharmaceuticals research team, Folkers, Fern P. Rathe, and Edward Anthony Kaczka were the first to isolate the antibiotic cathomycin in 1955. His team also isolated the antibiotic cycloserine. In 1958 his Merck team determined the structure of coenzyme Q10. He later served as director of the Institute of Biomedical Research at the University of Texas at Austin, where he was also Ashbel Smith Professor of Chemistry. In recognition for his scien ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Staphylococcus
''Staphylococcus'' is a genus of Gram-positive bacteria in the family Staphylococcaceae from the order Bacillales. Under the microscope, they appear spherical (cocci), and form in grape-like clusters. ''Staphylococcus'' species are facultative anaerobic organisms (capable of growth both aerobically and anaerobically). The name was coined in 1880 by Scottish surgeon and bacteriologist Alexander Ogston (1844–1929), following the pattern established five years earlier with the naming of ''Streptococcus''. It combines the prefix "staphylo-" (from grc, σταφυλή, staphylē, bunch of grapes), and suffixed by the Modern (from ). Staphylococcus was one of the leading infections in hospitals and many strains of this bacterium have become antibiotic resistant. Despite strong attempts to get rid of them, staph bacteria stay present in hospitals, where they can infect people who are most at risk of infection. Staphylococcus includes at least 43 species. Of these, nine have two su ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rahway, New Jersey
Rahway () is a city in southern Union County, in the U.S. state of New Jersey. A bedroom community of New York City, it is centrally located in the Rahway Valley region, in the New York metropolitan area. The city is southwest of Manhattan and west of Staten Island. Built on the navigable Rahway River, it was an industrial and artisanal craft city for much of its history. The city has increasingly reinvented itself in recent years as a diverse regional hub for the arts. As of the 2010 United States Census, the city's population was 27,346,DP-1 - Profile of General Population and Housing Characteristics: 2010 Demographic Profile Data for Rahway city, Union County, New Jersey [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
