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Fermentek
Fermentek Ltd. is a biotechnological company in the Atarot industrial zone of Jerusalem, Israel. It specializes in the research, development and manufacture of biologically active, natural products isolated from microorganisms as well as from other natural sources such as plants and algae. The main microorganisms used are nonpathogenic actinomycetes, Nocardia and Streptomycetes. The fungi used are: Penicillium, Aspergillus, Fusarium and the like. None of these is a human pathogen. Fermentek does not sell to individuals. Most of its products are marketed through major international distributors specializing in chemicals, under their own brand names. Nevertheless, Fermentek has specific impact on the biochemical market, especially in the field of mycotoxins. Mycotoxins are toxic compounds produced by molds in human food and farm animal feeds, thus being economically important factors. Fermentek manufactures an extensive line of pure mycotoxins used as standards in food analysis. I ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Zearalenone
Zearalenone (ZEN), also known as RAL and F-2 mycotoxin, is a potent estrogenic metabolite produced by some ''Fusarium'' and ''Gibberella'' species. Specifically, the ''Gibberella zeae ,'' the fungal species where zearalenone was initially detected, in its asexual/anamorph stage is known as ''Fusarium graminearum.'' Several ''Fusarium'' species produce toxic substances of considerable concern to livestock and poultry producers, namely deoxynivalenol, T-2 toxin, HT-2 toxin, diacetoxyscirpenol (DAS) and zearalenone. Particularly, ZEN is produced by ''Fusarium graminearum'', ''Fusarium culmorum'', '' Fusarium cerealis'', '' Fusarium equiseti'', ''Fusarium verticillioides'', and '' Fusarium incarnatum''. Zearalenone is the primary toxin that binds to estrogen receptors, causing infertility, abortion or other breeding problems, especially in swine. Often, ZEN is detected together with deoxynivalenol in contaminated samples and its toxicity needs to be considered in combination with the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gliotoxin
Gliotoxin is a sulfur-containing mycotoxin that belongs to a class of naturally occurring 2,5-diketopiperazines produced by several species of fungi, especially those of marine origin. It is the most prominent member of the epipolythiopiperazines, a large class of natural products featuring a diketopiperazine with di- or polysulfide linkage. These highly bioactive compounds have been the subject of numerous studies aimed at new therapeutics. Gliotoxin was originally isolated from '' Gliocladium fimbriatum'', and was named accordingly. It is an epipolythiodioxopiperazine metabolite. Occurrence The compound is produced by human pathogens such as ''Aspergillus fumigatus'', and also by species of ''Trichoderma'' and ''Penicillium''. Gliotoxin has also been reported from yeasts of the genus '' Candida'', but results from other studies have cast doubt on the production of this metabolite by ''Candida'' fungi. Mechanism of action Gliotoxin is suspected to be an important virulence ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Patulin
Patulin is an organic compound classified as a polyketide. It is a white powder soluble in acidic water and in organic solvents. It is a lactone that is heat-stable, so it is not destroyed by pasteurization or thermal denaturation.http://www.sigmaaldrich.com/catalog/product/sigma/p1639?lang=en®ion=US However, stability following fermentation is lessened. It is a mycotoxin produced by a variety of molds, in particular, ''Aspergillus'' and ''Penicillium'' and '' Byssochlamys''. Most commonly found in rotting apples, the amount of patulin in apple products is generally viewed as a measure of the quality of the apples used in production. In addition, patulin has been found in other foods such as grains, fruits, and vegetables. Its presence is highly regulated. Biosynthesis, synthesis, and reactivity The immediate precursor is 6-methylsalicylic acid. Isoepoxydon dehydrogenase (IDH) is an important enzyme in the multi-step biosynthesis of patulin. Its gene is present in other fu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alternariol
Alternariol is a toxic metabolite of ''Alternaria'' fungi. It is an important contaminant in cereals and fruits. Alternariol exhibits antifungal and phytotoxic activity. It is reported to inhibit cholinesterase enzymes. product page from It is also a . Alternariol is reported to be a full agonist in an '' |
Tenuazonic Acid
Tenuazonic acid is a mycotoxin produced by ''Alternaria'' species. It is a powerful eukaryotic protein synthesis inhibitor. It is a tetrameric acid that is ubiquitous in biological environments and prevents the release of newly synthesized protein from the ribosome. Its toxicity is the highest among all ''Alternaria'' mycotoxins and has both phytotoxic and cytotoxic properties. In 1991 Tenuazonic acid was reported to inhibit skin tumor promotion in mice. page from Inhibitory properties Tenuazonic acid (TeA) is a potent and an effective bio-herbicide d ...[...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Moniliformin
Moniliformin is an unusual mycotoxin, a feed contaminant that is lethal to fowl, especially ducklings. Moniliformin is formed in many cereals by a number of ''Fusarium'' species that include Fusarium moniliforme, Fusarium avenaceum, Fusarium subglutinans, Fusarium proliferatum, Fusarium fujikuroi and others. It is mainly cardiotoxic and causes ventricular hypertrophy. Moniliformin actually causes competitive inhibition of the activity of pyruvate dehydrogenase complex of respiratory reaction, which prevents pyruvic acid, product of glycolysis, to convert to acetyl CoA. Ultrastructural examination of right ventricular wall of 9 month old female mink (''Mustela vison'') fed acute doses of moniliformin (2.2 and 2.8 mg/kg diet) and sub-acute doses (1.5 to 3.2 mg/kg diet) reveals significant damage to myofiber, mitochondria, Z and M lines and sarcoplasmic reticulum as well as increased extracellular collagen deposition. Mink is considered most sensitive mammals to the toxic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aflatoxin
Aflatoxins are various poisonous carcinogens and mutagens that are produced by certain molds, particularly ''Aspergillus'' species. The fungi grow in soil, decaying vegetation and various staple foodstuffs and commodities such as hay, sweetcorn, wheat, millet, sorghum, cassava, rice, chili peppers, cottonseed, peanuts, tree nuts, sesame seeds, sunflower seeds, and various spices. In short, the relevant fungi grow on almost any crop or food. When such contaminated food is processed or consumed, the aflatoxins enter the general food supply. They have been found in both pet and human foods, as well as in feedstocks for agricultural animals. Animals fed contaminated food can pass aflatoxin transformation products into eggs, milk products, and meat. For example, contaminated poultry feed is the suspected source of aflatoxin-contaminated chicken meat and eggs in Pakistan. Children are particularly affected by aflatoxin exposure, which is associated with stunted growth, delayed de ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tacrolimus
Tacrolimus, sold under the brand name Prograf among others, is an immunosuppressive drug. After allogeneic organ transplant, the risk of organ rejection is moderate. To lower the risk of organ rejection, tacrolimus is given. The drug can also be sold as a topical medication in the treatment of T-cell-mediated diseases such as eczema and psoriasis. For example, it is prescribed for severe refractory uveitis after a bone marrow transplant, exacerbations of minimal change disease, Kimura's disease, and vitiligo. It can be used to treat dry eye syndrome in cats and dogs. Tacrolimus inhibits calcineurin, which is involved in the production of interleukin-2, a molecule that promotes the development and proliferation of T cells, as part of the body's learned (or adaptive) immune response. Chemically, it is a macrolide lactone that was first discovered in 1987, from the fermentation broth of a Japanese soil sample that contained the bacterium ''Streptomyces tsukubensis''. It is on ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nivalenol
Nivalenol (NIV) is a mycotoxin of the trichothecene group. In nature it is mainly found in fungi of the ''Fusarium'' species. The ''Fusarium'' species belongs to the most prevalent mycotoxin producing fungi in the temperate regions of the northern hemisphere, therefore making them a considerable risk for the food crop production industry. The fungi are abundant in various agricultural products (cereal crops) and their further processed products (malt, beer and bread). "The ''Fusarium'' species invade and grow on crops, and may produce nivalenol under moist and cool conditions". The symptoms observed after being affected with nivalenol are "feed refusal, vomiting, gastroenteric and dermal irritation or necrosis and immunological dysfunction", as well as haematotoxicity, resulting in a low leukocyte count. History In the period of 1946-1963 several cases of intoxication due to the ingestion of ''Fusarium'' infected grains (Scrabby grain disease) were reported in Japan, Korea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Beauvericin
Beauvericin is a depsipeptide with antibiotic and insecticidal effects belonging to the enniatin family. It was isolated from the fungus ''Beauveria bassiana'', but is also produced by several other fungi, including several ''Fusarium'' species; it may therefore occur in grain (such as corn, wheat and barley) contaminated with these fungi. Beauvericin is active against Gram-positive bacteria and mycobacteria, and is also capable of inducing programmed cell death in mammals. Chemically, beauvericin is a cyclic hexadepsipeptide with alternating N-methyl- phenylalanyl and D-hydroxy-iso-valeryl residues. Its ion-complexing capability allows beauvericin to transport alkaline earth metal and alkali metal ions across cell membranes. Beauvericin has ''in vitro'' fungicidal effects on ''Candida parapsilosis'' when used in combination with the antifungal drug ketoconazole at dosages of 0.1 μg/ml. Increased survivability rates and low cytotoxicity were also observed in mouse model A m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Citreoviridin
Citreoviridin is a mycotoxin which is produced by ''Penicillium'' and ''Aspergillus'' species. If rice, corn, cereals or meat products are contaminated with ''Penicillin citreoviridin'', citreoviridin can be produced if the food is stored in a damp place. Consuming food which is contaminated with citreoviridin can cause the disease cardiac beri beri. Furthermore it damages liver and kidneys. References Further reading * {{refend Mycotoxins, Citreoviridin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
T2 Toxin
T-2 Mycotoxin (pronounced as 'Tee-Two') is a trichothecene mycotoxin. It is a naturally occurring Mold (fungus), mold byproduct of ''Fusarium'' spp. fungus which is toxic to humans and animals. The clinical condition it causes is ''alimentary toxic aleukia'' and a host of symptoms related to organs as diverse as the skin, airway, and stomach. Ingestion may come from consumption of moldy whole grains. T-2 can be Absorption (skin), absorbed through human skin. Although no significant systemic effects are expected after dermal contact in normal agriculture, agricultural or residential environments, local skin effects can not be excluded. Hence, skin contact with T-2 should be limited. History Alimentary toxic aleukia (ATA), a disease which is caused by trichothecenes like T-2 mycotoxin, killed many thousands of USSR citizens in the Orenburg Oblast, Orenburg District in the 1940s. It was reported that the mortality rate was 10% of the entire population in that area. During the 1970s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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