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FAM63B
FAM63B is a protein which in humans is encoded by the gene FAM63B. This gene is highly expressed in humans. The FAM63B gene is also highly conserved throughout evolutionary history. The discovered function of FAM63B is an interaction with the kinesin-1 light chain and the transportation of Vaccinia, vaccinia virus from the nucleus to the cell periphery. Gene Locus FAM63B is located at 15q21.3-q22.1, spanning 90,707 base pairs on chromosome 15. Alternative Names The full name of FAM63B is family with sequence similarity 63, member B. FAM63B is also listed by its alias, KIAA1164, in some publications. mRNA Isoforms The FAM63B gene encodes a primary transcript that can be alternatively spliced into 9 protein variants. FAM63B variant a is the most common isoform found in humans. http://seqtool.sdsc.edu/CGI/BW.cgi#! Protein Structure Primary Structure FAM63B is a member of the Pfam super family, and contains a domain of unknown function (DUF544) that is homologou ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
FAM63B Tertiary Structure
FAM63B is a protein which in humans is encoded by the gene FAM63B. This gene is highly expressed in humans. The FAM63B gene is also highly conserved throughout evolutionary history. The discovered function of FAM63B is an interaction with the kinesin-1 light chain and the transportation of Vaccinia, vaccinia virus from the nucleus to the cell periphery. Gene Locus FAM63B is located at 15q21.3-q22.1, spanning 90,707 base pairs on chromosome 15. Alternative Names The full name of FAM63B is family with sequence similarity 63, member B. FAM63B is also listed by its alias, KIAA1164, in some publications. mRNA Isoforms The FAM63B gene encodes a primary transcript that can be alternatively spliced into 9 protein variants. FAM63B variant a is the most common isoform found in humans. http://seqtool.sdsc.edu/CGI/BW.cgi#! Protein Structure Primary Structure FAM63B is a member of the Pfam super family, and contains a domain of unknown function (DUF544) that is homologou ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
FAM63B Locus
FAM63B is a protein which in humans is encoded by the gene FAM63B. This gene is highly expressed in humans. The FAM63B gene is also highly conserved throughout evolutionary history. The discovered function of FAM63B is an interaction with the kinesin-1 light chain and the transportation of vaccinia virus from the nucleus to the cell periphery. Gene Locus FAM63B is located at 15q21.3-q22.1, spanning 90,707 base pairs on chromosome 15. Alternative Names The full name of FAM63B is family with sequence similarity 63, member B. FAM63B is also listed by its alias, KIAA1164, in some publications. mRNA Isoforms The FAM63B gene encodes a primary transcript that can be alternatively spliced into 9 protein variants. FAM63B variant a is the most common isoform found in humans. http://seqtool.sdsc.edu/CGI/BW.cgi#! Protein Structure Primary Structure FAM63B is a member of the Pfam super family, and contains a domain of unknown function (DUF544) that is homologous with ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
FAM63B Protein Structure
FAM63B is a protein which in humans is encoded by the gene FAM63B. This gene is highly expressed in humans. The FAM63B gene is also highly conserved throughout evolutionary history. The discovered function of FAM63B is an interaction with the kinesin-1 light chain and the transportation of vaccinia virus from the nucleus to the cell periphery. Gene Locus FAM63B is located at 15q21.3-q22.1, spanning 90,707 base pairs on chromosome 15. Alternative Names The full name of FAM63B is family with sequence similarity 63, member B. FAM63B is also listed by its alias, KIAA1164, in some publications. mRNA Isoforms The FAM63B gene encodes a primary transcript that can be alternatively spliced into 9 protein variants. FAM63B variant a is the most common isoform found in humans. http://seqtool.sdsc.edu/CGI/BW.cgi#! Protein Structure Primary Structure FAM63B is a member of the Pfam super family, and contains a domain of unknown function (DUF544) that is homologous with ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Glycation
Glycation (sometimes called non-enzymatic glycosylation) is the covalent attachment of a sugar to a protein or lipid. Typical sugars that participate in glycation are glucose, fructose, and their derivatives. Glycation is the non-enzymatic process responsible for many (e.g. micro and macrovascular) complications in diabetes mellitus and is implicated in some diseases and in aging. Glycation end products are believed to play a causative role in the vascular complications of diabetes mellitus. In contrast with glycation, glycosylation is the enzyme-mediated ATP-dependent attachment of sugars to protein or lipid. Glycosylation occurs at defined sites on the target molecule. It is a common form of post-translational modification of proteins and is required for the functioning of the mature protein. Biochemistry Glycations occur mainly in the bloodstream to a small proportion of the absorbed simple sugars: glucose, fructose, and galactose. It appears that fructose has approximately ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Unipotency
Pluripotency: These are the cells that can generate into any of the three Germ layers which imply Endodermal, Mesodermal, and Ectodermal cells except tissues like the placenta. According to Latin terms, Pluripotentia means the ability for many things. We can generate Induced Pluripotent cells by using the Induced pluripotency technique by triggering or expressing the genes or the transcription factors of the normal somatic cells. They are abbreviated as iPSC or IPS. We can forcefully express the transcription factors like Oct4, Sox2, Klf4, and c-Myc of a non-pluripotent cell and convert them into a stem cell. This procedure is first studied in a Mouse fibroblast cell in 2006 and followed the same instructions in developing a Human pluripotent cell from a Human epidermal fibroblast cell. The technique is called Regeneration. Though the iPSC has similar properties to embryonic stem cells they were never approved for clinical stage research because they are highly Tumerogenic, hav ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pluripotency
Pluripotency: These are the cells that can generate into any of the three Germ layers which imply Endodermal, Mesodermal, and Ectodermal cells except tissues like the placenta. According to Latin terms, Pluripotentia means the ability for many things. We can generate Induced Pluripotent cells by using the Induced pluripotency technique by triggering or expressing the genes or the transcription factors of the normal somatic cells. They are abbreviated as iPSC or IPS. We can forcefully express the transcription factors like Oct4, Sox2, Klf4, and c-Myc of a non-pluripotent cell and convert them into a stem cell. This procedure is first studied in a Mouse fibroblast cell in 2006 and followed the same instructions in developing a Human pluripotent cell from a Human epidermal fibroblast cell. The technique is called Regeneration. Though the iPSC has similar properties to embryonic stem cells they were never approved for clinical stage research because they are highly Tumerogenic, hav ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mesenchymal Stem Cells
Mesenchymal stem cells (MSCs) also known as mesenchymal stromal cells or medicinal signaling cells are multipotent stromal cells that can differentiate into a variety of cell types, including osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells which give rise to marrow adipose tissue). Structure Definition While the terms ''mesenchymal stem cell'' (MSC) and ''marrow stromal cell'' have been used interchangeably for many years, neither term is sufficiently descriptive: * Mesenchyme is embryonic connective tissue that is derived from the mesoderm and that differentiates into hematopoietic and connective tissue, whereas MSCs do not differentiate into hematopoietic cells. * Stromal cells are connective tissue cells that form the supportive structure in which the functional cells of the tissue reside. While this is an accurate description for one function of MSCs, the term fails to convey the relatively recently discovered ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Multipotent
Pluripotency: These are the cells that can generate into any of the three Germ layers which imply Endodermal, Mesodermal, and Ectodermal cells except tissues like the placenta. According to Latin terms, Pluripotentia means the ability for many things. We can generate Induced Pluripotent cells by using the Induced pluripotency technique by triggering or expressing the genes or the transcription factors of the normal somatic cells. They are abbreviated as iPSC or IPS. We can forcefully express the transcription factors like Oct4, Sox2, Klf4, and c-Myc of a non-pluripotent cell and convert them into a stem cell. This procedure is first studied in a Mouse fibroblast cell in 2006 and followed the same instructions in developing a Human pluripotent cell from a Human epidermal fibroblast cell. The technique is called Regeneration. Though the iPSC has similar properties to embryonic stem cells they were never approved for clinical stage research because they are highly Tumerogenic, hav ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Progenitor Cell
A progenitor cell is a Cell (biology), biological cell that can Cellular differentiation, differentiate into a specific cell type. Stem cells and progenitor cells have this ability in common. However, stem cells are less specified than progenitor cells. Progenitor cells can only differentiate into their "target" cell type. The most important difference between stem cells and progenitor cells is that stem cells can replicate indefinitely, whereas progenitor cells can divide only a limited number of times. Controversy about the exact definition remains and the concept is still evolving. The terms "progenitor cell" and "stem cell" are sometimes equated. Properties Most progenitors are identified as Oligopotency, oligopotent. In this point of view, they can compare to adult stem cells, but progenitors are said to be in a further stage of cell differentiation. They are in the "center" between stem cells and fully differentiated cells. The kind of potency they have depends on the type ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Embryoid Body
Embryoid bodies (EBs) are three-dimensional aggregates of pluripotent stem cells. EBs are differentiation of human embryonic stem cells into embryoid bodies comprising the three embryonic germ layers. Background The pluripotent cell types that comprise embryoid bodies include embryonic stem cells (ESCs) derived from the blastocyst stage of embryos from mouse (mESC), primate, and human (hESC) sources. Additionally, EBs can be formed from embryonic stem cells derived through alternative techniques, including somatic cell nuclear transfer or the reprogramming of somatic cells to yield induced pluripotent stem cells (iPS). Similar to ESCs cell culture, cultured in monolayer formats, ESCs within embryoid bodies undergo differentiation and cell specification along the three germ layer, germ lineages – endoderm, ectoderm, and mesoderm – which comprise all somatic (biology), somatic cell types. In contrast to monolayer cultures, however, the spheroid structures that are ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ubiquitously
Omnipresence or ubiquity is the property of being present anywhere and everywhere. The term omnipresence is most often used in a religious context as an attribute of a deity or supreme being, while the term ubiquity is generally used to describe something "existing or being everywhere at the same time, constantly encountered, widespread, common". Ubiquitous can also be used as a synonym for words like worldwide, universal, global, pervasive, all over the place. The omnipresence of a supreme being is conceived differently by different religious systems. In monotheistic beliefs like Christianity and Judaism, the divine and the universe are separate, but the divine is present everywhere. In pantheistic beliefs, the divine and the universe are identical. In panentheistic beliefs, the divine interpenetrates the universe, but extends beyond it in time and space. Introduction Hinduism, and other religions that derive from it, incorporate the theory of ''transcendent and immanent omnip ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nuclear Localization Signal
A nuclear localization signal ''or'' sequence (NLS) is an amino acid sequence that 'tags' a protein for import into the cell nucleus by nuclear transport. Typically, this signal consists of one or more short sequences of positively charged lysines or arginines exposed on the protein surface. Different nuclear localized proteins may share the same NLS. An NLS has the opposite function of a nuclear export signal (NES), which targets proteins out of the nucleus. Types Classical These types of NLSs can be further classified as either monopartite or bipartite. The major structural differences between the two are that the two basic amino acid clusters in bipartite NLSs are separated by a relatively short spacer sequence (hence bipartite - 2 parts), while monopartite NLSs are not. The first NLS to be discovered was the sequence PKKKRKV in the SV40 Large T-antigen (a monopartite NLS). The NLS of nucleoplasmin, KR AATKKAGQAKKK, is the prototype of the ubiquitous bipartite signal: two cluster ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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