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E–Z Notation
''E''–''Z'' configuration, or the ''E''–''Z'' convention, is the IUPAC preferred method of describing the absolute stereochemistry of double bonds in organic chemistry. It is an extension of ''cis''–''trans'' isomer notation (which only describes ''relative stereochemistry'') that can be used to describe double bonds having two, three or four substituents. Following the Cahn–Ingold–Prelog priority rules (CIP rules), each substituent on a double bond is assigned a priority, then positions of the higher of the two substituents on each carbon are compared to each other. If the two groups of higher priority are on opposite sides of the double bond (''trans'' to each other), the bond is assigned the configuration ''E'' (from ''entgegen'', , the German word for "opposite"). If the two groups of higher priority are on the same side of the double bond (''cis'' to each other), the bond is assigned the configuration ''Z'' (from ''zusammen'', , the German word for "together" ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
IUPAC
The International Union of Pure and Applied Chemistry (IUPAC ) is an international federation of National Adhering Organizations working for the advancement of the chemical sciences, especially by developing nomenclature and terminology. It is a member of the International Science Council (ISC). IUPAC is registered in Zürich, Switzerland, and the administrative office, known as the "IUPAC Secretariat", is in Research Triangle Park, North Carolina, United States. This administrative office is headed by IUPAC's executive director, currently Lynn Soby. IUPAC was established in 1919 as the successor of the International Congress of Applied Chemistry for the advancement of chemistry. Its members, the National Adhering Organizations, can be national chemistry societies, national academies of sciences, or other bodies representing chemists. There are fifty-four National Adhering Organizations and three Associate National Adhering Organizations. IUPAC's Inter-divisional Committee on ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hyphen
The hyphen is a punctuation mark used to join words and to separate syllables of a single word. The use of hyphens is called hyphenation. ''Son-in-law'' is an example of a hyphenated word. The hyphen is sometimes confused with dashes (figure dash , en dash , em dash , Horizontal bar (punctuation), horizontal bar ), which are longer and have different uses, or with the minus sign , which is also longer and more vertically centred in some typefaces. Although hyphens are not to be confused with en dashes, there are some overlaps in #Use in English, usage (in which either a hyphen or an en dash may be acceptable, depending on user preference, as #En dash, hyphen, or either one, discussed below). In addition, the hyphen often substitutes for the en dash elsewhere in informal writing. As an Orthography, orthographic concept, the hyphen is a single entity. In terms of character encoding and display, it is represented by any of several character (computing), characters and glyphs, inc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Geometry
Molecular geometry is the three-dimensional arrangement of the atoms that constitute a molecule. It includes the general shape of the molecule as well as bond lengths, bond angles, torsional angles and any other geometrical parameters that determine the position of each atom. Molecular geometry influences several properties of a substance including its reactivity, polarity, phase of matter, color, magnetism and biological activity. The angles between bonds that an atom forms depend only weakly on the rest of molecule, i.e. they can be understood as approximately local and hence transferable properties. Determination The molecular geometry can be determined by various spectroscopic methods and diffraction methods. IR, microwave and Raman spectroscopy can give information about the molecule geometry from the details of the vibrational and rotational absorbance detected by these techniques. X-ray crystallography, neutron diffraction and electron diffraction can give molecular ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Geometric Isomerism
Geometry (; ) is, with arithmetic, one of the oldest branches of mathematics. It is concerned with properties of space such as the distance, shape, size, and relative position of figures. A mathematician who works in the field of geometry is called a ''geometer''. Until the 19th century, geometry was almost exclusively devoted to Euclidean geometry, which includes the notions of point, line, plane, distance, angle, surface, and curve, as fundamental concepts. During the 19th century several discoveries enlarged dramatically the scope of geometry. One of the oldest such discoveries is Carl Friedrich Gauss' ("remarkable theorem") that asserts roughly that the Gaussian curvature of a surface is independent from any specific embedding in a Euclidean space. This implies that surfaces can be studied ''intrinsically'', that is, as stand-alone spaces, and has been expanded into the theory of manifolds and Riemannian geometry. Later in the 19th century, it appeared that geometries wi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Descriptor (chemistry)
A descriptor is in chemical nomenclature a prefix placed before the systematic substance name, which describes the configuration or the stereochemistry of the molecule. Some listed descriptors are only of historical interest and should not be used in publications anymore as they do not correspond with the modern recommendations of the IUPAC. Stereodescriptors are often used in combination with locants to clearly identify a chemical structure unambiguously. The descriptors, usually placed at the beginning of the systematic name, are not taken into account in the alphabetical sorting. Configuration descriptors ''cis'', ''trans'' See: cis–trans isomerism The descriptors ''cis'' (lat. ''on this side of'') and ''trans'' (lat. ''over, beyond'') are used in various contexts for the description of chemical configurations: In organic structural chemistry, the configuration of a double bond can be described with ''cis'' and ''trans'', in case it has a simple substitution pattern w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alitretinoin
Alitretinoin, or 9-cis-retinoic acid, is a form of vitamin A. It is also used in medicine as an antineoplastic (anti-cancer) agent developed by Ligand Pharmaceuticals. It is a first generation retinoid. Ligand gained Food and Drug Administration (FDA) approval for alitretinoin in February 1999. Medical uses Kaposi’s sarcoma In the United States, topical alitretinoin is indicated for the treatment of skin lesions in AIDS-related Kaposi's sarcoma. Alitretinoin is not indicated when systemic therapy against Kaposi's sarcoma is required. It has received EMA (11 October 2000) and FDA (2 March 1999) approval for this indication. Chronic hand eczema Alitretinoin has been granted prescription rights in the UK (08/09/2008) for in chronic hand eczema as used by mouth. In May 2009 the National Institute for Health and Clinical Excellence (NICE) issued preliminary guidance on the use of alitretinoin for the treatment of severe chronic hand eczema in adults. The recommendation stated tha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alitretinoin2DACS
Alitretinoin, or 9-cis-retinoic acid, is a form of vitamin A. It is also used in medicine as an antineoplastic (anti-cancer) agent developed by Ligand Pharmaceuticals. It is a first generation retinoid. Ligand gained Food and Drug Administration (FDA) approval for alitretinoin in February 1999. Medical uses Kaposi’s sarcoma In the United States, topical alitretinoin is indicated for the treatment of skin lesions in AIDS-related Kaposi's sarcoma. Alitretinoin is not indicated when systemic therapy against Kaposi's sarcoma is required. It has received EMA (11 October 2000) and FDA (2 March 1999) approval for this indication. Chronic hand eczema Alitretinoin has been granted prescription rights in the UK (08/09/2008) for in chronic hand eczema as used by mouth. In May 2009 the National Institute for Health and Clinical Excellence (NICE) issued preliminary guidance on the use of alitretinoin for the treatment of severe chronic hand eczema in adults. The recommendation stated tha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Small Capitals
In typography, small caps (short for "small capitals") are grapheme, characters typeset with glyphs that resemble letter case, uppercase letters (capitals) but reduced in height and weight close to the surrounding letter case, lowercase letters or text figures. This is technically not a case-transformation, but a substitution of glyphs, although the effect is often approximated by case-transformation and scaling. Small caps are used in running text as a form of emphasis that is less dominant than all uppercase text, and as a method of emphasis or distinctiveness for text alongside or instead of italics, or when boldface is inappropriate. For example, the text "Text in small caps" appears as in small caps. Small caps can be used to draw attention to the opening phrase or line of a new section of text, or to provide an additional style in a dictionary entry where many parts must be typographically differentiated. Well-designed small capitals are not simply scaled-down versions of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lowercase
Letter case is the distinction between the Letter (alphabet), letters that are in larger uppercase or capitals (or more formally ''majuscule'') and smaller lowercase (or more formally ''minuscule'') in the written representation of certain languages. The writing systems that distinguish between the upper and lowercase have two parallel sets of letters, with each letter in one set usually having an equivalent in the other set. The two case variants are alternative representations of the same letter: they have the same name and pronunciation and are treated identically when sorting in alphabetical order. Letter case is generally applied in a mixed-case fashion, with both upper and lowercase letters appearing in a given piece of text for legibility. The choice of case is often prescribed by the grammar of a language or by the conventions of a particular discipline. In orthography, the uppercase is primarily reserved for special purposes, such as the first letter of a Sentence (ling ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Parentheses
A bracket is either of two tall fore- or back-facing punctuation marks commonly used to isolate a segment of text or data from its surroundings. Typically deployed in symmetric pairs, an individual bracket may be identified as a 'left' or 'right' bracket or, alternatively, an "opening bracket" or "closing bracket", respectively, depending on the directionality of the context. Specific forms of the mark include parentheses (also called "rounded brackets"), square brackets, curly brackets (also called 'braces'), and angle brackets (also called 'chevrons'), as well as various less common pairs of symbols. As well as signifying the overall class of punctuation, the word "bracket" is commonly used to refer to a specific form of bracket, which varies from region to region. In most English-speaking countries, an unqualified word "bracket" refers to the parenthesis (round bracket); in the United States, the square bracket. Various forms of brackets are used in mathematics, with s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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