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EuPathDB
The Eukaryotic Pathgen Database, or EuPathDB, is a database of bioinformatic and experimental data related to a variety of eukaryotic pathogens. It was established in 2006 under a National Institutes of Health program to create Bioinformatics Resource Centers to facilitate research on pathogens that may pose biodefense threats. EuPathDB stores data related to its organisms of interest and provides tools for searching through and analyzing the data. It currently consists of 14 component databases, each dedicated to a certain research topic. EuPathDB includes: * Genomics resources covering eukaryotic protozoan parasites * Host responses to parasite infection (HostDB) * Orthologs (OrthoMCL) * Clinical study data (ClinEpiDB) * Microbiome data (MicrobiomeDB) History EuPathDB was established under the NIH Bioinformatics Resource Centers program as ApiDB, a resource meant to cover Apicomplexan parasites. ApiDB originally consisted of component sites CryptoDB (for ''Cryptosporidium''), Pla ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
EuPathDB Logo
The Eukaryotic Pathgen Database, or EuPathDB, is a database of bioinformatic and experimental data related to a variety of eukaryotic pathogens. It was established in 2006 under a National Institutes of Health program to create Bioinformatics Resource Centers to facilitate research on pathogens that may pose biodefense threats. EuPathDB stores data related to its organisms of interest and provides tools for searching through and analyzing the data. It currently consists of 14 component databases, each dedicated to a certain research topic. EuPathDB includes: * Genomics resources covering eukaryotic protozoan parasites * Host responses to parasite infection (HostDB) * Orthologs (OrthoMCL) * Clinical study data (ClinEpiDB) * Microbiome data (MicrobiomeDB) History EuPathDB was established under the NIH Bioinformatics Resource Centers program as ApiDB, a resource meant to cover Apicomplexan parasites. ApiDB originally consisted of component sites CryptoDB (for ''Cryptosporidium''), Pla ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jessica Kissinger
Jessica Kissinger is a Distinguished Research Professor at the Franklin College of Arts and Sciences, University of Georgia and director of the Institute of Bioinformatics. Her research focus is on the evolution, assembly and data curation of protozoan parasite genomes, particularly Cryptosporidium, ''Toxoplasma gondii'' and Plasmodium. Biography Kissinger obtained her PhD at Indiana University in 1995. During her PostDoc she worked with David Roos to help establish the Eukaryotic Pathogen Database (EuPathDB) series of genome collections, including the malaria specific PlasmoDB, for easy querying and access by scientists. Since its launch in 1999 the database has accrued 9TB of data, has been received renewed grant contributions by the NIH at every funding cycle, and now receives 6 million searches a year from 13,000 individuals. Most recently Kissinger and Roos were awarded a grant that is expected to total US$23.4million for maintaining the resource. The success of EuPathDB ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bioinformatics Resource Centers
The Bioinformatics Resource Centers (BRCs) are a group of five Internet-based research centers established in 2004 and funded by NIAID (the National Institute of Allergy and Infectious Diseases.)Overview, Bioinformatics Resource Centers , National Institute of Allergy and Infectious Diseases (NIAID), January 10, 2008. The BRCs were formed in response to the threats posed by emerging and re-emerging s, particularly (CDC) C ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Apicomplexa
The Apicomplexa (also called Apicomplexia) are a large phylum of parasitic alveolates. Most of them possess a unique form of organelle that comprises a type of non-photosynthetic plastid called an apicoplast, and an apical complex structure. The organelle is an adaptation that the apicomplexan applies in penetration of a host cell. The Apicomplexa are unicellular and spore-forming. All species are obligate endoparasites of animals, except '' Nephromyces'', a symbiont in marine animals, originally classified as a chytrid fungus. Motile structures such as flagella or pseudopods are present only in certain gamete stages. The Apicomplexa are a diverse group that includes organisms such as the coccidia, gregarines, piroplasms, haemogregarines, and plasmodia. Diseases caused by Apicomplexa include: * Babesiosis (''Babesia'') * Malaria (''Plasmodium'') * Cryptosporidiosis (''Cryptosporidium parvum'') * Cyclosporiasis (''Cyclospora cayetanensis'') * Cystoisosporiasis (''Cystoisosp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Apicomplexans
The Apicomplexa (also called Apicomplexia) are a large phylum of parasitic alveolates. Most of them possess a unique form of organelle that comprises a type of non-photosynthetic plastid called an apicoplast, and an apical complex structure. The organelle is an adaptation that the apicomplexan applies in penetration of a host cell. The Apicomplexa are unicellular and spore-forming. All species are obligate endoparasites of animals, except '' Nephromyces'', a symbiont in marine animals, originally classified as a chytrid fungus. Motile structures such as flagella or pseudopods are present only in certain gamete stages. The Apicomplexa are a diverse group that includes organisms such as the coccidia, gregarines, piroplasms, haemogregarines, and plasmodia. Diseases caused by Apicomplexa include: * Babesiosis (''Babesia'') * Malaria (''Plasmodium'') * Cryptosporidiosis (''Cryptosporidium parvum'') * Cyclosporiasis (''Cyclospora cayetanensis'') * Cystoisosporiasis (''Cystoi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PlasmoDB
PlasmoDB is a ''biological database'' for the genus ''Plasmodium''. The database is a member of the ''EuPathDB'' project. The database contains extensive ''genome'', ''proteome'' and ''metabolome'' information relating to malaria parasites. See also * ''Plasmodium'' * ''Malaria Malaria is a mosquito-borne infectious disease that affects humans and other animals. Malaria causes symptoms that typically include fever, tiredness, vomiting, and headaches. In severe cases, it can cause jaundice, seizures, coma, or death. S ...'' References External links * Genome databases *PlasmoDB {{Biodatabase-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Toxoplasma Gondii
''Toxoplasma gondii'' () is an obligate intracellular parasitic protozoan (specifically an apicomplexan) that causes toxoplasmosis. Found worldwide, ''T. gondii'' is capable of infecting virtually all warm-blooded animals, but felids, such as domestic cats, are the only known definitive hosts in which the parasite may undergo sexual reproduction. ''T. gondii'' has been shown to alter the behavior of infected rodents in ways that increase the rodents' chances of being preyed upon by felids. Support for this "manipulation hypothesis" stems from studies showing that ''T. gondii''-infected rats have a decreased aversion to cat urine. Because cats are the only hosts within which ''T. gondii'' can sexually reproduce to complete and begin its lifecycle, such behavioral manipulations are thought to be evolutionary adaptations that increase the parasite's reproductive success. Rats that do not avoid cat habitations will more likely become cat prey. ''Toxoplasma gondii'' infection i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Theileria
''Theileria'' is a genus of parasites that belongs to the phylum Apicomplexa, and is closely related to ''Plasmodium''. Two ''Theileria'' species, ''T. annulata'' and ''T. parva'', are important cattle parasites. ''T. annulata'' causes tropical theileriosis and ''T. parva'' causes East Coast fever. ''Theileria'' species are transmitted by ticks. The genomes of ''T. orientalis'' Shintoku'', Theileria equi'' WA, ''Theileria annulata'' Ankara and ''Theileria parva'' Muguga have been sequenced and published. ''Theileria equi'' is a known cause of equine piroplasmosis. Vaccines against ''Theileria'' are in development. In May 2010, a vaccine that was reported to protect cattle against East Coast fever had been approved and registered by the governments of Kenya, Malawi, and Tanzania. Description Species in this genus undergo exoerythrocytic merogony in the lymphocytes, histiocytes, erythroblasts, and other cells of the internal organs. This is followed by invasion of the erythroc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
