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Ephylone
''N''-Ethylpentylone (β-keto-ethylbenzodioxolylpentanamine, βk-ethyl-K, βk-EBDP, ephylone) is a substituted cathinone and stimulant drug which was developed in the 1960s. It has been reported as a novel designer drug in several countries including the United Kingdom, South Africa, New Zealand, the United States, and Australia.Pill testing at festivals has hidden benefits that could reduce drug taking
Claudia Long, , 2018-07-20
In 2018, ''N''-ethylpentylone was the most common drug of the cathinone class to be identified in

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N-Ethylhexedrone
''N''-Ethylhexedrone (also known as α-ethylaminocaprophenone, ''N''-ethylnorhexedrone, hexen, and NEH) is a stimulant of the cathinone class that acts as a norepinephrine–dopamine reuptake inhibitor (NDRI) with IC50 values of 0.0978 and 0.0467 μM, respectively. ''N''-Ethylhexedrone was first mentioned in a series of patents by Boehringer Ingelheim in the 1960s which led to the development of the better-known drug methylenedioxypyrovalerone (MDPV). Since the mid-2010s, ''N''-ethylhexedrone has been sold online as a designer drug. In 2018, ''N''-ethylhexedrone was the second most common drug of the cathinone class to be identified in Drug Enforcement Administration seizures. ''N''-Ethylhexedrone was first synthesized by Boehringer Ingelheim in 1964. It appears to have emerged on the online research chemical market in late 2015. It is an example of a novel psychoactive substance specifically chosen to mimic the features of prohibited substances and bypass drug laws. It is one ...
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N-Ethylheptylone
''N''-Ethylheptylone (HEP) is a recreational designer drug from the substituted cathinone family, with stimulant effects. It is a homologue of related drugs such as ethylone, eutylone, ephylone and ''N''-ethylhexylone but with a longer heptyl side chain. It was first reported in Sweden in 2019. See also * α-PEP * 3F-NEH * 4F-PV9 * MDPHP * N-Ethylheptedrone ''N''-Ethylheptedrone is a recreational designer drug from the substituted cathinone family, with stimulant effects. It is a homologue of related drugs such as ethcathinone, ''N''-ethylbuphedrone and ''N''-ethylhexedrone but with a longer p ... References Designer drugs Cathinones {{nervous-system-drug-stub ...
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Eutylone
Eutylone (also known as β-keto-1,3-benzodioxolyl-''N''-ethylbutanamine, bk-EBDB, and ''N''-ethylbutylone) is a stimulant and empathogenic compound developed in the 1960s, which is classified as a designer drug. It was first reported to the EMCDDA in 2014 and became widespread internationally in 2019-2020 following bans on the related compound ephylone. It is not a natural, but a synthetic cathinone. In 2021, eutylone was the most common cathinone identified by the Drug Enforcement Administration in the United States. Legal status Sweden's public health agency suggested classifying eutylone as a hazardous substance, on September 25, 2019. In the United States Eutylone is considered a schedule 1 controlled substance as a positional isomer of Pentylonehttps://www.deadiversion.usdoj.gov/schedules/orangebook/orangebook.pdf See also * 5-Methylethylone * Butylone * Ethyl-J * Ethylone * Ephylone ''N''-Ethylpentylone (β-keto-ethylbenzodioxolylpentanamine, βk-ethyl-K, βk-E ...
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Substituted Cathinone
Substituted cathinones, which include some stimulants and entactogens, are derivatives of cathinone. They feature a phenethylamine core with an alkyl group attached to the alpha carbon, and a ketone group attached to the beta carbon, along with additional substitutions. Cathinone occurs naturally in the plant khat whose leaves are chewed as a recreational drug. List of substituted cathinones The derivatives may be produced by substitutions at four locations of the cathinone molecule: * R1 = hydrogen, or any combination of one or more alkyl, alkoxy, alkylenedioxy, haloalkyl or halide substituents * R2 = hydrogen or any alkyl group * R3 = hydrogen, any alkyl group, or incorporation in a cyclic structure * R4 = hydrogen, any alkyl group, or incorporation in a cyclic structure The following table displays notable derivatives that have been reported: Legality On 2 April 2010, the Advisory Council on the Misuse of Drugs in the UK announced that a broad structure-based ba ...
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Controlled Substances Act
The Controlled Substances Act (CSA) is the statute establishing federal government of the United States, federal drug policy of the United States, U.S. drug policy under which the manufacture, importation, possession, use, and distribution of certain substances is regulated. It was passed by the 91st United States Congress as Title II of the Comprehensive Drug Abuse Prevention and Control Act of 1970 and signed into law by President Richard Nixon. The Act also served as the national implementing legislation for the Single Convention on Narcotic Drugs. The legislation created five schedules (classifications), with varying qualifications for a substance to be included in each. Two federal agencies, the Drug Enforcement Administration (DEA) and the Food and Drug Administration (FDA), determine which substances are added to or removed from the various schedules, although the statute passed by Congress created the initial listing. Congress has sometimes scheduled other substances th ...
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Cathinones
Substituted cathinones, which include some stimulants and entactogens, are derivatives of cathinone. They feature a phenethylamine core with an alkyl group attached to the alpha carbon, and a ketone group attached to the beta carbon, along with additional substitutions. Cathinone occurs naturally in the plant khat whose leaves are chewed as a recreational drug. List of substituted cathinones The derivatives may be produced by substitutions at four locations of the cathinone molecule: * R1 = hydrogen, or any combination of one or more alkyl, alkoxy, alkylenedioxy, haloalkyl or halide substituents * R2 = hydrogen or any alkyl group * R3 = hydrogen, any alkyl group, or incorporation in a cyclic structure * R4 = hydrogen, any alkyl group, or incorporation in a cyclic structure The following table displays notable derivatives that have been reported: Legality On 2 April 2010, the Advisory Council on the Misuse of Drugs in the UK announced that a broad structure-based b ...
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Isohexylone
Isohexylone is a recreational designer drug from the substituted cathinone family, with stimulant effects. It was first identified in the United Kingdom in June 2019. See also * Methylone * 5-Methylethylone * Butylone * Desmethylsibutramine * Eutylone * Pentylone * Ephylone * N-Ethylhexylone * α-PHiP * 3F-PiHP * UWA-101 UWA-101 (also known as α-cyclopropyl-MDMA) is a phenethylamine derivative invented by Dr Matthew Piggott at the University of Western Australia, and researched as a potential treatment for Parkinson's disease. Its chemical structure is very sim ... References Cathinones Designer drugs Serotonin-norepinephrine-dopamine releasing agents {{nervous-system-drug-stub ...
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Pentylone
Pentylone (β-Keto-Methylbenzodioxolylpentanamine, βk-Methyl-K, βk-MBDP, methylenedioxypentedrone, or 1‐(3,4‐methylenedioxyphenyl)‐2‐(methylamino)pentan‐1‐one) is a stimulant developed in the 1960s. It is a substituted cathinone (a type of substituted phenethylamine). It has been identified in some samples of powders sold as "NRG-1", along with varying blends of other cathinone derivatives including flephedrone, MDPBP, MDPV and 4-MePPP. It was also found in combination with 4-MePPP being sold as "NRG-3". Reports indicate side effects include feelings of paranoia, agitation and inability to sleep, with effects lasting for several days at high doses. Pharmacology Pentylone acts as a serotonin-norepinephrine-dopamine reuptake inhibitor and a serotonin releasing agent. Legality Pentylone is banned in Canada, Germany, Sweden, the United States and in the UK. See also * α-PVP * Dipentylone * Methylenedioxypyrovalerone (MDPV) * Methyl-K * N-Ethylpentylone * Pe ...
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N-Ethylhexylone
''N''-Ethylhexylone is a recreational designer drug from the substituted cathinone family, with stimulant effects. It was first identified in Poland in August 2019. It is illegal in Taiwan since July 2020, where it had been sold mixed with plant material under the name 彩虹菸 ("Rainbow Tobacco" or "Rainbow Smoke"). See also * 3F-NEH * 4F-PHP * 5-Methylethylone * Ethylone * Eutylone * Ephylone * Isohexylone * MDPV * MDPHP * N-Ethylhexedrone * N-Ethylheptylone ''N''-Ethylheptylone (HEP) is a recreational designer drug from the substituted cathinone family, with stimulant effects. It is a homologue of related drugs such as ethylone, eutylone, ephylone and ''N''-ethylhexylone but with a longer hepty ... References Cathinones Designer drugs Norepinephrine–dopamine reuptake inhibitors {{nervous-system-drug-stub ...
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Methylenedioxypyrovalerone
Methylenedioxypyrovalerone (MDPV) is a stimulant of the cathinone class that acts as a norepinephrine–dopamine reuptake inhibitor (NDRI). It was first developed in the 1960s by a team at Boehringer Ingelheim. Its activity at the dopamine transporter is six times stronger than at the norepinephrine transporter and it is virtually inactive at the serotonin transporter. MDPV remained an obscure stimulant until around 2004 when it was reportedly sold as a designer drug. In the USA, products containing MDPV and labeled as bath salts were sold as recreational drugs in gas stations, similar to the marketing for Spice and K2 as incense, until it was banned in 2011. Appearance The hydrochloride salt exists as a very fine crystalline powder; it is hygroscopic and thus tends to form clumps, resembling something like powdered sugar. Its color can range from pure white to a yellowish-tan and has a slight odor that strengthens as it colors. Impurities are likely to consist of either pyr ...
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Ethyl-K
''N''-Ethyl-1,3-benzodioxolylpentanamine (EBDP; Ethyl-K; 3,4-methylenedioxy-''N''-ethyl-α-propylphenethylamine) is a psychoactive drug and member of the phenethylamine chemical class which acts as an entactogen, psychedelic, and stimulant. It is the ''N''- ethyl analog of 1,3-benzodioxolylpentanamine (BDP; K). Ethyl-K was first synthesized by Alexander Shulgin. In his book '' PiHKAL'' ("Phenethylamines i Have Known And Loved"), the minimum dosage is listed as 40 mg and the duration is unknown. Very little is known about the pharmacology, pharmacokinetics, effects, and toxicity of Ethyl-K. Legality United Kingdom This substance is a Class A drug in the Drugs controlled by the UK Misuse of Drugs Act. See also * Methylbenzodioxolylpentanamine (MBDP; Methyl-K) * Ethylbenzodioxolylbutanamine (EBDB; Ethyl-J) * Ephylone ''N''-Ethylpentylone (β-keto-ethylbenzodioxolylpentanamine, βk-ethyl-K, βk-EBDP, ephylone) is a substituted cathinone and stimulant drug ...
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