|
Eosinophilic Granuloma
Humans Human eosinophilic granuloma is characterized by abnormal proliferation of Langerhans cells (LCs). LCs are antigen-presenting cells derived from dendritic cells. In humans, eosinophilic granulomas are considered as a benign tumors that occurs mainly in children and adolescents. EG is a quite rare condition, and its incidence is higher in white than in black population, also slightly more affecting males than females. EG develops in 4-5 children (aged under 15) per million/year and in 1 or 2 adults per million/year. The etiology of EG is not fully understood yet. However, the onset of abnormal LC proliferation may be triggered by viral stimuli ( EBV, Human Herpes virus 6), bacterial toxins or defective regulation of IL-1 and IL-10 production. Another possible explanation may be a defect in Ras/MAPK signaling pathway due to mutation of signaling proteins. Particularly, it was published that about 50% of the EG cases had mutated BRAF V600 E gene and about 21% displayed a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Facial Eosinophilic Granuloma
A facial is a family of skin care treatments for the face, including steam, exfoliation (cosmetology), exfoliation (physical and chemical), Comedo extraction, extraction, creams, lotions, facial masks, chemical peel, peels, and massage. They are normally performed in beauty salons, but are also a common spa treatment. They are used for general skin health as well as for specific skin conditions. Types of facials include European facial, LED Deep penetrating light therapy, light therapy facials, hydrafacials and mini-facials. Facial mask There are different kinds of masks (e.g., clay, cactus, cucumber) for different purposes: deep-cleansing, by penetrating the Sweat pore, pores; healing acne scars or hyper-pigmentation; brightening, for a gradual illumination of the skin tone. Facial masks also help with anti-aging, acne, Wrinkle, crows feet, under eye bags, sagging lids, dark circles, puffiness, and more. Some masks are designed to dry or solidify on the face, almost like pla ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Corticosteroid
Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones. Two main classes of corticosteroids, glucocorticoids and mineralocorticoids, are involved in a wide range of physiological processes, including stress response, immune response, and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. Some common naturally occurring steroid hormones are cortisol (), corticosterone (), cortisone () and aldosterone (). (Note that cortisone and aldosterone are isomers.) The main corticosteroids produced by the adrenal cortex are cortisol and aldosterone. Classes * Glucocorticoids such as cortisol affect carbohydrate, fat, and protein metabolism, and have anti-inflammatory, immunosuppressive, anti-proliferative, and vasoconstrictive effects. Anti-inflammatory effects are mediated by blocking the action of inflammatory medi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mast Cell
A mast cell (also known as a mastocyte or a labrocyte) is a resident cell of connective tissue that contains many granules rich in histamine and heparin. Specifically, it is a type of granulocyte derived from the myeloid stem cell that is a part of the immune and neuroimmune systems. Mast cells were discovered by Paul Ehrlich in 1877. Although best known for their role in allergy and anaphylaxis, mast cells play an important protective role as well, being intimately involved in wound healing, angiogenesis, immune tolerance, defense against pathogens, and vascular permeability in brain tumours. The mast cell is very similar in both appearance and function to the basophil, another type of white blood cell. Although mast cells were once thought to be tissue-resident basophils, it has been shown that the two cells develop from different hematopoietic lineages and thus cannot be the same cells. Structure Mast cells are very similar to basophil granulocytes (a class of white ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lymphocyte
A lymphocyte is a type of white blood cell (leukocyte) in the immune system of most vertebrates. Lymphocytes include natural killer cells (which function in cell-mediated, cytotoxic innate immunity), T cells (for cell-mediated, cytotoxic adaptive immunity), and B cells (for humoral, antibody-driven adaptive immunity). They are the main type of cell found in lymph, which prompted the name "lymphocyte". Lymphocytes make up between 18% and 42% of circulating white blood cells. Types The three major types of lymphocyte are T cells, B cells and natural killer (NK) cells. Lymphocytes can be identified by their large nucleus. T cells and B cells T cells (thymus cells) and B cells ( bone marrow- or bursa-derived cells) are the major cellular components of the adaptive immune response. T cells are involved in cell-mediated immunity, whereas B cells are primarily responsible for humoral immunity (relating to antibodies). The function of T cells and B cells is to recognize sp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Plasma Cell
Plasma cells, also called plasma B cells or effector B cells, are white blood cells that originate in the lymphoid organs as B lymphocytes and secrete large quantities of proteins called antibodies in response to being presented specific substances called antigens. These antibodies are transported from the plasma cells by the blood plasma and the lymphatic system to the site of the target antigen (foreign substance), where they initiate its neutralization or destruction. B cells differentiate into plasma cells that produce antibody molecules closely modeled after the receptors of the precursor B cell. Structure Plasma cells are large lymphocytes with abundant cytoplasm and a characteristic appearance on light microscopy. They have basophilic cytoplasm and an eccentric nucleus with heterochromatin in a characteristic cartwheel or clock face arrangement. Their cytoplasm also contains a pale zone that on electron microscopy contains an extensive Golgi apparatus and centrioles ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neutrophil
Neutrophils (also known as neutrocytes or heterophils) are the most abundant type of granulocytes and make up 40% to 70% of all white blood cells in humans. They form an essential part of the innate immune system, with their functions varying in different animals. They are formed from stem cells in the bone marrow and Cellular differentiation, differentiated into #Subpopulations, subpopulations of neutrophil-killers and neutrophil-cagers. They are short-lived and highly mobile, as they can enter parts of tissue where other cells/molecules cannot. Neutrophils may be subdivided into segmented neutrophils and banded neutrophils (or Band cell, bands). They form part of the polymorphonuclear cells family (PMNs) together with basophils and eosinophils. The name ''neutrophil'' derives from staining characteristics on hematoxylin and eosin (H&E stain, H&E) histology, histological or cell biology, cytological preparations. Whereas basophilic white blood cells stain dark blue and eosinoph ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Macrophage
Macrophages (abbreviated as M φ, MΦ or MP) ( el, large eaters, from Greek ''μακρός'' (') = large, ''φαγεῖν'' (') = to eat) are a type of white blood cell of the immune system that engulfs and digests pathogens, such as cancer cells, microbes, cellular debris, and foreign substances, which do not have proteins that are specific to healthy body cells on their surface. The process is called phagocytosis, which acts to defend the host against infection and injury. These large phagocytes are found in essentially all tissues, where they patrol for potential pathogens by amoeboid movement. They take various forms (with various names) throughout the body (e.g., histiocytes, Kupffer cells, alveolar macrophages, microglia, and others), but all are part of the mononuclear phagocyte system. Besides phagocytosis, they play a critical role in nonspecific defense (innate immunity) and also help initiate specific defense mechanisms (adaptive immunity) by recruiting other immune ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cavalier King Charles Spaniel
The Cavalier King Charles Spaniel is a British breed of toy dog of spaniel type. Four colours are recognised: Blenheim (chestnut and white), tricolour (black/white/tan), black and tan, and ruby; the coat is smooth and silky. The lifespan is usually between eight and twelve years. The Cavalier King Charles changed dramatically in the late seventeenth century, when it was inter-bred with flat-nosed breeds. Until the 1920s, it shared the same history as the smaller King Charles Spaniel. Breeders attempted to recreate what they considered to be the original configuration – a dog resembling Charles II's spaniel of the English Civil War period, when supporters of the king were known as Cavaliers. History During the early part of the 18th century, John Churchill, 1st Duke of Marlborough, kept red and white King Charles type spaniels for hunting. The duke recorded that they were able to keep up with a trotting horse. His estate was named Blenheim in honour of his victory at t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
German Shepherd
The German Shepherd or Alsatian is a German breed of working dog of medium to large size. The breed was developed by Max von Stephanitz using various traditional German herding dogs from 1899. It was originally bred as a herding dog, for herding sheep. It has since been used in many other types of work, including disability assistance, search-and-rescue, police work, and warfare. It is commonly kept as a companion dog, and according to the Fédération Cynologique Internationale had the second-highest number of annual registrations in 2013. History During the 1890s, attempts were being made to standardise dog breeds. Dogs were being bred to preserve traits that assisted in their job of herding sheep and protecting their flocks from predators. In Germany this was practised within local communities, where shepherds selected and bred dogs. It was recognised that the breed had the necessary skills for herding sheep, such as intelligence, speed, strength and keen senses o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Feline Immunodeficiency Virus
Feline immunodeficiency virus (FIV) is a '' Lentivirus'' that affects cats worldwide, with 2.5% to 4.4% of felines being infected. FIV was first isolated in 1986, by Niels C Pedersen and Janet K. Yamamoto at the UC Davis School of Veterinary Medicine in a colony of cats that had a high prevalence of opportunistic infections and degenerative conditions and was originally called Feline T-lymphotropic virus. It has since been identified in domestic cats. It has been suggested FIV originated in Africa and has since spread to feline species worldwide. Effects FIV compromises the immune system of cats by infecting many cell types, including CD4+ and CD8+ T lymphocytes, B lymphocytes, and macrophages. FIV can be tolerated well by cats, but can eventually lead to debilitation of the immune system in its feline hosts by the infection and exhaustion of T-helper (CD4+) cells. FIV and HIV are both lentiviruses. However, humans cannot be infected by FIV, nor can cats be infected ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
