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E. Yvonne Jones
Edith Yvonne Jones FLSW (born 1960) is director of the Cancer Research UK Receptor Structure Research Group at the University of Oxford One or more of the preceding sentences incorporates text from the royalsociety.org website where: and a Fellow of Jesus College, Oxford. She is widely known for her research on the molecular biology of cell surface receptors and signalling complexes. Early life and education Jones was born in 1960 in Oswestry, Shropshire, England. She was educated at Llanfyllin High School in Wales. She earned a Bachelor of Arts degree in Physics at Jesus College, Oxford in 1982. She was awarded a Doctor of Philosophy degree from Oxford in 1985 for structural and dynamic studies of biological macromolecules supervised by Andrew Miller and David Chilton Phillips. Research and career During postdoctoral research at the University of Edinburgh Jones performed neutron scattering experiments at the Institut Laue–Langevin in Grenoble to investigate ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Royal Society
The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, recognising excellence in science, supporting outstanding science, providing scientific advice for policy, education and public engagement and fostering international and global co-operation. Founded on 28 November 1660, it was granted a royal charter by King Charles II as The Royal Society and is the oldest continuously existing scientific academy in the world. The society is governed by its Council, which is chaired by the Society's President, according to a set of statutes and standing orders. The members of Council and the President are elected from and by its Fellows, the basic members of the society, who are themselves elected by existing Fellows. , there are about 1,700 fellows, allowed to use the postnominal title FRS (Fellow of the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oxford University Press
Oxford University Press (OUP) is the university press of the University of Oxford. It is the largest university press in the world, and its printing history dates back to the 1480s. Having been officially granted the legal right to print books by decree in 1586, it is the second oldest university press after Cambridge University Press. It is a department of the University of Oxford and is governed by a group of 15 academics known as the Delegates of the Press, who are appointed by the vice-chancellor of the University of Oxford. The Delegates of the Press are led by the Secretary to the Delegates, who serves as OUP's chief executive and as its major representative on other university bodies. Oxford University Press has had a similar governance structure since the 17th century. The press is located on Walton Street, Oxford, opposite Somerville College, in the inner suburb of Jericho. For the last 500 years, OUP has primarily focused on the publication of pedagogical texts and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nature (journal)
''Nature'' is a British weekly scientific journal founded and based in London, England. As a multidisciplinary publication, ''Nature'' features peer-reviewed research from a variety of academic disciplines, mainly in science and technology. It has core editorial offices across the United States, continental Europe, and Asia under the international scientific publishing company Springer Nature. ''Nature'' was one of the world's most cited scientific journals by the Science Edition of the 2019 ''Journal Citation Reports'' (with an ascribed impact factor of 42.778), making it one of the world's most-read and most prestigious academic journals. , it claimed an online readership of about three million unique readers per month. Founded in autumn 1869, ''Nature'' was first circulated by Norman Lockyer and Alexander Macmillan as a public forum for scientific innovations. The mid-20th century facilitated an editorial expansion for the journal; ''Nature'' redoubled its efforts in exp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
David Ian Stuart
Sir David Ian Stuart (born 8 December 1953) is a Medical Research Council Professor of Structural Biology at the Wellcome Trust Centre for Human Genetics at the University of Oxford where he is also a Fellow of Hertford College, Oxford. He is best known for his contributions to the X-ray crystallography of viruses, in particular for determining the structures of foot-and-mouth disease virus, bluetongue virus and the membrane-containing phages PRD1 (the first structure of an enveloped virus) and PM2. He is also director of Instruct and Life Sciences Director at Diamond Light Source. Education Stuart was born in 1953 in Lancashire. He was educated initially in Helmshore, Lancashire, and then in North Devon, at Barnstaple Grammar School. He studied Biophysics at King's College London, where he graduated with a BSc degree in 1974. He subsequently attended the University of Bristol and completed a PhD degree in the Biochemistry Department in 1979, working on the structure of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tumour Necrosis Factor
The tumor necrosis factor (TNF) superfamily is a protein superfamily of type II transmembrane proteins containing TNF homology domain and forming trimers. Members of this superfamily can be released from the cell membrane by extracellular proteolytic cleavage and function as a cytokine. These proteins are expressed predominantly by immune cells and they regulate diverse cell functions, including immune response and inflammation, but also proliferation, differentiation, apoptosis and embryogenesis. The superfamily contains 19 members that bind to 29 members of TNF receptor superfamily. An occurrence of orthologs in invertebrates hints at ancient origin of this superfamily in evolution. The PROSITE pattern of this superfamily is located in a beta sheet The beta sheet, (β-sheet) (also β-pleated sheet) is a common motif of the regular protein secondary structure. Beta sheets consist of beta strands (β-strands) connected laterally by at least two or three backbone hydrog ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cytokine
Cytokines are a broad and loose category of small proteins (~5–25 kDa) important in cell signaling. Cytokines are peptides and cannot cross the lipid bilayer of cells to enter the cytoplasm. Cytokines have been shown to be involved in autocrine, paracrine and endocrine signaling as immunomodulating agents. Cytokines include chemokines, interferons, interleukins, lymphokines, and tumour necrosis factors, but generally not hormones or growth factors (despite some overlap in the terminology). Cytokines are produced by a broad range of cells, including immune cells like macrophages, B lymphocytes, T lymphocytes and mast cells, as well as endothelial cells, fibroblasts, and various stromal cells; a given cytokine may be produced by more than one type of cell. They act through cell surface receptors and are especially important in the immune system; cytokines modulate the balance between humoral and cell-based immune responses, and they regulate the maturation, growth, and res ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Crystallography
Crystallography is the experimental science of determining the arrangement of atoms in crystalline solids. Crystallography is a fundamental subject in the fields of materials science and solid-state physics (condensed matter physics). The word "crystallography" is derived from the Greek word κρύσταλλος (''krystallos'') "clear ice, rock-crystal", with its meaning extending to all solids with some degree of transparency, and γράφειν (''graphein'') "to write". In July 2012, the United Nations recognised the importance of the science of crystallography by proclaiming that 2014 would be the International Year of Crystallography. denote a direction vector (in real space). * Coordinates in ''angle brackets'' or ''chevrons'' such as <100> denote a ''family'' of directions which are related by symmetry operations. In the cubic crystal system for example, would mean 00 10 01/nowiki> or the negative of any of those directions. * Miller indices in ''parentheses'' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Collagen
Collagen () is the main structural protein in the extracellular matrix found in the body's various connective tissues. As the main component of connective tissue, it is the most abundant protein in mammals, making up from 25% to 35% of the whole-body protein content. Collagen consists of amino acids bound together to form a triple helix of elongated fibril known as a collagen helix. It is mostly found in connective tissue such as cartilage, bones, tendons, ligaments, and skin. Depending upon the degree of mineralization, collagen tissues may be rigid (bone) or compliant (tendon) or have a gradient from rigid to compliant (cartilage). Collagen is also abundant in corneas, blood vessels, the gut, intervertebral discs, and the dentin in teeth. In muscle tissue, it serves as a major component of the endomysium. Collagen constitutes one to two percent of muscle tissue and accounts for 6% of the weight of the skeletal muscle tissue. The fibroblast is the most common cell that crea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Grenoble
lat, Gratianopolis , commune status = Prefecture and commune , image = Panorama grenoble.png , image size = , caption = From upper left: Panorama of the city, Grenoble’s cable cars, place Saint-André, jardin de ville, banks of the Isère , arrondissement = Grenoble , canton = Grenoble-1, 2, 3 and 4 , INSEE = 38185 , postal code = 38000, 38100 , mayor = Éric Piolle , term = 2020–2026 , party = EELV , image flag = Flag of Grenoble.svg , image coat of arms = Coat of Arms of Grenoble.svg , intercommunality = Grenoble-Alpes Métropole , coordinates = , elevation min m = 212 , elevation m = 398 , elevation max m = 500 , area km2 = 18.13 , population = , population date = , population footnotes = , urban pop = 451096 , urban area km2 = 358.1 , u ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Institut Laue–Langevin
The Institut Laue–Langevin (ILL) is an internationally financed scientific facility, situated on the Polygone Scientifique in Grenoble, France. It is one of the world centres for research using neutrons. Founded in 1967 and honouring the physicists Max von Laue and Paul Langevin, the ILL provides one of the most intense neutron sources in the world and the most intense continuous neutron flux in the world in the moderator region: 1.5×1015 neutrons per second per cm2, with a thermal power of typically 58.3 MW. The ILL neutron scattering facilities allow the analysis of the structure of conducting and magnetic materials for future electronic devices, the measurement of stresses in mechanical materials. It also allows investigations into macromolecular assemblies, particularly protein dynamics and biomolecular structure. It is a world-renowned centre for Nanoscopic scale, nanoscale science. History The institute was founded by France and Germany, with the United King ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neutron Scattering
Neutron scattering, the irregular dispersal of free neutrons by matter, can refer to either the naturally occurring physical process itself or to the man-made experimental techniques that use the natural process for investigating materials. The natural/physical phenomenon is of elemental importance in nuclear engineering and the nuclear sciences. Regarding the experimental technique, understanding and manipulating neutron scattering is fundamental to the applications used in crystallography, physics, physical chemistry, biophysics, and materials research. Neutron scattering is practiced at research reactors and spallation neutron sources that provide neutron radiation of varying intensities. Neutron diffraction (elastic scattering) techniques are used for analyzing structures; where inelastic neutron scattering is used in studying atomic vibrations and other excitations. Scattering of fast neutrons "Fast neutrons" (see neutron temperature) have a kinetic energy above ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Postdoctoral Research
A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). The ultimate goal of a postdoctoral research position is to pursue additional research, training, or teaching in order to have better skills to pursue a career in academia, research, or any other field. Postdocs often, but not always, have a temporary academic appointment, sometimes in preparation for an academic faculty position. They continue their studies or carry out research and further increase expertise in a specialist subject, including integrating a team and acquiring novel skills and research methods. Postdoctoral research is often considered essential while advancing the scholarly mission of the host institution; it is expected to produce relevant publications in peer-reviewed academic journals or conferences. In some countries, postdoctoral research may lead to further formal qualificati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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