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Diamphotoxin
Diamphotoxin is a toxin produced by larvae and pupae of the beetle genus '' Diamphidia''. Diamphotoxin is a hemolytic, cardiotoxic, and highly labile single-chain polypeptide bound to a protein that protects it from deactivation. Diamphotoxin increases the permeability of cell membranes of red blood cells. Although this does not affect the normal flow of ions between cells, it allows ''all'' small ions to pass through cell membranes easily, which fatally disrupts the cells' ion levels. Although diamphotoxin has no neurotoxic effect, its hemolytic effect is lethal, and may reduce hemoglobin levels by as much as 75%. The San people of Southern Africa use diamphotoxin as an arrow poison for hunting game. The toxin paralyses muscles gradually. Large mammals hunted in this way die slowly from a small injection of the poison. Several leaf beetles species of genus ''Leptinotarsa'' produce a similar toxin, leptinotarsin. See also * Palytoxin - A non-peptide fatty alcohol toxin with ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
San People
The San peoples (also Saan), or Bushmen, are members of various Khoe, Tuu, or Kxʼa-speaking indigenous hunter-gatherer cultures that are the first cultures of Southern Africa, and whose territories span Botswana, Namibia, Angola, Zambia, Zimbabwe, Lesotho and South Africa. In 2017, Botswana was home to approximately 63,500 San people (roughly 2.8% of the population) making it the country with the highest number of San people. Definition The term "San" has a long vowel and is spelled Sān (in Khoekhoegowab orthography). It is a Khoekhoe exonym with the meaning of "foragers" and was often used in a derogatory manner to describe nomadic, foraging people. Based on observation of lifestyle, this term has been applied to speakers of three distinct language families living between the Okavango River in Botswana and Etosha National Park in northwestern Namibia, extending up into southern Angola; central peoples of most of Namibia and Botswana, extending into Zambia and Zimbabwe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Leptinotarsa
''Leptinotarsa'' is a genus of leaf beetles. Several species in the genus produce leptinotarsin, a toxin similar to the diamphotoxin produced by species of the African leaf beetle genus '' Diamphidia''. Some ''Leptinotarsa'' species are parasitised by ground beetles of genus '' Lebia''. Species *'' Leptinotarsa behrensi'' Harold, 1877 *'' Leptinotarsa collinsi'' Wilcox, 1972 *''Leptinotarsa decemlineata'' Say, 1824 (Colorado potato beetle) *'' Leptinotarsa defecta'' Stål, 1859 *'' Leptinotarsa dellacasai'' Daccordi & Zoia, 2017 *'' Leptinotarsa gilberti'' Daccordi & Zoia, 2017 *'' Leptinotarsa haldemani'' Rogers, 1856 *'' Leptinotarsa heydeni'' *'' Leptinotarsa juncta'' (Germar, 1824) (false potato beetle) *'' Leptinotarsa lineolata'' Stål, 1863 *'' Leptinotarsa mariachia'' Daccordi & Zoia, 2017 *'' Leptinotarsa peninsularis'' Horn, 1894 *'' Leptinotarsa rubiginosa'' Rogers, 1856 *'' Leptinotarsa texana'' *'' Leptinotarsa tlascalana'' Stål, 1858 *'' Leptinotarsa tumamoca'' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Toxin
A toxin is a naturally occurring organic poison produced by metabolic activities of living cells or organisms. Toxins occur especially as a protein or conjugated protein. The term toxin was first used by organic chemist Ludwig Brieger (1849–1919) and is derived from the word toxic. Toxins can be small molecules, peptides, or proteins that are capable of causing disease on contact with or absorption by body tissues interacting with biological macromolecules such as enzymes or cellular receptors. Toxins vary greatly in their toxicity, ranging from usually minor (such as a bee sting) to potentially fatal even at extremely low doses (such as botulinum toxin). Toxins are largely secondary metabolites, which are organic compounds that are not directly involved in an organism's growth, development, or reproduction, instead often aiding it in matters of defense. Terminology Toxins are often distinguished from other chemical agents strictly based on their biological origin. Le ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neurotoxic
Neurotoxicity is a form of toxicity in which a biological, chemical, or physical agent produces an adverse effect on the structure or function of the central and/or peripheral nervous system. It occurs when exposure to a substance – specifically, a neurotoxin or neurotoxicant– alters the normal activity of the nervous system in such a way as to cause permanent or reversible damage to nervous tissue. This can eventually disrupt or even kill neurons, which are cells that transmit and process signals in the brain and other parts of the nervous system. Neurotoxicity can result from organ transplants, radiation treatment, certain drug therapies, recreational drug use, and exposure to heavy metals, bites from certain species of venomous snakes, pesticides, certain industrial cleaning solvents, fuels and certain naturally occurring substances. Symptoms may appear immediately after exposure or be delayed. They may include limb weakness or numbness, loss of memory, vision, and/or ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PubChem
PubChem is a database of chemical molecules and their activities against biological assays. The system is maintained by the National Center for Biotechnology Information (NCBI), a component of the National Library of Medicine, which is part of the United States National Institutes of Health (NIH). PubChem can be accessed for free through a web user interface. Millions of compound structures and descriptive datasets can be freely downloaded via FTP. PubChem contains multiple substance descriptions and small molecules with fewer than 100 atoms and 1,000 bonds. More than 80 database vendors contribute to the growing PubChem database. History PubChem was released in 2004 as a component of the Molecular Libraries Program (MLP) of the NIH. As of November 2015, PubChem contains more than 150 million depositor-provided substance descriptions, 60 million unique chemical structures, and 225 million biological activity test results (from over 1 million assay experiments performed on more t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Palythoa
''Palythoa'' is a genus of anthozoans in the order Zoantharia.Reimer, J. (2018). Palythoa Lamouroux, 1816. Accessed through: World Register of Marine Species at http://www.marinespecies.org/aphia.php?p=taxdetails&id=205785 on 2018-08-27 Description The polyps of ''Palythoa'' are partially embedded in an encrusting mat of tissue (coenenchyme) covering the substrate on which the colony grows. The individual polyps have flattened oral discs surrounded by a fringe of tentacles. The tentacles' shape and size can vary considerably between species, and even between colonies of the same species. Their colors are also highly variable, with relatively dull shades like cream, coffee, white, brown, or yellow, being the most common. Fluorescent colored colonies also exist, but these are more rare. Palytoxin Palytoxin is a highly toxic fatty alcohol produced by many species of ''Palythoa'', and is also found in other corals and certain marine invertebrates. The substance was first isolated ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fatty Alcohol
Fatty alcohols (or long-chain alcohols) are usually high-molecular-weight, straight-chain primary alcohols, but can also range from as few as 4–6 carbons to as many as 22–26, derived from natural fats and oils. The precise chain length varies with the source. Some commercially important fatty alcohols are lauryl, stearyl, and oleyl alcohols. They are colourless oily liquids (for smaller carbon numbers) or waxy solids, although impure samples may appear yellow. Fatty alcohols usually have an even number of carbon atoms and a single alcohol group (–OH) attached to the terminal carbon. Some are unsaturated and some are branched. They are widely used in industry. As with fatty acids, they are often referred to generically by the number of carbon atoms in the molecule, such as "a C12 alcohol", that is an alcohol having 12 carbons, for example dodecanol. Production and occurrence Most fatty alcohols in nature are found as waxes which are esters of fatty acids and fatty alcohols. T ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Palytoxin
Palytoxin, PTX or PLTX is an intense vasoconstrictor, and is considered to be one of the most poisonous non-protein substances known, second only to maitotoxin in terms of toxicity in mice. Palytoxin is a polyhydroxylated and partially unsaturated compound (8 double bonds) with a long carbon chain. It has water-soluble and fat-soluble parts, 40 hydroxy groups and 64 chiral centers. Due to chirality and possible double bond ''cis-trans'' isomerism, it has over 1021 alternative stereoisomers. It is thermostable, and treatment with boiling water does not remove its toxicity. It remains stable in aqueous solutions for prolonged periods but rapidly decomposes and loses its toxicity in acidic or alkaline solutions. It has multiple analogues with a similar structure like ostreocin-D, mascarenotoxin-A and -B. Palytoxin occurs at least in tropics and subtropics where it is made by '' Palythoa'' corals and ''Ostreopsis'' dinoflagellates, or possibly by bacteria occurring in these orga ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Springer Verlag
Springer Science+Business Media, commonly known as Springer, is a German multinational publishing company of books, e-books and peer-reviewed journals in science, humanities, technical and medical (STM) publishing. Originally founded in 1842 in Berlin, it expanded internationally in the 1960s, and through mergers in the 1990s and a sale to venture capitalists it fused with Wolters Kluwer and eventually became part of Springer Nature in 2015. Springer has major offices in Berlin, Heidelberg, Dordrecht, and New York City. History Julius Springer founded Springer-Verlag in Berlin in 1842 and his son Ferdinand Springer grew it from a small firm of 4 employees into Germany's then second largest academic publisher with 65 staff in 1872.Chronology ". Springer Science+Business Media. In 1964, Springer expanded its business internationally, o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Game (food)
Game or quarry is any wild animal hunted for animal products (primarily meat), for recreation (" sporting"), or for trophies. The species of animals hunted as game varies in different parts of the world and by different local jurisdictions, though most are terrestrial mammals and birds. Fish caught non-commercially (recreational fishing) are also referred to as game fish. By continent and region The range of animal species hunted by humans varies in different parts of the world. This is influenced by climate, faunal diversity, popular taste and locally accepted views about what can or cannot be legitimately hunted. Sometimes a distinction is also made between varieties and breeds of a particular animal, such as wild turkey and domestic turkey. The flesh of the animal, when butchered for consumption, is often described as having a "gamey" flavour. This difference in taste can be attributed to the natural diet of the animal, which usually results in a lower fat content compar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arrow Poison
Arrow poisons are used to poison arrow heads or darts for the purposes of hunting and warfare. They have been used by indigenous peoples worldwide and are still in use in areas of South America, Africa and Asia. Notable examples are the poisons secreted from the skin of the poison dart frog, and curare (or 'ampi'), a general term for a range of plant-derived arrow poisons used by the indigenous peoples of South America. Poisoned arrows have featured in mythology, notably the Greek story of Heracles slaying the centaur Nessus using arrows poisoned with the blood of the Lernaean Hydra. The Greek hero Odysseus poisons his arrows with hellebore in Homer's ''Odyssey''. Poisoned arrows also figure in Homer's epic about the Trojan War, the ''Iliad'', in which both Achaeans and Trojans used toxic arrows and spears. Poisoned arrows are referred to in the Book of Job in the Bible, descriptive of the sufferings experienced by the just man, Job. The modern terms "toxic" and "toxin" derive f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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