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Discodermia Dissoluta
''Discodermia dissoluta'' is a deep-water sea sponge found in the Eastern, Southern, and Southwestern Caribbean, and in the Greater Antilles. ''D. dissoluta'' is of interest to bio and organic chemists because it produces (+)-discodermolide, a polyketide natural product with immunosuppressive Immunosuppression is a reduction of the activation or efficacy of the immune system. Some portions of the immune system itself have immunosuppressive effects on other parts of the immune system, and immunosuppression may occur as an adverse reacti ... and cancer killing properties. References Tetractinellida Sponges described in 1880 {{Demosponge-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
World Register Of Marine Species
The World Register of Marine Species (WoRMS) is a taxonomic database that aims to provide an authoritative and comprehensive list of names of marine organisms. Content The content of the registry is edited and maintained by scientific specialists on each group of organism. These taxonomists control the quality of the information, which is gathered from the primary scientific literature as well as from some external regional and taxon-specific databases. WoRMS maintains valid names of all marine organisms, but also provides information on synonyms and invalid names. It is an ongoing task to maintain the registry, since new species are constantly being discovered and described by scientists; in addition, the nomenclature and taxonomy of existing species is often corrected or changed as new research is constantly being published. Subsets of WoRMS content are made available, and can have separate badging and their own home/launch pages, as "subregisters", such as the ''World List of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sea Sponge
Sponges, the members of the phylum Porifera (; meaning 'pore bearer'), are a basal animal clade as a sister of the diploblasts. They are multicellular organisms that have bodies full of pores and channels allowing water to circulate through them, consisting of jelly-like mesohyl sandwiched between two thin layers of cells. Sponges have unspecialized cells that can transform into other types and that often migrate between the main cell layers and the mesohyl in the process. Sponges do not have nervous, digestive or circulatory systems. Instead, most rely on maintaining a constant water flow through their bodies to obtain food and oxygen and to remove wastes. Sponges were first to branch off the evolutionary tree from the last common ancestor of all animals, making them the sister group of all other animals. Etymology The term ''sponge'' derives from the Ancient Greek word ( 'sponge'). Overview Sponges are similar to other animals in that they are multicellular, he ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Caribbean
The Caribbean (, ) ( es, El Caribe; french: la Caraïbe; ht, Karayib; nl, De Caraïben) is a region of the Americas that consists of the Caribbean Sea, its islands (some surrounded by the Caribbean Sea and some bordering both the Caribbean Sea and the North Atlantic Ocean) and the surrounding coasts. The region is southeast of the Gulf of Mexico and the North American mainland, east of Central America, and north of South America. Situated largely on the Caribbean Plate, the region has more than 700 islands, islets, reefs and cays (see the list of Caribbean islands). Island arcs delineate the eastern and northern edges of the Caribbean Sea: The Greater Antilles and the Lucayan Archipelago on the north and the Lesser Antilles and the on the south and east (which includes the Leeward Antilles). They form the West Indies with the nearby Lucayan Archipelago (the Bahamas and Turks and Caicos Islands), which are considered to be part of the Caribbean despite not bordering the Caribbe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Greater Antilles
The Greater Antilles ( es, Grandes Antillas or Antillas Mayores; french: Grandes Antilles; ht, Gwo Zantiy; jam, Grieta hAntiliiz) is a grouping of the larger islands in the Caribbean Sea, including Cuba, Hispaniola, Puerto Rico, Jamaica, and the Cayman Islands. Six island states share the region of the Greater Antilles, with Haiti and the Dominican Republic sharing the island of Hispaniola. Together with the Lesser Antilles, they make up the Antilles. While most of the Greater Antilles consists of independent countries, Puerto Rico is an unincorporated territory of the United States, while the Cayman Islands are a British Overseas Territory. The largest island by area is Cuba, which extends to the western end of the island group. Puerto Rico lies on the eastern end, and the island of Hispaniola, the largest island by population, is located in the middle. Jamaica lies to the south of Cuba, while the Cayman Islands are located to the west. The state of Florida is the closes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Discodermolide
(+)-Discodermolide is a polyketide natural product found to stabilize microtubules. (+)-discodermolide was isolated by Gunasekera and his co-workers at the Harbor Branch Oceanographic Institute from the deep-sea sponge ''Discodermia dissoluta'' in 1990.Gunasekera, S. P.; Gunasekera, M.; Longley, R. E.; Schulte, G. K. ''J. Org. Chem.'' 1990, ''55'', 4912-4915. () (+)-Discodermolide was found to be a potent inhibitor of tumor cell growth in several MDR cancer cell lines. (+)-discodermolide also shows some unique characters, including a linear backbone structure, immunosuppressive properties both in vitro and in vivo,Longley, R. E.; Caddigan, D.; Harmody, D.; Gunasekera, M.; Gunasekera, S. P. Transplantation 1991, 52, 650-655.Longley, R. E.; Caddigan, D.; Harmody, D.; Gunasekera, M.; Gunasekera, S. P. Transplantation 1991, 52, 656-661. potent induction of an accelerated senescence phenotype,Klein, L.; Freeze, B. S.; Smith, A. B., III; Horwitz, S. B. Cell Cycle 2005, 4, 501–507. and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polyketide
Polyketides are a class of natural products derived from a precursor molecule consisting of a chain of alternating ketone (or reduced forms of a ketone) and methylene groups: (-CO-CH2-). First studied in the early 20th century, discovery, biosynthesis, and application of polyketides has evolved. It is a large and diverse group of secondary metabolites caused by its complex biosynthesis which resembles that of fatty acid synthesis. Because of this diversity, polyketides can have various medicinal, agricultural, and industrial applications. Many polyketides are medicinal or exhibit acute toxicity. Biotechnology has enabled discovery of more naturally-occurring polyketides and evolution of new polyketides with novel or improved bioactivity. History Naturally produced polyketides by various plants and organisms have been used by humans since before studies on them began in the 19th and 20th century. In 1893, J. Norman Collie synthesized detectable amounts of orcinol by heating dehy ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Natural Product
A natural product is a natural compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life. Natural products can also be prepared by chemical synthesis (both semisynthesis and total synthesis) and have played a central role in the development of the field of organic chemistry by providing challenging synthetic targets. The term natural product has also been extended for commercial purposes to refer to cosmetics, dietary supplements, and foods produced from natural sources without added artificial ingredients. Within the field of organic chemistry, the definition of natural products is usually restricted to organic compounds isolated from natural sources that are produced by the pathways of primary or secondary metabolism. Within the field of medicinal chemistry, the definition is often further restricted to secondary metabolites. Secondary metabolites (or specialized metabolites ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immunosuppressive
Immunosuppression is a reduction of the activation or efficacy of the immune system. Some portions of the immune system itself have immunosuppressive effects on other parts of the immune system, and immunosuppression may occur as an adverse reaction to treatment of other conditions. In general, deliberately induced immunosuppression is performed to prevent the body from rejecting an organ transplant. Additionally, it is used for treating graft-versus-host disease after a bone marrow transplant, or for the treatment of auto-immune diseases such as systemic lupus erythematosus, rheumatoid arthritis, Sjögren's syndrome, or Crohn's disease. This is typically done using medications, but may involve surgery (splenectomy), plasmapheresis, or radiation. A person who is undergoing immunosuppression, or whose immune system is weak for some other reasons (such as chemotherapy or HIV), is said to be ''immunocompromised''. Deliberately induced Administration of immunosuppressive medica ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tetractinellida
Tetractinellida is an order of sea sponges belonging to the Class Demospongiae. First described in 1876, this order received a new description in 2012 and replaced the two orders Astrophorida and Spirophorida, which then became sub-orders as Astrophorina and Spirophorina. Families ; Suborder Astrophorina Sollas, 1887 * Family Ancorinidae Schmidt, 1870 * Family Calthropellidae Lendenfeld, 1907 * Family Corallistidae Sollas, 1888 * Family Geodiidae Gray, 1867 * Family Isoraphiniidae Schrammen, 1924 * Family Macandrewiidae Schrammen, 1924 * Family Neopeltidae Sollas, 1888 * Family Pachastrellidae Carter, 1875 * Family Phymaraphiniidae Schrammen, 1924 * Family Phymatellidae Schrammen, 1910 * Family Pleromidae Sollas, 1888 * Family Theneidae Carter, 1883 * Family Theonellidae Lendenfeld, 1903 * Family Thrombidae Sollas, 1888 * Family Vulcanellidae Vulcanellidae is a family of sponges belonging to the order Tetractinellida Tetractinellida is an Order (biology), order of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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