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Derek George Smyth
Derek Smyth (born 24 April 1927) is a British biochemist who specialises in peptide structure and function. In 2002, he was admitted as a Fellow of the Royal Society of Chemistry. Background Derek Smyth was Head of the Laboratory of Peptide Chemistry at the National Institute for Medical Research (NIMR) in Mill Hill, London from 1972 to 1992. He had worked previously with Professor Joseph Fruton, Head of the Biochemistry Department at Yale University, where he gained experience in protein and peptide chemistry (1-3) and in 1960 transferred to Rockefeller University in New York City where in the laboratory of Stanford Moore and William Howard Stein (Nobel Prize winners) he reinvestigated and established the definitive amino acid sequence of pancreatic ribonuclease (4-8), the first enzyme (some say the first protein) to have its primary structure determined (9). On moving to NIMR in 1963, Smyth prepared two novel derivatives of oxytocin, N-carbamylcystine-1-oxytocin and N- ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kingston Upon Thames
Kingston upon Thames (hyphenated until 1965, colloquially known as Kingston) is a town in the Royal Borough of Kingston upon Thames, southwest London, England. It is situated on the River Thames and southwest of Charing Cross. It is notable as the ancient market town in which Saxon kings were crowned and today is the administrative centre of the Royal Borough. Historically in the county of Surrey, the ancient parish of Kingston became absorbed in the Municipal Borough of Kingston-upon-Thames, reformed in 1835. From 1893 to 2021 it was the location of Surrey County Council, extraterritorially in terms of local government administration since 1965, when Kingston became a part of Greater London. Today, most of the town centre is part of the KT1 postcode area, but some areas north of Kingston railway station are within KT2. The United Kingdom Census 2011 recorded the population of the town (comprising the four wards of Canbury, Grove, Norbiton and Tudor) as 43,013, w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Yale University
Yale University is a Private university, private research university in New Haven, Connecticut. Established in 1701 as the Collegiate School, it is the List of Colonial Colleges, third-oldest institution of higher education in the United States and among the most prestigious in the world. It is a member of the Ivy League. Chartered by the Connecticut Colony, the Collegiate School was established in 1701 by clergy to educate Congregationalism in the United States, Congregational ministers before moving to New Haven in 1716. Originally restricted to theology and sacred languages, the curriculum began to incorporate humanities and sciences by the time of the American Revolution. In the 19th century, the college expanded into graduate and professional instruction, awarding the first Doctor of Philosophy, PhD in the United States in 1861 and organizing as a university in 1887. Yale's faculty and student populations grew after 1890 with rapid expansion of the physical campus and sc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dial Press
The Dial Press was a publishing house founded in 1923 by Lincoln MacVeagh. The Dial Press shared a building with '' The Dial'' and Scofield Thayer worked with both. The first imprint was issued in 1924. Authors included Elizabeth Bowen, W. R. Burnett and Glenway Wescott, Frank Yerby, James Baldwin, Roy Campbell, Susan Berman, Herbert Gold, Thomas Berger, Vance Bourjaily, Judith Rossner, and Norman Mailer. In 1963, Dell Publishing Company acquired 60% of the Dial Press stock but the Press remained an independent subsidiary. It was jointly owned by Richard Baron and Dell Publishing; E. L. Doctorow was editor-in-chief. In 1969 the Dial Press became wholly owned by Dell Publishing Company. In 1976 Doubleday bought Dell Publishing and the children's division of Dial Press (Dial Books for Young Readers) was sold to E. P. Dutton. The children's division of Dial Press published books under the Pied Piper imprint. Dutton would be bought by New American Library, which in tu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Proopiomelanocortin
Pro-opiomelanocortin (POMC) is a precursor polypeptide with 241 amino acid residues. POMC is synthesized in corticotrophs of the anterior pituitary from the 267-amino-acid-long polypeptide precursor pre-pro-opiomelanocortin (pre-POMC), by the removal of a 26-amino-acid-long signal peptide sequence during translation. POMC is part of the central melanocortin system. Function POMC is cut (cleaved) to give rise to multiple peptide hormones. Each of these peptides is packaged in large dense-core vesicles that are released from the cells by exocytosis in response to appropriate stimulation: * α-MSH produced by neurons in the ventromedial nucleus has important roles in the regulation of appetite (POMC neuron stimulation results in satiety.) and sexual behavior, while α-MSH secreted from the intermediate lobe of the pituitary regulates the movement of melanin produced from melanocytes in skin. * ACTH is a peptide hormone that regulates the secretion of mainly glucocorti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lipotropin
Lipotropin is the name for two hormones produced by the cleavage of pro-opiomelanocortin (POMC). The anterior pituitary gland produces the pro-hormone POMC, which is then cleaved again to form adrenocorticotropin (ACTH) and β-lipotropin (β-LPH). β-Lipotropin β-Lipotropin is a 90-amino acid polypeptide that is the carboxy-terminal fragment of POMC. It was initially reported to stimulate melanocytes to produce melanin. It was also reported to perform lipid-mobilizing functions such as lipolysis and steroidogenesis. However, no subsequent studies have been published that support these early findings and no receptor has been identified for β-lipotropin. β-Lipotropin can be cleaved into smaller peptides. In humans, γ-lipotropin, β-MSH, and β-endorphin, are all possible fragments of β-lipotropin. β-endorphin is the predominant opioid of the anterior human and rat pituitary gland. Birdsall and Hulme demonstrated that the C-fragment of lipotropin (β-endorphin) has ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Proinsulin
Proinsulin is the prohormone precursor to insulin made in the beta cells of the islets of Langerhans, specialized regions of the pancreas. In humans, proinsulin is encoded by the ''INS'' gene. The islets of Langerhans only secrete between 1% and 3% of proinsulin intact. However, because proinsulin has a longer half life than insulin, it can account for anywhere from 5–30% of the insulin-like structures circulating in the blood. There are higher concentrations of proinsulin after meals and lower levels when a person is fasting. Additionally, while proinsulin and insulin have structural differences, proinsulin does demonstrate some affinity for the insulin receptor. Due to the relative similarities in structure, proinsulin can produce between 5% and 10% of the metabolic activity similarly induced by insulin. Proinsulin is the final single chain protein structure secreted by cells before cleavage into mature insulin. Proinsulin was discovered by Professor Donald F. Steiner of the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oligosaccharide
An oligosaccharide (/ˌɑlɪgoʊˈsækəˌɹaɪd/; from the Greek ὀλίγος ''olígos'', "a few", and σάκχαρ ''sácchar'', "sugar") is a saccharide polymer containing a small number (typically two to ten) of monosaccharides (simple sugars). Oligosaccharides can have many functions including cell recognition and cell adhesion. They are normally present as glycans: oligosaccharide chains are linked to lipids or to compatible amino acid side chains in proteins, by ''N''- or ''O''-glycosidic bonds. ''N''-Linked oligosaccharides are always pentasaccharides attached to asparagine via a beta linkage to the amine nitrogen of the side chain.. Alternately, ''O''-linked oligosaccharides are generally attached to threonine or serine on the alcohol group of the side chain. Not all natural oligosaccharides occur as components of glycoproteins or glycolipids. Some, such as the raffinose series, occur as storage or transport carbohydrates in plants. Others, such as maltodextr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gamma Globulin
Gamma globulins are a class of globulins, identified by their position after serum protein electrophoresis. The most significant gamma globulins are immunoglobulins (antibodies), although some immunoglobulins are not gamma globulins, and some gamma globulins are not immunoglobulins. Use as medical treatment Gamma globulin injections are usually given in an attempt to temporarily boost a patient's immunity against disease. Injections are most commonly used on patients having been exposed to hepatitis A or measles, or to make a kidney donor and a recipient compatible regardless of blood type or tissue match. Injections are also used to boost immunity in patients unable to produce gamma globulins naturally because of an immune deficiency, such as X-linked agammaglobulinemia and hyper IgM syndrome. Such injections are less common in modern medical practice than they were previously, and injections of gamma globulin previously recommended for travelers have largely been replace ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oxytocin
Oxytocin (Oxt or OT) is a peptide hormone and neuropeptide normally produced in the hypothalamus and released by the posterior pituitary. It plays a role in social bonding, reproduction, childbirth, and the period after childbirth. Oxytocin is released into the bloodstream as a hormone in response to sexual activity and during labour. It is also available in pharmaceutical form. In either form, oxytocin stimulates uterine contractions to speed up the process of childbirth. In its natural form, it also plays a role in bonding with the baby and milk production. Production and secretion of oxytocin is controlled by a positive feedback mechanism, where its initial release stimulates production and release of further oxytocin. For example, when oxytocin is released during a contraction of the uterus at the start of childbirth, this stimulates production and release of more oxytocin and an increase in the intensity and frequency of contractions. This process compounds in inte ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
McGraw-Hill
McGraw Hill is an American educational publishing company and one of the "big three" educational publishers that publishes educational content, software, and services for pre-K through postgraduate education. The company also publishes reference and trade publications for the medical, business, and engineering professions. McGraw Hill operates in 28 countries, has about 4,000 employees globally, and offers products and services to about 140 countries in about 60 languages. Formerly a division of The McGraw Hill Companies (later renamed McGraw Hill Financial, now S&P Global), McGraw Hill Education was divested and acquired by Apollo Global Management in March 2013 for $2.4 billion in cash. McGraw Hill was sold in 2021 to Platinum Equity for $4.5 billion. Corporate History McGraw Hill was founded in 1888 when James H. McGraw, co-founder of the company, purchased the ''American Journal of Railway Appliances''. He continued to add further publications, eventually establishin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Saunders (imprint)
Saunders is an American academic publisher based in the United States. It is currently an imprint (trade name), imprint of Elsevier. Formerly independent, the W. B. Saunders company was acquired by CBS in 1968, who added it to their publishing division Henry Holt and Company, Holt, Rinehart & Winston. When CBS left the publishing field in 1986, it sold the academic publishing units to Harcourt (publisher), Harcourt Brace Jovanovich. Harcourt was acquired by Reed Elsevier in 2001. . Northern Illinois University Libraries. Retrieved May 2, 2015. W. B. Saunders published the Kinsey Reports and Dorland's medical reference works. Elsevier still sells the latter under the Saunders imprint. References External links * Book publishing companies based in Pennsylvania El ...[...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pancreatic Ribonuclease
Pancreatic ribonuclease family (, ''RNase'', ''RNase I'', ''RNase A'', ''pancreatic RNase'', ''ribonuclease I'', ''endoribonuclease I'', ''ribonucleic phosphatase'', ''alkaline ribonuclease'', ''ribonuclease'', ''gene S glycoproteins'', ''Ceratitis capitata alkaline ribonuclease'', ''SLSG glycoproteins'', ''gene S locus-specific glycoproteins'', ''S-genotype-assocd. glycoproteins'', ''ribonucleate 3'-pyrimidino-oligonucleotidohydrolase'') is a superfamily of pyrimidine-specific endonucleases found in high quantity in the pancreas of certain mammals and of some reptiles. Specifically, the enzymes are involved in endonucleolytic cleavage of 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates. Ribonuclease can unwind the RNA helix by complexing with single-stranded RNA; the complex arises by an extended multi-site cation-anion interaction between lysine and arginine residues of the enzyme and phosphate groups of the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
