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Dependoparvovirus
''Dependoparvovirus'' (formerly ''Dependovirus'' or Adeno-associated virus group) is a genus in the subfamily ''Parvovirinae'' of the virus family ''Parvoviridae''; they are Group II viruses according to the Baltimore classification. Some dependoparvoviruses are also known as adeno-associated viruses because they cannot replicate productively in their host cell without the cell being coinfected by a helper virus such as an adenovirus, a herpesvirus, or a vaccinia virus. Species There are eleven recognized species: * ''Adeno-associated dependoparvovirus A'' * '' Adeno-associated dependoparvovirus B'' * ''Anseriform dependoparvovirus 1'' * '' Avian dependoparvovirus 1'' * '' Carnivore dependoparvovirus 1'' * '' Chiropteran dependoparvovirus 1'' * '' Pinniped dependoparvovirus 1'' * '' Rodent dependoparvovirus 1'' * '' Rodent dependoparvovirus 2'' * '' Squamate dependoparvovirus 1'' * '' Squamate dependoparvovirus 2'' Virology Dependoparvoviruses have an icosahedral shape, mea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adeno-associated Dependoparvovirus A
Adeno-associated viruses (AAV) are small viruses that infect humans and some other Primate, primate species. They belong to the genus ''Dependoparvovirus'', which in turn belongs to the family (biology), family ''Parvoviridae''. They are small (approximately 26 nanometre, nm in diameter) Replication-defective virus, replication-defective, Enveloped virus, nonenveloped viruses and have linear single-stranded DNA (ssDNA) genome of approximately 4.8 Base pair#Length measurements, kilobases (kb). AAV are not currently known to cause disease. The viruses cause a very mild immune response. Several additional features make AAV an attractive candidate for creating viral vectors for gene therapy, and for the creation of isogenic human disease models. Gene therapy Vectors in Gene Therapy, vectors using AAV can infect both dividing and quiescent cells and persist in an extrachromosomal state without integrating into the genome of the host cell. In the native virus, however, integration of v ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adeno-associated Dependoparvovirus B
Adeno-associated viruses (AAV) are small viruses that infect humans and some other primate species. They belong to the genus ''Dependoparvovirus'', which in turn belongs to the family ''Parvoviridae''. They are small (approximately 26 nm in diameter) replication-defective, nonenveloped viruses and have linear single-stranded DNA (ssDNA) genome of approximately 4.8 kilobases (kb). AAV are not currently known to cause disease. The viruses cause a very mild immune response. Several additional features make AAV an attractive candidate for creating viral vectors for gene therapy, and for the creation of isogenic human disease models. Gene therapy vectors using AAV can infect both dividing and quiescent cells and persist in an extrachromosomal state without integrating into the genome of the host cell. In the native virus, however, integration of virally carried genes into the host genome does occur. Integration can be important for certain applications, but can also have unwant ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Parvovirinae
''Parvovirinae'' is a subfamily of viruses in the family ''Parvoviridae''. There are ten genera and 84 species assigned to this subfamily. Taxonomy The following 10 genera are recognized: *'' Amdoparvovirus'' *'' Artiparvovirus'' *'' Aveparvovirus'' *'' Bocaparvovirus'' *'' Copiparvovirus'' *''Dependoparvovirus'' *'' Erythroparvovirus'' *'' Loriparvovirus'' *''Protoparvovirus'' *''Tetraparvovirus Tetraparvovirus are a genus of viruses in the family ''Parvoviridae''. There are six recognized species: '' Chiropteran tetraparvovirus 1'', '' Primate tetraparvovirus 1'', '' Ungulate tetraparvovirus 1'', '' Ungulate tetraparvovirus 2'', '' Ungu ...'' References External links ICTV ''Parvovirinae'' {{Taxonbar, from=Q2055184 Parvoviruses Virus subfamilies ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Parvoviridae
Parvoviruses are a family of animal viruses that constitute the family ''Parvoviridae''. They have linear, single-stranded DNA (ssDNA) genomes that typically contain two genes encoding for a replication initiator protein, called NS1, and the protein the viral capsid is made of. The coding portion of the genome is flanked by telomeres at each end that form into hairpin loops that are important during replication. Parvovirus virions are small compared to most viruses, at 23–28 nanometers in diameter, and contain the genome enclosed in an icosahedral capsid that has a rugged surface. Parvoviruses enter a host cell by endocytosis, travelling to the nucleus where they wait until the cell enters its replication stage. At that point, the genome is uncoated and the coding portion is replicated. Viral messenger RNA (mRNA) is then transcribed and translated, resulting in NS1 initiating replication. During replication, the hairpins repeatedly unfold, are replicated, and refold to chang ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anseriform Dependoparvovirus 1
Derzsy's disease is caused by ''Anseriform dependoparvovirus 1'', in the ''Parvoviridae'' family. It affects geese and Muscovy ducks. The virus is shed in the faeces and thus transmission is horizontal, via the direct faecal-oral route and also indirectly via fomites. Vertical transmission is also possible. Clinical disease only occurs in young geese and ducks between birth and 4–5 weeks of age. Epidemiology Several genotypes have been described.Liu HM, Wang H, Tian XJ, Zhang S, Zhou XH, Qi KZ, Pan L (2013) Complete genome sequence of goose parvovirus Y strain isolated from Muscovy ducks in China. Virus Genes The genotype is based upon the sequence of the VP3 protein. Clinical signs and diagnosis Acute disease leads to death in most birds between the ages of 7–10 days. Clinical signs are quite limited in those cases. Older animals tend to show severe systemic and neurological signs and diarrhoea. Adults do not show any clinical signs. [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Squamate Dependoparvovirus 1
Squamata (, Latin ''squamatus'', 'scaly, having scales') is the largest order of reptiles, comprising lizards, snakes, and amphisbaenians (worm lizards), which are collectively known as squamates or scaled reptiles. With over 10,900 species, it is also the second-largest order of extant (living) vertebrates, after the perciform fish. Members of the order are distinguished by their skins, which bear horny scales or shields, and must periodically engage in molting. They also possess movable quadrate bones, making possible movement of the upper jaw relative to the neurocranium. This is particularly visible in snakes, which are able to open their mouths very wide to accommodate comparatively large prey. Squamata is the most variably sized order of reptiles, ranging from the dwarf gecko (''Sphaerodactylus ariasae'') to the Reticulated python (''Malayopython reticulatus'') and the now-extinct mosasaurs, which reached lengths over . Among other reptiles, squamates are most closely ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Squamate Dependoparvovirus 2
Squamata (, Latin ''squamatus'', 'scaly, having scales') is the largest order of reptiles, comprising lizards, snakes, and amphisbaenians (worm lizards), which are collectively known as squamates or scaled reptiles. With over 10,900 species, it is also the second-largest order of extant (living) vertebrates, after the perciform fish. Members of the order are distinguished by their skins, which bear horny scales or shields, and must periodically engage in molting. They also possess movable quadrate bones, making possible movement of the upper jaw relative to the neurocranium. This is particularly visible in snakes, which are able to open their mouths very wide to accommodate comparatively large prey. Squamata is the most variably sized order of reptiles, ranging from the dwarf gecko (''Sphaerodactylus ariasae'') to the Reticulated python (''Malayopython reticulatus'') and the now-extinct mosasaurs, which reached lengths over . Among other reptiles, squamates are most closely ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Secondary Structure
Protein secondary structure is the three dimensional conformational isomerism, form of ''local segments'' of proteins. The two most common Protein structure#Secondary structure, secondary structural elements are alpha helix, alpha helices and beta sheets, though beta turns and omega loops occur as well. Secondary structure elements typically spontaneously form as an intermediate before the protein protein folding, folds into its three dimensional protein tertiary structure, tertiary structure. Secondary structure is formally defined by the pattern of hydrogen bonds between the Amine, amino hydrogen and carboxyl oxygen atoms in the peptide backbone chain, backbone. Secondary structure may alternatively be defined based on the regular pattern of backbone Dihedral angle#Dihedral angles of proteins, dihedral angles in a particular region of the Ramachandran plot regardless of whether it has the correct hydrogen bonds. The concept of secondary structure was first introduced by Kaj Ulrik ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Icosahedral
In geometry, an icosahedron ( or ) is a polyhedron with 20 faces. The name comes and . The plural can be either "icosahedra" () or "icosahedrons". There are infinitely many non- similar shapes of icosahedra, some of them being more symmetrical than others. The best known is the (convex, non- stellated) regular icosahedron—one of the Platonic solids—whose faces are 20 equilateral triangles. Regular icosahedra There are two objects, one convex and one nonconvex, that can both be called regular icosahedra. Each has 30 edges and 20 equilateral triangle faces with five meeting at each of its twelve vertices. Both have icosahedral symmetry. The term "regular icosahedron" generally refers to the convex variety, while the nonconvex form is called a ''great icosahedron''. Convex regular icosahedron The convex regular icosahedron is usually referred to simply as the ''regular icosahedron'', one of the five regular Platonic solids, and is represented by its Schläfli symbol , co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rodent Dependoparvovirus 1
Rodents (from Latin , 'to gnaw') are mammals of the order Rodentia (), which are characterized by a single pair of continuously growing incisors in each of the upper and lower jaws. About 40% of all mammal species are rodents. They are native to all major land masses except for New Zealand, Antarctica, and several oceanic islands, though they have subsequently been introduced to most of these land masses by human activity. Rodents are extremely diverse in their ecology and lifestyles and can be found in almost every terrestrial habitat, including human-made environments. Species can be arboreal, fossorial (burrowing), saltatorial/richochetal (leaping on their hind legs), or semiaquatic. However, all rodents share several morphological features, including having only a single upper and lower pair of ever-growing incisors. Well-known rodents include mice, rats, squirrels, prairie dogs, porcupines, beavers, guinea pigs, and hamsters. Rabbits, hares, and pikas, whose incisors al ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
