Delphinium Staphisagria
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Delphinium Staphisagria
''Staphisagria macrosperma'', formerly known as ''Delphinium staphisagria'', is a species of '' Staphisagria'' of the family Ranunculaceae. It used to belong to the subgenus or section ''Staphisagria'' of the genus ''Delphinium'', but molecular evidence suggests ''Staphisagria'' should be a genus which is a sister group to the ''Aconitum''-''Delphinium'' clade. It is described botanically as a stoutly-stemmed, hairy biennial with large palmate leaves up to 6 inches (15 cm) across. The flowers are mauve-blue to blue, short-spurred, and up to 1 inch (2.5 cm) across, occurring in racemes. The plant grows to a height of 4–5 feet. It grows throughout the Mediterranean. All parts of this plant are highly toxic and should not be ingested in any quantity. Names The genus name ''Staphisagria'' and the common name stavesacre come from the Ancient Greek name mentioned by Dioscorides, σταφὶς ἀγρία (''staphis agria'', "wild raisin"). Dioscorides described the plant a ...
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Édouard Spach
Édouard Spach (23 November 1801 – 18 May 1879) was a French botanist. The son of a merchant in Strasbourg, in 1824 he went to Paris, where he studied botany with René Desfontaines (1750–1831) and Antoine-Laurent de Jussieu (1748–1836). He then became the secretary of Charles-François Brisseau de Mirbel (1776–1854). When de Mirbel became a professor at the Muséum national d'histoire naturelle (National Museum of Natural History), he followed him and remained at the museum for the remainder of his career. He published many monographs, including ''Histoire naturelle des végétaux. Phanérogames'' ("Natural history of plants: Spermatophytes"; fourteen volumes and an atlas, Roret, Paris, 1834–1848), and with Hippolyte François Jaubert (1798–1874), ''Illustrationes plantarum orientalium'' ("Illustrations of plants of the East"; five volumes, Roret, Paris, 1842–1857). The genus ''Spachea'' was named after him by Adrien-Henri de Jussieu
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John Uri Lloyd
John Uri Lloyd (April 19, 1849 – April 9, 1936) was an American pharmacist and leader of the eclectic medicine movement who was influential in the development of pharmacognosy, ethnobotany, economic botany, and herbalism.Michael A. Flannery, ''John Uri Lloyd: The Great American Eclectic'', Carbondale: Southern Illinois University Press, 1998. He also wrote novels set in northern Kentucky. His most popular novel was the science fiction or allegorical '' Etidorhpa, or, the end of the earth: the strange history of a mysterious being and the account of a remarkable journey'' (1895). First distributed privately, it was later illustrated and printed in eighteen editions. Translated into seven languages, it was widely read in Europe as well as the United States. Life and career John Uri Lloyd was born in upstate New York to teachers Sophia Webster and Nelson Marvin Lloyd. His family relocated to Florence and Petersburg in northern Kentucky, near Cincinnati, Ohio, in 1853. Lloyd ...
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Alkaloid
Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar structure may also be termed alkaloids. In addition to carbon, hydrogen and nitrogen, alkaloids may also contain oxygen, sulfur and, more rarely, other elements such as chlorine, bromine, and phosphorus.Chemical Encyclopedia: alkaloids
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Alkaloids are produced by a large variety of organisms including , , Medicinal plant, plants, an ...
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Diterpenoid
Diterpenes are a class of chemical compounds composed of four isoprene units, often with the molecular formula C20H32. They are biosynthesized by plants, animals and fungi via the HMG-CoA reductase pathway, with geranylgeranyl pyrophosphate being a primary intermediate. Diterpenes form the basis for biologically important compounds such as retinol, retinal, and phytol. They are known to be antimicrobial and antiinflammatory. Structures As with most terpenes a huge number of potential structures exists, which may be broadly divided according to the number of rings present. Biosynthesis Diterpenes are derived from the addition of one IPP unit to FPP to form geranylgeranyl-pyrophosphate (GGPP). From GGPP, structural diversity is achieved mainly by two classes of enzymes; the diterpene synthases and cytochromes P450. Several diterpenes are produced by plants and cyanobacteria. GGPP is also the precursor for the synthesis of the phytane by the action of the enzyme geranylger ...
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Delphinine
Delphinine is a toxic diterpenoid alkaloid found in plants from the ''Delphinium'' (larkspur) and '' Atragene'' (a clematis) genera, both in the family ''Ranunculaceae''. Delphinine is the principal alkaloid found in ''Delphinium staphisagria'' seeds – at one time, under the name stavesacre, a very well known herbal treatment for body lice. It is related in structure and has similar effects to aconitine, acting as an allosteric modulator of voltage gated sodium channels, and producing low blood pressure, slowed heart rate and abnormal heart rhythms. These effects make it highly poisonous ( 1.5–3.0 mg/kg in rabbit and dog; frogs are ~10x more susceptible). While it has been used in some alternative medicines (e.g. in herbal medicine), most of the medical community does not recommend using it due to its extreme toxicity. Isolation One of the earliest reports of the isolation of delphinine, from ''D. staphisagria'', was that of the French chemists Lassaigne and Feneulle, i ...
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Jean Louis Lassaigne
Jean Louis Lassaigne (22 September 1800 – 18 March 1859) was a French chemist. He is best known for the sodium fusion test named after him. Early life Lassaigne was born in Paris. Initially he worked in the laboratory of Louis Nicolas Vauquelin, and in 1828 was named professor of chemistry and physics at the ''École Royale Vétérinaire d’Alfort'' (Royal School of Veterinary) in Maisons-Alfort. He filled this role until 1854. Contributions and major works In 1825 Lassaigne partnered with François Leuret to publish ''"Recherches physiques et chimiques pour servir à l’historie de la digestion"'' (Physical and chemical research for understanding digestion). Four years later Lassaigne wrote an investigation about chemistry as part of medical sciences ''"Abrégé élémentaire de chimie considérée comme science accessoire à l'étude de la médecine, de la pharmacie et de l'histoire naturelle"'' (Elementary summary of chemistry considered as an ancillary science to the study ...
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Vermifuge
Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. They may also be called vermifuges (those that stun) or vermicides (those that kill). Anthelmintics are used to treat people who are infected by helminths, a condition called helminthiasis. These drugs are also used to treat infected animals. Pills containing anthelmintics are used in mass deworming campaigns of school-aged children in many developing countries. The drugs of choice for soil-transmitted helminths are mebendazole and albendazole; for schistosomiasis and tapeworms it is praziquantel. Types Antiparasitics that specifically target worms of the genus ''Ascaris'' are called ascaricides. * Benzimidazoles: ** Albendazole – effective against threadworms, roundworms, whipworms, tapeworms, hookworms ** Mebendazole – effective against va ...
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Maud Grieve
Maud Grieve in 1928 Sophie Emma Magdalene Grieve (née Law; 4 May 1858 – 21 December 1941) also known as Maud, Margaret, Maude or Mrs. Grieve, was the principal and founder of The Whins Medicinal and Commercial Herb School and Farm at Chalfont St. Peter in Buckinghamshire, England. Grieve was a Fellow of the Royal Horticultural Society, President of the British Guild of Herb Growers, and Fellow of the British Science Guild. She is best known for her 1931 book, ''A Modern Herbal''. Life Grieve was born in 1858 at 75 Upper Street, Islington, London.Baker, A. (2004-09-23). Grieve ée Law Sophia Emma Magdalene aud(1858–1941), herb grower. Oxford Dictionary of National Biography. Retrieved 2 Jan. 2018, Selink/ref> Grieve's father died in 1864 and she grew up in the care of relatives in Beckenham, London, where she received a good education. Following the death of her uncle in 1879, she was left an inheritance of a £1000. There is no record of her whereabouts or activities d ...
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Pediculicide
The treatment of human lice is the removal of head lice parasites from human hair. It has been debated and studied for centuries. However, the number of cases of human louse infestations (or pediculosis) has increased worldwide since the mid-1960s, reaching hundreds of millions annually. There is no product or method that assures 100% destruction of the eggs and hatched lice after a single treatment. However, there are a number of treatment modalities that can be employed with varying degrees of success. These methods include chemical treatments, natural products, combs, shaving, hot air, and silicone-based lotions. Treatment is recommended only after a clear diagnosis since all treatments have potential side effects. Louse eggs hatch 6–9 days after oviposition. Therefore, a common recommendation is to repeat treatment with a pediculicide at least once after 10 days, when all lice have hatched. Between the two treatments (Days 2–9) the person will still be infested with lice th ...
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Battle Of Waterloo
The Battle of Waterloo was fought on Sunday 18 June 1815, near Waterloo, Belgium, Waterloo (at that time in the United Kingdom of the Netherlands, now in Belgium). A French army under the command of Napoleon was defeated by two of the armies of the Seventh Coalition. One of these was a British-led coalition consisting of units from the United Kingdom of Great Britain and Ireland, United Kingdom, the Netherlands, Kingdom of Hanover, Hanover, Duchy of Brunswick, Brunswick, and Duchy of Nassau, Nassau, under the command of the Duke of Wellington (referred to by many authors as ''the Anglo-allied army'' or ''Wellington's army''). The other was composed of three corps of the Kingdom of Prussia, Prussian army under the command of Field Marshal Gebhard Leberecht von Blücher, von Blücher (the fourth corps of this army fought at the Battle of Wavre on the same day). The battle marked the end of the Napoleonic Wars. The battle was contemporaneously known as the Battle of Mont Saint-J ...
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Erection
An erection (clinically: penile erection or penile tumescence) is a physiological phenomenon in which the penis becomes firm, engorged, and enlarged. Penile erection is the result of a complex interaction of psychological, neural, vascular, and endocrine factors, and is often associated with sexual arousal or sexual attraction, although erections can also be spontaneous. The shape, angle, and direction of an erection varies considerably between humans. Physiologically, an erection is required for a male to effect vaginal penetration or sexual intercourse and is triggered by the parasympathetic division of the autonomic nervous system, causing the levels of nitric oxide (a vasodilator) to rise in the trabecular arteries and smooth muscle of the penis. The arteries dilate causing the corpora cavernosa of the penis (and to a lesser extent the corpus spongiosum) to fill with blood; simultaneously the ischiocavernosus and bulbospongiosus muscles compress the veins of the ...
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Papyrus
Papyrus ( ) is a material similar to thick paper that was used in ancient times as a writing surface. It was made from the pith of the papyrus plant, '' Cyperus papyrus'', a wetland sedge. ''Papyrus'' (plural: ''papyri'') can also refer to a document written on sheets of such material, joined side by side and rolled up into a scroll, an early form of a book. Papyrus is first known to have been used in Egypt (at least as far back as the First Dynasty), as the papyrus plant was once abundant across the Nile Delta. It was also used throughout the Mediterranean region. Apart from a writing material, ancient Egyptians employed papyrus in the construction of other artifacts, such as reed boats, mats, rope, sandals, and baskets. History Papyrus was first manufactured in Egypt as far back as the fourth millennium BCE.H. Idris Bell and T.C. Skeat, 1935"Papyrus and its uses"(British Museum pamphlet). The earliest archaeological evidence of papyrus was excavated in 2012 and 2 ...
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