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Deepak Shukla
Deepak Shukla (born in India) is an American molecular virologist with expertise in herpesviruses. He contributed to the discovery of HSV-1 entry receptors and establishing a link between the receptors and HSV-1 induced ocular diseases such as keratitis and retinitis. He has authored over 100 published papers and several book chapters on herpes viruses. Early life and education Shukla was born in Sir Sunderlal Hospital of Banaras Hindu University, Varanasi. He studied at Kendriya Vidyalaya BHU and obtained his bachelor's degree in chemistry from BHU. He also obtained a master's degree in biochemistry before joining the University of Illinois at Chicago (UIC) for a PhD degree in microbiology and immunology. In 1996 he was awarded his PhD. He received his postdoctoral training with Patricia Spear at Northwestern University in Chicago. Family He is the youngest son of Kala Rani Shukla and Ram Chandra Shukla. He has six siblings: Rekha, Pradeep, Dileep, Prakash, Rachana, and Anan ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Varanasi
Varanasi (; ; also Banaras or Benares (; ), and Kashi.) is a city on the Ganges river in northern India that has a central place in the traditions of pilgrimage, death, and mourning in the Hindu world. * * * * The city has a syncretic tradition of Muslim artisanship that underpins its religious tourism. * * * * * Located in the middle-Ganges valley in the southeastern part of the state of Uttar Pradesh, Varanasi lies on the left bank of the river. It is to the southeast of India's capital New Delhi and to the east of the state capital, Lucknow. It lies downstream of Allahabad (officially Prayagraj), where the confluence with the Yamuna river is another major Hindu pilgrimage site. Varanasi is one of the world's oldest continually inhabited cities. Kashi, its ancient name, was associated with a kingdom of the same name of 2,500 years ago. The Lion capital of Ashoka at nearby Sarnath has been interpreted to be a commemoration of the Buddha's first sermon there ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ram Chandra Shukla
Ram Chandra Shukla (1925–2016) was an Indian painter and art critic. Early life Shukla was born in a small village called Shukulpura of district Basti, Uttar Pradesh in a farmer's family. Soon after that his father shifted to a prominent, cultural city, Allahabad in Uttar Pradesh, where he grew up. He graduated from the Allahabad University and studied painting under a renowned Indian painter of the Bengal School, Kshitindra Nath Majumdar. He is honoured as "Proud Past Alumni" of Allahabad University by Allahabad University Alumni Association. Career Shukla joined Banaras Hindu University as a teacher of art in the Department of Painting. He retired as a professor and the Head of Department of Painting of Banaras Hindu University in the year 1985. Subsequently, he shifted to his native place, Allahabad, and started his studio there. Shukla does not try to sell his paintings; he simply wants to go in the depth of art itself and work as a spiritual painter, enjoying the bliss ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Living People
Related categories * :Year of birth missing (living people) / :Year of birth unknown * :Date of birth missing (living people) / :Date of birth unknown * :Place of birth missing (living people) / :Place of birth unknown * :Year of death missing / :Year of death unknown * :Date of death missing / :Date of death unknown * :Place of death missing / :Place of death unknown * :Missing middle or first names See also * :Dead people * :Template:L, which generates this category or death years, and birth year and sort keys. : {{DEFAULTSORT:Living people 21st-century people People by status ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Eye Institute
The National Eye Institute (NEI) was established in 1968. It is located in Bethesda, Maryland, United States. The NEI is one of 27 institutes and centers of the US National Institutes of Health (NIH), an agency of the US Department of Health and Human Services. The mission of NEI is to prolong and protect the vision of the American people. The NEI conducts and performs research into treating and preventing diseases affecting the eye or vision. History Before the NEI was established, primary responsibility for vision research at NIH was done by the National Institute of Neurological Disease and Blindness (NINDB) (which is now known as the National Institute of Neurological Disorders and Stroke). NINDB was established in 1950, after President Harry S. Truman signed the Omnibus Medical Research Act. The bill agreed to establish new separate institutes within NIH. This marked the beginning of vision research at a federal level. Organizing, structuring, and separating vision ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Syndecans
Syndecans are single transmembrane domain proteins that are thought to act as coreceptors, especially for G protein-coupled receptors. More specifically, these core proteins carry three to five heparan sulfate and chondroitin sulfate chains, i.e. they are proteoglycans, which allow for interaction with a large variety of ligands including fibroblast growth factors, vascular endothelial growth factor, transforming growth factor-beta, fibronectin and antithrombin-1. Interactions between fibronectin and some syndecans can be modulated by the extracellular matrix protein tenascin C. Family members and Structure The syndecan protein family has four members. Syndecans 1 and 3 and syndecans 2 and 4, making up separate subfamilies, arose by gene duplication and divergent evolution from a single ancestral gene. The syndecan numbers reflect the order in which the cDNAs for each family member were cloned. All syndecans have an N-terminal signal peptide, an ectodomain, a single hydroph ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Heparanase
Heparanase, also known as HPSE, is an enzyme that acts both at the cell-surface and within the extracellular matrix to degrade polymeric heparan sulfate molecules into shorter chain length oligosaccharides. Synthesis and structure The protein is originally synthesised in an inactive 65 kDa proheparanase form in the golgi apparatus and transferred to late endosomes/lysosomes for transport to the cell-surface. In the lysosome it is proteolytically processed into its active form. Proteolytic processing results in the production of three products, * a linker peptide * an 8 kDa proheparanase fragment and * a 50 kDa proheparanase fragment The 8 kDa and 50 kDa fragments form a heterodimer and it is this heterodimer that constitutes the active heparanase molecule. The linker protein is so called because prior to its excision it physically links the 8 kDa and 50 kDa proheparanase fragments. Complete excision of the linker peptide appears to be a prerequisite to the complete activation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Autophagy
Autophagy (or autophagocytosis; from the Ancient Greek , , meaning "self-devouring" and , , meaning "hollow") is the natural, conserved degradation of the cell that removes unnecessary or dysfunctional components through a lysosome-dependent regulated mechanism. It allows the orderly degradation and recycling of cellular components. Although initially characterized as a primordial degradation pathway induced to protect against starvation, it has become increasingly clear that autophagy also plays a major role in the homeostasis of non-starved cells. Defects in autophagy have been linked to various human diseases, including neurodegeneration and cancer, and interest in modulating autophagy as a potential treatment for these diseases has grown rapidly. Four forms of autophagy have been identified: macroautophagy, microautophagy, chaperone-mediated autophagy (CMA), and crinophagy. In macroautophagy (the most thoroughly researched form of autophagy), cytoplasmic components (like mit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ocular Infection
Eyes are organs of the visual system. They provide living organisms with vision, the ability to receive and process visual detail, as well as enabling several photo response functions that are independent of vision. Eyes detect light and convert it into electro-chemical impulses in neurons (neurones). In higher organisms, the eye is a complex optical system which collects light from the surrounding environment, regulates its intensity through a diaphragm, focuses it through an adjustable assembly of lenses to form an image, converts this image into a set of electrical signals, and transmits these signals to the brain through complex neural pathways that connect the eye via the optic nerve to the visual cortex and other areas of the brain. Eyes with resolving power have come in ten fundamentally different forms, and 96% of animal species possess a complex optical system. Image-resolving eyes are present in molluscs, chordates and arthropods. The most simple eyes, pit eyes, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nectin-1
Poliovirus receptor-related 1 (PVRL1), also known as nectin-1 and CD111 (formerly herpesvirus entry mediator C, HVEC) is a human protein of the immunoglobulin superfamily (IgSF), also considered a member of the nectins. It is a membrane protein with three extracellular immunoglobulin domains, a single transmembrane helix and a cytoplasmic tail. The protein can mediate Calcium in biology, Ca2+-independent cellular adhesion further characterizing it as IgSF cell adhesion molecule (IgSF CAM). Function PVRL1 is an adhesion molecule found in a wide range of tissues where it localizes in various junctions such as the adherens junction of epithelial tissue or the chemical synapse of neurons. The cytoplasmic tail of PVRL1 can bind the protein MLLT4, afadin which is a scaffolding protein that binds actin. In the chemical synapse PVRL1 interacts with PVRL3 (nectin-3) and both proteins can be found in neuronal tissue already in early stages of brain development as well as in aging brains ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HVEM
Herpesvirus entry mediator (HVEM), also known as tumor necrosis factor receptor superfamily member 14 (TNFRSF14), is a human cell surface receptor of the TNF-receptor superfamily. Nomenclature This protein was originally known as herpesvirus entry mediator A (HveA); HveB and HveC are structurally unrelated proteins of the immunoglobulin superfamily. It is also known as CD270 in the cluster of differentiation classification. Moreover, it is also referred to as ATAR (another TRAF-associated receptor). Function The protein encoded by this gene is a member of the TNF-receptor superfamily. The cytoplasmic region of this receptor was found to bind to several TNF receptor associated factor (TRAF) family members, which may mediate the signal transduction pathways that activate the immune response. In melanocytic cells TNFRSF14 gene expression may be regulated by MITF. Interactions TNFRSF14 has been shown to interact with TRAF2, TNFSF14 and TRAF5. Clinical relevance Mutations in t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Heparan Sulfate
Heparan sulfate (HS) is a linear polysaccharide found in all animal tissues. It occurs as a proteoglycan (HSPG, i.e. Heparan Sulfate ProteoGlycan) in which two or three HS chains are attached in close proximity to cell surface or extracellular matrix proteins. It is in this form that HS binds to a variety of protein ligands, including Wnt, and regulates a wide range of biological activities, including developmental processes, angiogenesis, blood coagulation, abolishing detachment activity by GrB (Granzyme B), and tumour metastasis. HS has also been shown to serve as cellular receptor for a number of viruses, including the respiratory syncytial virus. One study suggests that cellular heparan sulfate has a role in SARS-CoV-2 Infection, particularly when the virus attaches with ACE2. Proteoglycans The major cell membrane HSPGs are the transmembrane syndecans and the glycosylphosphatidylinositol (GPI) anchored glypicans. Other minor forms of membrane HSPG include betaglycan and the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immunology
Immunology is a branch of medicineImmunology for Medical Students, Roderick Nairn, Matthew Helbert, Mosby, 2007 and biology that covers the medical study of immune systems in humans, animals, plants and sapient species. In such we can see there is a difference of human immunology and comparative immunology in veterinary medicine and animal biosciences. Immunology measures, uses charts and differentiate in context in medicine the studies of immunity on cell and molecular level, and the immune system as part of the physiological level as its functioning is of major importance. In the different states of both health, occurring symptoms and diseases; the functioning of the immune system and immunological responses such as autoimmune diseases, allergic hypersensitivities, or in some cases malfunctioning of immune system as for example in immunological disorders or in immune deficiency, and the specific transplant rejection) Immunology has applications in numerous disciplines of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
