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David Leigh (scientist)
David Alan Leigh (born 1963) FRS FRSE FRSC is a British chemist, Royal Society Research Professor and, since 2014, the Sir Samuel Hall Chair of Chemistry in the Department of Chemistry at the University of Manchester. He was previously the Forbes Chair of Organic Chemistry at the University of Edinburgh (2001–2012) and Professor of Synthetic Chemistry at the University of Warwick (1998–2001). Education Leigh was educated at Codsall Community High School and the University of Sheffield. Career and research He is noted for the invention of fundamental methods to control molecular-level dynamics and entanglement, including strategies to construct rotaxanes, catenanes and molecular knots and some of the earliest synthetic molecular motors, molecular robots and functional nanomachines. Using mechanically-interlocked molecular architectures he prepared a novel molecular information ratchet that employs a mechanism reminiscent of Maxwell's demon (although it requires an energy i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oxford University Press
Oxford University Press (OUP) is the university press of the University of Oxford. It is the largest university press in the world, and its printing history dates back to the 1480s. Having been officially granted the legal right to print books by decree in 1586, it is the second oldest university press after Cambridge University Press. It is a department of the University of Oxford and is governed by a group of 15 academics known as the Delegates of the Press, who are appointed by the vice-chancellor of the University of Oxford. The Delegates of the Press are led by the Secretary to the Delegates, who serves as OUP's chief executive and as its major representative on other university bodies. Oxford University Press has had a similar governance structure since the 17th century. The press is located on Walton Street, Oxford, opposite Somerville College, in the inner suburb of Jericho. For the last 500 years, OUP has primarily focused on the publication of pedagogical texts and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fellow Of The Royal Society Of Chemistry
Fellowship of the Royal Society of Chemistry (FRSC) is an award conferred by the Royal Society of Chemistry (RSC) in the United Kingdom. FRSC award Achieving Fellow status in the chemical profession denotes to the wider community a high level of accomplishment as a professional chemist. Eligibility for Fellow status applies to applicants who are Members of the Royal Society of Chemistry (MRSC), with a minimum of 5 years professional experience. In addition, they must have made an outstanding contribution to the advancement of the chemical sciences; or to the advancement of the chemical sciences as a profession; or have been distinguished in the management of a chemical sciences organization. In all cases FRSC sponsor references are required. The award of designatory letters FRSC is subject to the final approval of the RSC Applications Committee. In addition to the above, all RSC membership requires acceptance and adherence to a specific code of conduct and an established set of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Trefoil Knot
In knot theory, a branch of mathematics, the trefoil knot is the simplest example of a nontrivial knot. The trefoil can be obtained by joining together the two loose ends of a common overhand knot, resulting in a knotted loop. As the simplest knot, the trefoil is fundamental to the study of mathematical knot theory. The trefoil knot is named after the three-leaf clover (or trefoil) plant. Descriptions The trefoil knot can be defined as the curve obtained from the following parametric equations: :\begin x &= \sin t + 2 \sin 2t \\ y &= \cos t - 2 \cos 2t \\ z &= -\sin 3t \end The (2,3)-torus knot is also a trefoil knot. The following parametric equations give a (2,3)-torus knot lying on torus (r-2)^2+z^2 = 1: :\begin x &= (2+\cos 3t) \cos 2t \\ y &= (2+\cos 3t )\sin 2t \\ z &= \sin 3t \end Any continuous deformation of the curve above is also considered a trefoil knot. Specifically, any curve isotopic to a trefoil knot is also considered to be a trefoil. In addition, the mi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Switch
A molecular switch is a molecule that can be reversibly shifted between two or more stable states. The molecules may be shifted between the states in response to environmental stimuli, such as changes in pH, light, temperature, an electric current, microenvironment, or in the presence of ions and other ligands. In some cases, a combination of stimuli is required. The oldest forms of synthetic molecular switches are pH indicators, which display distinct colors as a function of pH. Currently synthetic molecular switches are of interest in the field of nanotechnology for application in molecular computers or responsive drug delivery systems. Molecular switches are also important in biology because many biological functions are based on it, for instance allosteric regulation and vision. They are also one of the simplest examples of molecular machines. Biological molecular switches In cellular biology, proteins act as intracellular signaling molecules by activating another protein i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Second Law Of Thermodynamics
The second law of thermodynamics is a physical law based on universal experience concerning heat and Energy transformation, energy interconversions. One simple statement of the law is that heat always moves from hotter objects to colder objects (or "downhill"), unless energy in some form is supplied to reverse the direction of heat flow. Another definition is: "Not all heat energy can be converted into Work (thermodynamics), work in a cyclic process."Young, H. D; Freedman, R. A. (2004). ''University Physics'', 11th edition. Pearson. p. 764. The second law of thermodynamics in other versions establishes the concept of entropy as a physical property of a thermodynamic system. It can be used to predict whether processes are forbidden despite obeying the requirement of conservation of energy as expressed in the first law of thermodynamics and provides necessary criteria for spontaneous processes. The second law may be formulated by the observation that the entropy of isolated systems ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Maxwell's Demon
Maxwell's demon is a thought experiment that would hypothetically violate the second law of thermodynamics. It was proposed by the physicist James Clerk Maxwell in 1867. In his first letter Maxwell called the demon a "finite being", while the ''Daemon'' name was first used by Lord Kelvin. In the thought experiment, a demon controls a small massless door between two chambers of gas. As individual gas molecules (or atoms) approach the door, the demon quickly opens and closes the door to allow only fast-moving molecules to pass through in one direction, and only slow-moving molecules to pass through in the other. Because the kinetic temperature of a gas depends on the velocities of its constituent molecules, the demon's actions cause one chamber to warm up and the other to cool down. This would decrease the total entropy of the two gases, without applying any work, thereby violating the second law of thermodynamics. The concept of Maxwell's demon has provoked substantial debate i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mechanically-interlocked Molecular Architectures
In chemistry, mechanically-interlocked molecular architectures (MIMAs) are molecules that are connected as a consequence of their topology. This connection of molecules is analogous to keys on a keychain loop. The keys are not directly connected to the keychain loop but they cannot be separated without breaking the loop. On the molecular level, the interlocked molecules cannot be separated without the breaking of the covalent bonds that comprise the conjoined molecules; this is referred to as a mechanical bond. Examples of mechanically interlocked molecular architectures include catenanes, rotaxanes, molecular knots, and molecular Borromean rings. Work in this area was recognized with the 2016 Nobel Prize in Chemistry to Bernard L. Feringa, Jean-Pierre Sauvage, and J. Fraser Stoddart. The synthesis of such entangled architectures has been made efficient by combining supramolecular chemistry with traditional covalent synthesis, however mechanically interlocked molecular architectu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Knots
In chemistry, a molecular knot is a mechanically interlocked molecular architecture that is analogous to a macroscopic knot. Naturally-forming molecular knots are found in organic molecules like DNA, RNA, and proteins. It is not certain that naturally occurring knots are evolutionarily advantageous to nucleic acids or proteins, though knotting is thought to play a role in the structure, stability, and function of knotted biological molecules. The mechanism by which knots naturally form in molecules, and the mechanism by which a molecule is stabilized or improved by knotting, is ambiguous. The study of molecular knots involves the formation and applications of both naturally occurring and chemically synthesized molecular knots. Applying chemical topology and knot theory to molecular knots allows biologists to better understand the structures and synthesis of knotted organic molecules. The term ''knotane'' was coined by Vögtle ''et al.'' in 2000 to describe molecular knots ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Catenane
In macromolecular chemistry, a catenane () is a mechanically interlocked molecular architecture consisting of two or more interlocked macrocycles, i.e. a molecule containing two or more intertwined rings. The interlocked rings cannot be separated without breaking the covalent bonds of the macrocycles. They are conceptually related to other mechanically interlocked molecular architectures, such as rotaxanes, molecular knots or molecular Borromean rings. Recently the terminology "mechanical bond" has been coined that describes the connection between the macrocycles of a catenane. Catenanes have been synthesised in two different ways: statistical synthesis and template-directed synthesis. Synthesis There are two primary approaches to the organic synthesis of catenanes. The first is to simply perform a ring-closing reaction with the hope that some of the rings will form around other rings giving the desired catenane product. This so-called "statistical approach" led to the fi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rotaxane
In chemistry, a rotaxane () is a mechanically interlocked molecular architecture consisting of a dumbbell-shaped molecule which is threaded through a macrocycle (see graphical representation). The two components of a rotaxane are kinetically trapped since the ends of the dumbbell (often called ''stoppers'') are larger than the internal diameter of the ring and prevent dissociation (unthreading) of the components since this would require significant distortion of the covalent bonds. Much of the research concerning rotaxanes and other mechanically interlocked molecular architectures, such as catenanes, has been focused on their efficient synthesis or their utilization as artificial molecular machines. However, examples of rotaxane substructure have been found in naturally occurring peptides, including: cystine knot peptides, cyclotides or lasso-peptides such as microcin J25. Synthesis The earliest reported synthesis of a rotaxane in 1967 relied on the statistical probabili ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Codsall Community High School
Codsall Community High School is a coeducational upper school and sixth form located in Codsall, Staffordshire, England. It is located in a large village in South Staffordshire, near Wolverhampton. A total of 1017 pupils (including more than 300 sixth formers) attend the school. History Codsall High School was opened in May 1940, taking 126 pupils aged 11 and over from the village's school by St Nicholas Church. The school also took pupils from the neighbouring village of Bilbrook. After the war, the school expanded; by 1954, there were 728 children on the roll. An extension was opened in 1957, including the school's present Main Hall. A small swimming pool was constructed in the school's quadrangle in 1964, a roof was added in the 1970s. The school became an 11-18 Comprehensive in 1969; at the same time, headteacher George Gibbs retired and was replaced by Ron Mitson. A further extension was built in the early 1970s, and the school's catchment area expanded to include the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Department Of Chemistry, University Of Manchester
The Department of Chemistry at the University of Manchester is one of the largest Departments of Chemistry in the United Kingdom, with over 600 undergraduate and more than 200 postgraduate research students. The department has comprehensive academic coverage across the chemical sciences and in all the core sub-disciplines of chemistry, with over 120 postdoctoral researchers. Current Management Board * Head of School: Prof. David Procter * Head of Education: Dr. Alan Brisdon * Undergraduate Program Director: Dr. Andrew Regan * Subject Lead (Inorganic): Prof. David Collison * Subject Lead (Organic): Dr. Andrew Regan * Subject Lead (Physical): Prof. Nick Lockyer * Head of Teaching and Scholarship: Dr. Jenny Slaughter * PASS Management Staff: Dr. Nicholas Weise * Undergraduate Admissions Tutor: Dr. Sam Hay * International Studies: Dr. Lu Shin Wong Notable faculty The department employs 34 full-time Professors and 11 Emeritus Professors including: * David Procter, Head of School, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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