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Dactylosporangium Aurantiacum
''Dactylosporangium aurantiacum'' is a Gram-positive soil-based actinobacterium in the family Micromonosporaceae. Like all '' Dactylosporangium'' species, ''aurantiacum'' is aerobic and mesophilic. One subspecies, ''hamdenesis'', produces a number of 18-membered macrolide antibiotics called tiacumicins as a byproduct of fermentation. One of these, tiacumicin B, commonly known as fidaxomicin Fidaxomicin, sold under the brand name Dificid among others, is the first member of a class of narrow spectrum macrocyclic antibiotic drugs called tiacumicins. It is a fermentation product obtained from the actinomycete '' Dactylosporangium aura ..., has narrow-spectrum bacteriocidal action against Gram-positive anaerobic bacteria, including '' Clostridium difficile''. References Micromonosporaceae {{Actinobacteria-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gram-positive
In bacteriology, gram-positive bacteria are bacteria that give a positive result in the Gram stain test, which is traditionally used to quickly classify bacteria into two broad categories according to their type of cell wall. Gram-positive bacteria take up the crystal violet stain used in the test, and then appear to be purple-coloured when seen through an optical microscope. This is because the thick peptidoglycan layer in the bacterial cell wall retains the stain after it is washed away from the rest of the sample, in the decolorization stage of the test. Conversely, gram-negative bacteria cannot retain the violet stain after the decolorization step; alcohol used in this stage degrades the outer membrane of gram-negative cells, making the cell wall more porous and incapable of retaining the crystal violet stain. Their peptidoglycan layer is much thinner and sandwiched between an inner cell membrane and a bacterial outer membrane, causing them to take up the counterstain (saf ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Actinobacterium
The ''Actinomycetota'' (or ''Actinobacteria'') are a phylum of all gram-positive bacteria. They can be terrestrial or aquatic. They are of great economic importance to humans because agriculture and forests depend on their contributions to soil systems. In soil they help to decompose the organic matter of dead organisms so the molecules can be taken up anew by plants. While this role is also played by fungi, ''Actinomycetota'' are much smaller and likely do not occupy the same ecological niche. In this role the colonies often grow extensive mycelia, like a fungus would, and the name of an important order of the phylum, '' Actinomycetales'' (the actinomycetes), reflects that they were long believed to be fungi. Some soil actinomycetota (such as ''Frankia'') live symbiotically with the plants whose roots pervade the soil, fixing nitrogen for the plants in exchange for access to some of the plant's saccharides. Other species, such as many members of the genus '' Mycobacterium'', ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Micromonosporaceae
Micromonosporaceae is a family of bacteria of the class ''Actinomycetia''. They are gram-positive, spore-forming soil organisms that form a true mycelium. Genera Micromonosporaceae comprises the following genera: * ''Actinocatenispora'' Thawai et al. 2006 * ''Actinoplanes'' Couch 1950 (Approved Lists 1980) * ''Actinorhabdospora'' Mingma et al. 2016 * '' Allocatelliglobosispora'' Lee and Lee 2011 * ''Allorhizocola'' Sun et al. 2019 * '' Asanoa'' Lee and Hah 2002 * '' Catellatospora'' Asano and Kawamoto 1986 * ''Catelliglobosispora'' Ara et al. 2008 * '' Catenuloplanes'' Yokota et al. 1993 * '' Couchioplanes'' Tamura et al. 1994 * ''Dactylosporangium'' Thiemann et al. 1967 (Approved Lists 1980) * ''Hamadaea'' Ara et al. 2008 * ''Krasilnikovia'' Ara and Kudo 2007 * ''Longispora'' Matsumoto et al. 2003 * ''Luedemannella'' Ara and Kudo 2007 * '' Mangrovihabitans'' Liu et al. 2017 * ''Micromonospora'' Ørskov 1923 (Approved Lists 1980) * "'' Natronosporangium''" Sorokin et al. 20 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dactylosporangium
''Dactylosporangium'' is a genus of bacteria in the phylum Actinomycetota. Etymology The name ''Dactylosporangium'' derives from:Greek noun ''daktulos'', finger; Greek noun ''spora (σπορά)'', a seed, and in biology a spore; Greek neuter gender noun ''angeion'' (Latin transliteration ''angium''), vessel ; New Latin neuter gender noun ''Dactylosporangium'' an organism with finger-shaped, spore-containing vessels (sporangia). Species The genus ''Dactylosporangium'' comprises the following species: * '' D. aurantiacum'' Thiemann et al. 1967 (Approved Lists 1980) (New Latin neuter gender adjective ''aurantiacum'', orange colored.) * '' D. cerinum'' Liu et al. 2015 * '' D. darangshiense'' Seo and Lee 2010 (New Latin neuter gender adjective ''darangshiense'', of or pertaining to Darangshi, referring to Darangshi Oreum in Jeju, Republic of Korea, the site from which the type strain was isolated.) * '' D. fulvum'' Shomura et al. 1986 (Latin neuter gender adjective ''fulvum'', deep y ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tiacumicin
Tiacumicins are a family of macrolide antibiotics derived from '' Dactylosporangium aurantiacum'' subspecies hamdenesis subspecies Nov. The tiacumicin family of antibiotics has substantial overlap with the clostomicin family. Six 18-membered antibiotics in the tiacumicin family have been identified: tiacumicins A through F. Currently, only one of these, tiacumicin B (also lipiarmycin, clostomicin B1) is commercially available, under the generic name fidaxomicin Fidaxomicin, sold under the brand name Dificid among others, is the first member of a class of narrow spectrum macrocyclic antibiotic drugs called tiacumicins. It is a fermentation product obtained from the actinomycete '' Dactylosporangium aura .... References {{antibiotic-stub Macrolide antibiotics ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fidaxomicin
Fidaxomicin, sold under the brand name Dificid among others, is the first member of a class of narrow spectrum macrocyclic antibiotic drugs called tiacumicins. It is a fermentation product obtained from the actinomycete ''Dactylosporangium aurantiacum'' subspecies ''hamdenesis''. Fidaxomicin is minimally absorbed into the bloodstream when taken orally, is bactericidal, and selectively eradicates pathogenic ''Clostridioides difficile'' with relatively little disruption to the multiple species of bacteria that make up the normal, healthy intestinal microbiota. The maintenance of normal physiological conditions in the colon may reduce the probability of recurrence of ''Clostridioides difficile'' infection. It is marketed by Merck, which acquired Cubist Pharmaceuticals in 2015, and had in turn bought the originating company, Optimer Pharmaceuticals. It is used for the treatment of ''Clostridioides difficile'' infection, which is also known as ''Clostridioides difficile''-associate ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clostridium Difficile (bacteria)
''Clostridioides difficile'' ( syn. ''Clostridium difficile'') is a bacterium that is well known for causing serious diarrheal infections, and may also cause colon cancer. Also known as ''C. difficile'', or ''C. diff'' (), is Gram-positive species of spore-forming bacteria. ''Clostridioides'' spp. are anaerobic, motile bacteria, ubiquitous in nature and especially prevalent in soil. Its vegetative cells are rod-shaped, pleomorphic, and occur in pairs or short chains. Under the microscope, they appear as long, irregular (often drumstick- or spindle-shaped) cells with a bulge at their terminal ends (forms subterminal spores). Under Gram staining, ''C. difficile'' cells are Gram-positive and show optimum growth on blood agar at human body temperatures in the absence of oxygen. ''C. difficile'' is catalase- and superoxide dismutase-negative, and produces up to three types of toxins: enterotoxin A, cytotoxin B and Clostridioides difficile transferase (CDT). Under stress condition ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
