Cécile Vogt-Mugnier
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Cécile Vogt-Mugnier
Cécile Vogt-Mugnier (27 March 1875 – 4 May 1962) was a French neurologist from Haute-Savoie. She and her husband Oskar Vogt are known for their extensive cytology, cytoarchetectonic studies on the brain. Professional life Education and career Vogt-Mugnier obtained her medical Doctorate degree, doctorate in Paris in 1900 and studied under Pierre Marie at the Bicêtre Hospital. At the time, women only made up 6% of those receiving medical doctorates, even though it had been thirty years since women were first admitted to medical studies.Helga Satzinger Femininity and Science: The Brain Researcher Cécile Vogt (1875-1962). Translation of: Weiblichkeit und Wissenschaft. In: Bleker, Johanna (ed.): Der Eintritt der Frauen in die Gelehrtenrepublik. Husum, 1998, 75-93. Vogt-Mugnier and her husband's findings on myelinogenesis led to her dissertation work on the fiber systems in the cat cerebral cortex (''Étude sur la myelination of hémishères cérébraux'') and the beginning of t ...
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Oskar Vogt
Oskar Vogt (6 April 1870, in Husum – 30 July 1959, in Freiburg im Breisgau) was a German physician and neurologist. He and his wife Cécile Vogt-Mugnier are known for their extensive cytoarchetectonic studies on the brain. Personal life He was born in Husum, Schleswig-Holstein, Germany. Vogt studied medicine at Kiel and Jena, obtaining his doctorate from Jena in 1894. The Vogts met in 1897 in Paris, and eventually married in 1899. The Vogts were close to the Krupp family. Friedrich Alfred Krupp financially supported them, and in 1898, Oskar and Cécile founded a private research institute called the ''Neurologische Zentralstation'' (Neurological Center) in Berlin, which was formally associated with the Physiological Institute of the Charité as the Neurobiological Laboratory of the Berlin University in 1902. This institute served as the basis for the 1914 formation of the ''Kaiser Institut für Hirnforschung'' (Kaiser Wilhelm Institute for Brain Research), of which Oskar was a ...
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Paris
Paris () is the capital and most populous city of France, with an estimated population of 2,165,423 residents in 2019 in an area of more than 105 km² (41 sq mi), making it the 30th most densely populated city in the world in 2020. Since the 17th century, Paris has been one of the world's major centres of finance, diplomacy, commerce, fashion, gastronomy, and science. For its leading role in the arts and sciences, as well as its very early system of street lighting, in the 19th century it became known as "the City of Light". Like London, prior to the Second World War, it was also sometimes called the capital of the world. The City of Paris is the centre of the Île-de-France region, or Paris Region, with an estimated population of 12,262,544 in 2019, or about 19% of the population of France, making the region France's primate city. The Paris Region had a GDP of €739 billion ($743 billion) in 2019, which is the highest in Europe. According to the Economis ...
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Cercopithecus
The guenons (, ) are Old World monkeys of the genus ''Cercopithecus'' (). Not all members of this genus have the word "guenon" in their common names; also, because of changes in scientific classification, some monkeys in other genera may have common names that include the word "guenon". Nonetheless, the use of the term guenon for monkeys of this genus is widely accepted. All members of the genus are endemic to sub-Saharan Africa, and most are forest monkeys. Many of the species are quite local in their ranges, and some have even more local subspecies. Many are threatened or endangered because of habitat loss. The species currently placed in the genus '' Chlorocebus'', such as vervet monkeys and green monkeys, were formerly considered as a single species in this genus, ''Cercopithecus aethiops''. In the English language, the word "guenon" is apparently of French origin. In French, ''guenon'' was the common name for all species and individuals, both males and females, from the ...
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Thalamus
The thalamus (from Greek θάλαμος, "chamber") is a large mass of gray matter located in the dorsal part of the diencephalon (a division of the forebrain). Nerve fibers project out of the thalamus to the cerebral cortex in all directions, allowing hub-like exchanges of information. It has several functions, such as the relaying of sensory signals, including motor signals to the cerebral cortex and the regulation of consciousness, sleep, and alertness. Anatomically, it is a paramedian symmetrical structure of two halves (left and right), within the vertebrate brain, situated between the cerebral cortex and the midbrain. It forms during embryonic development as the main product of the diencephalon, as first recognized by the Swiss embryologist and anatomist Wilhelm His Sr. in 1893. Anatomy The thalamus is a paired structure of gray matter located in the forebrain which is superior to the midbrain, near the center of the brain, with nerve fibers projecting out to th ...
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Cytoarchitecture
Cytoarchitecture ( Greek '' κύτος''= "cell" + '' ἀρχιτεκτονική''= "architecture"), also known as cytoarchitectonics, is the study of the cellular composition of the central nervous system's tissues under the microscope. Cytoarchitectonics is one of the ways to parse the brain, by obtaining sections of the brain using a microtome and staining them with chemical agents which reveal where different neurons are located. The study of the parcellation of ''nerve fibers'' (primarily axons) into layers forms the subject of myeloarchitectonics (


History of the cerebral cytoarchitecture

Defining cerebral cytoarchitecture began with the advent of histology—the science of slicing and staining brain slices fo ...
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Paul Flechsig
Paul Emil Flechsig (29 June 1847, Zwickau, Kingdom of Saxony – 22 July 1929, Leipzig) was a German neuroanatomist, psychiatrist and neuropathologist. He is mainly remembered today for his research of myelinogenesis. Biography Born in Zwickau, he received his education at the University of Leipzig and in 1884 became professor of psychiatry there. In 1882, he became director of the Clinical Institute of Psychiatry and Neurology at Leipzig. He made personal investigations of the European systems for the treatment of the insane, on which he was a recognized authority. He spent over fifty years of his medical career at Leipzig. Although Flechsig contributed much in his study of neurological disorders, he is mainly remembered today for his research of myelinogenesis. Among his students were Emil Kraepelin and Oskar Vogt (mentor to Korbinian Brodmann). Flechsig was the treating psychiatrist for Daniel Paul Schreber, whose memoir inspired Sigmund Freud to publish a detailed analysi ...
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Myelination
Myelin is a lipid-rich material that surrounds nerve cell axons (the nervous system's "wires") to insulate them and increase the rate at which electrical impulses (called action potentials) are passed along the axon. The myelinated axon can be likened to an electrical wire (the axon) with insulating material (myelin) around it. However, unlike the plastic covering on an electrical wire, myelin does not form a single long sheath over the entire length of the axon. Rather, myelin sheaths the nerve in segments: in general, each axon is encased with multiple long myelinated sections with short gaps in between called nodes of Ranvier. Myelin is formed in the central nervous system (CNS; brain, spinal cord and optic nerve) by glial cells called oligodendrocytes and in the peripheral nervous system (PNS) by glial cells called Schwann cells. In the CNS, axons carry electrical signals from one nerve cell body to another. In the PNS, axons carry signals to muscles and glands or from senso ...
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Monograph
A monograph is a specialist work of writing (in contrast to reference works) or exhibition on a single subject or an aspect of a subject, often by a single author or artist, and usually on a scholarly subject. In library cataloging, ''monograph'' has a broader meaning—that of a nonserial publication complete in one volume (book) or a definite number of volumes. Thus it differs from a serial or periodical publication such as a magazine, academic journal, or newspaper. In this context only, books such as novels are considered monographs.__FORCETOC__ Academia The English term "monograph" is derived from modern Latin "monographia", which has its root in Greek. In the English word, "mono-" means "single" and "-graph" means "something written". Unlike a textbook, which surveys the state of knowledge in a field, the main purpose of a monograph is to present primary research and original scholarship ascertaining reliable credibility to the required recipient. This research is ...
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Korbinian Brodmann
Korbinian Brodmann (17 November 1868 – 22 August 1918) was a German neurologist who became famous for mapping the cerebral cortex and defining 52 distinct regions, known as Brodmann areas, based on their cytoarchitectonic ( histological) characteristics. Life and career Brodmann was born in Liggersdorf, Province of Hohenzollern. He studied medicine in Munich, Würzburg, Berlin, and Freiburg, where he received his medical diploma in 1895. Subsequently he studied at the Medical School in the University of Lausanne in Switzerland, and then worked in the University Clinic in Munich. He received a doctor of medicine degree from the University of Leipzig in 1898, with a thesis on chronic ependymal sclerosis. From 1900 to 1901, Brodmann also worked in the Psychiatric Clinic at the University of Jena, with Ludwig Binswanger, and in the Municipal Mental Asylum in Frankfurt. There, he met Alois Alzheimer, who was influential in his decision to pursue basic neuroscience research ...
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Bioelectromagnetics
Bioelectromagnetics, also known as bioelectromagnetism, is the study of the interaction between electromagnetic fields and biological entities. Areas of study include electromagnetic fields produced by living cells, tissues or organisms, the effects of man-made sources of electromagnetic fields like mobile phones, and the application of electromagnetic radiation toward therapies for the treatment of various conditions. Biological phenomena Bioelectromagnetism is studied primarily through the techniques of electrophysiology. In the late eighteenth century, the Italian physician and physicist Luigi Galvani first recorded the phenomenon while dissecting a frog at a table where he had been conducting experiments with static electricity. Galvani coined the term ''animal electricity'' to describe the phenomenon, while contemporaries labeled it galvanism. Galvani and contemporaries regarded muscle activation as resulting from an electrical fluid or substance in the nerves. Short ...
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Cerebral Cortex
The cerebral cortex, also known as the cerebral mantle, is the outer layer of neural tissue of the cerebrum of the brain in humans and other mammals. The cerebral cortex mostly consists of the six-layered neocortex, with just 10% consisting of allocortex. It is separated into two cortices, by the longitudinal fissure that divides the cerebrum into the left and right cerebral hemispheres. The two hemispheres are joined beneath the cortex by the corpus callosum. The cerebral cortex is the largest site of neural integration in the central nervous system. It plays a key role in attention, perception, awareness, thought, memory, language, and consciousness. The cerebral cortex is part of the brain responsible for cognition. In most mammals, apart from small mammals that have small brains, the cerebral cortex is folded, providing a greater surface area in the confined volume of the cranium. Apart from minimising brain and cranial volume, cortical folding is crucial for ...
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Neocortex
The neocortex, also called the neopallium, isocortex, or the six-layered cortex, is a set of layers of the mammalian cerebral cortex involved in higher-order brain functions such as sensory perception, cognition, generation of motor commands, spatial reasoning and language. The neocortex is further subdivided into the true isocortex and the proisocortex. In the human brain, the neocortex is the largest part of the cerebral cortex (the outer layer of the cerebrum). The neocortex makes up the largest part of the cerebral cortex, with the allocortex making up the rest. The neocortex is made up of six layers, labelled from the outermost inwards, I to VI. Etymology The term is from ''cortex'', Latin, "bark" or "rind", combined with ''neo-'', Greek, "new". ''Neopallium'' is a similar hybrid, from Latin ''pallium'', "cloak". ''Isocortex'' and ''allocortex'' are hybrids with Greek ''isos'', "same", and ''allos'', "other". Anatomy The neocortex is the most developed in its organis ...
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