Croton Lechleri
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Croton Lechleri
''Croton lechleri'' is a species of flowering plant in the spurge family, Euphorbiaceae, that is native to northwestern South America. It is commonly known as ''sangre de grado'' (Peruvian Spanish), ''sangre de drago'' (Ecuadorian Spanish) or ''sangre de grada'' (Bolivian Spanish), both of which translate to "dragon's blood".Meza, E.N.(Editor). 1999. They refer to this tree's (and several related species') thick red latex. The latex has medicinal properties, and is used by local peoples as a liquid bandage, applied to seal wounds, as it dries quickly to form a protective skin-like barrier. Its use by native people has led to scientific study and observation of its ''in vitro'' antioxidant activity as well as both mutagenic and antimutagenic behavior. The latex also contains a number of chemicals, including taspine. Oligomeric proanthocyanidins, another kind of chemical contained in the latex, have been investigated for the treatment of HIV-associated diarrhea under the name c ...
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Jatropha Dioica
''Jatropha dioica'' is a species of flowering plant in the spurge family, Euphorbiaceae, that is native to Texas in the United States as well as Mexico as far south as Oaxaca. Common names include leatherstem and sangre de drago. The specific name refers to the dioecious nature of the plants. Description ''Jatropha dioica'' forms colonies from subterranean rhizomes. The arching, succulent stems reach a height of 20–60 cm and have few branches. They are tough and sufficiently flexible to be tied into overhand knots without breaking. The orange rootstock spreads to a length of around 1 m. Leaves are arranged simply, alternately, or fascicularly and are clustered on short shoots extending from the stems. They are subsessile and have entire margins. The leaves of the nominate variety are linear and measure up to 6 × 1 cm, whereas the leaves of ''J. dioica'' var. ''graminea'' may be 2 to 3-lobed and measure up to 6.5 × 0.5 cm. Male inflorescences are clustered ...
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Food And Drug Administration
The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is responsible for protecting and promoting public health through the control and supervision of food safety, tobacco products, caffeine products, dietary supplements, Prescription drug, prescription and Over-the-counter drug, over-the-counter pharmaceutical drugs (medications), vaccines, biopharmaceuticals, blood transfusions, medical devices, electromagnetic radiation emitting devices (ERED), cosmetics, Animal feed, animal foods & feed and Veterinary medicine, veterinary products. The FDA's primary focus is enforcement of the Federal Food, Drug, and Cosmetic Act (FD&C), but the agency also enforces other laws, notably Section 361 of the Public Health Service Act, as well as associated regulations. Much of this regulatory-enforcement work is not d ...
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Trichophyton
''Trichophyton'' is a genus of fungi, which includes the parasitic varieties that cause tinea, including athlete's foot, ringworm, jock itch, and similar infections of the nail, beard, skin and scalp. Trichophyton fungi are molds characterized by the development of both smooth-walled macro- and microconidia. Macroconidia are mostly borne laterally directly on the hyphae or on short pedicels, and are thin- or thick-walled, clavate to fusiform, and range from 4 to 8 by 8 to 50 μm in size. Macroconidia are few or absent in many species. Microconidia are spherical, pyriform to clavate or of irregular shape, and range from 2 to 3 by 2 to 4 μm in size. Species and their habitat preference According to current classification, the genus includes anthropophilic and zoophilic species. Anthropophilic fungi prefer to infect humans. Zoophilic fungi prefer to infect animals other than humans. Humans and animals are natural reservoirs for parasitic or dermatophytic fungi. Other accepted ...
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Taspine
Taspine is an alkaloid which acts as a potent acetylcholinesterase inhibitor and cicatrizant. It is found in various plants including '' Magnolia x soulangeana'' and ''Croton lechleri ''Croton lechleri'' is a species of flowering plant in the spurge family, Euphorbiaceae, that is native to northwestern South America. It is commonly known as ''sangre de grado'' (Peruvian Spanish), ''sangre de drago'' (Ecuadorian Spanish) or '' ...''. The first total synthesis was reported by T. Ross Kelly and Roger L. Xie in 1998. References Acetylcholinesterase inhibitors Alkaloids found in Euphorbiaceae Phenethylamine alkaloids Lactones Dimethylamino compounds {{Alkaloid-stub ...
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Quinine
Quinine is a medication used to treat malaria and babesiosis. This includes the treatment of malaria due to ''Plasmodium falciparum'' that is resistant to chloroquine when artesunate is not available. While sometimes used for nocturnal leg cramps, quinine is not recommended for this purpose due to the risk of serious side effects. It can be taken by mouth or intravenously. Malaria resistance to quinine occurs in certain areas of the world. Quinine is also used as an ingredient in tonic water to impart a bitter taste. Common side effects include headache, ringing in the ears, vision issues, and sweating. More severe side effects include deafness, low blood platelets, and an irregular heartbeat. Use can make one more prone to sunburn. While it is unclear if use during pregnancy causes harm to the baby, treating malaria during pregnancy with quinine when appropriate is still recommended. Quinine is an alkaloid, a naturally occurring chemical compound. How it works as a medicin ...
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Jesuit's Bark
Jesuit's bark, also known as cinchona bark, Peruvian bark or China bark, is a former remedy for malaria, as the bark contains quinine used to treat the disease. The bark of several species of the genus ''Cinchona'', family Rubiaceae indigenous to the western Andes of South America, was discovered as a folk medicine treatment for malaria by Jesuit missionaries in Peru during the 17th century. History The western history of cinchona bark dates back more than 350 years. Circa 1650, the physician Sebastiano Bado declared that this bark had proved more precious to mankind than all the gold and silver that the Spaniards had obtained from South America. In the 18th century, the Italian professor of medicine Bernardino Ramazzini said that the introduction of Peruvian bark would be of the same importance to medicine that the discovery of gunpowder was to the art of war, an opinion endorsed by contemporary writers on the history of medicine. The value of Jesuit's bark, and the controvers ...
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Cinchona
''Cinchona'' (pronounced or ) is a genus of flowering plants in the family Rubiaceae containing at least 23 species of trees and shrubs. All are native to the Tropical Andes, tropical Andean forests of western South America. A few species are reportedly naturalization (biology), naturalized in Central America, Jamaica, French Polynesia, Sulawesi, Saint Helena in the South Atlantic, and São Tomé and Príncipe off the coast of tropical Africa, and others have been cultivated in India and Java, where they have formed hybrids. ''Cinchona'' has been historically sought after for its medicinal value, as the bark of several species yields quinine and other alkaloids. These were the only effective treatments against malaria during the height of European colonialism, which made them of great economic and political importance. Trees in the genus are also known as fever trees because of their anti-malarial properties. The artificial Quinine total synthesis, synthesis of quinine in 1944 ...
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Bernabé Cobo
Padre Bernabé Cobo (born at Lopera in Spain, 1582; died at Lima, Peru, 9 October 1657) was a Spanish Jesuit missionary and writer. He played a part in the early history of quinine by his description of cinchona bark; he brought some to Europe on a visit in 1632. He was a thorough student of nature and man in Spanish America. His long residence (61 years), his position as a priest and, several times, as a missionary, gave him unusual opportunities for obtaining reliable information. The Spanish botanist Cavanilles gave the name of ''Cobaea'' to a genus of plants belonging to the Polemoniaceae of Mexico, '' Cobaea scandens'' being its most striking representative. Life He went to America in 1596, visiting the Antilles and Venezuela and landing at Lima in 1599. Entering the Society of Jesus, 14 October 1601, he was sent by his superiors in 1615 to the mission of Juli, where, and at Potosí, Cochabamba, Oruro, and La Paz, he laboured until 1618. He was rector of the college of ...
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Venezuela
Venezuela (; ), officially the Bolivarian Republic of Venezuela ( es, link=no, República Bolivariana de Venezuela), is a country on the northern coast of South America, consisting of a continental landmass and many islands and islets in the Caribbean Sea. It has a territorial extension of , and its population was estimated at 29 million in 2022. The capital and largest urban agglomeration is the city of Caracas. The continental territory is bordered on the north by the Caribbean Sea and the Atlantic Ocean, on the west by Colombia, Brazil on the south, Trinidad and Tobago to the north-east and on the east by Guyana. The Venezuelan government maintains a claim against Guyana to Guayana Esequiba. Venezuela is a federal presidential republic consisting of 23 states, the Capital District and federal dependencies covering Venezuela's offshore islands. Venezuela is among the most urbanized countries in Latin America; the vast majority of Venezuelans live in the cities of the n ...
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Peru
, image_flag = Flag of Peru.svg , image_coat = Escudo nacional del Perú.svg , other_symbol = Great Seal of the State , other_symbol_type = Seal (emblem), National seal , national_motto = "Firm and Happy for the Union" , national_anthem = "National Anthem of Peru" , march = "March of Flags" , image_map = PER orthographic.svg , map_caption = , image_map2 = , capital = Lima , coordinates = , largest_city = capital , official_languages = Peruvian Spanish, Spanish , languages_type = Co-official languages , languages = , ethnic_groups = , ethnic_groups_year = 2017 , demonym = Peruvians, Peruvian , government_type = Unitary state, Unitary Semi-presidential system, semi-presidential republic , leader_title1 = President of Peru, President ...
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Ecuador
Ecuador ( ; ; Quechua: ''Ikwayur''; Shuar: ''Ecuador'' or ''Ekuatur''), officially the Republic of Ecuador ( es, República del Ecuador, which literally translates as "Republic of the Equator"; Quechua: ''Ikwadur Ripuwlika''; Shuar: ''Ekuatur Nunka''), is a country in northwestern South America, bordered by Colombia on the north, Peru on the east and south, and the Pacific Ocean on the west. Ecuador also includes the Galápagos Islands in the Pacific, about west of the mainland. The country's capital and largest city is Quito. The territories of modern-day Ecuador were once home to a variety of Indigenous groups that were gradually incorporated into the Inca Empire during the 15th century. The territory was colonized by Spain during the 16th century, achieving independence in 1820 as part of Gran Colombia, from which it emerged as its own sovereign state in 1830. The legacy of both empires is reflected in Ecuador's ethnically diverse population, with most of its mill ...
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Colombia
Colombia (, ; ), officially the Republic of Colombia, is a country in South America with insular regions in North America—near Nicaragua's Caribbean coast—as well as in the Pacific Ocean. The Colombian mainland is bordered by the Caribbean Sea to the north, Venezuela to the east and northeast, Brazil to the southeast, Ecuador and Peru to the south and southwest, the Pacific Ocean to the west, and Panama to the northwest. Colombia is divided into 32 departments and the Capital District of Bogotá, the country's largest city. It covers an area of 1,141,748 square kilometers (440,831 sq mi), and has a population of 52 million. Colombia's cultural heritage—including language, religion, cuisine, and art—reflects its history as a Spanish colony, fusing cultural elements brought by immigration from Europe and the Middle East, with those brought by enslaved Africans, as well as with those of the various Amerindian civilizations that predate colonization. Spanish is th ...
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