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Corydalis Yanhusuo
''Corydalis yanhusuo'' is a plant species in the genus ''Corydalis''. The Chinese name for ''Corydalis yanhusuo'' is ''yan hu suo'' (). The Japanese common name is engosaku (エンゴサク) and the Korean common name is hyeonhosaek (현호색). English common names include yanhusuo, corydalis, and Asian corydalis. The tuber of this plant, frequently mislabeled as the root, is an important therapeutic agent in traditional Chinese medicine. It is native to high-altitude grasslands across China including in the provinces of Anhui, Henan, Hubei, Hunan, Jiangsu, and Zhejiang, but is more widely cultivated. Description According to the Flora of China, this perennial herbaceous plant produces 5 to 15 purple-blue tubular flowers in clusters that curve out at the opening. The yellow, round tubers are up to in diameter. History Yanhusuo is first mentioned in ''Ben Cao Shi Yi'' (''Omissions from the Materia Medica''), written by Chen Cang-Qi in 720 CE. Chemical compounds The alkaloid de ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Corydalis
''Corydalis'' (from Greek ''korydalís'' "crested lark") is a genus of about 470 species of annual and perennial herbaceous plants in the family Papaveraceae, native to the temperate Northern Hemisphere and the high mountains of tropical eastern Africa. They are most diverse in China and the Himalayas, with at least 357 species in China. Ecology ''Corydalis'' species are used as food plants by the larvae of some Lepidoptera species (butterflies), especially the clouded Apollo. Toxicity ''Corydalis cava'' and some other tuberous species contain the alkaloid bulbocapnine, which is occasionally used in medicine but scientific evidence is lacking in the correct dosages and side effects. Many of the species in ''Corydalis'' contain other toxins and alkaloids like canadine, which blocks calcium. The species ''C. caseana'' is poisonous to livestock. Taxonomy Current species There are about 470 species, including: * ''Corydalis ambigua'' * ''Corydalis aurea'' * ''Corydalis buschii' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dehydrocorybulbine
Dehydrocorybulbine (DHCB) is an alkaloid isolated from ''Corydalis yanhusuo''. Dehydrocorybulbine binds to the dopamine D1 receptor Dopamine receptor D1, also known as DRD1. It is one of the two types of D1-like receptor family - receptors D1 and D5. It is a protein that in humans is encoded by the DRD1 gene. Tissue distribution D1 receptors are the most abundant kind of do .... Research has indicated that DHCB can be helpful in reducing neuropathic pain. References Isoquinoline alkaloids Heterocyclic compounds with 4 rings Methoxy compounds {{alkaloid-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Plants Described In 1985
Plants are predominantly photosynthetic eukaryotes of the kingdom Plantae. Historically, the plant kingdom encompassed all living things that were not animals, and included algae and fungi; however, all current definitions of Plantae exclude the fungi and some algae, as well as the prokaryotes (the archaea and bacteria). By one definition, plants form the clade Viridiplantae (Latin name for "green plants") which is sister of the Glaucophyta, and consists of the green algae and Embryophyta (land plants). The latter includes the flowering plants, conifers and other gymnosperms, ferns and their allies, hornworts, liverworts, and mosses. Most plants are multicellular organisms. Green plants obtain most of their energy from sunlight via photosynthesis by primary chloroplasts that are derived from endosymbiosis with cyanobacteria. Their chloroplasts contain chlorophylls a and b, which gives them their green color. Some plants are parasitic or mycotrophic and have los ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Corydaline
Corydaline is an acetylcholinesterase inhibitor Acetylcholinesterase inhibitors (AChEIs) also often called cholinesterase inhibitors, inhibit the enzyme acetylcholinesterase from breaking down the neurotransmitter acetylcholine into choline and acetate, thereby increasing both the level and ... isolated from '' Corydalis yanhusuo''. Corydaline is a pharmacologically active isoquinoline alkaloid isolated from Corydalis tubers. It also has diverse biological activities. It exhibits the antiacetylcholinesterase(AChE; IC50 = 15 μM), antiallergic, antinociceptive, and gastric emptying activities. Corydaline exhibited strong nematocidal activity, showed little cytotoxicity and represents a potential treatment for Strongyloidiasis. Corydaline is nematocidal against S. ratti and S. venezuelensis third instar larvae with 50% paralysis (PC50) values of 18 and 30 μM, respectively. Corydaline exhibits gastrointestinal modulatory, antinociceptive, anti-allergic, and anti-parasitic act ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acetylcholinesterase Inhibitor
Acetylcholinesterase inhibitors (AChEIs) also often called cholinesterase inhibitors, inhibit the enzyme acetylcholinesterase from breaking down the neurotransmitter acetylcholine into choline and acetate, thereby increasing both the level and duration of action of acetylcholine in the central nervous system, autonomic ganglia and neuromuscular junctions, which are rich in acetylcholine receptors. Acetylcholinesterase inhibitors are one of two types of cholinesterase inhibitors; the other being butyryl-cholinesterase inhibitors. Acetylcholinesterase is the primary member of the cholinesterase enzyme family. Acetylcholinesterase inhibitors are classified as reversible, irreversible, or quasi-irreversible (also called pseudo-irreversible). Mechanism of action Organophosphates Organophosphates like TEPP and sarin inhibit cholinesterases, enzymes that hydrolyze the neurotransmitter acetylcholine. The active centre of cholinesterases feature two important sites, namely the a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Palmatine
Palmatine is a protoberberine alkaloid found in several plants including ''Phellodendron amurense'', ''Coptis Chinensis'' (Rhizoma coptidis, chinese goldthread) and '' Corydalis yanhusuo'', ''Tinospora cordifolia'' (gurjo, heart-leaved moonseed), ''Tinospora sagittata'', ''Phellodendron amurense'' (amur cork tree), '' Stephania yunnanensis.'' It is the major component of the protoberberine extract from ''Enantia chlorantha''. It has been studied for its potential use in the treatment of jaundice, dysentery, hypertension, inflammation, and liver-related diseases. This compound also has weak ''in vitro'' activity against flavivirus. Pharmacology Neuroprotective activity Palmatine can be used to treat Alzheimer’s disease, mainly by inhibiting the activity of acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and neuraminidase-1 (NA-1). It was found, that the positively charged nitrogen on palmatine binds in the gorge of active sire of AChE. Research show that palma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Glaucine
Glaucine is an aporphine alkaloid found in several different plant species in the family Papaveraceae such as ''Glaucium flavum'', '' Glaucium oxylobum'' and '' Corydalis yanhusuo'', and in other plants like ''Croton lechleri'' in the family Euphorbiaceae. It has bronchodilator, neuroleptic and antiinflammatory effects, acting as a PDE4 inhibitor and calcium channel blocker, and is used medically as an antitussive in some countries. TLRs plays role in its anti inflammatory effects. Glaucine may produce side effects such as sedation, fatigue, and a hallucinogenic effect characterised by colourful visual images, and has been detected as a novel psychoactive drug. In a 2019 publication,Heng, HL, Chee, CF, Thy, CK, et al. In vitro functional evaluation of isolaureline, dicentrine and glaucine enantiomers at 5‐HT2 and α1 receptors. Chem Biol Drug Des. 2019; 93: 132– 138. https://doi.org/10.1111/cbdd.13390 the isomer (R)-glaucine is reported to be a positive allosteric modula ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tetrahydropalmatine
Tetrahydropalmatine (THP) is an isoquinoline alkaloid found in several different plant species, mainly in the genus '' Corydalis'' ( Yan Hu Suo), but also in other plants such as '' Stephania rotunda''. These plants have traditional uses in Chinese herbal medicine. The pharmaceutical industry has synthetically produced the more potent enantiomer Levo-tetrahydropalmatine (Levo-THP), which has been marketed worldwide under different brand names as an alternative to anxiolytic and sedative drugs of the benzodiazepine group and analgesics such as opiates. It is also sold as a dietary supplement. In 1940, a Vietnamese scientist Sang Dinh Bui extracted an alkaloid from the root of '' Stephania rotunda'' with the yield of 1.2 - 1.5% and he named this compound rotundine. From 1950 to 1952, two Indian scientists studied and extracted from ''Stephania glabra'' another alkaloid named hyndanrine. In 1965, the structure of rotundine and hyndarin was proved to be the same as tetrahy ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alkaloid
Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar structure may also be termed alkaloids. In addition to carbon, hydrogen and nitrogen, alkaloids may also contain oxygen, sulfur and, more rarely, other elements such as chlorine, bromine, and phosphorus.Chemical Encyclopedia: alkaloids xumuk.ru Alkaloids are produced by a large variety of organisms including , , Medicinal plant, plants, an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chinese Language
Chinese (, especially when referring to written Chinese) is a group of languages spoken natively by the ethnic Han Chinese majority and many minority ethnic groups in Greater China. About 1.3 billion people (or approximately 16% of the world's population) speak a variety of Chinese as their first language. Chinese languages form the Sinitic branch of the Sino-Tibetan languages family. The spoken varieties of Chinese are usually considered by native speakers to be variants of a single language. However, their lack of mutual intelligibility means they are sometimes considered separate languages in a family. Investigation of the historical relationships among the varieties of Chinese is ongoing. Currently, most classifications posit 7 to 13 main regional groups based on phonetic developments from Middle Chinese, of which the most spoken by far is Mandarin (with about 800 million speakers, or 66%), followed by Min (75 million, e.g. Southern Min), Wu (74 million, e.g. Shangh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Zhejiang
Zhejiang ( or , ; , also romanized as Chekiang) is an eastern, coastal province of the People's Republic of China. Its capital and largest city is Hangzhou, and other notable cities include Ningbo and Wenzhou. Zhejiang is bordered by Jiangsu and Shanghai to the north, Anhui to the northwest, Jiangxi to the west and Fujian to the south. To the east is the East China Sea, beyond which lies the Ryukyu Islands. The population of Zhejiang stands at 64.6 million, the 8th highest among China. It has been called 'the backbone of China' due to being a major driving force in the Chinese economy and being the birthplace of several notable persons, including the Chinese Nationalist leader Chiang Kai-shek and entrepreneur Jack Ma. Zhejiang consists of 90 counties (incl. county-level cities and districts). The area of Zhejiang was controlled by the Kingdom of Yue during the Spring and Autumn period. The Qin Empire later annexed it in 222 BC. Under the late Ming dynasty and the Qing ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jiangsu
Jiangsu (; ; pinyin: Jiāngsū, Postal romanization, alternatively romanized as Kiangsu or Chiangsu) is an Eastern China, eastern coastal Provinces of the People's Republic of China, province of the China, People's Republic of China. It is one of the leading provinces in finance, education, technology, and tourism, with its capital in Nanjing. Jiangsu is the List of Chinese administrative divisions by area, third smallest, but the List of Chinese administrative divisions by population, fifth most populous and the List of Chinese administrative divisions by population density, most densely populated of the 23 provinces of the People's Republic of China. Jiangsu has the highest GDP per capita of Chinese provinces and second-highest GDP of Chinese provinces, after Guangdong. Jiangsu borders Shandong in the north, Anhui to the west, and Zhejiang and Shanghai to the south. Jiangsu has a coastline of over along the Yellow Sea, and the Yangtze River passes through the southern part ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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