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Conus Tulipa
''Conus tulipa'', common name the tulip cone, is a species of sea snail, a marine gastropod mollusk in the family Conidae, the cone snails and their allies. Like all species within the genus ''Conus'', these snails are predatory and venomous. They are capable of "stinging" humans, therefore live ones should be handled carefully. A class of conopeptides named rho-TIA was discovered in ''Conus tulipa'' in 2001. This class of conopetides targets (react with) alpha1- adrenergic receptors. Description The size of the shell varies between 45 mm and 95 mm. The shell is variegated with violet and white, clouded with chestnut, with numerous revolving rows of minute chestnut and white articulations. The interior of the aperture is violaceous. Conantokin-T is a toxin derived from the venom of ''Conus tulipa''. Distribution The marine species occurs in the Indo-Western Pacific. * Madagascar * Mauritius * Tanzania * India * the Philippines * Queensland (Australia) Feeding ha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gastropod Shell
The gastropod shell is part of the body of a Gastropoda, gastropod or snail, a kind of mollusc. The shell is an exoskeleton, which protects from predators, mechanical damage, and dehydration, but also serves for muscle attachment and calcium storage. Some gastropods appear shell-less (slugs) but may have a remnant within the mantle, or in some cases the shell is reduced such that the body cannot be retracted within it (semi-slug). Some snails also possess an operculum that seals the opening of the shell, known as the Aperture (mollusc), aperture, which provides further protection. The study of mollusc shells is known as conchology. The biological study of gastropods, and other molluscs in general, is malacology. Shell morphology terms vary by species group. Shell layers The gastropod shell has three major layers secreted by the Mantle (mollusc), mantle. The calcareous central layer, tracum, is typically made of calcium carbonate precipitated into an organic matrix known as c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nature Neuroscience
''Nature Neuroscience'' is a monthly scientific journal published by Nature Publishing Group. Its focus is original research papers relating specifically to neuroscience and was established in May 1998. The chief editor is Shari Wiseman. According to the ''Journal Citation Reports'', ''Nature Neuroscience'' had a 2020 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly mean number of citations of articles published in the last two years in a given journal, as i ... of 24.884. References External links * Neuroscience journals Nature Research academic journals Publications established in 1998 Monthly journals English-language journals {{neuroscience-journal-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Queensland
) , nickname = Sunshine State , image_map = Queensland in Australia.svg , map_caption = Location of Queensland in Australia , subdivision_type = Country , subdivision_name = Australia , established_title = Before federation , established_date = Colony of Queensland , established_title2 = Separation from New South Wales , established_date2 = 6 June 1859 , established_title3 = Federation , established_date3 = 1 January 1901 , named_for = Queen Victoria , demonym = , capital = Brisbane , largest_city = capital , coordinates = , admin_center_type = Administration , admin_center = 77 local government areas , leader_title1 = Monarch , leader_name1 = Charles III , leader_title2 = Governor , leader_name2 = Jeannette Young , leader_title3 = Premier , leader_name3 = Annastacia Palaszczuk ( ALP) , legislature = Parliament of Queensland , judiciary = Supreme Court of Queensland , national_representation = Parliament of Australia , national_representation_type ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Philippines
The Philippines (; fil, Pilipinas, links=no), officially the Republic of the Philippines ( fil, Republika ng Pilipinas, links=no), * bik, Republika kan Filipinas * ceb, Republika sa Pilipinas * cbk, República de Filipinas * hil, Republika sang Filipinas * ibg, Republika nat Filipinas * ilo, Republika ti Filipinas * ivv, Republika nu Filipinas * pam, Republika ning Filipinas * krj, Republika kang Pilipinas * mdh, Republika nu Pilipinas * mrw, Republika a Pilipinas * pag, Republika na Filipinas * xsb, Republika nin Pilipinas * sgd, Republika nan Pilipinas * tgl, Republika ng Pilipinas * tsg, Republika sin Pilipinas * war, Republika han Pilipinas * yka, Republika si Pilipinas In the recognized optional languages of the Philippines: * es, República de las Filipinas * ar, جمهورية الفلبين, Jumhūriyyat al-Filibbīn is an archipelagic country in Southeast Asia. It is situated in the western Pacific Ocean and consists of around 7,641 islands t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
India
India, officially the Republic of India (Hindi: ), is a country in South Asia. It is the seventh-largest country by area, the second-most populous country, and the most populous democracy in the world. Bounded by the Indian Ocean on the south, the Arabian Sea on the southwest, and the Bay of Bengal on the southeast, it shares land borders with Pakistan to the west; China, Nepal, and Bhutan to the north; and Bangladesh and Myanmar to the east. In the Indian Ocean, India is in the vicinity of Sri Lanka and the Maldives; its Andaman and Nicobar Islands share a maritime border with Thailand, Myanmar, and Indonesia. Modern humans arrived on the Indian subcontinent from Africa no later than 55,000 years ago., "Y-Chromosome and Mt-DNA data support the colonization of South Asia by modern humans originating in Africa. ... Coalescence dates for most non-European populations average to between 73–55 ka.", "Modern human beings—''Homo sapiens''—originated in Africa. Then, int ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tanzania
Tanzania (; ), officially the United Republic of Tanzania ( sw, Jamhuri ya Muungano wa Tanzania), is a country in East Africa within the African Great Lakes region. It borders Uganda to the north; Kenya to the northeast; Comoro Islands and the Indian Ocean to the east; Mozambique and Malawi to the south; Zambia to the southwest; and Rwanda, Burundi, and the Democratic Republic of the Congo to the west. Mount Kilimanjaro, Africa's highest mountain, is in northeastern Tanzania. According to the United Nations, Tanzania has a population of million, making it the most populous country located entirely south of the equator. Many important hominid fossils have been found in Tanzania, such as 6-million-year-old Pliocene hominid fossils. The genus Australopithecus ranged across Africa between 4 and 2 million years ago, and the oldest remains of the genus ''Homo'' are found near Lake Olduvai. Following the rise of '' Homo erectus'' 1.8 million years ago, humanity spread ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mauritius
Mauritius ( ; french: Maurice, link=no ; mfe, label=Mauritian Creole, Moris ), officially the Republic of Mauritius, is an island nation in the Indian Ocean about off the southeast coast of the African continent, east of Madagascar. It includes the main island (also called Mauritius), as well as Rodrigues, Agaléga and St. Brandon. The islands of Mauritius and Rodrigues, along with nearby Réunion (a French overseas department), are part of the Mascarene Islands. The main island of Mauritius, where most of the population is concentrated, hosts the capital and largest city, Port Louis. The country spans and has an exclusive economic zone covering . Arab sailors were the first to discover the uninhabited island, around 975, and they called it ''Dina Arobi''. The earliest discovery was in 1507 by Portuguese sailors, who otherwise took little interest in the islands. The Dutch took possession in 1598, establishing a succession of short-lived settlements over a period of about ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Madagascar
Madagascar (; mg, Madagasikara, ), officially the Republic of Madagascar ( mg, Repoblikan'i Madagasikara, links=no, ; french: République de Madagascar), is an island country in the Indian Ocean, approximately off the coast of East Africa across the Mozambique Channel. At Madagascar is the world's List of island countries, second-largest island country, after Indonesia. The nation is home to around 30 million inhabitants and consists of the island of Geography of Madagascar, Madagascar (the List of islands by area, fourth-largest island in the world), along with numerous smaller peripheral islands. Following the prehistoric breakup of the supercontinent Gondwana, Madagascar split from the Indian subcontinent around 90 million years ago, allowing native plants and animals to evolve in relative isolation. Consequently, Madagascar is a biodiversity hotspot; over 90% of wildlife of Madagascar, its wildlife is endemic. Human settlement of Madagascar occurred during or befo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Conantokin
Conantokins are a small family of helical peptides that are derived from the venom of predatory marine snails of the genus ''Conus''. Conantokins act as potent and specific NMDA receptor antagonist, antagonists of the N-methyl-D-aspartate receptor (NMDAR). They are the only naturally-derived peptides to do so. The subtypes of conantokins exhibit a surprising variability of selectivity across the NMDAR subunits, and are therefore uniquely useful in developing subunit-specific pharmacological probes. Chemically, conantokins are unique in that they possess a number (generally 4 or 5) of carboxyglutamic acid, gamma-carboxyglutamyl (Gla) residues, generated by the post-translational modification of glutamyl (Glu) residues. These Gla residues induce a conformational change from a 3 10 helix to an alpha helix on binding to Calcium. In the broader scheme of genetic conotoxin classification, Conanotokins are also known as "Conotoxin Superfamily B." The word "conantokin" is derived from the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aperture (mollusc)
The aperture is an opening in certain kinds of mollusc shells: it is the main opening of the shell, where the head-foot part of the body of the animal emerges for locomotion, feeding, etc. The term ''aperture'' is used for the main opening in gastropod shells, scaphopod shells, and also for ''Nautilus'' and ammonite shells. The word is not used to describe bivalve shells, where a natural opening between the two shell valves in the closed position is usually called a ''gape''. Scaphopod shells are tubular, and thus they have two openings: a main anterior aperture and a smaller posterior aperture. As well as the aperture, some gastropod shells have additional openings in their shells for respiration; this is the case in some Fissurellidae (keyhole limpets) where the central smaller opening at the apex of the shell is called an orifice, and in the Haliotidae (abalones) where the row of respiratory openings in the shell are also called orifices. In gastropods In some prosobranch ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adrenergic Receptor
The adrenergic receptors or adrenoceptors are a class of G protein-coupled receptors that are targets of many catecholamines like norepinephrine (noradrenaline) and epinephrine (adrenaline) produced by the body, but also many medications like beta blockers, beta-2 (β2) agonists and alpha-2 (α2) agonists, which are used to treat high blood pressure and asthma, for example. Many cells have these receptors, and the binding of a catecholamine to the receptor will generally stimulate the sympathetic nervous system (SNS). The SNS is responsible for the fight-or-flight response, which is triggered by experiences such as exercise or fear-causing situations. This response dilates pupils, increases heart rate, mobilizes energy, and diverts blood flow from non-essential organs to skeletal muscle. These effects together tend to increase physical performance momentarily. History By the turn of the 19th century, it was agreed that the stimulation of sympathetic nerves could cause different ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Conopeptide
A conotoxin is one of a group of neurotoxic peptides isolated from the venom of the marine cone snail, genus ''Conus''. Conotoxins, which are peptides consisting of 10 to 30 amino acid residues, typically have one or more disulfide bonds. Conotoxins have a variety of mechanisms of actions, most of which have not been determined. However, it appears that many of these peptides modulate the activity of ion channels. Over the last few decades conotoxins have been the subject of pharmacological interest. The LD50 of conotoxin ranges from 5-25 μg/kg. Hypervariability Conotoxins are hypervariable even within the same species. They do not act within a body where they are produced (endogenously) but act on other organisms. Therefore, conotoxin genes experience less selection against mutations (like gene duplication and nonsynonymous substitution), and mutations remain in the genome longer, allowing more time for potentially beneficial novel functions to arise. Variability in c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
