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Confounding
In statistics, a confounder (also confounding variable, confounding factor, extraneous determinant or lurking variable) is a variable that influences both the dependent variable and independent variable, causing a spurious association. Confounding is a causal concept, and as such, cannot be described in terms of correlations or associations.Pearl, J., (2009). Simpson's Paradox, Confounding, and Collapsibility In ''Causality: Models, Reasoning and Inference'' (2nd ed.). New York : Cambridge University Press. The existence of confounders is an important quantitative explanation why correlation does not imply causation. Confounds are threats to internal validity. Definition Confounding is defined in terms of the data generating model. Let ''X'' be some independent variable, and ''Y'' some dependent variable. To estimate the effect of ''X'' on ''Y'', the statistician must suppress the effects of extraneous variables that influence both ''X'' and ''Y''. We say that ''X'' a ...
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Epidemiology
Epidemiology is the study and analysis of the distribution (who, when, and where), patterns and determinants of health and disease conditions in a defined population. It is a cornerstone of public health, and shapes policy decisions and evidence-based practice by identifying risk factors for disease and targets for preventive healthcare. Epidemiologists help with study design, collection, and statistical analysis of data, amend interpretation and dissemination of results (including peer review and occasional systematic review). Epidemiology has helped develop methodology used in clinical research, public health studies, and, to a lesser extent, basic research in the biological sciences. Major areas of epidemiological study include disease causation, transmission, outbreak investigation, disease surveillance, environmental epidemiology, forensic epidemiology, occupational epidemiology, screening, biomonitoring, and comparisons of treatment effects such as in clinical t ...
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Internal Validity
Internal validity is the extent to which a piece of evidence supports a claim about cause and effect, within the context of a particular study. It is one of the most important properties of scientific studies and is an important concept in reasoning about evidence more generally. Internal validity is determined by how well a study can rule out alternative explanations for its findings (usually, sources of systematic error or 'bias'). It contrasts with external validity, the extent to which results can justify conclusions about other contexts (that is, the extent to which results can be generalized). Details Inferences are said to possess internal validity if a causal relationship between two variables is properly demonstrated.Shadish, W., Cook, T., and Campbell, D. (2002). Experimental and Quasi-Experimental Designs for Generilized Causal Inference Boston:Houghton Mifflin. A valid causal inference may be made when three criteria are satisfied: # the "cause" precedes the ...
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Simpson's Paradox
Simpson's paradox is a phenomenon in probability and statistics in which a trend appears in several groups of data but disappears or reverses when the groups are combined. This result is often encountered in social-science and medical-science statistics, and is particularly problematic when frequency data are unduly given causal interpretations. Judea Pearl. ''Causality: Models, Reasoning, and Inference'', Cambridge University Press (2000, 2nd edition 2009). . The paradox can be resolved when confounding variables and causal relations are appropriately addressed in the statistical modeling. Simpson's paradox has been used to illustrate the kind of misleading results that the misuse of statistics can generate. Edward H. Simpson first described this phenomenon in a technical paper in 1951, but the statisticians Karl Pearson (in 1899) and Udny Yule (in 1903 ) had mentioned similar effects earlier. The name ''Simpson's paradox'' was introduced by Colin R. Blyth in 1972. It is also ...
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Collider (epidemiology)
In statistics and causal graphs, a variable is a collider when it is causally influenced by two or more variables. The name "collider" reflects the fact that in graphical models, the arrow heads from variables that lead into the collider appear to "collide" on the node that is the collider. They are sometimes also referred to as inverted forks. The causal variables influencing the collider are themselves not necessarily associated. If they are not adjacent, the collider is ''unshielded''. Otherwise, the collider is shielded and part of a triangle. The result of having a collider in the path is that the collider blocks the association between the variables that influence it. Thus, the collider does not generate an unconditional association between the variables that determine it. Conditioning on the collider via regression analysis, stratification, experimental design, or sample selection based on values of the collider create a non-causal association between X and Y (Berkson's ...
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Experiment
An experiment is a procedure carried out to support or refute a hypothesis, or determine the efficacy or likelihood of something previously untried. Experiments provide insight into cause-and-effect by demonstrating what outcome occurs when a particular factor is manipulated. Experiments vary greatly in goal and scale but always rely on repeatable procedure and logical analysis of the results. There also exist natural experimental studies. A child may carry out basic experiments to understand how things fall to the ground, while teams of scientists may take years of systematic investigation to advance their understanding of a phenomenon. Experiments and other types of hands-on activities are very important to student learning in the science classroom. Experiments can raise test scores and help a student become more engaged and interested in the material they are learning, especially when used over time. Experiments can vary from personal and informal natural comparisons ...
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Correlation Does Not Imply Causation
The phrase "correlation does not imply causation" refers to the inability to legitimately deduce a cause-and-effect relationship between two events or variables solely on the basis of an observed association or correlation between them. The idea that "correlation implies causation" is an example of a questionable-cause logical fallacy, in which two events occurring together are taken to have established a cause-and-effect relationship. This fallacy is also known by the Latin phrase ''cum hoc ergo propter hoc'' ('with this, therefore because of this'). This differs from the fallacy known as ''post hoc ergo propter hoc'' ("after this, therefore because of this"), in which an event following another is seen as a necessary consequence of the former event, and from conflation, the errant merging of two events, ideas, databases, etc., into one. As with any logical fallacy, identifying that the reasoning behind an argument is flawed does not necessarily imply that the resulting co ...
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Jerzy Neyman
Jerzy Neyman (April 16, 1894 – August 5, 1981; born Jerzy Spława-Neyman; ) was a Polish mathematician and statistician who spent the first part of his professional career at various institutions in Warsaw, Poland and then at University College London, and the second part at the University of California, Berkeley. Neyman first introduced the modern concept of a confidence interval into statistical hypothesis testing and co-revised Ronald Fisher's null hypothesis testing (in collaboration with Egon Pearson). Life and career He was born into a Polish family in Bendery, in the Bessarabia Governorate of the Russian Empire, the fourth of four children of Czesław Spława-Neyman and Kazimiera Lutosławska. His family was Roman Catholic and Neyman served as an altar boy during his early childhood. Later, Neyman would become an agnostic. Neyman's family descended from a long line of Polish nobles and military heroes. He graduated from the Kamieniec Podolski gubernial gymnasium for ...
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Ronald Fisher
Sir Ronald Aylmer Fisher (17 February 1890 – 29 July 1962) was a British polymath who was active as a mathematician, statistician, biologist, geneticist, and academic. For his work in statistics, he has been described as "a genius who almost single-handedly created the foundations for modern statistical science" and "the single most important figure in 20th century statistics". In genetics, his work used mathematics to combine Mendelian genetics and natural selection; this contributed to the revival of Darwinism in the early 20th-century revision of the theory of evolution known as the modern synthesis. For his contributions to biology, Fisher has been called "the greatest of Darwin’s successors". Fisher held strong views on race and eugenics, insisting on racial differences. Although he was clearly a eugenist and advocated for the legalization of voluntary sterilization of those with heritable mental disabilities, there is some debate as to whether Fisher support ...
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Leslie Kish
Leslie Kish (born László Kiss, July 27, 1910 – October 7, 2000) was a Hungarian- American statistician and survey methodologist.. Reprint of an obituary from '' International Statistical Institute (ISI) Newsletter'', Volume 25, No. 73. Life and career Kish emigrated with his family to the USA in 1925. His father soon died, and Kish helped support the family by working while continuing his studies in the evenings. In 1937 he volunteered for the International Brigade to fight against Francisco Franco in the Spanish Civil War. He saw action in a Hungarian battalion, was wounded, and returned to the United States in 1939. In 1939, he finished his baccalaureate in mathematics at the City College of New York. He worked at the U.S. Bureau of the Census from 1940 until 1941, when he moved to the Division of Program Surveys of the Department of Agriculture. For the remainder of World War II he served as a meteorologist in the U.S. Army Air Corps. After the war he returned to the D ...
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Comparison Confounder Mediator
Comparison or comparing is the act of evaluating two or more things by determining the relevant, comparable characteristics of each thing, and then determining which characteristics of each are similar to the other, which are different, and to what degree. Where characteristics are different, the differences may then be evaluated to determine which thing is best suited for a particular purpose. The description of similarities and differences found between the two things is also called a comparison. Comparison can take many distinct forms, varying by field: To compare things, they must have characteristics that are similar enough in relevant ways to merit comparison. If two things are too different to compare in a useful way, an attempt to compare them is colloquially referred to in English as "comparing apples and oranges." Comparison is widely used in society, in science and in the arts. General usage Comparison is a natural activity, which even animals engage in when deci ...
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Donald Rubin
Donald is a masculine given name derived from the Gaelic name ''Dòmhnall''.. This comes from the Proto-Celtic *''Dumno-ualos'' ("world-ruler" or "world-wielder"). The final -''d'' in ''Donald'' is partly derived from a misinterpretation of the Gaelic pronunciation by English speakers, and partly associated with the spelling of similar-sounding Germanic names, such as '' Ronald''. A short form of ''Donald'' is '' Don''. Pet forms of ''Donald'' include ''Donnie'' and ''Donny''. The feminine given name ''Donella'' is derived from ''Donald''. ''Donald'' has cognates in other Celtic languages: Modern Irish ''Dónal'' (anglicised as ''Donal'' and ''Donall'');. Scottish Gaelic ''Dòmhnall'', ''Domhnull'' and ''Dòmhnull''; Welsh '' Dyfnwal'' and Cumbric ''Dumnagual''. Although the feminine given name '' Donna'' is sometimes used as a feminine form of ''Donald'', the names are not etymologically related. Variations Kings and noblemen Domnall or Domhnall is the name of many ...
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