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Computational Clinical Neuroscience
Computational neuroscience (also known as theoretical neuroscience or mathematical neuroscience) is a branch of neuroscience which employs mathematical models, computer simulations, theoretical analysis and abstractions of the brain to understand the principles that govern the development, structure, physiology and cognitive abilities of the nervous system. Computational neuroscience employs computational simulations to validate and solve mathematical models, and so can be seen as a sub-field of theoretical neuroscience; however, the two fields are often synonymous. The term mathematical neuroscience is also used sometimes, to stress the quantitative nature of the field. Computational neuroscience focuses on the description of biologically plausible neurons (and neural systems) and their physiology and dynamics, and it is therefore not directly concerned with biologically unrealistic models used in connectionism, control theory, cybernetics, quantitative psychol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neuroscience
Neuroscience is the scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its functions and disorders. It is a multidisciplinary science that combines physiology, anatomy, molecular biology, developmental biology, cytology, psychology, physics, computer science, chemistry, medicine, statistics, and Mathematical Modeling, mathematical modeling to understand the fundamental and emergent properties of neurons, glia and neural circuits. The understanding of the biological basis of learning, memory, behavior, perception, and consciousness has been described by Eric Kandel as the "epic challenge" of the Biology, biological sciences. The scope of neuroscience has broadened over time to include different approaches used to study the nervous system at different scales. The techniques used by neuroscientists have expanded enormously, from molecular biology, molecular and cell biology, cellular studies of individual neurons to neuroimaging, imaging ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neural Oscillation
Neural oscillations, or brainwaves, are rhythmic or repetitive patterns of neural activity in the central nervous system. Neural tissue can generate oscillatory activity in many ways, driven either by mechanisms within individual neurons or by interactions between neurons. In individual neurons, oscillations can appear either as oscillations in membrane potential or as rhythmic patterns of action potentials, which then produce oscillatory activation of post-synaptic neurons. At the level of neural ensembles, synchronized activity of large numbers of neurons can give rise to macroscopic oscillations, which can be observed in an electroencephalogram. Oscillatory activity in groups of neurons generally arises from feedback connections between the neurons that result in the synchronization of their firing patterns. The interaction between neurons can give rise to oscillations at a different frequency than the firing frequency of individual neurons. A well-known example of macrosco ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Voltage Clamp
The voltage clamp is an experimental method used by electrophysiologists to measure the ion currents through the membranes of excitable cells, such as neurons, while holding the membrane voltage at a set level. A basic voltage clamp will iteratively measure the membrane potential, and then change the membrane potential (voltage) to a desired value by adding the necessary current. This "clamps" the cell membrane at a desired constant voltage, allowing the voltage clamp to record what currents are delivered. Because the currents applied to the cell must be equal to (and opposite in charge to) the current going across the cell membrane at the set voltage, the recorded currents indicate how the cell reacts to changes in membrane potential. Cell membranes of excitable cells contain many different kinds of ion channels, some of which are voltage-gated. The voltage clamp allows the membrane voltage to be manipulated independently of the ionic currents, allowing the current–voltage rel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Integrate And Fire
Biological neuron models, also known as a spiking neuron models, are mathematical descriptions of the properties of certain cells in the nervous system that generate sharp electrical potentials across their cell membrane, roughly one millisecond in duration, called action potentials or spikes (Fig. 2). Since spikes are transmitted along the axon and synapses from the sending neuron to many other neurons, spiking neurons are considered to be a major information processing unit of the nervous system. Spiking neuron models can be divided into different categories: the most detailed mathematical models are biophysical neuron models (also called Hodgkin-Huxley models) that describe the membrane voltage as a function of the input current and the activation of ion channels. Mathematically simpler are integrate-and-fire models that describe the membrane voltage as a function of the input current and predict the spike times without a description of the biophysical processes that shape ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
David Marr (psychologist)
David Courtenay Marr (19 January 1945 – 17 November 1980) from the ''International Encyclopaedia of Social and Behavioral Sciences'', by Shimon Edelman and Lucia M. Vaina; published 2001-01-08; archived at ; retrieved 2021-07-21 was a British and . Marr integrated results from , |
Torsten Wiesel
Torsten Nils Wiesel (born 3 June 1924) is a Swedish neurophysiologist. With David H. Hubel, he received the 1981 Nobel Prize in Physiology or Medicine, for their discoveries concerning information processing in the visual system; the prize was shared with Roger W. Sperry for his independent research on the cerebral hemispheres. Career Wiesel was born in Uppsala, Sweden in 1924, the youngest of five children. In 1947, he began his scientific career in Carl Gustaf Bernhard's laboratory at the Karolinska Institute, where he received his medical degree in 1954. He went on to teach in the Institute's department of physiology and worked in the child psychiatry unit of the Karolinska Hospital. In 1955 he moved to the United States to work at Johns Hopkins School of Medicine under Stephen Kuffler. Wiesel began a fellowship in ophthalmology, and in 1958 he became an assistant professor. That same year, he met David Hubel, beginning a collaboration that would last over twenty years. In ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
David H
David (; , "beloved one") (traditional spelling), , ''Dāwūd''; grc-koi, Δαυΐδ, Dauíd; la, Davidus, David; gez , ዳዊት, ''Dawit''; xcl, Դաւիթ, ''Dawitʿ''; cu, Давíдъ, ''Davidŭ''; possibly meaning "beloved one". was, according to the Hebrew Bible, the Kings of Israel and Judah, third king of the Kingdom of Israel (united monarchy), United Kingdom of Israel. In the Books of Samuel, he is described as a young shepherd and Lyre, harpist who gains fame by slaying Goliath, a champion of the Philistines, in southern Canaan. David becomes a favourite of Saul, the first king of Israel; he also forges David and Jonathan, a notably close friendship with Jonathan (1 Samuel), Jonathan, a son of Saul. However, under the paranoia that David is seeking to usurp the throne, Saul attempts to kill David, forcing the latter to go into hiding and effectively operate as a fugitive for several years. After Saul and Jonathan are both killed in battle against the Philistin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Andrew Huxley
Sir Andrew Fielding Huxley (22 November 191730 May 2012) was an English physiologist and biophysicist. He was born into the prominent Huxley family. After leaving Westminster School in central London, he went to Trinity College, Cambridge on a scholarship, after which he joined Alan Lloyd Hodgkin to study nerve impulses. Their eventual discovery of the basis for propagation of nerve impulses (called an action potential) earned them the Nobel Prize in Physiology or Medicine in 1963. They made their discovery from the giant axon of the Atlantic squid. Soon after the outbreak of the Second World War, Huxley was recruited by the British Anti-Aircraft Command and later transferred to the Admiralty. After the war he resumed research at the University of Cambridge, where he developed interference microscopy that would be suitable for studying muscle fibres. In 1952, he was joined by a German physiologist Rolf Niedergerke. Together they discovered in 1954 the mechanism of muscle con ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alan Hodgkin
Sir Alan Lloyd Hodgkin (5 February 1914 – 20 December 1998) was an English physiologist and biophysicist who shared the 1963 Nobel Prize in Physiology or Medicine with Andrew Huxley and John Eccles. Early life and education Hodgkin was born in Banbury, Oxfordshire, on 5 February 1914. He was the oldest of three sons of Quakers George Hodgkin and Mary Wilson Hodgkin. His father was the son of Thomas Hodgkin and had read for the Natural Science Tripos at Cambridge where he had befriended electrophysiologist Keith Lucas. Because of poor eyesight he was unable to study medicine and eventually ended up working for a bank in Banbury. As members of the Society of Friends, George and Mary opposed the Military Service Act of 1916 and had to endure a great deal of abuse from their local community, including an attempt to throw George in one of the town canals. In 1916 George Hodgkin travelled to Armenia as part of an investigation of distress. Moved by the misery and suffering of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Louis Lapicque
Louis Édouard Lapicque (1 August 1866 – 6 December 1952) was a French neuroscientist, socialist activist, antiboulangist, dreyfusard and freemason who was very influential in the early 20th century. One of his main contributions was to propose the integrate-and-fire model of the neuron in a seminal article published in 1907. Today, this model of the neuron is still one of the most popular models in computational neuroscience for both cellular and neural networks studies, as well as in mathematical neuroscience because of its simplicity. A review article was published for the centenary of the original Lapicque's 1907 paper - this review also contains an English translation of the original paper. His wife, Marcelle Lapicque Marcelle de Heredia Lapicque (1873 – 1960) was a French Neurophysiology, neurophysiologist known for her research on nerve impulses (chronaxie) and the effects of poisons, especially strychnine, on chronaxie. She was in charge of the Laboratoire ..., w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
California Institute Of Technology
The California Institute of Technology (branded as Caltech or CIT)The university itself only spells its short form as "Caltech"; the institution considers other spellings such a"Cal Tech" and "CalTech" incorrect. The institute is also occasionally referred to as "CIT", most notably in its alma mater, but this is uncommon. is a private research university in Pasadena, California. Caltech is ranked among the best and most selective academic institutions in the world, and with an enrollment of approximately 2400 students (acceptance rate of only 5.7%), it is one of the world's most selective universities. The university is known for its strength in science and engineering, and is among a small group of institutes of technology in the United States which is primarily devoted to the instruction of pure and applied sciences. The institution was founded as a preparatory and vocational school by Amos G. Throop in 1891 and began attracting influential scientists such as George Ellery H ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
San Francisco, California
San Francisco (; Spanish for " Saint Francis"), officially the City and County of San Francisco, is the commercial, financial, and cultural center of Northern California. The city proper is the fourth most populous in California and 17th most populous in the United States, with 815,201 residents as of 2021. It covers a land area of , at the end of the San Francisco Peninsula, making it the second most densely populated large U.S. city after New York City, and the fifth most densely populated U.S. county, behind only four of the five New York City boroughs. Among the 91 U.S. cities proper with over 250,000 residents, San Francisco was ranked first by per capita income (at $160,749) and sixth by aggregate income as of 2021. Colloquial nicknames for San Francisco include ''SF'', ''San Fran'', ''The '', ''Frisco'', and ''Baghdad by the Bay''. San Francisco and the surrounding San Francisco Bay Area are a global center of economic activity and the arts and sciences, spurred ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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