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Committee On The Safety Of Medicines
The Committee on Safety of Medicines (CSM) was an independent advisory committee that advised the UK Licensing Authority on the quality, efficacy, and safety of medicines. Following the thalidomide tragedy of 1957 to 1961, in 1963 the government asked Sir Derrick Dunlop to set up a committee to investigate the control and introduction of new medicines in the United Kingdom. In June 1963 the Committee on Safety of Drugs (CSD) was established. As a result of the subsequent report to the Department of Health, which reinforced the need for specially trained doctors (clinical pharmacologists) in pharmaceutical companies and academic departments of medicine, Dunlop became the first chairman of the Committee. Under the Medicines Act 1968, the CSD was replaced in 1970 by the Medicines Commission, which established the Committee on Safety of Medicines (CSM) as a Government advisory committee under Section 4 of the Act. It was replaced on 30 October 2005 by the Commission on Human Medici ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
United Kingdom
The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom (UK) or Britain, is a country in Northwestern Europe, off the coast of European mainland, the continental mainland. It comprises England, Scotland, Wales and Northern Ireland. The UK includes the island of Great Britain, the north-eastern part of the island of Ireland, and most of List of islands of the United Kingdom, the smaller islands within the British Isles, covering . Northern Ireland shares Republic of Ireland–United Kingdom border, a land border with the Republic of Ireland; otherwise, the UK is surrounded by the Atlantic Ocean, the North Sea, the English Channel, the Celtic Sea and the Irish Sea. It maintains sovereignty over the British Overseas Territories, which are located across various oceans and seas globally. The UK had an estimated population of over 68.2 million people in 2023. The capital and largest city of both England and the UK is London. The cities o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medication
Medication (also called medicament, medicine, pharmaceutical drug, medicinal product, medicinal drug or simply drug) is a drug used to medical diagnosis, diagnose, cure, treat, or preventive medicine, prevent disease. Drug therapy (pharmacotherapy) is an important part of the medicine, medical field and relies on the science of pharmacology for continual advancement and on pharmacy for appropriate management. Drugs are Drug class, classified in many ways. One of the key divisions is by level of controlled substance, control, which distinguishes prescription drugs (those that a pharmacist dispenses only on the medical prescription) from over-the-counter drugs (those that consumers can order for themselves). Medicines may be classified by mode of action, route of administration, biological system affected, or therapeutic effects. The World Health Organization keeps a list of essential medicines. Drug discovery and drug development are complex and expensive endeavors undertake ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thalidomide
Thalidomide, sold under the brand names Contergan and Thalomid among others, is an oral administered medication used to treat a number of cancers (e.g., multiple myeloma), graft-versus-host disease, and many skin disorders (e.g., complications of leprosy such as skin lesions). Updated as required. Thalidomide has been used to treat conditions associated with HIV: aphthous ulcers, HIV-associated wasting syndrome, diarrhea, and Kaposi's sarcoma, but increases in HIV viral load have been reported. Common side effects include sleepiness, rash, and dizziness. Severe side effects include tumor lysis syndrome, blood clots, and peripheral neuropathy. Thalidomide is a known human teratogen and carries an extremely high risk of severe, life-threatening birth defects if administered or taken during pregnancy. It causes skeletal deformities such as Amelia (birth defect), amelia (absence of legs and/or arms), absence of bones, and phocomelia (malformation of the limbs). A single dose of t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Derrick Dunlop
Sir Derrick Melville Dunlop (3 April 1902 – 9 June 1980) was a Scottish physician and pharmacologist in British medical administration and policy-making in the late 20th century. He established the Dunlop Committee which investigates the side-effects of new drugs in the UK. Life Dunlop was born in Edinburgh on 3 April 1902 to Dr George Harry Melville Dunlop (1859–1916) of 20 Abercromby Place, an expert in child health and physician at the Edinburgh Sick Children’s Hospital, and Margaret Eliot Boog Scott. His father, a Major in the Royal Army Medical Corps and one of the oldest physicians to volunteer for active service, died of pneumonia at Étaples in France during the First World War. Dunlop attended Edinburgh Academy from 1909 until 1919. He went up to Brasenose College, Oxford, and then the University of Edinburgh, graduating as MB ChB in 1926, followed by an MD awarded in 1927. He worked briefly in London before returning to Edinburgh to work under Sir Ro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Department Of Health
A health department or health ministry is a part of government which focuses on issues related to the general health of the citizenry. Subnational entities, such as states, counties and cities, often also operate a health department of their own. Health departments perform food inspections and other health related inspections (the person who performs this job is often called a public health inspector), vaccination programs, free STD and HIV tests, tobacco enforcement and cessation programs, and other medical assistance programs. Health departments also compile statistics about health issues within their area. The role of a health department may vary from one country to the other, but their primary objective is always the same; safeguarding and promoting health. In 1986, several of the world's national health departments met to establish an international guideline by which health departments operate. The meeting was in Ottawa, Ontario, Canada, and hence the guidelines establi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medicines Act 1968
The Medicines Act 1968 (c. 67) is an act of Parliament of the United Kingdom. Its official long title is "An Act to make new provision with respect to medicinal products and related matters, and for purposes connected therewith." It governs the control of medicines for human use and for veterinary use, which includes the manufacture and supply of medicines, and the manufacture and supply of (medicated) animal feeding stuffs. The act defines three categories of medicine: prescription only medicines (POM), which are available only from a pharmacist if prescribed by an appropriate practitioner (including, but not limited to doctors, dentists, optometrists, prescribing pharmacists and nurses); pharmacy medicines (P), available only from a pharmacist but without a prescription; and general sales list (GSL) medicines which may be bought from any shop without a prescription. The act controls supply of the drugs it covers, but does not define any offence of simple possession. P ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Commission On Human Medicines
The Commission on Human Medicines (CHM) is a committee of the UK's Medicines and Healthcare products Regulatory Agency. It was formed in October 2005, and assumed the responsibilities of the Medicines Commission and the Committee on Safety of Medicines. Membership in this various and extensive body is listed oa governmental website The CHM's responsibilities include advising the UK government ministers on matters relating to regulation of human medicinal products, giving advice in relation to the safety, quality and efficacy of human medicinal products, and promoting the collection and investigation of information relating to adverse reactions for human medicines. Background to the establishment The Medicines and Healthcare products Regulatory Agency undertook a public consultation on proposals to amend the advisory body structure laid down in the Medicines Act 1968 in February 2005. Ministers agreed to a new structure with the establishment of the Commission that amalgamated t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
William Asscher
Sir Adolf William Asscher (1930 – 20 July 2014) was a Dutch-born British consultant nephrologist. Asscher was born in the Netherlands. His family was of Jewish heritage; they were thus deported to Westerbork transit camp, from where his mother secured their release in 1943 by fabricating claims to be of English descent, helped in part by her son's blond hair. The family left the Netherlands in 1947, when his father obtained a position with Shell in London. After national service in the Royal Engineers, he studied medicine at the University of London. He rose to be Professor of Medicine at the University of Cardiff from 1976 to 1987 and Director of the Institute of Nephrology there from 1970 to 1987. He was appointed Dean of St George's Hospital Medical School in 1988, subsequently becoming its Principal until his retirement in 1996. He chaired the United Kingdom Department of Health's Committee on the Review of Medicines from 1985 to 1987 and its successor, the Committee on ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Committee On The Review Of Medicines
A committee or commission is a body of one or more persons subordinate to a deliberative assembly or other form of organization. A committee may not itself be considered to be a form of assembly or a decision-making body. Usually, an assembly or organization sends matters to a committee as a way to explore them more fully than would be possible if the whole assembly or organization were considering them. Committees may have different functions and their types of work differ depending on the type of organization and its needs. A member of a legislature may be delegated a committee assignment, which gives them the right to serve on a certain committee. Purpose A deliberative assembly or other organization may form a committee (or "commission") consisting of one or more persons to assist with the work of the assembly. For larger organizations, much work is done in committees. They can be a way to formally draw together people of relevant expertise from different parts of an organi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Michael Rawlins
Sir Michael David Rawlins (28 March 1941 – 1 January 2023) was a British clinical pharmacologist and emeritus professor at the University of Newcastle upon Tyne. During his medical career he chaired several executive agencies including the Committee on Safety of Medicines from 1993 to 1998, followed by the National Institute for Health and Care Excellence (NICE) for 14 years from its formation in 1999 and then the Medicines and Healthcare products Regulatory Agency (MHRA) for six years from 2014. From 2012 to 2014 he was president of the Royal Society of Medicine. Rawlins delivered several eponymous lectures during his medical career including the 2008 Harveian Oration at the Royal College of Physicians (RCP), where he argued that there were other ways of collecting useful clinical evidence other than only randomised controlled trials and he encouraged a range of methods to provide a more holistic evaluation. For his contributions to protecting people from the side-effects ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medicines And Healthcare Products Regulatory Agency
The Medicines and Healthcare products Regulatory Agency (MHRA) is an executive agency of the Department of Health and Social Care in the United Kingdom which is responsible for ensuring that medicines and medical devices work and are acceptably safe. The MHRA was formed in 2003 with the merger of the Medicines Control Agency (MCA) and the Medical Devices Agency (MDA). In April 2013, it merged with the National Institute for Biological Standards and Control (NIBSC) and was rebranded, with the MHRA identity being used solely for the regulatory centre within the group. The agency employs more than 1,200 people in London, York and South Mimms, Hertfordshire. Structure The MHRA is divided into three main centres: * MHRA Regulatory – the regulator for the pharmaceutical and medical devices industries * Clinical Practice Research Datalink – licences anonymised health care data to pharmaceutical companies, academics and other regulators for research * National Institute for ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
