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Combination Antihypertensive Drugs
In mathematics, a combination is a selection of items from a set that has distinct members, such that the order of selection does not matter (unlike permutations). For example, given three fruits, say an apple, an orange and a pear, there are three combinations of two that can be drawn from this set: an apple and a pear; an apple and an orange; or a pear and an orange. More formally, a ''k''-combination of a set ''S'' is a subset of ''k'' distinct elements of ''S''. So, two combinations are identical if and only if each combination has the same members. (The arrangement of the members in each set does not matter.) If the set has ''n'' elements, the number of ''k''-combinations, denoted as C^n_k, is equal to the binomial coefficient \binom nk = \frac, which can be written using factorials as \textstyle\frac whenever k\leq n, and which is zero when k>n. This formula can be derived from the fact that each ''k''-combination of a set ''S'' of ''n'' members has k! permutations so P^n ...
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Mathematics
Mathematics is an area of knowledge that includes the topics of numbers, formulas and related structures, shapes and the spaces in which they are contained, and quantities and their changes. These topics are represented in modern mathematics with the major subdisciplines of number theory, algebra, geometry, and analysis, respectively. There is no general consensus among mathematicians about a common definition for their academic discipline. Most mathematical activity involves the discovery of properties of abstract objects and the use of pure reason to prove them. These objects consist of either abstractions from nature orin modern mathematicsentities that are stipulated to have certain properties, called axioms. A ''proof'' consists of a succession of applications of deductive rules to already established results. These results include previously proved theorems, axioms, andin case of abstraction from naturesome basic properties that are considered true starting points of ...
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Combinatorial Number System
In mathematics, and in particular in combinatorics, the combinatorial number system of degree ''k'' (for some positive integer ''k''), also referred to as combinadics, or the Macaulay representation of an integer, is a correspondence between natural numbers (taken to include 0) ''N'' and ''k''-combinations. The combinations are represented as strictly decreasing sequences ''c''''k'' > ... > ''c''2 > ''c''1 ≥ 0 where each ''ci'' corresponds to the index of a chosen element in a given ''k''-combination. Distinct numbers correspond to distinct ''k''-combinations, and produce them in lexicographic order. The numbers less than \tbinom nk correspond to all of . The correspondence does not depend on the size ''n'' of the set that the ''k''-combinations are taken from, so it can be interpreted as a map from N to the ''k''-combinations taken from N; in this view the correspondence is a bijection. The number ''N'' corresponding to ...
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Block Design
In combinatorial mathematics, a block design is an incidence structure consisting of a set together with a family of subsets known as ''blocks'', chosen such that frequency of the elements satisfies certain conditions making the collection of blocks exhibit symmetry (balance). They have applications in many areas, including experimental design, finite geometry, physical chemistry, software testing, cryptography, and algebraic geometry. Without further specifications the term ''block design'' usually refers to a balanced incomplete block design (BIBD), specifically (and also synonymously) a 2-design, which has been the most intensely studied type historically due to its application in the design of experiments. Its generalization is known as a t-design. Overview A design is said to be ''balanced'' (up to ''t'') if all ''t''-subsets of the original set occur in equally many (i.e., ''λ'') blocks. When ''t'' is unspecified, it can usually be assumed to be 2, which means that ea ...
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Combinatorics
Combinatorics is an area of mathematics primarily concerned with counting, both as a means and an end in obtaining results, and certain properties of finite structures. It is closely related to many other areas of mathematics and has many applications ranging from logic to statistical physics and from evolutionary biology to computer science. Combinatorics is well known for the breadth of the problems it tackles. Combinatorial problems arise in many areas of pure mathematics, notably in algebra, probability theory, topology, and geometry, as well as in its many application areas. Many combinatorial questions have historically been considered in isolation, giving an ''ad hoc'' solution to a problem arising in some mathematical context. In the later twentieth century, however, powerful and general theoretical methods were developed, making combinatorics into an independent branch of mathematics in its own right. One of the oldest and most accessible parts of combinatorics is gra ...
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Multinomial Theorem
In mathematics, the multinomial theorem describes how to expand a power of a sum in terms of powers of the terms in that sum. It is the generalization of the binomial theorem from binomials to multinomials. Theorem For any positive integer and any non-negative integer , the multinomial formula describes how a sum with terms expands when raised to an arbitrary power : :(x_1 + x_2 + \cdots + x_m)^n = \sum_ \prod_^m x_t^\,, where : = \frac is a multinomial coefficient. The sum is taken over all combinations of nonnegative integer indices through such that the sum of all is . That is, for each term in the expansion, the exponents of the must add up to . Also, as with the binomial theorem, quantities of the form that appear are taken to equal 1 ( even when equals zero). In the case , this statement reduces to that of the binomial theorem. Example The third power of the trinomial is given by :(a+b+c)^3 = a^3 + b^3 + c^3 + 3 a^2 b + 3 a^2 c + 3 b^2 a + 3 b^2 c + ...
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Reservoir Sampling
Reservoir sampling is a family of randomized algorithms for choosing a simple random sample, without replacement, of items from a population of unknown size in a single pass over the items. The size of the population is not known to the algorithm and is typically too large for all items to fit into main memory. The population is revealed to the algorithm over time, and the algorithm cannot look back at previous items. At any point, the current state of the algorithm must permit extraction of a simple random sample without replacement of size over the part of the population seen so far. Motivation Suppose we see a sequence of items, one at a time. We want to keep ten items in memory, and we want them to be selected at random from the sequence. If we know the total number of items and can access the items arbitrarily, then the solution is easy: select 10 distinct indices between 1 and with equal probability, and keep the -th elements. The problem is that we do not always k ...
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Rejection Sampling
In numerical analysis and computational statistics, rejection sampling is a basic technique used to generate observations from a distribution. It is also commonly called the acceptance-rejection method or "accept-reject algorithm" and is a type of exact simulation method. The method works for any distribution in \mathbb^m with a density. Rejection sampling is based on the observation that to sample a random variable in one dimension, one can perform a uniformly random sampling of the two-dimensional Cartesian graph, and keep the samples in the region under the graph of its density function. Note that this property can be extended to ''N''-dimension functions. Description To visualize the motivation behind rejection sampling, imagine graphing the density function of a random variable onto a large rectangular board and throwing darts at it. Assume that the darts are uniformly distributed around the board. Now remove all of the darts that are outside the area under the curve. The rem ...
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Algorithms
In mathematics and computer science, an algorithm () is a finite sequence of rigorous instructions, typically used to solve a class of specific problems or to perform a computation. Algorithms are used as specifications for performing calculations and data processing. More advanced algorithms can perform automated deductions (referred to as automated reasoning) and use mathematical and logical tests to divert the code execution through various routes (referred to as automated decision-making). Using human characteristics as descriptors of machines in metaphorical ways was already practiced by Alan Turing with terms such as "memory", "search" and "stimulus". In contrast, a heuristic is an approach to problem solving that may not be fully specified or may not guarantee correct or optimal results, especially in problem domains where there is no well-defined correct or optimal result. As an effective method, an algorithm can be expressed within a finite amount of space and ...
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Empty Set
In mathematics, the empty set is the unique set having no elements; its size or cardinality (count of elements in a set) is zero. Some axiomatic set theories ensure that the empty set exists by including an axiom of empty set, while in other theories, its existence can be deduced. Many possible properties of sets are vacuously true for the empty set. Any set other than the empty set is called non-empty. In some textbooks and popularizations, the empty set is referred to as the "null set". However, null set is a distinct notion within the context of measure theory, in which it describes a set of measure zero (which is not necessarily empty). The empty set may also be called the void set. Notation Common notations for the empty set include "", "\emptyset", and "∅". The latter two symbols were introduced by the Bourbaki group (specifically André Weil) in 1939, inspired by the letter Ø in the Danish and Norwegian alphabets. In the past, "0" was occasionally used as a ...
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Subsets
In mathematics, set ''A'' is a subset of a set ''B'' if all elements of ''A'' are also elements of ''B''; ''B'' is then a superset of ''A''. It is possible for ''A'' and ''B'' to be equal; if they are unequal, then ''A'' is a proper subset of ''B''. The relationship of one set being a subset of another is called inclusion (or sometimes containment). ''A'' is a subset of ''B'' may also be expressed as ''B'' includes (or contains) ''A'' or ''A'' is included (or contained) in ''B''. A ''k''-subset is a subset with ''k'' elements. The subset relation defines a partial order on sets. In fact, the subsets of a given set form a Boolean algebra under the subset relation, in which the join and meet are given by intersection and union, and the subset relation itself is the Boolean inclusion relation. Definition If ''A'' and ''B'' are sets and every element of ''A'' is also an element of ''B'', then: :*''A'' is a subset of ''B'', denoted by A \subseteq B, or equivalently, :* ''B'' is ...
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Binomial Coefficient
In mathematics, the binomial coefficients are the positive integers that occur as coefficients in the binomial theorem. Commonly, a binomial coefficient is indexed by a pair of integers and is written \tbinom. It is the coefficient of the term in the polynomial expansion of the binomial power ; this coefficient can be computed by the multiplicative formula :\binom nk = \frac, which using factorial notation can be compactly expressed as :\binom = \frac. For example, the fourth power of is :\begin (1 + x)^4 &= \tbinom x^0 + \tbinom x^1 + \tbinom x^2 + \tbinom x^3 + \tbinom x^4 \\ &= 1 + 4x + 6 x^2 + 4x^3 + x^4, \end and the binomial coefficient \tbinom =\tfrac = \tfrac = 6 is the coefficient of the term. Arranging the numbers \tbinom, \tbinom, \ldots, \tbinom in successive rows for n=0,1,2,\ldots gives a triangular array called Pascal's triangle, satisfying the recurrence relation :\binom = \binom + \binom. The binomial coefficients occur in many areas of mathematics, a ...
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